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Han, Gyoon-hee The Pharmaceutical Society of Korea 2000 Archives of Pharmacal Research Vol.23 No.3
A new series of phosphonate side chain analogues of 1$\alpha$,25-dihydroxyvitamin $D_3$ (1) have been synthesized. Antiproliferative activities of theses analogues (8a,b and 9a,b) using human keratinocyte cell shows that analogues which have natural A-ring show higher activity than unnatural A-ring series and almost equally active to 1 $\alpha$,25-Dihydroxyvitamin $D_3$(1) at 1 $\mu$M level.
Diagnosis and Treatment of Discoid Meniscus
( Jae-gyoon Kim ),( Seung-woo Han ),( Dae-hee Lee ) 대한슬관절학회 2016 대한슬관절학회지 Vol.28 No.4
There is a greater incidence of discoid meniscus in Asian countries than in Western countries, and bilateral discoid menisci are also common. The discoid meniscus may be a congenital anomaly, and genetics or family history may play a role in the development of discoid menisci. Because the histology of discoid meniscus is different from that of normal meniscus, it is prone to tearing. Individuals with a discoid meniscus can be asymptomatic or symptomatic. Asymptomatic discoid menisci do not require treatment. However, operative treatment is necessary if there are symptoms. Total meniscectomy leads to an increased risk of osteoarthritis. Therefore, total meniscectomy is generally reserved for rare unsalvageable cases. Partial meniscectomy (saucerization) with preservation of a stable peripheral rim combined with or without peripheral repair is effective, and good short-, mid-, and long-term clinical results have been reported.
Yoon, Ju-Hee,Song, Hyun-Min,Kim, Sang-Wong,Han, Gyoon-Hee,Park Choo, Hea-Young 이화여자대학교 약학연구소 2005 藥學硏究論文集 Vol.- No.16
2-Aminothiazolo[5,4-b]pyridines and 2-aminobenzoxazoles have been synthesized from 2-hydroxy-3-thioureidopyridine and 2-hydroxy-3-thioureidobenzene respectively via acid catalyzed cyclization, which were prepared by the reaction of isothiocyanates with 2-hydroxy-3-aminopyridine or 2-aminophenol, The hydroxyl group of N-(2-hydroxy-5-phenyl)- N'-phenyl thiourea reacted as nucleophile to thioureido carbon to give 2-aminobenzoxazoles, whereas that of N-(2-hydroxypyridino)-N'-Phenylthiourea was reacted as leaving group upon nuclephillic sulfur of thiourea group in the presence of trifluoroacetic acid or phosphoric acid.
김상균(Sang-Gyoon Kim),한희정(Hee Jeong Han) 한국언론정보학회 2014 한국언론정보학보 Vol.66 No.2
2010년 3월 발생한 천안함 침몰 사건과 관련하여 사건발생 원인에 대한 수많은 의혹이 있었음에도 불구하고 2010년 11월 이후 후속 탐사보도 프로그램 제작이 중단되었다. 본 연구는 탐사보도 프로그램의 생산자 연구를 통해 그 이유를 탐색했다. 탐사보도 프로그램의 제작진들을 대상으로 심층 인터뷰 분석 결과 다음 네 가지 이유를 제시했다. 첫째, 군 작전과 관련된 기밀이란 이유로 군이 정보를 독점함으로써 PD와 기자의 사실(fact) 접근이 불가능하거나 충분한 정보를 얻을 수 없었기 때문이다. 둘째, 천안함 침몰을 다룬 <추적60분>(KBS)에 대해 방송통신위원회의 ‘경고’ 징계 등 관련 보도에 대한 탄압으로 위축효과가 일어났고, 이후 다큐멘터리 영화 <천안함 프로젝트>에 대한 상영 제한에서도 드러났듯이 국가 권력에 의한 미디어 통제가 지속됐기 때문이다. 셋째, 지상파 방송에서 자율적 제작을 주장한 제작진에 대해 이루어진 강제 인사, 조직 개편 및 국장책임제도 폐지 등으로 PD 저널리즘과 제작의 자율성이 현저하게 약화되었기 때문이다. 넷째, 방송과 사회 전반에서 나타난 “종북몰이” 현상의 확산에 따라 방송사나 제작진에게 자기검열 기제가 작동했기 때문이다. 결론적으로 탐사보도 프로그램의 구조적 주변화 환경 속에서 PD 저널리즘이 지향하는 “합리적인 의심과 검증으로 진실을 밝히기 위해 기록하는” 방송 공론장 확립을 위한 제도적 보완이 시급하다. This study examines why follow-up investigative programs about the sinking of the Cheonan Patrol Combat Corvette(ROKS Cheonan) have not been produced, despite much speculation surrounding the cause of the sinking since November 2010, when KBS investigative program, In-Depth 60 Minutes which had covered the incident was aired. We have uncovered four reasons through a series of in-depth interviews with producers and reporters, as follows. First, Korean military authorities monopolized relevant information, while the producers could not prove or confirm the validity of the findings of the JIG(Joint Civilian-Military Investigation Group)’s report because the facts had been revealed partially and selectively by the authorities and the press’ scientific investigation were rejected by the authorities. Second, the crew of In-Depth 60 Minutes was subjected to severe disciplinary action by the Korea Communications Commission. This caused a chilling effect, - it broke the producers’ resolve to further explore the reason behind the sinking. Furthermore, the screening of the investigative documentary, Project Cheonan Ship was cancelled without prior notice, presumably by the power of the State and markets. Third, the reorganization and shake-up of personnel by broadcasting stations’ presidents appointed by the power of the State crushed the spirit of PD Journalism. Finally, the “red purge” factions stigmatized by the political or military, or the mainstream press, caused the producers or broadcasters to engage in self-censorship. The idea has been used in Korea as a smoke screen to deflect public attention. Nevertheless, the producers hope to shed light on the Cheonan sinking incident and to prove reasonable doubts by pursuing follow-up investigations.
Lee, Sang Hee,Han, Ji Hoon,Lee, Sung Jae,Cho, Hwi Young,Baek, Jung Heum,Kim, Jae Gyoon korean Academy of Physical Therapy Rehabilitation 2019 Physical therapy rehabilitation science Vol.8 No.1
Objective: For knee osteoarthritis (OA), there is a demand for alternative modalities in order to delay surgery and to avoid the side effects of medications. This study compared the effects of applying seaweed pack and mudpack for the treatment of knee OA. Design: Randomized controlled trial. Methods: Twenty-five patients with knee OA who satisfied the criteria were included. The patients were divided into two groups according to the treatment method: mudpack (n=12) and seaweed pack (n=13). The two groups were treated for 20 minutes, twice a day for five continuous days at the Ocean Healing Center at Wando Island, South Korea. Participants were assessed by clinical scores (Western Ontario and McMaster Universities Osteoarthritis Index, Hospital for Special Surgery Knee Score, Knee injury and Osteoarthritis Outcome Score and 36-Item Short Form Health Survey) and lab results (erythrocyte sedimentation rate, C-reactive protein, insulin-like growth factor-1 [IGF-1], tumor necrosis $factor-{\alpha}$ [$TNF-{\alpha}$]) during the follow-up period. Results: For the most part, clinical scores improved after therapy and maintained improvements for four weeks in both groups (p<0.05). In the seaweed group, $TNF-{\alpha}$ was significantly decreased at two weeks post-therapy (p<0.05). In both groups, IGF-1 was significantly increased immediately post-therapy (p<0.05). There were no statistically significant differences after therapy between the groups in clinical scores and labs. Conclusions: Seaweed packs and mudpacks had similar positive effects for knee OA. Additionally, the seaweed pack group showed decreased levels of $TNF-{\alpha}$ at two weeks post-treatment, which may explain the reduced inflammatory reaction. For rehabilitation therapy, use of seaweed packs may serve as an alternative modality for the treatment of knee OA.
Prediction of Relative Stability between TACE/Gelastatin and TACE/Gelastatin Hydroxamate
Nam, Ky-Youb,Han, Gyoon-Hee,Kim, Hwan-Mook,No, Kyoung-Tai Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.11
A gelastatins (1), natural MMP inhibitors, and their hydroxamate analogues (2) in TACE enzyme evaluated for discovery of potent TACE inhibitors. We have employed molecular dynamics simulations to compute the relative free energy of hydration and binding to TACE for gelastatin (1) and its hydroxamate analogue (2). The relative free energy difference is directly described in this article using the free energy perturbation approach as a means to accurately predict the TACE inhibitor of gelastatin analogues. The results show that the good agreement between the experimental and theoretical relative free energies of binding, gelastatin hydroxamate (2) binds stronger to TACE by -3.37 kcal/mol. The desolvation energy costs significantly reduced binding affinity, hydroxamate group associated with high desolvation energy formed strong favorable interactions with TACE with more than compensated for the solvation costs and therefore led to an improvement in relative binding affinity.
Dong-Yoon Lim,Jae-Bong Heo,Cheol-Hee Choi,Geon-Han Lim,Yong-Gyoon Lee,Song-Hoon Oh,Il-Sik Kim,Jong-In Kim 대한생리학회-대한약리학회 1998 The Korean Journal of Physiology & Pharmacology Vol.2 No.4
<P> The present study was attempted to investigate the effect of vasoactive intestinal polypeptide (VIP) on secretion of catecholamines (CA) and to establish whether there is the existence of a noncholinergic mechanism in adrenomedullary CA secretion from the isolated perfused rat adrenal gland. The perfusion into an adrenal vein of VIP (3⁓10<SUP>6 </SUP>M) for 5 min or the injection of acetylcholine (ACh, 5.32⁓10<SUP>3 </SUP>M) resulted in great increases in CA secretion. Tachyphylaxis to releasing effect of CA evoked by VIP was not observed by the repeated perfusion. The net increase in adrenal CA secretion evoked by VIP still remained unaffected in the presence of atropine or chlorisondamine. However, the CA release in response to ACh was greatly inhibited by the pretreatment with atropine or chlorisondamine. The releasing effects of CA evoked by either VIP or ACh were depressed by pretreatment with nicardipine, TMB-8, and the perfusion of Ca<SUP>2</SUP>-free medium. Moreover, VIP- as well as ACh-evoked CA secretory responses were markedly inhibited under the presence of (Lys<SUP>1</SUP>, Pro<SUP>2.5</SUP>, Arg<SUP>3.4</SUP>, Tyr<SUP>6</SUP>)-VIP or naloxone. CA secretory responses induced by ACh and high K<SUP></SUP> (5.6⁓10<SUP>2 </SUP>M) were potentiated by infusion of VIP (3⁓10<SUP>6</SUP>M for 5 min). Taken together, these experimental results indicate that VIP causes CA release in a fashion of calcium ion -dependence, suggesting strongly that there exists a noncholinergic mechanism that may be involved in the regulation of adrenomedullary CA secretion through VIP receptors in the rat adrenal gland, and that VIP may be the noncholinergic excitatory secretagogue present in the chromaffin cells.
박석,이예리,김호현,이희주,김윤균,염정록,한상범 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.6
A sensitive method for quantification of pinaverium bromide in human plasma was established using liquid chromatography-electrospray ionization tandem mass spectrometrv(LC-ESI-MS/MS). Glimepiride was used as internal standard. Pinaverium bromide and internal standard in plasma sample were extracted using tert-but}lmethvlether(TBME). A centrifuged upper laver was then evaporated and reconstituted with mobile phase of acetonitrile-5 m1VI ammonium formate (8020. pH 3.0). The reconstituted samples were injected into a C_(18) reversed-phase column. Using MS/MS with multiple reaction monitoring (MRM) mode. pinaverium and glimepirde were detected without severe interference from human plasma matrix. Pinaverium produced a protonated precursor ion ([M+H]^(+)) at m/z 510.3 and a corresponding product ion at m/z 228.9. Internal standard produced a protonated precursor ion ([M+H] ^(+)) at m/z 491.5 and a corresponding product ion at m/z 352.0. Detection of pinaverium bromide in human plasma was accurate and precise. with limit of quantitation at 0.5 ng/ml. The method has been successfully applied to bioavailability study of pinaverium bromide tablet in Korean healthy male volunteers. Pharmacokinetic parameters such as AUCr. C_(max) T_(max). K_(el) and t_(l/2) were calculated.