흰 쥐에 있어서 사염화탄소 투여로 인한 간독성 및 신장독성에 미치는 5-Aminosalicylic Acid의 영향

강정해,권용준 대구효성가톨릭대학교 응용과학연구소 1997 응용과학연구논문집 Vol.5 No.-

The present study was carried out to evaluate the effect of 5 - amino salicylic acid(5 - ASA) on the hepatotoxicity and nephrotoxicity in carbon tetrachloride(CCl_4) administered male rats. It was investigated by measuring the activity of monoamine oxidase(MAO), the levels of lipid peroxidation, and lipid accumulation in the liver and the kidney. The results obtained were as follows. Activity of MAO in the liver mitochondrial fraction was reduced by CCl_4 administration compared to normal group. This reduction caused by CCl_4 administration wree significantly improved by pretreatment with 5 - ASA. Hepatic lipid peroxidation, and the amounts of total lipid, total chloesterol, and triglyceride of the liver were significantly increased by CCl_4 administration. These increases caused by CCl_4 administration were significantly reduced by pretreatment with 5 - ASA. Renal lipid peroxidation, and and the amounts of total lipid, and triglyceride of the kidney were significantly increased by CCl_4 administration. These increases caused by CCl_4 administration were slightly reduced by pretreatment with 5 - ASA. These results suggest that 5 - ASA exerts a chemoprotective effect against carbon tetrachloride toxicity in male rats by mechanism that appears to involve its antioxidants property, just like scavenger of free radicals, and detoxification of electrophilic compounds by the metabolism of carbon tetrachloride.

직업적 아크릴아미드 폭로에 의한 다발성 신경병증

정해관,권용욱,어경윤,김병준,양정선,정철,진영우,이미영,강성규 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.3

Authors report a first Korean case of polyneuropathy in an acrylamide producing factory together with an environmental and epidemiologic survey for the ten workers of the same workplace and 46 workers in the production and manufacturing acrylamide in Ulsan, Korea. The case is 30 years old man who worked in the production of the acrylamide for two years. In August, 1997, he had a weakness of the lower extremity with loss of body weight of 15 Kg which progressed to paresthesia of the limbs, the loss of vibration sense, difficulty in walking, speech disturbance, dysuria, constipation, difficulty in erection and swallowing difficulty. Neurologic examination showed a complete loss of vibration and position sense, and loss of deep tendon reflex in all the limbs. There was a contact dermatitis-like skin lesion on the feet. Electrodiagnostic test showed a generalized polyneuropathy of moderate degree involving motor and sensory component of peripheral and cranial nerves. After 8 months' cessation from exposure and supportive care, his symptoms were completely resolved, but abnormality in electrodiagnostic test and vibrotactile perception threshold still persisted, although much improved than before. There were 11 workers in the same workplace of the case, producing acrylamide by microorganism as a catalyst. Environmental monitoring of the workplace revealed air borne concentration of the acrylamide to be from 0.05 to 0.23 mg/m3 by personal sampling and from 7.65 to 11.65 mg/m3 by area sampling during filter exchanging process, which far exceeds TLV-TWA of 0.03 mg/m3. However, acrylamide was not detected from the plasma of the workers. Symptom questionnaire showed a markedly higher complain of neurologic symptoms, compared to the workers of the other acrylamide producing companies. Electrodiagnostic test showed a several workers are in the lower normal range without definite abnormality. Vibrotactile perception threshold by Vibratron Ⅱ showed a significantly increased threshold in the workers of the same workplace compared to the other acrylamide workers and significantly decreased test score of color vision compared to normal controls. After improvement of the production process and strict wearing of the protective device, most workers reported the improvement of clinical symptoms, but vibrotactile perception threshold was not improved. These result suggests the need for the effective environmental monitoring together with a periodic biological monitoring. Development of effective screening test is urgently needed to control and assess the skin absorption of acrylamide.

전화번호안내원의 누적외상성 장애

정해관,최병순,김지용,유선희,임현술,김용민,어경윤,권용욱 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.1

To evaluate the prevalence of cumulative trauma disorders in relation to ergonomic evaluation of their work, 260 female directory assistance operators employed in three branch facilities of the nation-wide telecommunication company. Ergonomic evaluation of the work status was done by two industrial hygienists through inspection. Workers were surveyed with standardized self-administered questionnaire and examined by family physicians and an orthopaedician for cumulative trauma disorders. Laboratory examination of serum aspartate aminotransferase(AST), creatinine phosphokinase(CPK), aldolase and rheumatoid factor was done and X-ray of cervical spine and both shoulders was taken from all subjects and nerve conduction velocity test was done on 57 subjects with suspected nerve entrapment cases. Cumulative trauma disorders were categorized into 3 category according to work-relatedness of the disorders. On ergonomic evaluation of the working posture and work environment, improvement of work posture revealed inappropriate postures and devices. Mean age of the subjects were 39 years old and more than 80% graduated high school or above. Ninety-eight percent of the workers employed in the company for more than 15 years and 74.6% of the workers worked at the VDT job for more than 4 years. Mean daily work hours was 8.0 hours per day and mean break hours was 90.5 minutes per day with mean extra work hours of 10.7 hours per month. Mean daily calls were 1128.6 calls in maximum and 864-8 calls in minimum. On laboratory examination, 13.(5.0%) workers had abnormal AST, 53(20.4%) had abnormal CPK, and 1(0.4%) had abnormal aldolase level. On x-ray examination of cervical spine, 111(42.7%) had loss of or reversed normal cervical lordosis, 10(3.8%) had narrowing of intervertebral space. Nerve conduction velocity test was abnormal in 11(19.2%) among 57 workers. Among disorders categorized as work-related, 131(50.4%) were diagnosed to have fatigue myalgia of levator scapulae, 108(41.5%) had cervical strain or sprain, 47(18.1%) had fatigue arthralgia of phalangeal joints, and 47(18.1%) had probable carpal tunnel syndrome, in 10(3.8%) of those diagnosis was confirmed electrophysiologically. Age, seniority, work duration at present job, workload nor location of facilities were associated with the prevalence of symptoms nor specific diagnoses on simple statistical analysis and multiple logistic regression, which seems to be due to highly selected and homogeneous characteristics of the study subjects. Above results shows that cumulative trauma disorders are very prevalent among directory assistance operators and elaborate effort is needed to reduce the cumulative trauma disorders among the operators.

객체지향형 교육용프로그래밍언어 두리틀의 다중 예약어 지원 체계

최해심,권대용,김형신,염용철,유승욱,이원규 한국컴퓨터교육학회 2005 컴퓨터교육학회 논문지 Vol.8 No.2

데이타베이스에 있어서의 시간지원 구현에 관한 연구

梁海權,김광훈,박용문 군산대학교 1987 論文集 Vol.14 No.-

Recently, the need for supporting time varying information in databases has been recognized for quite some time.Thus, attention has been focused on Temporal Databases, representing an enterprise over time.Many authors have proposed numerous schemes to satisfy this need by incorporating one or two time attributes in the database. In this paper, We have introduced to this field, and surveyed a taxonomy of time and implementation issues which are the versioning methods, storage structures, and it's performance evaluation, and suggested the versioning method, storage structure, and approach to the development of a model for DBMS with time and revision-history supporting. And we'll expend this paper to design and develop the relational DBMS with time and revision history supporting.

이중언어자에서 보인 두 형태의 실어증 : 증례보고 A Case Report

나해리,이정욱,박성민,박수열,권순용,이현정 대한치매학회 2004 Dementia and Neurocognitive Disorders Vol.3 No.2

Since many people in Korea know more than one language, bilingual aphasia is an important line of research in clinical and theoretical neurolinguistics. Nowadays we meet many people who speak other languages along with Korean, who are immigrants from foreign countries, especially from China. Differential recovery of language affected by an aphasic deficit is documented. In the present work, we introduced a patient with bilingual aphasia who showed different recovery patterns in Korean and Chinese. A 66-year-old man was presented with language disturbance and right hemiplegia. On past medical history, he had received a hematoma evacuation through burr-hole due to left basal ganglia hemorrhage. After the event, he showed nearly global aphasia in Korean, but he showed minimally preserved language function on comprehension and fluency in Chinese. This result suggests that aphasia in bilingual subject may show different pat-terns of recovery between two languages.

난소 임신 10예의 분석

김용진,이충일,이해혁,남계현,이임순,이권해 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2

Ovarian pregnancy is an uncommon form of the ectopic pregnancies. The ovarian vascularity results in maternal hemorrhage early in the first trimester, which disrupts the pregnancy and usually ruptures the ovary with sufficient hemoperitoneum to require emergency operation. This report presents 10 cases of ovarian pregnancy by retrospective review between January 1986 and December 1995 at the Department of Obstetrics and Gynecology, Soonchunhyang University Hospital. There was 19,849 deliveries and 637 ectopic pregnancies during same period. It showed that the incidence of ovarian pregnancy was 3.21 % of all ectopic pregnancies. The clinical features of ovarian pregnancy revealed that abdominal pain was the major symptom, and history of amenorrhea was obscure. Because of life-threatening course, the early diagnosis and treatment of ovarian pregnancy is important. The clinical diagnosis of ovarian pregnancy was more difficult than that of tubal pregnancy.

Vital Bleaching이 법랑질 접착에 미치는 영향

김종해,권태엽,권용훈,김교한 大韓齒科器材學會 2003 대한치과재료학회지 Vol.30 No.4

The objective of this in vitro study was to evaluate the effect of bleaching on the composite to enamel bond and surface hardness change. Extracted human premolars were treated with 35% hydrogen peroxide (Sigma Chemical Co, USA) for 1hr/day at 0, 3, 6 and 9 day respectively. For the obsrvation of surface mophology alteration due to the treatment with hydogen peroxide, a SEM (S-4300, Hitachi, Japan) was used. The specimens were ground flat using serial SiC papers and ground ultra-finely using a 0.1㎛ diamond compound paste. To measure the microhardness, five non-carious premolars were ground using SiC papers and ten indentations were made on the surfacd with Vickers hardness tester (FM-7 FUTURE-TEC Inc., Japan). To evaluate shear bond strength, composite was bonded with One Up Bond-F, Prompt L-Pop, AQ Bond to the non-bleached and bleached enamel surface of sixty non-carious premolars. The bonding procedure is postponed for 1 week after bleaching and shear bond strength was measured. All specimens with a SEM. Bleaching created some enamel porosity but the teeth showed nonsignificant morphological chonge as bleaching time increased from SEM analysis. Most microhardness change occured on the first day of bleaching. Bleaching with 35% hydrogen peroxide did not result in significant change in the shear bond strength of composite resin to enamel. In the shear bond strength test, the fractured surfaces of specimens showed mixed adhesive and cohesive failure behavior.

자동차용 컨트롤 링크 업셋 용접부의 용접성 및 피로강도 향상에 관한 유한요소 해석

조해용,권혁홍,이봉규 한국공작기계학회 2001 한국생산제조학회지 Vol.10 No.6

This study is concerned with Finite Element Analysis on welded part of control link for automobile. For analysis, control link was modeled into two parts, ring and rod. Heating condition, temperature distributions and fatigue fracture strength were analyzed using "HEAT Ⅲ" and "ENDURE" module of NISA Ⅱ. Metal flow in the process of welding was simulated by DEFORM^TM 2D. The analyzed results were compared with experimental inspection. Quality of welded part was able to be improved by controlling metal flow in the process of welding by increase the friction constant of ring part. Heat transfer analysis and flow simulations were in good agreement with welding experiments.

야생 노랑제비꽃(Viola orientalis W.Becker)의 형태적 특성 및 Callus유도에 관하여

정용모,서정해,조만현,권오창 東亞大學校生命資源科學大學附設 農業資原硏究所 1996 農業生命資援硏究 Vol.5 No.1

부산근교의 고산 지대에 자생하는 야생 노랑제비꽃(Viola orientalis W. Becker)의 외부 형태적 특성과 줄기 조직으로부터 callus형성에 미치는 식물 생장조절제의 영양에 관한 실험을 실시하였던 바 그 결과를 요약하면 다음과 같다. 잎은 근생엽과 줄기상의 잎으로 구별할 수 있었으며, 엽장, 엽폭, 그리고 엽면적 각각 3.9㎝, 4.7㎝ and 15㎠로 모두 근생엽이 skjawl 줄기상의 잎보다 컸다. 그러나 엽형지수에 있어서는 근생엽이 0.83으로 가장 작았고 줄기상의 가장 작은 잎이 1.30으로 제일 크게 나타났다. 식물 생장조절물질의 단용에서 callus 유도는 Auxin의 NAA5×10??, 5×10??, 5×10??M에서 양호하였다. Auxin과 Cytokinin의 혼용에서 callus유도는 NAA 5×10??M 및 5×10??M에 BA 5×10??, 5×10??, 5×10??M의 전구에서 양호하였다. Callus 성장이 가장 양호한 조합은 NAA 5×10??M + BA 5×10??M 및 NAA 5×10??M + BA 5×10??M이었다. This experiment was conducted to study morphological feature and effect of plant growth regulators on callus induction of wild viola(Viola orientalis W. Becker). The results obtained were summarized as follows: In morphological feature, there was two distinctive leaf-forming types : one was rosette type derived from subterranean stem and the other was leaves formed on stem. Generally rosette type leaves were larger than others and the leaf length, leaf width, and leaf area were 3.9㎝, 4.7㎝ and 15㎠ on average, respectively. In the leaf shape index(the ratio of leaf length/width), the smallest value(0.83) was shown on rosette leaf while the greatest value(1.30) was determined from leaves on stems. Callus induction from the stem segments of wild viola was relatively higher at NAA concentrations of 5x10??M, 5x10??M or 5x10??M than at the same ones of other regulators used. The most effective combined concentrations of Auxin and Cytokinin for the callus formation were 5×10??M of NAA plus 5×10??M of BA or 5×10??M of NAA plus 5×10??M of BA.