양극성 장애 환자에서 한국어판 Bipolar Spectrum Diagnostic Scale의 타당성 연구

왕희령,김상억,강시현,주연호,김창윤 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.6

본 연구는 한국어판 BSDS의 민감도와 특이도, 최적의 절단값을 조사하기 위해 시행되었다. SCID를 사용하여 DSM-IV에 의거하여 진단된 양극성 장애 및 주요우울장애 환자들을 대상으로 본 연구를 시행하였고, 가장 적절한 절단값은 10점, 이 때의 특이도, 민감도는 각각 0.85, 0.73 수준으로 나왔다. 본 연구 결과를 통해, 한국어판 BSDS는 양극성 장애에 선별에 있어서 높은 민감도와 특이도를 지닌 타당성 있는 자가보고형 선별도구임이 밝혀졌다. Objectives : Because bipolar spectrum disorders frequently go unrecognized in clinical practice, sensitive screening tools for bipolar spectrum disorders are much needed. This study was conducted to confirm the validity of the Korean version of the Bipolar Spectrum Diagnostic Scale (BSDS), which was originally designed by Ronald Pies. Methods : The BSDS, which was translated into Korean by the authors, was dministered to patients with known bipolar disorders (N=60) and unipolar depressive disorders (N=27). Using various cut-off scores, we calculated the sensitivities and specificities of the Korean version of the BSDS in order to determine the optimal cut-off score. Results : In this study,a cut-off score of 10 was shown to be optima1, with a sensitivity of 0.73 and a specificity of 0.85, although a cut-off score of 13 was proposed to be optima1 by the original authors of the BSDS. Conclusion : These results indicate that the Korean version of the BSDS is a valid screening tool for bipolar spectrum disorder.

강원지역 태권도 대중화를 위한 태권도 민간시설 운영 실태에 관한 연구

나윤수,김희철,김륭희 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

The question survey on the realities of the T'aekwondo facilities under private management result in a quarter tendency respond to better the male teacher than schoolmistress. After all, for popularization, the policy make an incentive offer to the male teacher better than schoolmistress consider, therefore ratio of female and male teacher is equal. The survey about type of facilities occupies an entire private management and the T'aekwondo facilities rely on private management because corporate, public and office facilities are not nearly. So, urgent questionsan make use of auxiliary organ of a university and public, office facilities. An aspect of facilities and equipment, significance test for the location depend on province and district result in somewhat discrepancy. That is, duty time of teacher depend on province better than district is somewhat much. T'aekwondo facilities and conditions for the location depend on province and district is somewhat discrepancy, but income of a month is no discrepancy. The period of duty better than other conditions an effect influence on income of a month. The most T'aekwondo teacher work on average 9 hours a day(about 46 %) and average duty period is between 2 and 3 year, if average duty period more than 4 years, tendency to workshop change or convert other types of business. therefore event is made from setting up concept of his whole workshop. The net payment, income of a month, most of teacher is between \1,000,000 and \1,200,000 , high frequency and the low income bracket better than other the kind of occupation. So, the system about payment based on ability and result, a bonus become established

브랜드 시각 아이덴티티를 이용한 프로스포츠구단의 브랜드 전략에 관한 연구

김숙자,김륭희,나윤수 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.2

Today, with the 21 century just around the conner, people and companies all over the world are concerned about how to make and manage a intangible asset named "brand". A brand is not a name of a product any more, but one of the most important elements of the field of image management and its successful strategy, which companies would use to obtain the competitive ascendancy. Especially, brand "Visual Identity" has an unification of different brands from one company( sports team) or differentiation of the brands for establishing its brand image. When a product design meets expectation of customers and the visual element of its unified image makes the product different showing special qualities of the product. A tendency of consumption of the professional sports is to bring its image(services) forward rather than it functional aspects, we need to have a new understanding of the symbol, emblem, character and color of a professional sports team. The professional sports team can win over customer(fan) unless they have to distinguish from other teams by their's own emblem, character and color. Also they make the best use of these visual factors, they strengthen the customer's(fan's) unity. In conclusion, professional sports teams are trying to communicate to their fans' the needs of the times with a consistent policy about brand visual identity. Thus each professional team must make strategy about the brand image, investigate, analyze and apply various customer needs(experiences) to business when developing brand.

H. pylori 제균으로 완전 관해된 위의 고도 MALT 림프종 1예 : a case report

황창연,류민희,강윤구,김태원,장흥문,엄대운,허주령 대한내과학회 2004 대한내과학회지 Vol.66 No.1

위의 저도 MALT 림프종은 H. pylori 제균 후에 60∼90%가 관해를 보이는 것으로 알려져 있으나 고도 MALT 림프종은 H. pylori 제균 만으로는 치료가 부족한 것으로 알려져 있다. 그러나 최근에 위의 고도 MALT 림프종에서도 H. pylori 제균 치료를 통해 관해에 이른 사례들이 보고 되었고, 저자들도 고도 MALT 림프종 환자에서 H. pylori 제균 치료를 통하여 내시경적 및 조직학적 완전 관해에 도달한 증례를 경험하여 이를 보고하는 바이다. Low grade MALT lymphoma of stomach is associated with H. pylori infection in more than 90% of cases, and eradication of H. pylori leads to regression of the low grade MALT lymphoma in 60∼90% of cases. On the contrary, high grade MALT lymphoma is thought to be independent from H. pylori for growth and usually is thought to require antitumor chemotherapy. However, there have been recent reports of high grade MALT lymphoma regressing after H. pylori eradication. We experienced and are reporting a case of high grade MALT lymphoma arising in the background of low grade MALT lymphoma that showed complete regression after H. pylori eradication.

관중의 관여도 수준에 따른 경기장 시설 및 서비스 만족에 관한 연구

김숙자,김륭희,나윤수 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.2

The purpose of this study was to assess the satisfaction of stadium physical environments among groups of spectators' involvement level. Stadium physical environmental factors evaluated in this study were ticketing system, parking area, restroom, signage, customer service, accessibility, convenience of using accommodation and comfort seating & layout accessibility. Spectators were divided into three involvement groups(Low-level, Medium-level, High-level) based on their level of frequency of spectators' visiting. Rresults showed that spectator who had different level of involvement satisfied the stadium physical environments differently. That is, spectator who has High- involvement level satisfied the stadium physical environments more positively compare to spectator who has low- and medium involvement level.Ⅰ

중추신경자극제를 사용할 수 없는 주의력결핍과잉행동장애 아동에서의 Modafinil 효과 : 예비 연구

유한익,김진용,박수진,전정원,왕희령,김붕년,홍진표,김성윤,김창윤 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.6

Objectives : This study was aimed to examine the efficacy and safety of modafinil in psychostimulant-inapplicable children with attention deficit hyperactivity disorder (ADHD) due to insufficient treatment response or intolerable adverse effects. Methods : Fifteen children (8.8±1.8 years, 14 boys, total IQ 107.22±13.4) were recruited for this study. ADHD was confirmed by K-SADS-PL. The efficacy was assessed by ADHD rating scale (ADHDRS), Conner's parental rating scale-revised(CPRS-R), ADHDRS school version, clinical global impression (CGI) and computerized neurocognitive function test. Mean dose of modafnil was 250. 0±103.3 mg. Results : Total score (p=0.012) and hyperactive/impulsive score (p=0.021) of ADHDRS for investigator, as well as CPRS-R score (p<0.01) and CGI-severity score (p<0.01) were significantly reduced after 39.2±8.7 days of modafmil administration. Response time of word color test was also significantly decreased after medication. Decreased appetite (2 subjects), insomnia (2 subjects), irritability (1 subject) and alopecia (1 subject) were observed during this study period. Conclusion : Modafinil was effective and well-tolerated for the psychostimulant-inapplicable children with ADHD.

Treatment with Nucleos(t)ide Analogues from HBeAg-Positive Hepatitis Phase is Associated with Lower Risk of Hepatocellular Carcinoma Development than from HBeAg-Negative Hepatitis Phase: A Multicenter Study Involving 10,390 Patients

( Hee Joon Jang ),( Jun Sik Yoon ),( Hwi Young Kim ),( Han Ah Lee ),( Jonggi Choi ),( Seung Up Kim ),( Young-suk Lim ),( Soo Young Park ),( Yeon Seok Seo ),( Na Ryung Choi ),( Minseok Albert Kim ),( H 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Recent studies indicate that the integration of hepatitis B virus (HBV) into host genome, which may directly develop hepatocellular carcinoma (HCC), occurs during HBV e antigen (HBeAg)-positive phase of chronic hepatitis B (CHB). However, it remains still unclear that an early antiviral treatment from HBeAg-positive hepatitis phase can reduce the risk of HCC more profoundly than antivirals from HBeAg-negative hepatitis. This study aimed to investigate the association between HBeAg-positivity and HCC risk in CHB patients who achieved viral suppression using nucleos(t)ide analogues (NAs). Methods: We performed a multicenter study involving 10,390 CHB patients who achieved viral suppression (HBV DNA <2,000 IU/mL) using tenofovir or entecavir from 6 hospitals in Korea from January 2008 to December 2018. The primary endpoint was development of HCC. Death or liver transplantation before HCC development were considered as competing risk events. Index date was set at the first time of viral suppression in each patient. We draw Kaplan-Meier (KM) curves before and after balancing baseline characteristics by inverse probability of treatment weighting (IPTW) according to HBeAg status. Cox regression analyses were performed to find independent predictors of HCC. Analyses were performed in the entire study population, as well as in the two subgroups stratified by the presence of liver cirrhosis (LC). Results: Of the 10,390 patients (median age, 50.9 years; male, 53.7%), 5,094 were HBeAg-positive and 5,296 were HBeAg-negative. During 4.8 years of median follow-up, 1,040 patients (10%) developed HCC: 423 (8.3%) were HBeAg-positive and 617 (11.7%) were HBeAg-negative (modified log-rank test P<0.001; Figure 1A). After adjusting baseline characteristics such as age and presence of LC using IPTW analysis, however, HBeAg status was not associated with HCC risk (modified logrank test P=0.93; Figure 1A). In the non-LC subgroup (n=5,957), HBeAg-positive patients showed a lower rate of HCC development than HBeAg-negative patients before and after IPTW adjustment (both modified log-rank P<0.001; Figure 1B). In the LC subgroup (n=4,433), however, HBeAg-positive patients showed a higher rate of HCC development than HBeAg-negative patients before and after IPTW adjustment (modified logrank P=0.004 for unadjusted KM curves; modified log-rank P=0.009 for adjusted KM curves; Figure 1C). In a multivariable analysis of the entire population, HBeAg-positivity was not an independent predictor of HCC (adjusted hazard ratio [aHR], 0.95; 95% confidence interval [CI], 0.84-1.08; P=0.50) after adjusting variables such as age and presence of LC. In the non- LC subgroup, however, HBeAg-positivity was associated with a significantly lower risk of HCC (aHR, 0.54; 95% CI, 0.42-0.70; P<0.001). In contrast, in the LC subgroup, HBeAg-positivity was associated with a higher risk of HCC (aHR, 1.20; 95% CI, 1.04-1.39; P=0.02). Conclusions: HBeAg status was not an independent predictor of HCC development in the overall CHB patients. In non-cirrhotic CHB patients, however, an earlier treatment with NAs from HBeAg-positive hepatitis phase is associated with a lower risk of HCC occurrence than from HBeAg-negative hepatitis phase. This result supports that an earlier antiviral treatment from HBeAg-positive CHB patients without LC might reduce the risk of HCC more profoundly.

Expression of the antioxidant response and autophagy markers in patients with vitiligo: An immunohistochemical study

( Ryung Kwon ),( Tae Heum Park ),( Hee Jung Yoon ),( Dong Sung Kim ),( Euy Hyun Chung ),( Sung Yul Lee ),( Sang Hoon Lee ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.73 No.1

Involvement of Extracellular Signal-Regulated Kinase in Nobiletin-Induced Melanogenesis in Murine B16/F10 Melanoma Cells

YOON, Hoon-Seok,LEE, Sun-Ryung,KO, Hee-Chul,CHOI, Soo-Youn,PARK, Ji-Gweon,KIM, Jeong-Kook,KIM, Se-Jae Japan Society for Bioscience, Biotechnology, and A 2007 Bioscience, Biotechnology, and Biochemistry Vol.71 No.7

<P>Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.</P>

MethA Fibrosarcoma Cells Expressing Membrane-Bound Forms of IL-2 Enhance Antitumor Immunity

( Chung Hee Sonn ),( Hee Ryung Yoon ),( In Ock Seong ),( Mi Ra Chang ),( Yong Chan Kim ),( Han Chul Kang ),( Seok Cheol Suh ),( Young Sang Kim ) 한국미생물생명공학회 2006 Journal of microbiology and biotechnology Vol.16 No.12