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정준민,서광석,이영은,한희정,한진희,김혜정,신터전,김현정,염광원,장주혜,Chung, Jun-Min,Seo, Kwang-Suk,Yi, Young-Eun,Han, Hee-Jung,Han, Jin-Hee,Kim, Hye-Jung,Shin, Teo-Jeon,Kim, Hyun-Jeong,Yum, Kwang-Won,Chang, Ju-He 대한치과마취과학회 2008 Journal of Dental Anesthesia and Pain Medicine Vol.8 No.1
Background: Cerebral palsy (CP) is non-progressive disorder of motion and posture. In CP patient, there are difficulties in dental treatment because of uncontrolled movement of limb and head, and conjoined disabilities such as cognitive impairment, sensory loss, seizures, communication and behavioral disturbances. It is reported that CP patients have high incidence in caries and a higher prevalence of periodontal disease. But, despite the need for oro-dental care, these patients often are unlikely to receive adequate treatment without sedation or general anesthesia because of uncontrolled movements of the trunk or head. Methods: We reviewed the 58 cases of 56 patients with CP who underwent outpatient general anesthesia for dental treatment at the clinic for the disabled in Seoul National University Dental Hospital. Results: The mean age was 19 (2-54) years. The number of male patient was 40 and that of female was 18. They all had severe spastic cerebral palsy and 22 had sever mental retardation, 15 epilepsy, 8 organic brain disorder, 1 blindness, 2 deafness and cleft palate. For anesthesia induction, 14 cases was needed physical restriction who had sever mental retardation and cooperation difficulty, but 44 cases showed good or moderate cooperation. Drugs used for anesthesia induction were thiopental (37 cases), sevoflurane (14 cases), ketamine (3 cases ) and propofol (4 cases). All patients except one were done nasotracheal intubation for airway management and 4 cases were needed difficult airway management and 1 patient already had tracheostomy tube. Mean total anesthetic time was $174{\pm}56$ min and staying time at PACU was $88{\pm}39$ min. There was no death or long term hospitalization because of severe complications. Conclusion: If general anesthesia is needed, pertinent diagnostic tests and workup about anomaly, and appropriate anesthetic planning are essential for safety.
Hyun, Sun-Hee,Jeon, Tae-Won,Lee, Sang-Kyu,Kim, Chun-Hwa,Seo, Young-Min,Kim, Ju-Hyun,Jeong, He-Min,Kang, Mi-Jeong,Lee, Jae-Sung,Jeong, Tae-Cheon Korean Society of ToxicologyKorea Environmental Mu 2007 Toxicological Research Vol.23 No.4
Paecilomyces tenuipes (PT), one of the Ascomycetes family, has been used for medicinal purposes due to its broad pharmacological activities. The present study was undertaken to investigate the hepatoprotective effects of PT water extracts against $CCl_4$-induced hepatotoxicity in primary cultures of adult rat hepatocytes. When the extract of PT was directly added into the culture medium at 1, 2, and 5 mg/ml, the extracts not only reduce the $CCl_4$-induced elevation of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase, and lipid peroxide, but also protect cultured hepatocytes from $CCl_4$-induced reduction of reduced glutathione, glutathione reductase, glutathione-S-transferase, glutathione peroxidase, catalase and superoxide dismutase. In addition, the effects of PT water extracts on cytochrome P450 enzymes were relatively marginal, indicating that the hepatoprotective effects of PT extract against $CCl_4$-induced toxicity might not be due to the inhibition of $CCl_4$ activation. In conclusion, the PT extracts were effective in protecting against $CCl_4$ induced hepatotoxicity in hepatocyte cultures, at least in part, by scavenging free radicals, and by modulating enzyme systems involved in cellular oxidative stress.
Development of Neutaribeosut Varieties (Pleurotus ostreatus) Chongpung, Myongwol
He-duck Lee,Hong-kyu Kim,Young-gyun Kim,Kyu-heng Han,Kwang-ho Min,Tae-wo Jeong,Jae-jung Lee,Tae-sun Jeon,Duck-hwan Kim,Hun-sick Kim,Jong-ku Han 한국자원식물학회 2000 Plant Resources Vol.3 No.2
This study was carried out to find a useful mushroom at Chungnam Agricultural Research And Extention Service. Twenty materials used were collected from domestic and exotic area. These races were compared bontanical characteristics to leading varieties by PCR-RAPD methods. Mycelial growth temperature of Chongpung and Myongwol were at 20 to 250 and 25 to 30°C at PDA medium, respectively mycelial growth of these varieties were similiar at pH 6.5 to 7,5. In case of mushroom cultivation temperature ranges, Chongpung was at 5 to 26 and Myongwol was at 7 to 28C, but the optimum temperature range of these were appeared at 15 to 190. Culture temperature of these was 23°C and period of mycelial culture was needed 23 to 24 days under 850 cc/pp, while was needed 11 to 12 days at waste cotton medium. Cap color of these at first inducing mushroom was all dark blue, but at late growing stages Chongpung was shown as grey, and Myongwol was shown as dark grey. Yield of Chongpung was appeared as 46kg/3.3m and that of Myongwol was 41 kg /3.3m , while Chunchu No2 as check was 40 kg/3.3m. Results from PDA medium and PCR RAPD analysis two of these were different from others.
Min Yeong Kim,Eun Ok Choi,Hyun HwangBo,Da He Kwon,Kyu Im Ahn,Hong Jae Kim,Seon Yeong Ji,Su-Hyun Hong,Jin-Woo Jeong,Gi Young Kim,Cheol Park,Yung Hyun Choi 한국영양학회 2018 Nutrition Research and Practice Vol.12 No.2
BACKGROUND/OBJECTIVES: Although several recent studies have reported the anti-cancer effects of extracts or components of Citrus unshiu peel, which has been used for various purposes in traditional medicine, the molecular mechanisms for their effects remain unclear. In the present study, the anti-cancer activity of a water-soluble extract of C. unshiu peel (WECU) in MDA-MB-231 human breast carcinoma cells at the level of apoptosis induction was investigated. MATERIALS/METHODS: Cytotoxicity was evaluated using the MTT assay. Apoptosis was detected using DAPI staining and flow cytometry analyses. Mitochondrial membrane potential, reactive oxygen species (ROS) assay, caspase activity and Western blotting were used to confirm the basis of apoptosis. RESULTS: The results indicated that WECU-induced apoptosis was related to the activation of caspase-8, and -9, representative initiator caspases of extrinsic and intrinsic apoptosis pathways, respectively, and caspase-3 accompanied by proteolytic degradation of poly(ADP-ribose) polymerase and down-regulation of the inhibitors of apoptosis protein family members. WECU also increased the pro-apoptotic BAX to anti-apoptotic BCL-2 ratio, loss of mitochondrial membrane potential and cytochrome c release from mitochondria to cytoplasm. Furthermore, WECU provoked the generation of ROS, but the reduction of cell viability and induction of apoptosis by WECU were prevented when ROS production was blocked by antioxidant N-acetyl cysteine. CONCLUSIONS: These results suggest that WECU suppressed proliferation of MDA-MB-231 cells by activating extrinsic and intrinsic apoptosis pathways in a ROS-dependent manner.
Physiological Activities of the Neem and the Comfrey Extracts as Cosmetic Ingredients
Bok He Kang,Min Jeong Ryu 한국피부과학연구원 2021 아시안뷰티화장품학술지 Vol.19 No.2
목적: 천연소재에 대한 연구개발이 활발히 이루어지고 있는 상황에 님과 컴프리 추출물의 항산화, 항균 및 항진균 효능을 확인함 으로써 천연방부 및 화장품 원료로 활용 가능성을 확인하기 위하여 수행하였다. 방법: 님과 컴프리를 각각70% 주정에탄올로 추출 하여 시료로 사용하였다. 항산화 효과 및 피부관련 균에 대해 paper disc법을 사용하여 항균 및 항진균 효과를 확인 하였다. 결과: 님과 컴프리 추출물의 항산화 효과에서는 님과 컴프리 추출물 모두 효과가 높게 확인되었지만 그 중에서 컴프리 추출물이 님 추출 물 보다 총 폴리페놀과 플라보노이드 함량, DPPH와 ABTS 라디컬 소거능이 높게 확인되었으며, SOD 유사활성도 컴프리 추출물 이 높게 확인 되었다. 님과 컴프리 추출물의 피부와 관련된 S. epidermidis, S. aureus, P. acnes, C. xerosis, P. ovale, M. furfur, C. albicans, T. rubrum, T. mentagrophytes에 대한 항균 및 항진균 효과를 측정한 결과 5 mg/mL 농도에서 님 추출물은 9개 균 모두에서 clear zone을 관찰할 수 있었고, 특히 P. acnes, C. xerosis, T. mentagrophytes에서 각각 8, 7, 7 mm clear zone 확인할 수 있었다. 컴프리 추출물도 9개 균 모두에서 clear zone을 관찰할 수 있었고, 특히 P. acnes, C. xerosis, P. ovale, T. rubrum, T. mentagrophytes에서 각각 10, 8, 8. 10, 11 mm의 clear zone을 확인할 수 있었다. 이러한 결과 컴프리 추출물이 님 추출물에 비해 항균 및 항진균 효과가 더 높게 확인 되었으며, 미생물에 따라서 님과 컴프리 추출물 모두 P. acnes, C. xerosis, T. mentagrophytes 에 대한 항균력이 우수함을 보여준다. 결론: 님과 컴프리 추출물은 항산화 효과가 우수하였으며 피부와 관련 9개의 균에 대한 항균 및 항진균 효과가 우수함이 확인 되어 천연방부 및 화장품 원료로 유용하게 사용될 수 있을 것으로 사료된다. Purpose: Recently, research and development on natural materials are actively carried out. It was conducted to confirm the applicability of Neem and Comfrey extracts as natural preservatives and cosmetic ingredients by investigating their antioxidative, antibacterial, and antifungal activities. Methods: Both Neem and Comfrey were extracted with 70% ethyl alcohol as samples, respectively. Their antibacterial and antifungal activities for antioxidative effect and against skin-related bacteria were confirmed by the Paper Disc method. Results: Both extracts were found to be highly effective in antioxidative effects, but the Comfrey extract showed higher total polyphenols and flavonoid content, stronger scavenging capability of 1,1-Diphenyl-2-picryhydrazyl (DPPH) and 2,2'-azino-bis-3-ehtylbenzothiazoline-6- sulfonic acid (ABTS) radicals as well as more robust superoxide dismutase (SOD) like activities than the Neem extract did. After measuring antibacterial and antifungal effects by the Neem and the Comfrey extracts against Staphylococcus epidermidis (S. epidermidis ), Staphylococcus aureus (S. aureus ), Propionibacterium acnes (P. acnes ), Corynebacterium xerosis (C. xerosis ), Pityrosporum ovale (P. ovale ), Malassezia furfur (M. furfur ), Candida albicans (C. albicans ), Trichophyton rubrum (T. rubrum) and Trichophyton mentagrophytes (T. mentagrophytes ), which are related to the skin, it was confirmed that the Neem extract treatment showed clear zones in all 9 bacteria at 5 mg/mL concentration and particularly, 8, 7, and 7 mm clear zones were observed from P. acnes, C. xerosis and T. mentagrophytes , respectively. The Comfrey extract treatment also showed clear zones in all 9 bacteria. Especially, it showed 10, 8, 8, 10, and 11 mm clear zones from P. acnes , C. xerosis , P. ovale , T. rubrum and T. mentagrophytes . From these results, it was confirmed that the Comfrey extract had higher antibacterial and antifungal effects than the Neem extract had, and therefore, both the Neem and Comfrey extracts have excellent antibacterial effects against P. acnes , C. xerosis , and T. mentagrophytes among various bacteria. Conclusion: The Neem and the Comfrey extracts had great antioxidative effects as well as antibacterial and antifungal effects against 9 different skin-related bacteria. Therefore, they can be considered to be useful as natural preservatives and cosmetic ingredients.