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Volumetric Measurements of Lung Nodules with Multi-Detector Row CT: Effect of Changes in Lung Volume
Jin Mo Goo,김광기,David S. Gierada,Mario Castro,Kyongtae T. Bae 대한영상의학회 2006 Korean Journal of Radiology Vol.7 No.4
Objective: To evaluate how changes in lung volume affect volumetric measurements of lung nodules using a multi-detector row CT. Materials and Methods: Ten subjects with asthma or chronic bronchitis who had one or more lung nodules were included. For each subject, two sets of CT images were obtained at inspiration and at expiration. A total of 33 nodules (23 nodules 3 mm) were identified and their volume measured using a semiautomatic volume measurement program. Differences between nodule volume on inspiration and expiration were compared using the paired t-test. Percent differences, between on inspiration and expiration, in nodule attenuation, total lung volume, whole lung attenuation, and regional lung attenuation, were computed and compared with percent difference in nodule volume determined by linear correlation analysis. Results: The difference in nodule volume observed between inspiration and expiration was significant (p < 0.01); the mean percent difference in lung nodule volume was 23.1% for all nodules and for nodules 3 mm. The volume of nodules was measured to be larger on expiration CT than on inspiration CT (28 out of 33 nodules; 19 out of 23 nodules 3 mm). A statistically significant correlation was found between the percent difference of lung nodule volume and lung volume or regional lung attenuation (p < 0.05) for nodules 3 mm. Conclusion: Volumetric measurements of pulmonary nodules were significantly affected by changes in lung volume. The variability in this respiration-related measurement should be considered to determine whether growth has occurred in a lung nodule.
A new record of Trichocladium griseum in Korea: morphological and molecular characterization
( Setu Bazie Tagele ),( Thuong T. T. Nguyen ),( Sang Woo Kim ),( Mahesh Adhikari ),( Sun Kumar Gurung ),( Hyun Goo Lee ),( Byeong Heon Gwon ),( Han Jun Ju ),( San Kosol ),( Hyang Burm Lee ),( Youn Su 한국균학회 2019 韓國菌學會誌 Vol.47 No.2
A unrecorded species of Trichocladium, Trichocladium griseum, was isolated in 2017 during a survey of fungal diversity in Ulsan province, South Korea. This species was identified based on morphological characteristics and phylogenetic analysis of the internal transcribed spacer (ITS) rDNA and β-tubulin gene sequences. T. griseum has not yet been reported in South Korea. Thus, we report for the first time a new record of Trichocladium griseum in Korea, and we include the descriptions and morphological illustrations of this fungus.
Kim, H.,Chae, K. J.,Yoon, S. H.,Kim, M.,Keam, B.,Kim, T. M.,Kim, D. W.,Goo, J. M.,Park, C. M. SPRINGER INTERNATIONAL 2018 EUROPEAN RADIOLOGY Vol.28 No.2
<P>Non-diagnostic repeat biopsy specimen acquisition was not related to the clinical or technical factors. However, detection of T790M at repeat biopsy might be associated with smaller target tumour size and selection of metastatic lesions as biopsy targets.</P>
구자삼,조효제,김경태 韓國海洋大學校 附設 海洋科學技術硏究所 1997 硏究論文集 Vol.6 No.-
본 논문에서는 3차원 특이점분포법, 파의 상호간섭이론 및 유한요소법을 결합한 Goo등[29]이 개발한 초대형 해양구조물의 동적응답 해석법과 스펙트럴 해석법을 이용하여 다수의 임의형상 지지부체간의 유체역학적 상호간섭을 고려한 다방향 불규칙파중의 초대형 해양구조물의 운동응답 및 구조응답의 유의치를 동시에 계산할 수 있는 동적응답 해석법을 개발하였으며, 반잠수식 Ring 형상의 초대형 해양구조물을 수치계산 모델로 하여 구조물의 동적응답에 미치는 상호간섭과 다방향파의 영향을 평가하였다. A numerical procedure is described for predicting the motion and structural responses of the very large floating offshore structures supported by multiple 3-D floating bodies of arbitrary shape in multi-directional irregular waves. The developed numerical approach taking into account of the hydrodynamic interactions among the multiple floating bodies is based on a combination of the 3-D source distribution method, the wave interaction theory, the finite element method and the spectral analysis method to get the significant values of the dynamic responses in the multi-directional irregular waves. The effects of wave interactions and directionality on the dynamic responses of a very large offshore structure, which is semisubmersible ring type, are numerically examined.
Jung, In Duk,Shin, Sung Jae,Lee, Min-Goo,Kang, Tae Heung,Han, Hee Dong,Lee, Seung Jun,Kim, Woo Sik,Kim, Hong Min,Park, Won Sun,Kim, Han Wool,Yun, Cheol-Heui,Lee, Eun Kyung,Wu, T.-C.,Park, Yeong-Min The American Association of Immunologists, Inc. 2014 JOURNAL OF IMMUNOLOGY Vol.193 No.3
<P>Despite the potential for stimulation of robust antitumor immunity by dendritic cells (DCs), clinical applications of DC-based immunotherapy are limited by the low potency in generating tumor Ag-specific T cell responses. Therefore, optimal conditions for generating potent immunostimulatory DCs that overcome tolerance and suppression are key factors in DC-based tumor immunotherapy. In this study, we demonstrate that use of the <I>Mycobacterium tuberculosis</I> heat shock protein X (HspX) as an immunoadjuvant in DC-based tumor immunotherapy has significant potential in therapeutics. In particular, the treatment aids the induction of tumor-reactive T cell responses, especially tumor-specific CTLs. The HspX protein induces DC maturation and proinflammatory cytokine production (TNF-α, IL-1β, IL-6, and IFN-β) through TLR4 binding partially mediated by both the MyD88 and the TRIF signaling pathways. We employed two models of tumor progression and metastasis to evaluate HspX-stimulated DCs in vivo. The administration of HspX-stimulated DCs increased the activation of naive T cells, effectively polarizing the CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T cells to secrete IFN-γ, as well as enhanced the cytotoxicity of splenocytes against HPV-16 E7 (E7)–expressing TC-1 murine tumor cells in therapeutic experimental animals. Moreover, the metastatic capacity of B16-BL6 melanoma cancer cells toward the lungs was remarkably attenuated in mice that received HspX-stimulated DCs. In conclusion, the high therapeutic response rates with tumor-targeted Th1-type T cell immunity as a result of HspX-stimulated DCs in two models suggest that HspX harnesses the exquisite immunological power and specificity of DCs for the treatment of tumors.</P>
전동차용 IGBT형 추진제어장치의 본선시험에 관한 연구
김태완(T.Y.KIM),박건태(G.T.PARK),정만규(M.K.JEONG),고영철(Y.C.GOO),방이석(L.S.BANG) 전력전자학회 2000 전력전자학술대회 논문집 Vol.2000 No.11
This paper describes about the field test of IGBT VVVF inverter for the propulsion system, The 1650kVA class IGBT VVVF inverter has been developed. Therefore, the field test is performed in SMG 6 Line to confirm its the reliability and performance, The train consists of 4M4T and the electrical equipment for field test are as follows: VVVF inverter 4 sets, 16 traction motors and Z SNs, The propulsion system is composed with 1 C4M. The results of propulsion system which have the excellent acceleration/deceleration and the jerk characteristics as well as starting ability on slope are taken through the field test.
Lee, E.K.,Kim, J.K.,Kim, T.J.,Song, H.,Kim, J.H.,Park, S.A.,Jeong, T.G.,Yun, S.W.,Lee, J.,Goo, J.,Kim, J.H.,Park, B.G.,Chun, H.H.,Song, P.K.,Kang, C.G.,Kim, Y.T. Pergamon ; Elsevier Science Ltd 2013 Energy conversion and management Vol.75 No.-
In this study, we investigated the effects of TiN/Ti and TiO<SUB>2</SUB>/Ti double layer coatings, with a metal buffer layer, on the corrosion resistance, and electrical properties of Al1050 substrates for using them as bipolar plates in PEMFCs. TiN/Ti and TiO<SUB>2</SUB>/Ti double layers were deposited using the electromagnetic-field-superpositioned DC and RF magnetron sputtering method. The surface resistivity and contact resistance of the specimens were measured using the van der Pauw method and a previously reported interfacial contact resistance (ICR) measurement method, respectively. Further, the corrosion resistance of the specimens was characterized using electrochemical tests such as potentiodynamic and potentiostatic polarization tests. The results obtained in this study indicated that coating of the Al1050 substrates significantly increased the corrosion resistance of bipolar plates in the operating environment of a fuel cell when compared to uncoated substrates. In particular, the substrate coated with a TiN/Ti double layer exhibited the best performance: its corrosion current density was 30 times lower than that of an uncoated substrate under anodic conditions. Further, the Al1050 bipolar plate coated with a TiN/Ti double layer showed performance enhancement over an uncoated bipolar plate in an actual fuel cell test.
Is the Computer-Aided Detection Scheme for Lung Nodule Also Useful in Detecting Lung Cancer?
Goo, Jin Mo,Kim, Hyae Young,Lee, Jeong Won,Lee, Hyun Ju,Lee, Chang Hyun,Lee, Kyung Won,Kim, Tae Jung,Lim, Kun Young,Park, Seong Ho,Bae, Kyongtae T. Lippincott Williams Wilkins, Inc. 2008 Journal of computer assisted tomography Vol.32 No.4
OBJECTIVE:: To evaluate the impact of a computer-aided diagnosis (CAD) system on the performance of observers for the detection of both lung nodules and lung cancers. MATERIALS AND METHODS:: One hundred fifty computed tomographic scans were evaluated. Database included 23 lung cancers (long diameter <20 mm), nodules stable for at least 2 years, and normal cases. Five chest radiologists and 5 radiology residents each independently recorded the locus of each nodule candidate and assigned a confidence score for the likelihood of nodule and malignancy without CAD; then, the interpretation was repeated with the use of CAD. A consensus panel of 2 chest radiologists served as a reference standard for the nodules. Histological confirmation was a reference standard for the cancers. The performances of the observers for the detection of nodules and cancer with and without CAD were compared using jackknife free-response receiver operating characteristic analysis. RESULTS:: The performance of detecting lung nodules was increased significantly with CAD for all radiologists and subgroups (P < 0.01). Although the overall performance of detecting lung cancers was not affected significantly with the use of CAD (P > 0.05), 4 lung cancers missed by 3 residents on their initial observation were additionally detected with CAD. Eighteen of 23 lung cancers were detected by CAD itself. CONCLUSIONS:: The overall radiologists' performance of detecting lung nodules was improved significantly with the use of CAD, whereas no statistical significance was observed for the detection of lung cancers. The use of CAD, however, contributed to the detection of additional lung cancers for less experienced readers.