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Eom, Ki-Seong,Kim, Hee-Je,Min, Woo-Sung,Lee, Seok,Min, Chang-Ki,Cho, Byung-Sik,Kim, Sung-Yong,Kim, Yoo-Jin,Lee, Dong-Gun,Choi, Su-Mi,Cho, Seok-Goo,Kim, Dong-Wook,Lee, Jong-Wook,Shin, Wan-Shik,Kim, Chu Munksgaard 2007 European journal of haematology Vol.79 No.5
<P>Abstract</P><P>Background: </P><P>In this study, the effectiveness and safety of combining gemtuzumab ozogamicin (GO) with an abbreviated schedule of standard induction chemotherapy were assessed in 37 patients (aged ≥55) yr with previously untreated acute myeloid leukemia (AML).</P><P>Methods: </P><P>GO was administered at a dose of 6 mg/m<SUP>2</SUP> as a single 2-h intravenous infusion on day 1. Following GO, an abbreviated schedule of induction chemotherapy consisting of idarubicin (12 mg/m<SUP>2</SUP>/d, days 2–4), and <I>N</I>4-behenoyl-1-<I>&bgr;</I>-arabinofuranosyl cytosine (300 mg/m<SUP>2</SUP>/d, days 2–6) was given.</P><P>Results: </P><P>Thirty-seven patients were treated with GO in combination with chemotherapy. Complete remission (CR) and CR with incomplete platelet recovery were achieved in 28 patients (75.7%) and one patient (2.7%) respectively. Two patients (5.4%) died during induction and two patients (5.4%) with grade 4 treatment emergent adverse effects during chemotherapy did not complete induction chemotherapy. The majority of toxicities were mild and manageable. Severe myelosuppresion was universal with significantly prolonged thrombocytopenic period. In total, 25 patients who received consolidation treatment, 19 patients remain alive at the time of analysis. Thirteen patients had undergone hematopoietic stem cell transplantation, three are preparing for transplantation and seven are receiving their consolidation chemotherapy course.</P><P>Conclusion: </P><P>Although only a relatively small number of cases were included in this preliminary study and the follow-up duration was short, frontline GO in combination with attenuated conventional chemotherapy was found to be effective and feasible in elderly patients with AML.</P>
An AC-PDP Single Sustaining Driver Employing the Voltage Stress Reduction Technique
Ki-Bum Park,Seong-Wook Choi,Chong-Eun Kim,Gun-Woo Moon,Myung-Joong Youn IEEE 2009 IEEE transactions on power electronics Vol.24 No.4
<P>The single sustaining driver (SSD) for an AC plasma display panel (AC-PDP) can simplify and optimize the circuit part of the PDP; however, it suffers from twice the high voltage stress of switches compared with the conventional sustaining driver. To solve this problem, a new SSD employing a voltage stress reduction technique is proposed. By adjusting the gate timing with the proposed simple structure, the voltage stresses of all devices are effectively ensured at the sustaining voltage.</P>
Single Sustaining Driver for AC-PDP employing Voltage Stress Reduction Technique
박기범(Ki-Bum Park),최성욱(Seong-Wook Choi),김정은(Chong-Eun Kim),문건우(Gun-Woo Moon),윤명중(Myung-Joong Youn) 전력전자학회 2006 전력전자학술대회 논문집 Vol.- No.-
Conventional sustaining driver (SD) of plasma display panel (PDP) employing auxiliary circuits on both side of a H-bridge inverter increases volume of PDP with cost. To solve this problem, a new single sustaining driver (SSD), which utilize only one side of auxiliary circuit is proposed. Moreover, using the voltage stress reduction technique (VSRT), the proposed SSD effectively reduces switch voltage stress with a simple structure.
Zero-Voltage Switching Flyback-Boost Converter with Voltage-Doubler Rectifier
Hyun-Wook Seong,Hyoung-Suk Kim,Ki-Bum Park,Gun-Woo Moon,Myung-Joong Youn 전력전자학회 2009 전력전자학술대회 논문집 Vol.2009 No.1
Novel zero-voltage switching(ZVS) flyback-boost converter with a voltage-double rectifier(VDR) has been proposed. By integrating the common part of a flyback converter and a boost converter, the proposed circuit can provide a switch voltage clamping and a high step-up ratio. An auxiliary switch instead of a boost diode enables to turn all switches on under ZVS conditions. The VDR can extend a step-up ratio as well as clamp the voltage of secondary rectifiers. The operational principle and theoretical analysis are presented. Experimental results based on a 42V input, 400V/0.5A output and 50㎑/100㎑ prototype are shown to verify the proposed scheme.
2006년 고리 주변해역에 출현하는 자치어의 종조성과 출현양상
백근욱 ( Gun Wook Baeck ),박주면 ( Joo Myun Park ),남기문 ( Ki Moon Nam ),허성회 ( Sung Hoi Huh ) 한국어업기술학회 2012 수산해양기술연구 Vol.48 No.3
Species composition and abundance of larval fishes in the coastal waters off Gori in the southeastern Korea were investigated from January to December in 2006. During the study period, 32 larvae species belonging to 20 families were collected. The dominant species were Engraulis japonicius, Hexagrammos agrammus, Sillago japonicus, Acropoma japonicum, Apogon lineatus, and Konosirus punctatus. These six species accounted for 87.0% of the total number of individuals collected. The number of species, number of individuals, and species diversity indices fluctuated by season. The peak numbers of species and individuals occurred in July and May, respectively. Correlation analysis showed that monthly variations in water temperature and salinity could act as an indicators of seasonal variations in the larval fish community structure and abundance of the dominant species; in particular, the abundance of S. japonicus, A. japonicum, and A. lineatus were significantly corrected with the water temperature.
동종 조혈모세포이식 후 폐합병증 : 미만성 폐침윤에서 기관지경의 유용성
민창기,엄기성,이동건,김동욱,이종욱,민우성,김춘추,정정임,김태연,송정섭 대한조혈모세포이식학회 2000 대한조혈모세포이식학회지 Vol.5 No.1
배경:동종 조혈모세포이식을 받고 백혈구수가 회복한 이후의 폐합병증은 대부분 국소적 폐렴이 아닌 미만성의 폐침윤(diffuse pulmonary infiltrate) 소견을 보이고 이식 후 불완전한 면역 재구성 또는 이식편대 숙주질환(graft-versus-host disease; GVHD) 등과 관련된다고 알려져 있다. 원인은 세균보다는 바이러스(주로 cytomegalovirus; CMV), Pneumocytis carinii (PC) 등이며 원인을 규명할 수 없는 특발성의 경우도 상당수를 차지하고 있으나 아직 국내에서는 자세히 보고된바 없다. 저자들은 본 센터에서 동종 조혈모세포이식 후 발생한 폐합병증의 진단 및 치료성적을 보고하고자한다. 방법:1997년 1월부터 1999년 8월까지 본 센터에서 동종 조혈모세포이식을 받은 321예의 환자 중에 방사선학적으로 미만성 폐침윤을 보여 기관지경 검사를 받은 환자 35예를 대상으로 하였으며 5예의 환자는 임상적인 경과의 변화로 기관지경 검사를 2회 실시 받았다. 환자들의 임상적 특성, 영상학적 검사 그리고 기관지경 검사로 기관지 폐포세척술을 실시하여 얻은 가검물에서 원인 미생물을 배양하거나 폐조직 생검을 통하여 진단하였다. 각 환자에서 진단에 따른 치료 및 반응을 관찰하였다. 결과:1) 환자연령의 중앙치는 31 (16~40)세, 이식 후 미만성 폐침윤이 발생하기까지 기간의 중앙치는 162 (55~965)일 이었다. 이식 당시 질환은 CML 16예, AML 10예, ALL 5예, NHL 2예, MDS 1예 그리고 CLL 1예 이었으며 35예 중 11예에서 2차 관해 이상의 진행된 질환을 갖고 있었다. 35예 중 비혈연간 또는 혈연간 HLA 부분일치 동종 조혈모세포이식 환자는 12예였고, 전처치에 전신 방사선조사를 받은 환자가 27예 항암제만 받은 환자는 8예 이었다. 2) GVHD 예방 약제로는 cyclosporin+methotrexate (n=26) 또는 tacrolimus+methotrexate (n=9) 조합을 사용하였다. 감염 예방으로 경구로 trimethoprim-sulfamethoxazole, acyclovir을 투여를 받은 환자는 9예(25.7%) 이었다. II도 이상의 급성 GVHD를 가진 환자가 12예(34.3%) 이었고, 27예(77.1%)에서 만성 GVHD를 갖고 있었다. 3) 기관지 폐포세척술의 가검물 배양 결과 미만성 폐침윤의 원인 미생물로는 CMV 8예, PC 6예, 두 미생물의 혼합감염 10예, 폐렴구균 1예, 그리고 Mycobacterium tuberculosis 1예 이었고, 나머지 14예(35%)에서는 원인균이 동정되지 않았다. 경기관지 폐조직생검은 19예 중 3예(15.8%)에서 진단적 가치가 있었다. 4) 기관지경을 시행한 40예 중 8예(20%)에서 폐포세척술 검체의 배양 및 경기관지 폐생검의 결과에 따라 치료를 하였음에도 불구하고 호전되지 않았다. 5) 35예 중 9예의 환자가 사망하였으며 이중 5예는 폐합병증으로 사망하였고 나머지 4예는 재발 또는 이식편대숙주질환에 의해 사망하였다. 폐합병증으로 사망한 환자의 원인으로는 CMV 1예, PC 1예, 혼합감염 1예, 그리고 원인 불명의 폐합병증이 2예 있었다. 결론:동종 조혈모세포이식 후 발생한 미만성의 폐침윤의 주된 원인은 CMV, PC 등이며 단독 감염보다는 혼합 감염의 형태를 보였다. 기관지경 검사 및 폐포세척술은 미만성 폐침윤의 진단에 유용하며 안전한 시술로 사료된다. 폐합병증은 주로 만성 GVHD 환자에서 출현하였으며 원인이 밝혀지지 않은 경우에 면역억제 치료가 효과적이었다. Background:Diffuse pulmonary infiltrates (DPI) after a neutropenic phase following allogeneic stem cell transplantation (allo-SCT) are common and include various causes. Multiple factors are thought to contribute to these pulmonary complications, including the graft-versus-host disease (GVHD), incomplete immune reconstruction and infections. This study was undertaken to determine the results of fiberoptic bronchoscopy (FOB) in patients with DPI after allo-SCT. Methods:Three hundreds twenty one patients underwent allo-SCT from January 1997 through August 1999 at Catholic Hemopoietic Stem Cell Transplantation Center. Out of 321 patients, 40 FOBs were performed in 35 patients who were aged 16 to 40 years (median age 31 years). In all cases, bronchoalveolar lavage (BAL) was achieved. Transbronchial forceps biopsy (TBFB) was also carried out in 47.5% (19/40). Clinical, radiologic, pulmonary function, microbiological and pathologic tests were reviewed. Results: 1)The underlying diseases were predominantly chronic myeloid leukemia and acute leukemia (31/35, 88.5%). Median time to FOB following SCT was 162 days (range, 55-965). The patients with acute GVHD more than grade II were 34.3% (12/35) and those with chronic GVHD were 77.1% (27/35). 3) An etiological diagnosis could be obtained in 26/40 (65%) of cases; mixed infection of cytomegalovirus (CMV) and Pneumocystis carinii (PC) was the most common finding (10/40, 25%), CMV and PC were isolated in BAL in 8/40 and 6/40 respectively, Pneumococci in one and Mycobacterium tuberculosis in one. In 14 procedures (35%), the results were negative. TBFB were valuable for diagnosis for only 3 out of 19 patients. There was one minor bleeding following FOB and TBFB. 4) Thirty two cases (80%) of FOB improved after treatment according to etiology. The patients with unknown etiology showed a good response to steroid (11/14, 78.6%). 5) Overall mortality in patients with DPI was 9/35 (25.7%). Five episodes of DPI were to refractory to treatment and were causes of death. Five causes consisted of 1 CMV, 1 PC, 1 mixed infection, and 2 unknown etiologies. Conclusion:FOB is a safe and valuable procedure for the evaluation of DPI after allo-SCT, which were commonly associated with GVHD, CMV and PC. The mixed infections were more predominant than those due to single isolated organism. Steroid was effective for patients with DPI in whom causative organisms were not able to be identified.