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炭素纖維板으로 補强한 鐵筋콘크리트보의 構造的擧動에 관한 實驗的 硏究
김하진,고송균,박영배,조창호,김정섭 朝鮮大學校 建設技術硏究所 1998 建設技術硏究 Vol.18 No.1
This study is a part of research to improve the yield strength of concrete structure with a structural damage and conducts the experiment with the variables such as the period of restrengthening of specimen, restrengthening length (1.9m, 1.5m, 1.0m) and restrengthening effect according to restrengthening mehthod of restrengthening materials (nonrestrengthening, Anchor, Angle) to test bending behavior and yield strength performance of reinforced concrete beams restrengthened with carbon fiber laminate. As a result of experiment, in the restrengthening effects by the period of restrengthening, specimen restrengthened before loading, during reloading and after loading show 1.9m, 1.5m and 1.0m respectively, in the restrengthening effects according to restrengthening length, specimen restrengthened with 1.9m, 1.5m and 1.0m show 113.7%, 122.4% and 112.7% and in restrengthening effects according to restrengthening method of restrengthening materials, non-restrengthening and restrengthening in anchor and angle show 113.7%, 115.9% and 184.4% of increase in yield strength respectively. Accordingly, the specimen restrengthened during loading, the specimen with 1.5m of restrengthening and the specimen restrengthened with angle show high restrengthening effects respectively. With the above results, a crack is closed by elastic behavior in the case of test materials, but since in the actual concrete strucutre, a crack is not closed like the specimen during loading, the influence of it on restrengthening should be considered. It is found that although restrengthening effect by the restrengthening length secures a sufficient length, the increase of yield strength by restrengthening cannot be expected when bonded performance is not secured and in deciding restrengthening method of restrengthening materials, the method which have not damage to restrengthening materials and can be integrated with restrengthening materials and structure is effective.
Shape memory alloy–based biopsy device for active locomotive intestinal capsule endoscope
Le, Viet Ha,Hernando, Leon-Rodriguez,Lee, Cheong,Choi, Hyunchul,Jin, Zhen,Nguyen, Kim Tien,Go, Gwangjun,Ko, Seong-Young,Park, Jong-Oh,Park, Sukho SAGE Publications 2015 Proceedings of the Institution of Mechanical Engin Vol.229 No.3
<P>Recently, capsule endoscopes have been used for diagnosis in digestive organs. However, because a capsule endoscope does not have a locomotive function, its use has been limited to small tubular digestive organs, such as small intestine and esophagus. To address this problem, researchers have begun studying an active locomotive intestine capsule endoscope as a medical instrument for the whole gastrointestinal tract. We have developed a capsule endoscope with a small permanent magnet that is actuated by an electromagnetic actuation system, allowing active and flexible movement in the patient's gut environment. In addition, researchers have noted the need for a biopsy function in capsule endoscope for the definitive diagnosis of digestive diseases. Therefore, this paper proposes a novel robotic biopsy device for active locomotive intestine capsule endoscope. The proposed biopsy device has a sharp blade connected with a shape memory alloy actuator. The biopsy device measuring 12mm in diameter and 3mm in length was integrated into our capsule endoscope prototype, where the device's sharp blade was activated and exposed by the shape memory alloy actuator. Then the electromagnetic actuation system generated a specific motion of the capsule endoscope to extract the tissue sample from the intestines. The final biopsy sample tissue had a volume of about 6mm(3), which is a sufficient amount for a histological analysis. Consequently, we proposed the working principle of the biopsy device and conducted an in-vitro biopsy test to verify the feasibility of the biopsy device integrated into the capsule endoscope prototype using the electro-magnetic actuation system.</P>
Pellino 1 promotes lymphomagenesis by deregulating BCL6 polyubiquitination.
Park, Hye-Young,Go, Heounjeong,Song, Ha Rim,Kim, Suhyeon,Ha, Geun-Hyoung,Jeon, Yoon-Kyung,Kim, Ji-Eun,Lee, Ho,Cho, Hyeseong,Kang, Ho Chul,Chung, Hee-Young,Kim, Chul-Woo,Chung, Doo Hyun,Lee, Chang-Woo American Society for Clinical Investigation 2014 The Journal of clinical investigation Vol.124 No.11
<P>The signal-responsive E3 ubiquitin ligase pellino 1 (PELI1) regulates TLR and T cell receptor (TCR) signaling and contributes to the maintenance of autoimmunity; however, little is known about the consequence of mutations that result in upregulation of PELI1. Here, we developed transgenic mice that constitutively express human PELI1 and determined that these mice have a shorter lifespan due to tumor formation. Constitutive expression of PELI1 resulted in ligand-independent hyperactivation of B cells and facilitated the development of a wide range of lymphoid tumors, with prominent B cell infiltration observed across multiple organs. PELI1 directly interacted with the oncoprotein B cell chronic lymphocytic leukemia (BCL6) and induced lysine 63-mediated BCL6 polyubiquitination. In samples from patients with diffuse large B cell lymphomas (DLBCLs), PELI1 expression levels positively correlated with BCL6 expression, and PELI1 overexpression was closely associated with poor prognosis in DLBCLs. Together, these results suggest that increased PELI1 expression and subsequent induction of BCL6 promotes lymphomagenesis and that this pathway may be a potential target for therapeutic strategies to treat B cell lymphomas.</P>