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Placental expression of D6 decoy receptor in preeclampsia
( Geumjoon Cho ),( Eunsung Lee ),( Hyemi Jin ),( Jihye Lee ),( Yeunsun Kim ),( Minjeong Oh ),( Hyunjoo Seol ),( Sooncheol Hong ),( Haijoong Kim ) 대한산부인과학회 2015 Obstetrics & Gynecology Science Vol.58 No.5
The purpose of this study was to investigate the expression of the D6 decoy receptor that can bind chemokines and target them for degradation, resulting in inhibition of inflammation in placentas from preeclamptic and normal pregnancies.The current study was carried out in 35 pregnant women (23 patients with preeclampsia and 12 healthy, normotensive pregnant women) during the third trimester of pregnancy. The expressions of D6 decoy receptor in the placenta were determined with real time reverse transcriptase polymerase chain reaction and western blotting.The mRNA and protein of D6 decoy receptor were detected in all of placentas from preeclamptic and normal pregnancies. Placental D6 decoy receptor mRNA expression was significantly lower in patients with preeclampsia than in patients with normal pregnancies. Western blot analyses revealed decreased protein expression in cases of preeclampsia.The expression of the D6 decoy receptor in preeclamptic placentas was significantly lower than in normal placentas. Further studies are needed to clarify the underlying mechanisms that link decreased expression of placental D6 decoy receptor and preeclampsia.
Cesarean section and risk factors: Secular tends in South Korea, 2006-2015
( Nayoung Bae ),( Hyejin Choi ),( Geumjoon Cho ),( Kyumin Lee ),( Sungwon Han ),( Kihoon Ahn ),( Sooncheol Hong ),( Haijoong Kim ),( Minjeong Oh ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: The aim of the study is to investigate the recent trend in the rate of cesarean section (CS) in South Korea from 2006 to 2015 and identify risk factors in association with these changes. Methods: Using the National Health Insurance Corporation data, we included every women who had delivery from 2006 to 2015. We investigated (1) mode of delivery, (2) the rate of complications during pregnancy (i.e. preeclampsia and placenta previa) and (3) pre-pregnancy factors (BMI, hypertension, DM and other pre-existing medical conditions) and its trends during study period. Results: During 10 years, the rate of CS increased from 36.3% in 2006 to 40.6% in 2015 (p <0.01). The rate of CS increased in primiparous women, women with multiple pregnancy and women with preeclampsia. Otherwise, the rate of vacuum delivery and VBAC decreased during study period. The rate of women with pre-pregnancy obesity increased but the rate of women with pre-pregnancy hypertension and DM decreased. Conclusion: The rate of CS in South Korea have been increasing from 2006 to 2015. This trend may reflect changes in the rate of risk factors. Identification of causes for increasing trend of CS observed in this study will allow the clinician to monitor for these factors and possibly reduce CS.