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팽이버섯의 저장기간 연장을 위한 1-methylcyclopropene(MCP) 처리 효과
이희범,이웅수 忠州大學校 2011 한국교통대학교 논문집 Vol.46 No.-
To verify the possibility of applying the new storage technology of 1-methylcyclopropene(1-MCP) treatments, we investigated the export simulated transport conditions; two path ways of local distribution for the 7 days separately at 8 ℃ and 20 ℃ after three weeks in the reefer container by sea in a set of 0 ℃ temperature. The quality of Enoki mushroom by 1-MCP treatment with various vacuum packaging films was compared with those of the normal packaging. Each group's visual quality change in particular was not observed during the period of 3 weeks marine transport, but as for two routes of the simulated overland cold storage distribution under 8 ℃ and 20 ℃ for 7 days, the 1-MCP treated group showed much better results than the control group in overall evaluations. It was observed that the off-flavor of 1-MCP treatments was lower, or relatively milder, than the control bags under heat stress conditions and its overall appearance rating was excellent. If we verify the optimal concentrations for 1-MCP treatment on Enoki mushroom in the future, its long-term export transportation will be able to be established as a new storage technology.
Thermal-structural Coupled Field Analysis for Fire Safety Type Ball Valve
김시범(Si-Pom Kim),이준호(Joon-Ho Lee),이권희(Kwon-Hee Lee),전락원(Rock-Won Jeon),도태완(Tae-Wan Do) 한국기계가공학회 2011 한국기계가공학회지 Vol.10 No.3
The safety of transporting equipment in a cryogenic condition is one of important problems under the circumstances that the application weight of natural gas is gradually increasing. As a larger disaster may be generated by leakage of oil or gas from valves in case of fire occurrence of a ship, the present research applied a numerical analysis method on thermal stress distribution and deformation, etc. to the design of ball valves satisfying fire safety test’s specification(API607) to prevent this. In addition, the present research progressed fire safety tests and compared the test result with numerical analysis results. The Max stress by parts was confirmed through thermal analysis of major parts to evaluate safety. The fire safety test was progressed according to the regulation of API607.
( Ung Soo Lee ),( Jung Ok Ban ),( Eung Tae Yeon ),( Hee Pom Lee ),( Venkatareddy Udumula ),( Young Wan Ham ),( Jin Tae Hong ) 한국응용약물학회 2012 Biomolecules & Therapeutics(구 응용약물학회지) Vol.20 No.6
The Maillard Reaction Products (MRPs) are chemical compounds which have been known to be effective in chemoprevention. Death receptors (DR) play a central role in directing apoptosis in several cancer cells. In our previous study, we demonstrated that (E)-2,4-bis(p-hydroxyphenyl)-2-butenal, a MRP product, inhibited human colon cancer cell growth by inducing apoptosis via nucle-ar factor-κB (NF-κB) inactivation and G2/M phase cell cycle arrest. In this study, (E)-2,4-bis(p-hydroxyphenyl)-2-butenal diacetate, a new (E)-2,4-bis(p-hydroxyphenyl)-2-butenal derivative, was synthesized to improve their solubility and stability in water and then evaluated against NCI-H460 and A549 human lung cancer cells. (E)-2,4-bis(p-hydroxyphenyl)-2-butenal diacetate reduced the viability in both cell lines in a time and dose-dependent manner. We also found that (E)-2,4-bis(p-hydroxyphenyl)-2-butenal diacetate increased apoptotic cell death through the upregulation of the expression of death receptor (DR)-3 and DR6 in both lung cancer cell lines. In addition to this, the transfection of DR3 siRNA diminished the growth inhibitory and apoptosis inducing effect of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal diacetate on lung cancer cells, however these effects of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal diacetate was not changed by DR6 siRNA. These results indicated that (E)-2,4-bis(p-hydroxyphenyl)-2-butenal diacetate inhibits human lung cancer cell growth via increasing apoptotic cell death by upregulation of the expression of DR3.
( Chul Ju Hwang ),( Hee Pom Lee ),( Dong Young Choi ),( Heon Sang Jeong ),( Tae Hoon Kim ),( Tae Hyung Lee ),( Young Min Kim ),( Dae Bong Moon ),( Sung Sik Park ),( Sun Young Kim ),( Ki Wan Oh ),( Dae 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
Neuroinflammation is implicated for dopaminergic neurodegeneration. Sulfur compounds extracted from garlic have been shown to have anti-inflammatory properties. Previously, we have investigated that thiacremonone, a sulfur compound isolated from garlic has anti-inflammatory effects on several inflammatory disease models. To investigate the protective effect of thiacremonone against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced behavioral impairment and dopaminergic neurodegeneration, 8 week old ICR mice were given thiacremonone (10 mg/kg) in drinking water for 1 month and received intraperitoneal injection of MPTP (15 mg/kg, four times with 2 h interval) during the last 7 days of treatment. Our data showed that thiacremonone decreased MPTP-induced behavioral impairments (Rotarod test, Pole test, and Gait test), dopamine depletion and microglia and astrocytes activations as well as neuroinflammation. Higher activation of p38 was found in the substantia nigra and striatum after MPTP injection, but p38 activation was reduced in thiacremonone treated group. In an in vitro study, thiacremonone (1, 2, and 5 μg/ml) effectively decreased MPP+ (0.5 mm)-induced glial activation, inflammatory mediators generation and dopaminergic neurodegeneration in cultured astrocytes and microglial BV-2 cells. Moreover, treatment of p38 MAPK inhibitor SB203580 (10 μM) further inhibited thiacremonone induced reduction of neurodegeneration and neuroinflammation. These results indicated that the anti-inflammatory compound, thiacremonone, inhibited neuroinflammation and dopaminergic neurodegeneration through inhibition of p38 activation.
Piperlongumine Improves Lipopolysaccharide-Induced Amyloidogenesis by Suppressing NF-KappaB Pathway
Gu, Sun Mi,Lee, Hee Pom,Ham, Young Wan,Son, Dong Ju,Kim, Hoi Yeong,Oh, Ki Wan,Han, Sang-Bae,Yun, Jaesuk,Hong, Jin Tae Springer US 2018 Neuromolecular medicine Vol.20 No.3
<P>Amyloidogenesis is known to cause Alzheimer’s disease. Our previous studies have found that lipopolysaccharide (LPS) causes neuroinflammation and amyloidogenesis through activation of nuclear factor kappaB (NF-κB). Piperlongumine (PL) is an alkaloid amide found naturally in long pepper (<I>Piper longum</I>) isolates; it was reported to have inhibitory effects on NF-κB activity. We therefore investigated whether PL exhibits anti-inflammatory and anti-amyloidogenic effects by inhibiting NF-κB. A murine model of LPS-induced memory impairment was made via the intraperitoneal (i.p.) injection of LPS (0.25 mg/kg/day, i.p.). We then injected PL (1.5 or 3.0 mg/kg/day, i.p.) for 7 days in three groups of mice to observe effects on memory. We also conducted an in vitro study with astrocytes and microglial BV-2 cells, which were treated with LPS (1 µg/mL) or PL (0.5 or 1.0 or 2.5 µM). Results from our behavioral tests showed that PL inhibited LPS-induced memory. PL also prevented LPS-induced beta-amyloid (Aβ) accumulation and inhibited the activities of β- and γ-secretases. The expression of inflammatory proteins also was decreased in PL-treated mice, cultured BV-2, and primary astrocyte cells. These effects were associated with the inhibition of NF-κB activity. A docking model analysis and pull-down assay showed that PL binds to p50. Taken together, our findings suggest that PL diminishes LPS-induced amyloidogenesis and neuroinflammation by inhibiting NF-κB signaling; PL therefore demonstrates potential for the treatment of Alzheimer’s disease.</P>
이기준(Kee-Joon Lee),조영수(Young-Soo Cho),김시범(Si-Pom Kim),이권희(Kwon-Hee Lee) 한국기계가공학회 2010 한국기계가공학회지 Vol.9 No.6
For orthodontic treatment, most commonly, an archwire is inserted into orthodontic brackets that can be made from stainless steel. Then, the archwires interact with the brackets to move teeth into the desired positions. However, the activation of an archwire may induce undesirable rotation of a tooth due to the moment application. An appropriate magnitude of the gable bends of an archwires prevents its rotation. However, it is not easy to predict the relationship between the rotation and the gable bend. This study presents the numerical approach to predict the rotation of a tooth with respect to the gable bend in the activation of an archwire. To predict the rotation of a tooth, the kriging interpolation method is introduced.