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류마티스 관절염 마우스 모델에서 뼈 손상 및 염증에 대한 Sphingosine-1 phosphate의 역할에 관한 연구
곽한복(Han Bok Kwak),권덕수(Deok-Su Kwon),장성조(Sung-Jo Jang),최은영(Eun-Yong Choi),이은경(Eun-Gyeong Lee),박병현(Byoung Hyun Park),김현대(Hyun Dai Kim),서필승(Phil-Seung Seo),김정중(Jeong-Joong Kim),최민규(Min-Kyu Choi),조해중(Hae 대한해부학회 2007 Anatomy & Cell Biology Vol.40 No.4
Sphingosine-1 phosphate (S1P)는 sphingolipid의 대사산물로 생체내에서 세포의 증식, 분화, 이동 및 혈관신생 등 여러 중요한 역할을 수행하고 있다. 그러나 S1P가 이렇게 중요한 역할을 수행하고 있음에도 불구하고 관절염에서의 역할에 대해서는 거의 알려진 바가 없다. 따라서 본 연구는 콜라겐으로 유도된 관절염 모델(collagen induced arthritis, CIA)에서 S1P의 역할을 규명하기 위하여 수행하였다. DBA/1J 쥐의 꼬리에 콜라겐을 피하 주사하여 관절염을 유도하였다. CIA 쥐에서 S1P의 효과를 분석하기 위하여 S1P를 관절염 유도 첫날부터 42일까지 복강에 2일마다 주사하여 관절염이 유발되는 상황을 관찰하였다. 관절염의 유발 정도는 육안으로 평가되었고 관절 염증의 진행정도와 뼈의 손상정도는 관절의 병리조직학적 검사와 CT 및 micro-radiography 등의 방사선적 검사를 통하여 관찰하였다. 또한 관절염의 병리과정에 중요한 역할을 하는 TNF-α, IL-6, RANKL 등 염증유도 및 골 파괴 매개물질들의 발현은 면역조직화학검사를 통하여 분석하였다. DBA/1J 생쥐의 꼬리에 콜라겐을 피하 주사하였을 때 무릎관절과 발목관절에 부종이 발생하면서 관절염이 유도되었다. 반면 S1P를 처리한 군에서는 CIA군에 비해 관절염의 유발 빈도 및 염증을 비롯한 관절의 손상 정도가 현저히 억제되었다. 관절의 조직학적인 소견 및 방사선적 소견에서도 콜라겐에 의한 세포의 침윤, 활막의 비후, 연골과 골의 미란 및 파괴등이 S1P 처리에 의하여 개선되었고 골의 손실도 현저히 억제되었다. 또한 콜라겐에 의하여 류마티스성 관절염에서 중요한 역할을 하는 TNF-α, IL-6, RANKL 등의 염증 매개물질들의 발현이 CIA군에서 증가한 반면 S1P를 처리한 군에서는 억제되었다. 더욱이 S1P는 골수세포가 RANKL에 의하여 파골세포로 분화되는 것을 현저히 억제하였다. 결론적으로 S1P가 CIA의 병리과정에서 발현되는 염증 및 골 파괴 매개 물질의 발현을 억제하여 염증 및 골 손상을 억제하는 것으로 생각되었고, 이는 S1P가 류마티스 관절염의 치료에 고려되어야 할 물질중의 하나임을 제시한다. Sphingosine 1-phosphate (S1P) is a bioactive lipid molecule that mediates cell proliferation, differentiation, migration, and angiogenesis in vivo. However, the roles of S1P on pathogenesis of arthritis have been not completely understood. This study was designed to determine the effects of S1P modulation on collageninduced arthritis (CIA) model. DBA/1J mice were injected with collagen into the tail for induction of CIA model. S1P was administered into the peritoneal cavity every other days from day 1 to day 42 after collagen injection. To determine the degree of damage in CIA, we examined macroscopic findings of CIA. The inflammation and bone destruction of CIA mice were evaluated by histo-patholigy and radiography (CT and microradiography). The expressions of TNF-α, IL-6, and RANKL which have important roles in pathogenesis of rheumatoid arthritis and bone destruction were observed by immuno-histochemical staining. After injection with collagen in the DBA/1J mice, CIA was induced by swelling in the knee and ankle joint. Administration of S1P suppressed damages and incidence of arthritis elicited by collagen. In histologic and radiographic studies, S1P strongly suppressed the infiltration of inflammatory cells, the swelling of synovial membrane, erosion, and the destruction of bone on CIA mice. Injection of S1P resulted in down-regulation of the expression of the pro-inflammatory and bone destruction mediators such as TNF-α, IL-6, and RANKL on CIA mice. Furthermore, S1P suppressed the differentiation of bone marrow cells into osteoclasts by RANKL. In conclusion, this study suggest that S1P has protective effects on inflammation and bone destruction during pathogenesis of CIA, which indicates S1P can be a new possible therapeutic strategy for rheumatoid arthritis
Atomic structure of conducting nanofilaments in TiO2 resistive switching memory
Kwon, Deok-Hwang,Kim, Kyung Min,Jang, Jae Hyuck,Jeon, Jong Myeong,Lee, Min Hwan,Kim, Gun Hwan,Li, Xiang-Shu,Park, Gyeong-Su,Lee, Bora,Han, Seungwu,Kim, Miyoung,Hwang, Cheol Seong Springer Science and Business Media LLC 2010 Nature nanotechnology Vol.5 No.2
이병한 ( Byeong Han Lee ),진영민 ( Young Min Jin ),성덕경 ( Deok-gyeong Seong ),황연현 ( Yeon-hyeon Hwang ),김영광 ( Young-gwang Kim ),이종기 ( Jong-ki Lee ),박진영 ( Jin Young Park ) 한국농업기계학회 2023 한국농업기계학회 학술발표논문집 Vol.28 No.1
합성곱신경망(Convolutional Neural Network, CNN)은 이미지 분류와 같은 컴퓨터 비전 문제에서 효과적인 딥러닝 모델이다. 본 연구는 벼 품종별 이미지 분류를 위해 합성곱신경망을 활용하였다. 분류에 사용된 벼 품종은 영호진미, 영진, 아람, 새일미이며, 각 품종당 7 반복으로 총 28개 시험구를 조성하여 2022년 6월 7일에 이앙하였다. 벼의 생육이미지는 다중분광센서(Red-Edge MX)를 장착한 드론을 지상 20m에서 경로비행 하도록 설정하여 8월 18일에 수집하였으며, 지상표식을 기준으로 계산한 GSD(Ground Sample Distance)는 13.8mm였다. 합성곱신경망에 수집된 이미지를 입력하기 위해 시험구 조성 도면과 정사이미지(Orthographic images)를 대응시켜 36×36pixel2 크기로 관심영역(Region of Interests)을 추출하고, 이미지의 밝기를 0~1,023 사이의 값으로 정규화 한 뒤 오츠의 기법(Otsu’s method)을 사용하여 논의 토양 영역을 검은색(채널별 밝기값 : 0, 0, 0, 0, 0)으로 처리하였다. 최종적으로 사용된 데이터세트는 5채널(Red, Green, Blue, Red-Edge, NIR) 이미지 1,008장과 각 이미지에 대한 품종별 라벨로 구성하고 학습데이터와 시험데이터를 8:2로 나누었다. 합성곱신경망은 3개의 은닉층(Hidden layer)과 1개의 전결합층(Fully connected Layer)으로 구성하고 활성화 함수로는 렐루(relu)와 소프트맥스(softmax)를 사용하였다. 학습 시의 정확도는 100%이며 시험데이터로 8회 검증한 결과, 정확도의 평균값은 77.4%로 나타났다. 본 연구에서는 데이터세트를 효율적으로 제작하기 위하여 시험구 도면 정보를 기반으로 관심영역을 일괄적으로 추출하였다. 하지만 이로 인해, 관심영역이 아닌 곳에 재식된 벼의 일부가 관심영역에 포함되거나 포함되지 않은 경우가 혼재하여 시험 성능에 영향을 미친 것으로 추측된다. 향후 벼의 중심점을 기준으로 관심영역을 한정하여 데이터세트의 품질을 개선할 계획이다.
Chin, Hang Gyeong,Park, Sung Han,Choe, Mi Sook,Park, Su Hyun,Oh, Byeong Keun,Lee, Gi Hwan,Choe, Hae Choon,Cho, Moo Je,Hong, Jong Chan,Han, Chang-Deok 한국식물학회 2000 Journal of Plant Biology Vol.43 No.1
Wheat dwarf virus (WDV) is a monocot-infecting geminivirus that replicates in infected tissue as double-stranded DMA. We evaluated whether the WDV vector system bearing Ds could be used as an effective insertional mutagen in rice. Molecular data showed that Ds was excised from WDV vectors once the WDV-carrying Ds (WDV::Ds) and the genomic Ac vector were co-introduced into rice calli. Mature T0 and T1 transgenic plants were analyzed for the distribution and inheritance of Ds inserts. Southern analysis indicated that the Ds elements excised from WDV vectors were stably inserted into genomes. The number of transposed Ds ranged from zero to three copies, among independent transformants. Meanwhile, untransposed Ds (WDV::Ds) were present in multiple-copies in genomes. Southern analysis of the selfed progeny of T0 plants demonstrated that most WDV::Ds were co-segregated among siblings. This indicated that these elements were integrated into the same single loci. However, a few Ds were found to segregate independently from the majority of Ds. In this report, we discuss the efficiency of WDV vectors in generating multicopy Ds in rice genomes.
조은덕 ( Eun Deok Jo ),한경순 ( Gyeong Soon Han ) 대한구강보건학회 2012 大韓口腔保健學會誌 Vol.36 No.4
Objectives: The aim of this study is to analyze the factors that influence adults halitosis, Methods: The subjects of this study were 186 adults aged from 35 to 69, between April 4 and May 30, 2012, Data were analyzed with t-test, one-way ANOVA, and binary logistic regression analysis SPSS 19.0, Results: The most influential factor of VSCs was halitosis perceived by others (OR: 5.18; 95% CI: 1.82-14.70), which was followed by oral respiration (OR: 3.65; 95% CI: 1.28-10.41), and O`Leary index (OR: 3.40; 95% CI: 1.55-7.46) in the order. The influential factors of ammonia were respiratory disease (OR: 30.72; 95% CI: 1.85-51.37), gastrointestinal disease (OR: 12.28; 95% CI: 1.78-44.79), missing tooth (OR: 3.75; 95% CI: 1.57-8.92), periodontal pocket (OR: 2.61; 95% CI: 1.10-6.18), tongue brushing (OR: 0.38; 95% CI: 0.15-0.95), and oral prophylaxis (within a year) (OR: 0.31; 95% CI: 0.13-0.75). Conclusions: Halitosis is the result of complex actions among individual characteristics, systematic disease, oral health state, and health behavior.
Isr (INHIBITOR OF STRIATE) CONDITIONALLY SUPPRESSES CELL PROLIFERATION IN VARIEGATED MAIZE
Park, Sung-Han,Park, Su-Hyun,Chin, Hang-Gyeong,Cho, Moo-Je,Robert A. Martienssen,Han, Chang-Deok Plant molecular biology and biotechnology research 1998 Proceedings the 2nd Korean-Germany joint symposium Vol.1998 No.-
A new lignan glycoside from the rhizomes of Imperata cylindrica
Lee, Dae-Young,Han, Kyung-Min,Song, Myoung-Chong,Lee, Do-Gyeong,Rho, Yeong-Deok,Baek, Nam-in Taylor Francis 2008 Journal of Asian natural products research Vol.10 No.4
<P> A new lignan glycoside, 6-acetyl-1-[1,3-(4,4'-dihydroxy-3,3'-dimethoxy-&bgr;-truxinyl)-&bgr;-d-fructofuranosyl]-α-d-glucopyranoside (1), named impecyloside, was isolated from the rhizomes of Imperata cylindrica. The structure of the compound was determined by spectroscopic data including FABMS, UV, IR, 1H NMR and 13C NMR (DEPT) and 2D NMR (COSY, HSQC, HMBC).</P>
호스피스 교육이 간호사의 죽음과 임종에 대한 두려움과 대응에 미치는 영향
정복례,한지영,김경덕,Jeong, Bok-Rye,Han, Ji-Yeong,Kim, Gyeong-Deok 한국호스피스협회 2005 호스피스 학술지 Vol.5 No.1
Purpose: The purpose of this study was to identify the effects of education of hospice for nurses on concern and coping about death and dying. Methods: The subjects of this study were 33 Korean nurses who participated in the education of hospice which consisted of lectures and practices for 5 months. Data were collected using questionnaire of concern and coping about Death and Dying. Data were analyzed with the mean, SDs and Wilcoxen test. Results: The mean score of concern about death and dying was 7.03. The highest items of concern about death and dying were 'thoughts of physical pain and being, 'thoughts of suffocating and choking, 'fear of darkness', The lowest items of concern about death and dying were. 'thoughts of burglars invading my possessions', 'rejection by God', thoughts of no one attending funeral', 'thoughts of no one paying respect or tribute', The mean score of coping about death and dying was 11.37. The highest items of coping about death and dying were 'call family member(s) into room and ask them ti sit close by, reminisce on happy events of the past, tell myself that there is nothing to be afraid of, look at family picture albums'. The lowest items of coping about death and dying were 'stay up stay up late till ready to fall asleep', 'look at family heirlooms', 'phone a prayer line', 'ask for a snack or something to drink'. In concern and coping about death and dying, significant differences were not found between pre and post test. But there was a tendency to decrease concern and increase coping about death and dying after education of hospice. Conclusion: According to these results, it is needed for nurses not only to do research for concern and coping about death and dying but also to develop an education program.