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생쥐 위장관의 Interstitial cells of Cajal(ICC)에 대한 면역조직화학적 연구
김영철,차경훈,신무경,임건한,김주영,안병수,김장만,양경철,박도영,오재욱,장인엽 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1
Background and Objectives : Interstitial cells of Cajal(ICC) are the pacemakers in gastrointestinal tract that modulates gastrointestinal motiliey and these cells also transmit neural input from enteric nerves to smooth muscles. Recent work on tissues from patients with motility disorders that suggest that loss or defect in ICC could be related to pathophysiology in human and animal models. Immunolabelling of ICC in intestinal wall is recently developed by using specific marker, anti-c-kit antibody. Immunohistochemistry was done for ICC network in attempt to provide a morphological basis for the mechanism regulating gastrointestinal motility Methods : Cryosection was done, and whole-mount preparations of mouse stomach, gastrointestinal tract were immunolabelled using the anti-c-Kit. Immunolabelled ICC networks were observed under a confocal laser scanning microscopy. Results : According to three dimensional reconstruction study, we found that the c-Kit-positive celluar networks were widely distributed in the gastrointestinal muscle (1) circular muscle layer(IC-IM), (2) myenteric plexus(IC-MY), (3) deep muscular plexus(IC-DMP) in ileum, (4) submucosal plexus(IC-SMP) and longitudinal muscle layer(IC-LM) in colon. Conclusion : The characteristic profiles of ICC celluar networks provide a morphological basis upon the mechanism regulating gastrointestinal motility. Additional studies for the enteric nerves-ICC interaction are need to evaluate the detailed roles of Icc in gastrointestinal tract.
Analysis of Cardiovascular Risk Factors and Metabolic Syndrome in Korean Patients with Psoriasis
( Gun Wook Kim ),( Hyun Je Park ),( Hoon Soo Kim ),( Su Han Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Eun Kyung Sim ) 대한피부과학회 2012 Annals of Dermatology Vol.24 No.1
Background: In previous studies, psoriasis has been reported to be associated with metabolic syndrome. Objective: The purpose of this study was to evaluate risk factors for metabolic syndrome in psoriasis patients and to compare the prevalence of metabolic syndrome in psoriasis and control groups. Methods: All patients (n=490) and controls (n=682) were investigated for cardiovascular risk factors, including central obesity, hypertension, fasting plasma glucose levels, and blood levels of triglycerides and high-density lipoprotein (HDL). Results: We found no statistical association between psoriasis and the prevalence of metabolic syndrome when controlling for age and gender. Among individual components of metabolic syndrome, only increased triglyceride levels was significantly prevalent in patients psoriasis. The incidence of other factors such as central obesity, hypertension, fasting plasma glucose and HDL in the psoriasis group were similar to or lower than those in the control group. Although psoriasis patients with metabolic syndrome had severe and large plaque-type psoriasis, the association of metabolic syndrome with the severity or clinical subtype of psoriasis was not significant after adjusting for age and gender. Conclusion: Our results suggest that there is no close correlation between psoriasis and metabolic syndrome in Korean patients. (Ann Dermatol 24(1) 11∼15, 2012)
( Gun Wook Kim ),( Hyun Ju Jin ),( Hyun Ho Cho ),( Won Jeong Kim ),( Je Ho Mun ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Labial melanotic macules are benign pigmented lesions that may clinically mimic melanoma. Whereas the dermoscopic features of other pigmented skin lesions have been extensively described, little is known about labial melanotic macules. Objectives: To describe the dermoscopic aspects of labial melanotic macules and find schematic dermoscopic patterns to these lesions. Methods: A retrospective dermoscopic study was conducted on 80 lesions with histopathologically proved labial melanotic macules. Results: We describe and define, for the first time to our knowledge, landscape painting patterns found in 65 of 80 melanotic lesions (81.3%), characterized by parallel lines orcircle lines, overlapping vessels with background brown pigmentation. The background brown pigmentations were observed in 74 of 80 lesions (92.5%), the parallel lines in 62 (77.5%), the circle lines in 20 (25.0%), and overlappin vessels in 69 (86.3%). The structureless black pigmentations were only presented in 26 of 80 melanotic lesions (32.5%). Conclusion: Dermoscopy can be useful for the clinical detection of labial melanotic macules, and “Landscape painting patterns” may represent a dermoscopic clue for the diagnosis of these lesions.
( Gun-wook Kim ),( Kihyuk Shin ),( Hyang-suk You ),( Hyun-ju Jin ),( Woo-haing Shim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ) 대한피부과학회 2018 Annals of Dermatology Vol.30 No.3
Background: Labial melanotic macules (LMMs) are benign pigmented lesions that usually take the shape of flat asymmetrical macules with tan-brown to black color and variable size. Whereas the dermoscopic features of other pigmented skin lesions have been relatively well described, little is known about LMMs. Objective: To describe the dermoscopic features and find typical and schematic dermoscopic patterns in LMMs. Methods: A retrospective dermoscopic study was conducted on 80 lesions with histopathologically proved LMMs. Results: We described and defined, for the first time to our knowledge, landscape painting patterns found in 65 of 80 melanotic lesions (81.3%), characterized by parallel lines or circle lines, overlapping vessels with background brown pigmentation. The background brown pigmentations were observed in 74 of 80 lesions (92.5%), the parallel lines in 62 (77.5%), the circle lines in 20 (25.0%), and overlapping vessels in 69 (86.3%). The structureless black pigmentations were only presented in 26 of 80 (32.5%). Conclusion: Dermoscopy can be useful for the clinical detection of LMMs, and “Landscape painting patterns” may represent a dermoscopic clue for the diagnosis of these lesions. (Ann Dermatol 30(3) 331∼334, 2018)
Case Reports : Giant Piloleiomyoma of the Forehead
( Gun Wook Kim ),( Hyun Je Park ),( Hoonsoo Kim ),( Suhan Kim ),( Hyunchang Ko ),( Byungsoo Kim ),( Moonbum Kim ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.2s
Cutaneous piloleiomyomas are benign smooth muscle tumors arising from the arrector pili muscles. Piloleiomyomas appear as firm dermal papules of skin color or with a reddish to brown surface, and are commonly located on the extremities. Histologically, these lesions are composed of interlacing bundles of smooth muscle cells in the reticular dermis. Our case presented with an unusually large nodule on the forehead that was accompanied by intermittent pain. Histological analysis was compatible with piloleiomyoma and the lesion showed haphazardly arranged bundles of smooth muscle in the dermis. We describe herein an interesting case of a giant piloleiomyoma occurring on the forehead. (Ann Dermatol 23(S2) S144~S146, 2011)
( Gun Wook Kim ),( Jin Hwa Son ),( Jeong Min Kim ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Acquired bilateral telangiectatic macules (ABTM) are a newly recognized clinical entity with multiple telangiectatic pigmented macules confined mostly to the upper arms. Objectives: To evaluate clinical and dermoscopic features in a group of 50 patients with ABTM and to determine the usefulness of dermoscopy for identifying patients with chronic liver diseases (CLD) Methods: Patients were selected from two tertiary teaching hospitals in Korea. Overall, 50 patients with ABTM in the skin were included in the study. The dermoscopic findings were graded on a 0-3 scale of severity: none (0), mild (1), moderate (2), severe (3). Results: We identified three valuable dermoscopic features in diagnosing ABTM including brown pigmentations, telangiectasia and angioid streak pattern. The brown pigmentations from the group without CLD were scored more severely than the group with CLD (mean score: 2.00 vs 1.48, P < 0.001). The mean severity score of telangiectasia from the group with CLD was higher than the mean from the group without CLD (2.14 vs 1.39, P < 0.001). The angioid streak pattern was characterized as bilateral, narrow and irregular lines configuring in a radiating fashion. The angioid streak pattern was observed in 63.0% of patients with and 26.1% of those without CLD (1.37 vs 0.35, P < 0.001). Conclusion: The detailed observations in ABTM with dermoscopy provide the first clues for the underlyingchronic liver disease.
( Gun Wook Kim ),( Hyun Je Park ),( Hoon Soo Kim ),( Su Han Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.3s
Herein, we report a case of an 8-year-old girl with dapsone hypersensitivity syndrome (DHS) that occurred during the treatment of erythema elevatum diutinum. She had fever, gross hematuria, and malaise for three weeks after initiation of dapsone therapy. Five days after stopping dapsone treatment, she returned to the emergency clinic because of high fever, emesis, diarrhea, upper respiratory symptoms, and worsening of exanthematous eruptions. A diagnosis of DHS was made, and it improved with oral prednisone. We recommend that pediatric patients who are treated with dapsone need to be observed carefully for the development of DHS. (Ann Dermatol 23(S3) S290~S295, 2011)