Slim Patch Type을 이용한 카페인의 경피흡수에 관한 연구

김정수,권동환,임도형,김구서,강진양 한국약제학회 2006 Journal of Pharmaceutical Investigation Vol.36 No.2

米堤貯水池의 水質特性에 관한 硏究

김환기,오태선,유선재,김종구 全北大學校 附設 都市및環境硏究所 1996 都市 및 環境硏究 Vol.11 No.1

To investigate the characteristic and the cause of the eutrophication in Mijae Reservoir, chemical analyses were made on surface, bottom waters collected from 7 stations in July, September in 1995 respectively. 1. The Water quality of Mijae reservoir were Ⅳ grade over lake water quality criteria. 2. The trophic state of Mijae reservoir is placed eutrophic or Hypereutrophic state. 3. In order to protect of eutrohication, It is necessary that get ride of sediments, Nutrients and algaes.

CO₂ 레이저 및 Interferon을 이용한 후두 유두종의 치료

박구진,하정환,김연기,이원용,김종애 釜算慶南耳鼻咽喉科學會 1994 임상이비인후과 Vol.5 No.2

기질성 뇌장애 환자의 구조적 뇌영상과 비교한 저해상 전자기 단층 촬영 영상

이승환,권구형,박영민,김 현,이강준,정영조 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.3

Objectives : Patients with organic brain lesion can produce unique slow waves (delta and theta) in the EEG. Basic assumption of this study was that the low resolution electro magnetic tomography (LORETA), an inverse source localization program, can provide functional images representing increased slow wave activity in these patients compared to normal subjects. Methods : The current study was performed by 18 channels digital EEG for 10 patients whose organic deficit have been Visually confirmed by CT or MRI. The source images of slow wave (1-7 Hz) frequency were produced by LORETA-key program. Results : We found that in eight out of ten subjects, LORETA successfully found out the source regions which were very closely matched to their original brain lesions. However in two subjects whose organic brain lesions were too small (<1cm) and located out of gray matter, we failed to find any increased slow wave activity compared with normal control. Conclusion : We can conclude that LORETA could be a useful method to provide functional imaging in patients with gray matter deficits in their brain. Its usefulness and limitations were discussed.

GIS와 RS를 이용한 생태지도 작성기법에 관한 기초연구

이기철,이원화,윤해순,남춘희,김구연,김승환,서상현 한국지리정보학회 2004 한국지리정보학회지 Vol.7 No.3

본 연구는 낙동강 하구 일대의 생태계 변화와 생태 관련자료를 GIS DB로 구축하고 생태지도를 작성하였다. 생태지도 작성을 위해 1984년 11월 21일, 1997년 5월 17일에 촬영된 공간해상도 30m의 Landsat TM 위성영상과 국립지리원에서 발행된 1:25,000 수치지형도, 부산시에서 조사한 생물현황 자료를 바탕으로 DB를 구축하였다. 생태지도를 작성하기 위해, 첫째, 낙동강 하구 생태계 조사 보고서와 현재까지 진행된 생태지도에 대한 문헌 연구, 둘째, 시계열적 토지피복분류도 제작, 셋째, 동·식물상, 수질 등 생태계 항목별 BB 구축과 3단계 방식에 의한 생태계 평가, 최종적으로는 이러한 분석 결과를 바탕으로 생태계 관리를 위한 생태지도를 작성하였다. This study developed an ecological mapping technique with GIS database using the analyses of existing ecological survey reports and the change detection on the Nakdong river estuary. The data which are used to establish GIS DB include 2 Landsat TM images on Nov. 31, 1984 and May 17, 1997, 1:25, 000 topographical maps established by National Geography Institution and various ecological survey reports published by Busan metropolitan city government. The details for producing ecological map are as follows. At first, the current methods of ecomapping efforts and previous ecological surveys of Nakdong river estuary were carefully examined. Secondly, the land cover maps were created from the classified Landsat images of 1984 and 1997 for the spatiotemporal ecosystem analysis. Thirdly, the ecosystem was evaluated by using GIS ecological database based on the criteria of botany, zoology and water quality etc. Each criteria was reclassified into 3 stages which describe the overall quality of ecological condition. At last, the comprehensive ecological map was suggested as a prototype of ecosystem assesment and management tool with the discussion of further study. The findings of this study would be a milestone for preserving and managing the ecosystem.

위의 유암종과 선종의 병발 1례

장재식,강혁주,이중현,서영범,윤병구,김용섭,이구,서정일,양창헌,이창우,김정란,윤환중 東國大學校醫學硏究所 2000 東國醫學 Vol.7 No.-

유암종은 전신에 퍼져 잇는 장크롬친화성 세포에서 기원하는데 위의 유암종은 비교적 드문 질환으로 모든 유암종의 1.9~2.2%에 해당하며 위에 발생하는 종양의 1% 미만에서 보고되고 있다. 유암종은 일반적으로 증상이 비특이적이고 면역조직화학검사에 의해서 진단되기 때문에 과거에는 드물게 발견되었으나 최근 내시경 기기 및 술기의 발전과 검사 빈도의 증가 및 면역조직화학검사의 발달로 진단율이 증가 추세에 있으며, 드물지만 유암종에서 선암과 공존하는 예들이 보고되고 있다. 저자들은 심와부 동통을 주소로 내원한 70세 남자 환자의 상부위장관내시경 검사에서 위체상부의 대만곡에서 0.4×0.4 cm 크기의 중간 함몰을 가진 Yamada 1형의 용종과 함께 전정부의 전벽에서 0.8×0.5 cm 크기의 융기된 점막 소견을 보여 조직학적으로 각각 위유암종 및 위선종임을 확진한 후 내시경적 용종 절제술로 치료한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Carcinoid tumors are arisen from enterochromaffin cells, which are scattered throughout the body. These tumors are composed of variable numbers of cells that contain endocrine granules in their cytoplasm, which can be identified by immunohistochemistry and electron microscopy. Gastric carcinoid tumors are relatively rare tumor, the reported incidence being 1.9~2.2% of all carcinoid tumors and less than 1% of all gastric tumors. Sometimes, composite carcinoid tumors and adenocarcinoma is reported. We experienced a case of the coincidence of carcinoid tumor and adenoma at the other site of the stomach in a 70 year old male patient. Gastrofiberscope showed 0.4×0.4 cm sized Yamada type I polyp with central depression on the greater curvature of the proximal body and 0.8×0.5 cm sized focal slightly elevated mucosa on the anterior wall of the antrum. The endoscopic biopsy specimens revealed carcinoid tumor and tubular adenoma with moderate atypism, respectively. The carcinoid tumor and adenoma were removed by endoscopic polypectomy. According to the follow-up gastrofiberoscopy after 7 month later, both lesions were nearly normal mucosa except whitish atrophic change after polypectomy.

Higher thermostability of l-lactate dehydrogenases is a key factor in decreasing the optical purity of d-lactic acid produced from Lactobacillus coryniformis

Gu, Sol-A.,Jun, Chanha,Joo, Jeong Chan,Kim, Seil,Lee, Seung Hwan,Kim, Yong Hwan Elsevier 2014 Enzyme and microbial technology Vol.58 No.-

<P>Lactobacillus coryniformis is known to produce D-lactic acid as a dominant fermentation product at a cultivation temperature of approximately 30° C. However, the considerable production of L-lactic acid is observed when the fermentation temperature is greater than 40°C. Because optically pure lactates are synthesized from pyruvate by the catalysis of chiral-specific D- or L-lactate dehydrogenase, the higher thermostability of L-LDHs is assumed to be one of the key factors decreasing the optical purity of D-lactic acid produced from L. coryniformis at high temperature. To verify this hypothesis, two types of d-ldh genes and six types of l-ldh genes based on the genomic information of L. coryniformis were synthesized and expressed in Escherichia coll. Among the LDHs tested, five LDHs showed activity and were used to construct polyclonal antibodies. D-LDH1, L-LDH2, and L-LDH3 were found to be expressed in L. coryniformis by Western blotting analysis. The half-life values (t<SUB>1/2</SUB>) of the LDHs at 40° C were estimated to be 10.50, 41.76, and 2311 min, and the T<SUB>50</SUB><SUP>10</SUP> values were 39.50,39.90, and 58.60° C, respectively. In addition, the T<SUB>m</SUB> values were 36.0, 41.0, and 62.4° C, respectively, which indicates that L-LDH has greater thermostability than D-LDH. The higher thermostability of L-LDHs compared with that of <SMALL>D</SMALL>-LDH1 may be a major reason why the enantiopurity of n-lactic acid is decreased at high fermentation temperatures. The key enzymes characterized will suggest a direction for the design of genetically modified lactic acid bacteria to produce optically pure D-lactic acid. (c) 2014 Elsevier Inc. All rights reserved.</P>

Functionalized Nanocellulose-Integrated Heterolayered Nanomats toward Smart Battery Separators

Kim, Jung-Hwan,Gu, Minsu,Lee, Do Hyun,Kim, Jeong-Hoon,Oh, Yeon-Su,Min, Sa Hoon,Kim, Byeong-Su,Lee, Sang-Young American Chemical Society 2016 NANO LETTERS Vol.16 No.9

<P>Alternative materials obtained from natural resources have recently garnered considerable attention as an innovative solution to bring unprecedented advances in various energy storage systems. Here, we present a new class of heterolayered nanomat-based hierarchical/asymmetric porous membrane with synergistically coupled chemical activity as a nanocellulose-mediated green material strategy to develop smart battery separator membranes far beyond their current state-of-the-art counterparts. This membrane consists of a terpyridine (TPY)-functionalized cellulose nanofibril (CNF) nanoporous thin mat as the top layer and an electrospun polyvinylpyrrolidone (PVP)/polyacrylonitrile (PAN) macroporous thick mat as the support layer. The hierarchical/asymmetric porous structure of the heterolayered nanomat is rationally designed with consideration of the trade-off between leakage current and ion transport rate. The TPY (to chelate Mn2+ ions) and PVP (to capture hydrofluoric acid)-mediated chemical functionalities bring a synergistic coupling in suppressing Mn2+-induced adverse effects, eventually enabling a substantial improvement in the high-temperature cycling performance of cells.</P>

Epidermal Growth Factor Receptor as a Predictor of Tumor Downs Taging in Locally Advanced Rectal Cancer Patients Treated With Preoperative Chemoradio Therapy

Kim, Jun-Sang,Kim, Jin-Man,Li, Sheng-Jin,Yoon, Wan-Hee,Song, Kyu-Sang,Kim, Ki-Hwan,Yeo, Seung-Gu,Nam, Ji-Sook,Cho, Moon-June 충남대학교 암연구소 2007 암연구소 업적집 Vol.6 No.-

Purpose: To examine retrospectively whether levels of epidermal growth factor receptor (EGFR) expression can predict tumor downstaging after preoperative chemoradiotherapy in patients with locally advanced rectal cancer. Methods and Materials: A total of 183 patients with rectal cancer (cT3-T4 or N+) were enrolled in this study. Preoperative chemoradiotherapy consisted of 50.4 Gy of pelvic radiation with concurrent 5-fluorouracil and leucovorin bolus intravenous chemotherapy in 94 patients or oral capecitabine and leucovoin in 89 patients. EGFR expression in pretreatment paraffin-embedded tumor biopsy specimens was assessed by immunohisto-chemistry. EGFR expression was determined from the intensity and extent of staining. Tumor downstaging was defined as a reduction of at least one T-stage level. Results: Tumor downstaging occurred in 97 patients (53%), and the tumors showed a pathologic complete response in 27 patients (15%). Positive EGFR expression was observed in 140 (76%) of 183 patients. EGFR expression levels were low in 113 patients (62%) and high in 70 patients (38%). On logistic regression analysis, the significant predictive factor for increased tumor downstaging was a low level of EGFR expression and preoperative chemotherapy using oral capecitabine (odds ratio, 0.437; p = 0.012 vs. odds ratio, 3.235; p < 0.001, respectively). Conclusion: A high level of EGFR expression may be a significant predictive molecular marker for decreased tumor downstaging after preoperative chemoradiotherapy in locally advanced rectal cancer.

Identification of two novel Duchenne muscular dystrophies mutations in patients with Becker muscular dystrophy

Kim, Dahye,Kim, Yoon-Myung,Seo, Go Hun,Kim, Gu Hwan,Yoo, Han Wook,Yum, Mi-Sun,Ko, Tae-Sung,Lee, Beom Hee Korean Society of Medical Genetics and Genomics 2017 대한의학유전학회지 Vol.14 No.2

Duchenne and Becker muscular dystrophies (DMD and BMD, respectively) are X-linked neuromuscular disorders characterized by progressive muscle weakness and severe skeletal muscle degeneration. BMD is a milder form with a later onset. Patients with BMD tend to survive much longer than those with DMD. The differentiation between DMD and BMD is important in the genetic counseling of affected patients and their families. Since muscle biopsies are invasive procedures, the differential diagnosis of BMD and DMD is often dependent on the mutation identified in the DMD gene in affected patients. However, when a novel DMD mutation is identified, the differential diagnosis should be based on muscle biopsy findings with other clinical findings. Here we describe two Korean patients with BMD confirmed by muscle biopsy and genetic testing. Two novel exonic deletions in the DMD gene were identified.