Three-Dimensional Z-Plasty(Yoon's Method)를 이용한 내안각 췌피 성형술

박흥식,김우신,윤진호,나민화,김한중 대한미용성형외과학회 1997 Archives of Aesthetic Plastic Surgery Vol.3 No.1

The presence of epicanthal folds in Asian eyelids is one of their unique features, in combination with the lack of supratarsal folds. Western culture has influenced many people to prefer to eliminate the prominent epicanthal fold. A number of surgical techniques have been suggested for their correction. However, difficulty with design, excessive and prominent scarring of medial canthal and nasal area, recurrence, and rigidity of application are potential problems associated with many procedures. This paper describes a epicanthoplasty with three-dimensional Z-plasty. Through epicanthal fold incision, the medial canthal tendon is medially advanced and sutured to the periosteum of nasal bone. After the transposition of the flaps, trimming of the flap is usually required. Three-dimensional Z-plasty creates the attractive eyes. From March, 1995 to March, 1997, the technique was applied to 37 patients with epicanthal fold and was performed with or without double-fold operation. There were 34 females and 3 males with ages ranging from 17 to 30 years. Through 2 years follow-up, this technique has delivered esthetically good results with minimal postoperative scar and could made the reduction of ICD from 40 ± 2.13 mm to 34 ± 1.98 mm. The advantages of epicanthoplasty procedure using three-dimensional Z-plasty(Yoon's method) are as follows; 1) simple in design 2)minimal postoperative scar in the medial canthal area 3) versatile in its application 4) no recurrence 5) no hypertrophic scar 6) preserving ethnic identity.

Sequence analysis of the fusion protein gene of Newcastle disease virus isolated from breeder ducks in Korea

Han, Mi Na,Byeon, Hyeon Seop,Lee, Cho Yeon,Jo, Nam Sin,Lee, Jong Hwa,Jang, Rae Hoon,Kim, Chang Seop,Na, Ki Jeong The Korean Society of Veterinary Service 2019 韓國家畜衛生學會誌 Vol.42 No.4

Newcastle disease (ND) is an infectious poultry disease that caused high mortality and reduced egg production. NDVs are regularly present in the domestic duck population. And ducks play a possible role in the maintenance and transmission of NDVs. While we were monitoring the Avian Influenza, NDVs were isolated from field samples by accident. So we analysed the biological and genetic characteristics of these viruses. Lentogenic NDVs were isolated from two farms among twenty breeder duck farms. The ages of ducks were 39 weeks old in the 'A' farm and 3~72 weeks old in the 'B' farm. And they were not inoculated with the NDVs vaccine. In the biological characteristics, the both viruses which separated from the farm 'A' and 'B' were thermostable. The amino acid sequence of a site from 112 to 119 in the fusion (F) protein was 'GKQGRLIG' which has monobasic motif in the samples of both farms. And this means the separated NDVs are lentogenic. Phylogenetic analysis was performed by entire nucleotide sequence of F protein. The virus strains from the A farm (MN095239) and the B farm (MN095240) belonged to class II genotype I. Using the analysis of whole F protein nucleic acid sequence, the MN095239 (GenBank) had homology with Ulster strain about 99.95% and the MN095239 (GenBank) had homology with KR/CK/KU_LBM255/09 strain about 99.89%. NDV surveillance is needed to investigate epidemiological relationship of domestic breeder duck isolates in Korea.

Sequence analysis of the fusion protein gene of Newcastle disease virus isolated from breeder ducks in Korea

Mi Na Han,Hyeon Seop Byeon,Cho Yeon Lee,Nam Sin Jo,Jong Hwa Lee,Rae Hoon Jang,Chang Seop Kim,Ki Jeong Na 한국동물위생학회 2019 韓國家畜衛生學會誌 Vol.42 No.4

Newcastle disease (ND) is an infectious poultry disease that caused high mortality and reduced egg production. NDVs are regularly present in the domestic duck population. And ducks play a possible role in the maintenance and transmission of NDVs. While we were monitoring the Avian Influenza, NDVs were isolated from field samples by accident. So we analysed the biological and genetic characteristics of these viruses. Lentogenic NDVs were isolated from two farms among twenty breeder duck farms. The ages of ducks were 39 weeks old in the ‘A’ farm and 3∼72 weeks old in the ‘B’ farm. And they were not inoculated with the NDVs vaccine. In the biological characteristics, the both viruses which separated from the farm ‘A’ and ‘B’ were thermostable. The amino acid sequence of a site from 112 to 119 in the fusion (F) protein was ‘GKQGRLIG’ which has monobasic motif in the samples of both farms. And this means the separated NDVs are lentogenic. Phylogenetic analysis was performed by en-tire nucleotide sequence of F protein. The virus strains from the A farm (MN095239) and the B farm (MN095240) belonged to class II genotype I. Using the analysis of whole F protein nucleic acid se-quence, the MN095239 (GenBank) had homology with Ulster strain about 99.95% and the MN095239 (GenBank) had homology with KR/CK/KU_LBM255/09 strain about 99.89%. NDV surveillance is needed to investigate epidemiological relationship of domestic breeder duck isolates in Korea.

산화아연계 무기질과 솔잎추출물 첨가에 의한 농산물 포장 필름의 광 및 미생물 열화능 개선

한신,나현정,강용구,박찬영 전남대학교 촉매연구소 2001 觸媒硏究 論文集 Vol.22 No.-

To invent environmentally friendly materials for packaging of agricultural produce, morphological and mechanical properly changes after daylight exposure and soil deposit for LDPE films composed of different incorporation substances have been investigated. Silver coated ceramic, zinc oxide, fine particle of ferrofluid and pine needle's extract were the incorporated substances. The pine needle's film degrades fast in soil while the silver coated ceramic's film shows daylight decay more on the morphological view. The mechanical strength keeps almost same. But turndown of elongation is explicit on the pine needle's film and silver coated ceramic's film.

수액가온요법이 전신마취 하 체온변화와 전율 및 회복에 미치는 영향

한효정,정소라,이성희,최경란,차나정,신유리 병원간호사회 2010 임상간호연구 Vol.16 No.1

Purpose: The study was aimed to investigate the effects of warm fluid used during surgery on the patients' hypothermia prophylaxis and recovery after surgery. Methods: This data were collected from Jul. 13 to Nov. 31. 2009 at S hospital in M City. 60 patients who met the selection criteria were recruited in the study and divided into two groups. The warmed fluids were used for 30 patients in the experimental group, and the fluids in room air temperature were used for the others in the control group. Collected data were statistically analyzed using SPSS/win 18.0. Results: The body temperatures of the control group were significantly lower during surgery than those of the experimental group (jtx.001). Shivering was significantly less occurred in the experimental group than the control group (p=.018). The experimental group used warmed fluids recovered faster than the control group. Conclusion: Warming fluid for the patients with general anesthesia was revealed to be effective in decreasing hypothermia during surgery, reducing shivering, helping recovery from the anesthesia. Further research is warranted to refine and apply this evidence in nursing practice.

Purification and Characterization of Extracellular Aspartic Proteinase of Candida albicans

Na, Byoung-Kuk,Lee, Seong-Il,Kim, Sin-Ok,Park, Young-Kil,Bai, Gill-Han,Kim, Sang-Jae,Song, Chul-Yong The Microbiological Society of Korea 1997 The journal of microbiology Vol.35 No.2

An extracellular proteinase of Candida albicans was purified by a combination of 0~75% ammonium sulfate precipitation, DEAE Sepharose Fast Flow ion exchange chromatography, and Sephacryl S-200 HR molecular sieve chromatography. Its mlecular weight was approximately 41 kDa on SDS-PAGE and isoelectric point was 4.4. The enzyme was inhibited by pepstain A. Optimum enzyme activity ranged from pH 2.0 to 3.5 with its maximum at pH 2.5 and a temperature of 45$^{\circ}C$. The addition of divalent cations, $Ca^{2+}$, Zn$^{2+}$ and $Mg^{2+}$, resulted in no significant inhibition of enzymatic activity. However, some inhibitory effects were observed by Fe$^{2+}$, Ag$^{2+}$ and Cu$^{2+}$. With BSA as substrate, an apparent $K_m$ was determined to be 7$\times$10$^{-7}$ M and $K_i$, using pepstatin A as an inhibitor, was 8.05$\times$10$^{-8}$ M. N-terminal amino acid sequence was QAVPVTLXNEQ. Degradation of BSA and fibronectin was shown but not collagen, hemoglobin, immunoglobulin G, or lysozyme. The enzyme preferred peptides with Glu and Leu at the P$_1$ position, but the enzyme activity was highly reduced when the P$_2$ position was phe or pro. This enzyme showed antigenicity against sera of patients with candidiasis.

Photosensitizer-Conjugated Hyaluronic Acid-Shielded Polydopamine Nanoparticles for Targeted Photomediated Tumor Therapy

Han, Jieun,Park, Wooram,Park, Sin-jung,Na, Kun American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.12

<P>Photodynamic therapy (PDT) is a widely used clinical option for tumor therapy. However, the clinical utilization of conventional small-molecule photosensitizers (PSs) for PDT has been limited by their low selectivity for disease sites, and undesirable photoactivation. To overcome these limitations, we demonstrated a tumor-specific and photoactivity-controllable nanoparticle photomedicine based on a combination of PS-biomacromolecule conjugates and polydopamine nanoparticles (PD-NP) for an effective tumor therapy. This novel photomedicine consisted of a PD-NP core and a PS-conjugated hyaluronic acid (PS-HA) shell. The PD-NP and the PS-HA play roles as a quencher for PSs and a cancer targeting moiety, respectively, The synthesized PS-HA-shielded PD-NPs (PHPD-NPs) had a relatively narrow size distribution (approximately 130 nm) with uniform spherical shapes. In response to cancer-specific intracellular enzymes (e.g., hyaluronidase), the PHPD-NPs exhibited an excellent singlet oxygen generation Capacity for PDT. Furthermore, an efficient photothermal conversion ability for photothermal therapy (PTT) was also shown in the PHPD-NPs system. These properties provide superior therapeutic efficacy against cancer cells. In mice tumor model, the photoactive restorative effects of the PHPD-NPs were much higher in cancer microenvironments compared to that in: the normal tissue. As a result, the PHPD-NPs showed a significant antitumor activity in in vivo mice tumor model. The nanoparticle photomedicine design is a novel strategy for effective tumor therapy.</P>

철인산염 코팅 바이오차를 이용한 복합 금속 오염 토양 안정화 및 상추 생육 평가

김한나(Han Na Kim),이승준(Seung Jun Lee),신수경(Su Kyeong Sin),김정연(Jeong Yeon Kim),이찬용(Chan Yong Lee),박진희(Jin Hee Park) 한국토양비료학회 2023 한국토양비료학회 학술발표회 초록집 Vol.2023 No.10

산전 진단된 수신증에 동반된 선천성 기형 및 염색체 이상

곽나현 ( Na Hyun Kwak ),한성우 ( Sung Woo Han ),정지미 ( Ji Mi Jung ),전가원 ( Ga Won Jeon ),신종범 ( Jong Beom Sin ) 대한주산의학회 2009 Perinatology Vol.20 No.4

목적: 산전 초음파의 발달로 수신증의 발견 빈도는 증가하고 있으며 진단시기는 점점 빨라지고 있으나, 검사지침이나 자연경과, 치료방침과 대한 명확한 지침은 부족한 실정이다. 저자들은 수신증으로 진단받는 신생아들에 동반된 선천성 기형의 종류와 염색체 이상에 대해 알아 봄으로써 출생 후 환자관리에 도움이 되고자 하였다. 방법: 2000년 1월부터 2008년 12월까지 산전 초음파에서 수신증이 발견되어 인제대 부산백병원에서 출생 후 3일 이후 1개월 이내 초음파 검사에서 수신증으로 진단된 297명, 381 신단위를 대상으로 의무기록을 후향적으로 분석하였다. 초음파소견에서 신우의 전후 길이가 5mm 이상인 경우를 수신증으로 정의하였고, The Society for Fetal Urology (SFU)의 기준에 따라 분류하여 수신증의 정도에 따라 동반 기형 및 염색체 이상의 종류 및 빈도를 알아보았다. 결과: 염색체이상의 빈도는 297예 중 31예(11%)였으며, trisomy 15예, deletion 8예, duplication 2예, 성염색체 이상 4예 이었으며, 가장 흔한 염색체 이상은 21 Trisomy, Turners syndrome, 상염색체 결실 순이었다. 수신증의 빈도와 달리 염색체 이상은 여아에서 남아보다 빈도가 2배 정도 높았으며, 일측성과 양측성 수신증에서 염색체 이상의 빈도 차이는 없었다. 동반된 기형은 요로생식기 기형이 46.5%, 심혈관계 기형이 22.8%, 소화기계 기형이 10.2% 중추신경계 기형이 11.1%, 안면기형이 7.1%, 기타 기형이 2.3%를 차지하였다. 수신증으로 진단받은 신생아 중, SFU Grade 3, 4인 중등도 이상의 수신증일수록 선천성 기형이 동반된 빈도가 높았으며, 동반된 기형의 수가 많을수록 염색체 이상의 빈도가 높았다. 결론: 수신증이 있는 신생아에서는 요로생식계 및 위장관계 기형에 대한 면밀한 방사선 검사 및 신체검사가 필요하며, 특히 동반된 기형이 발견된 경우에는 염색체 검사도 시행하는 것이 분만 후 신생아 관리에 도움이 될 것이다. Purpose: With the increasing use of antenatal sonography, fetal hydronephrosis has been reported more frequently. But, despite extensive clinical and scientific research much controversy still exists about the assessment and management of hydronephrosis. We performed a retrospective study to determine the frequency of associated malformations and chromosomal defects in prenatally diagnosed hydronephrosis. Methods: The records of 297 neonates who were diagnosed with hydronephrosis through antenatal ultrasonographic screening, were retrospectively analyzed. They were confirmed at 3 days to 1 month after birth with postnatal ultrasonography in Busan Paik Hospital, between January 2000 and December 2008. We karyotyped 297 neonates after ultrasonographic examination revealed hydronephrosis and malformations. Results: Chromosomal abnormalities were detected in 31 (11%) cases of 297 cases and more common in female than male. The commonest chromosomal abnormality was trisomy 21, followed by Turner syndrome, deletion of autosome, unbalanced translocation. 127 cases in 109 infants had associated malformations such as urogenital and cardiovascular and gastrointestinal anomalies. The associated malformations were more common in moderate to severe hydronephrosis than mild and the number of additional abnormalities increased with the chromosomal defects. Conclusion: Particular attention should be paid for the cases in congenital hydronephrosis with any associated malformation such as urogenital and cardiac malformation, to investigate chromosomal abnormalities. This will enable clinicians to establish appropriate management and postnatal care.

Bilateral acromial stress fractures in a patient with a massive rotator cuff tear

Du-Han Kim,Sang-Soo Na,Chung-Sin Baek,조철현 대한견주관절학회 2020 대한견주관절의학회지 Vol.23 No.2

Stress fractures of the acromion and scapular spine are well-known complications following reverse total shoulder arthroplasty. However, these fractures in patients with massive rotator cuff tear or cuff tear arthropathy are extremely rare, and the pathogenesis, clinical features, diagnosis, and treatment of these fractures are poorly understood. We report a case of bilateral stress fracture of the posterior angle of the acromion in a patient with massive rotator cuff tear and discuss the pathogenesis, clinical manifestation, and treatment with a review of the literature.