http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Hayoung Choi ),( Yun Su Sim ),( Tae Rim Shin ),( Dong-gyu Kim ),( Dong Won Park ),( Tai Sun Park ),( Ji-yong Moon ),( Sang-heon Kim ),( Tae-hyung Kim ),( Jang Won Sohn ),( Ho Joo Yoon ),( Hyun Lee ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: The characteristics of bronchiectasis and its clinical implications in patients with previous pulmonary tuberculosis have not been well elucidated using a nationally representative database. Methods: We compared respiratory symptoms, comorbidities, lung function, quality of life, and socioeconomic status in post-tuberculosis subjects with bronchiectasis versus those without bronchiectasis participating in the Korean National Health and Nutritional Examination Survey 2007-2009. Results: The prevalence of bronchiectasis was 2.6% (n = 35) in the 1,352 subjects with previous pulmonary tuberculosis. Bronchiectasis subjects showed lower body mass index (BMI) (21.9 vs. 23.4 kg/m2, P = 0.002) and higher asthma rate (26.8% vs. 4.5%, P < 0.001) compared with those without bronchiectasis. There were no significant intergroup differences in age, lung function, respiratory symptoms, family income, and education. However, compared with subjects without bronchiectasis, bronchiectasis subjects showed lower EuroQoL five dimensions (EQ-5D) index (0.86 vs. 0.93, P = 0.010), which denotes the poor quality of life. Among EQ-5D components, there was a significant difference in the anxiety/depression component (38.5 vs. 12.1, P = 0.002) between two groups. Bronchiectasis subjects were associated with lower EQ-5D index (difference = 0.077, 95% confidence interval: 0.002-0.151), as compared with those without bronchiectasis, using multivariable linear regression with adjustment for demographic characteristics, BMI, education, and family income. Conclusion: The prevalence of bronchiectasis was 2.6% in the subjects with previous pulmonary tuberculosis. Post-tuberculosis subjects with bronchiectasis had higher asthma rate and reduced quality of life than those without bronchiectasis.
Hayoung Kim,Minhye Shin,Sangdon Ryu,Bohyun Yun,Sangnam Oh,Dong-Jun Park,Younghoon Kim 한국축산식품학회 2021 한국축산식품학회지 Vol.41 No.3
Dry aging is a traditional method that improves meat quality, and diverse microbial communities are changed during the process. Lactic acid bacteria (LAB) are widely present in fermented foods and has many beneficial effects, such as immune enhancement and maintenance of intestinal homeostasis. In this study, we conducted metagenomic analysis to evaluate the changes in the microbial composition of dry-aged beef. We found that lactic acid bacterial strains were abundant in dry-aged beef including Lactobacillus sakei and Enterococcus faecalis. We investigated their abilities in acid and bile tolerance, adhesion to the host, antibiotic resistance, and antimicrobial activity as potential probiotics, confirming that L. sakei and E. faecalis strains had remarkable capability as probiotics. The isolates from dry-aged beef showed at least 70% survival under acidic conditions in addition to an increase in the survival level under bile conditions. Antibiotic susceptibility and antibacterial activity assays further verified their effectiveness in inhibiting all pathogenic bacteria tested, and most of them had low resistance to antibiotics. Finally, we used the Caenorhabditis elegans model to confirm their life extension and influence on host resistance. In the model system, 12D26 and 20D48 strains had great abilities to extend the nematode lifespan and to improve host resistance, respectively. These results suggest the potential use of newly isolated LAB strains from dry-aged beef as probiotic candidates for production of fermented meat.
( Hayoung Choi ),( Hyun Lee ),( Yeon-mok Oh ),( Sei Won Lee ),( Yun Su Sim ),( Dong-gyu Kim ),( Hyun Kuk Kim ),( Jae Ha Lee ),( Seung Won Ra ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: Although respiratory infections, including tuberculosis, are the major cause of bronchiectasis in Asia, there is limited information on the clinical features of bronchiectasis patients with pulmonary tuberculosis (TB) history. Methods: We evaluated 436 bronchiectasis patients enrolled in the Korean Multicenter Bronchiectasis Audit and Research Collaboration (KMBARC) registry between August 2018 and July 2019. We compared respiratory symptoms, comorbidities, lung function, radiologic features, quality of life, exacerbations, and disease severity in bronchiectasis patients with TB history versus those without TB history. Results: Of the patients, 139 (31.9%) had TB history (51.8% [72/139] of whom was diagnosed with post-TB bronchiectasis). Bronchiectasis patients with TB history had lower body mass index (BMI) (22.4 vs. 23.2 kg/m2, P=0.002) and a higher rate of chronic obstructive pulmonary disease (COPD) (48.2% vs. 33.7%, P=0.004) than those without TB history. There were no significant intergroup differences in sputum color and volume, quality of life measured by the bronchiectasis health questionnaire, and other comorbidities. The involvement of right upper lobe (57.9% vs. 35.6%, P<0.001) and left upper lobe upper division (48.8% vs. 32.7%, P=0.002) on chest CT were more observed in patients with TB history than those without TB history. Regarding respiratory medications, bronchiectasis patients with TB history used LAMA/LABA more frequently (35.5% vs. 21.1%, P=0.001) and ICS/LABA less frequently (8.7% vs. 20.4%, P=0.002) than those without TB history. Bronchiectasis severity index (6 vs. 5, P=0.038) was significantly higher in patients with TB history than in those without TB history; however, there were no significant differences in exacerbations between two groups. Conclusion: Bronchiectasis patients with TB history had lower BMI, higher COPD rate, and received LAMA/ LABA more frequently than those without TB history. Despite higher bronchiectasis severity index in patients with TB history, there was no significant intergroup difference in the quality of life and exacerbation rates.