Mechanical and Creep Properties of Concrete containing Apricot Shell Lightweight Aggregate

Fan Wu,Changwu Liu,Wei Sun,Lianwei Zhang,Yuanjun Ma 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.7

In this study, the mechanical and creep properties of the apricot shell (AS) as a replacement for the coarse aggregate were investigated. The alternative volume ratio of the coarse aggregate was set as 0%, 25%, 50%, 75% and 100%, respectively. The results showed that the coarse aggregate was completely replaced by the AS, the compressive strength, splitting tensile and flexural strength, and modulus of elasticity of apricot shell concrete (ASC) were 26.1 MPa, 1.85 MPa, 3.18 MPa, and 9.3 GPa, respectively, and decreased by 32.6%, 30.7%, 24.8%, and 34.5% compared to the concrete without AS, respectively. However, the oven dry density of AS100 mixture was 1,762 kg/m3, which fulfilled the density requirement of structural lightweight aggregate concrete (LWAC). The creep strain of concrete increased by increasing AS content. When the coarse aggregate was replaced by 100% AS, the strain of AS100 mixture at 380 hours was 16.84 × 10−4. The results indicate that LWAC with an acceptable performance can be produced by using AS as coarse aggregates in concrete.

CONTINUOUS DEPENDENCE PROPERTIES ON SOLUTIONS OF BACKWARD STOCHASTIC DIFFERENTIAL EQUATION

Fan, Sheng-Jun,Wu, Zhu-Wu,Zhu, Kai-Yong 한국전산응용수학회 2007 Journal of applied mathematics & informatics Vol.24 No.1

The existence theorem and continuous dependence property in $"L^2"$ sense for solutions of backward stochastic differential equation (shortly BSDE) with Lipschitz coefficients were respectively established by Pardoux-Peng and Peng in [1,2], Mao and Cao generalized the Pardoux-Peng's existence and uniqueness theorem to BSDE with non-Lipschitz coefficients in [3,4]. The present paper generalizes the Peng's continuous dependence property in $"L^2"$ sense to BSDE with Mao and Cao's conditions. Furthermore, this paper investigates the continuous dependence property in "almost surely" sense for BSDE with Mao and Cao's conditions, based on the comparison with the classical mathematical expectation.

Preparation of Monascus-fermented ginkgo seeds: optimization of fermentation parameters and evaluation of bioactivity

Wu Zhihao,Miao Wen,Yang Yuhan,Fan Gongjian,Wu Caie,Li Tingting,Xie Chunyan,Shen Dongbei 한국식품과학회 2022 Food Science and Biotechnology Vol.31 No.6

In this study, a high monacolin K yield was achieved through solid-state fermentation of Ginkgo biloba seeds. Monascus purpureus suspension made from red yeast rice was used as spore inoculum. Fermentation conditions in solid-state fermentation were optimized using response surface methodology, and the optimal conditions for the maximum monacolin K yield (17.71 ± 1.57 mg/g) were 0.22% ammonium sulfate, 0.34% ammonium chloride, 0.05% magnesium sulfate, fermentation time of 12 days, inoculation volume of 11%, and temperature of 27 °C. The total phenolic content of Monascus-fermented ginkgo seeds attained 9.67 mg GAE/g, 4.88-fold higher than that of unfermented ginkgo seeds. The scavenging abilities of DPPH and ABTS free radicals increased to 9.79 mg TE/g and 13.92 mg TE/g, respectively. These findings highlight the importance of investigating the optimal fermentation conditions for maximum monacolin K yield and the utilization value of ginkgo seed as fermentation substrate for higher bioactivities.

중국 안지놀이(Anji Play)의 특징 및 한국의 놀이중심 유아교육과정에 주는 함의 탐색

FAN WU,김은주 부산대학교 교육발전연구소 2021 교육혁신연구 Vol.31 No.1

Purpose: The purpose of this study is to explore the characteristics of Anji Play, a representative “play” based early childhood curriculum in China, to provide suggestions for Korea's early childhood education. Method: To achieve the purpose of the current study, a literaure review was conducted. Results: As a result of this research, first, to support children’s play Anji Play gave enough play time, integrated various spaces, and provided many play materials that can be combined indefinitely. Second, teachers maximize observations and records of play, and minimized interventions. Parents were reminded of their childhood play memories, given the opportunity to play in the nursery, and empathized with children’s play. And the Anji County government has innovatively implemented integrated management of nurseries, evaluating the level of development of early childhood education together with the local economy and other indicators, thus leading the development of early childhood education. Conclusion: It is necessary to provide sufficient play time, while creating various spaces for children to play more actively, and to provide risky play materials. It is necessary to consider parental education that provides parents with the opportunity to fall in love with real play and watch their children's play. The government and local governments expect to expand financial support along with their continued interest in early childhood education. 연구목적: 본 연구의 목적은 중국의 대표적인 놀이중심 유아교육과정인 안지놀이의 특징을 놀이특징 및 운영특징으로 나누어 살펴보고, 이를 통해 한국의 놀이중심 유아교육 실천에 대한 시사점을 얻는데 있다. 연구방법: 안지놀이를 소개하고 있는 중국 및 국외 논문 및 문헌 자료를 수집하여 내용분석 하였다. 연구결과: 놀이특징을 살펴본 결과, 안지놀이 유아원은 유아에게 충분한 놀이시간을 주고 다양한 공간의 통합을 이루며 무한의 조합이 가능한 인공재료 및 자연재료를 충분히 제공함으로써 유아들이 경계를 넘어 마음껏 놀 수 있도록 하고 있음을 알 수 있었다. 운영특징을 살펴본 결과, 교사교육 면에서는 교사가 놀이에 대한 관찰과 기록을 최대화하고 개입은 최소화하도록 하고, 부모교육 면에서는 부모들에게 자신의 아동기 놀이기억을 회상시키고 유아원에서 직접 놀이하는 기회를 제공함으로써 유아의 놀이를 공감시키고 있는 것으로 나타났다. 지방정부 지원 면에서는 유아원을 통합관리하면서 유아교육의 발전이 지역 경제, 의료 등 지표와 함께 하도록 평가하며 유아교육의 발전을 이끌어가고 있음을 알 수 있었다. 논의 및 결론: 중국 안지놀이의 특징에서 한국의 놀이중심 유아교육에 주는 함의를 찾아보자면, 유아교육기관은 유아에게 놀이가 지속될 수 있는 충분한 시간을 제공해줌과 동시에 공간에 대한 고민과 함께 다양한 공간을 만들어주기 위한 노력이 필요할 것이다. ‘위험’을 감수하는 놀이자료 제공도 의미있게 고려해볼 부분이다. 교사에게는 다양한 형태의 유아 놀이지원에 대한 교육과 지속적이고 체계화된 현직교육이 이루어질 필요가 있으며, 부모에게는 실제 놀이에 푹 빠질 기회와 자녀 놀이를 지켜보는 경험을 제공해 줄 필요가 있다. 놀이중심 교육과정이 제대로 정착되도록 하기 위해서는 중앙정부와 지자체의 관심과 지원이 무엇보다 필요함을 인식해야 할 것이다.

Polarization-Independent Metamaterial Analog of Electromagnetically Induced Transparency for a Refractive-Index-Based Sensor

Fan-Yi Meng,Qun Wu,Erni, D.,Ke Wu,Jong-Chul Lee IEEE 2012 IEEE transactions on microwave theory and techniqu Vol.60 No.10

<P>A polarization-independent metamaterial analog of electromagnetically induced transparency (EIT) at microwave frequencies for normal incidence and linearly polarized waves is experimentally and numerically demonstrated. The metamaterial consists of coupled “bright” split-ring resonators (SRRs) and “dark” spiral resonators (SRs) with virtually equal resonance frequencies. Normally incident plane waves with linear polarization strongly couple to the SRR, but are weakly interacting with the SR, regardless of the polarization state. A sharp transmission peak (i.e., the transparency window) with narrow spectral width and slow wave property is observed for the metamaterial at the resonant frequency of both, the bright SRR and the dark SR. The influence of the coupling strength between the SRR and SR on the frequency, width, magnitude, and quality factor of the metamaterial's transparency window is theoretically predicted by a two-particle model, and numerically validated using full-wave electromagnetic simulation. In addition, it is numerically demonstrated that the EIT-like metamaterial can be employed as a refractive-index-based sensor with a sensitivity of 77.25 mm/RIU, which means that the resonance wavelength of the sensor shifts 77.25 mm per unit change of refractive index of the surrounding medium.</P>

Identification of crystal variants in shape-memory alloys using molecular dynamics simulations

Wu, Jo-Fan,Yang, Chia-Wei,Tsou, Nien-Ti,Chen, Chuin-Shan Techno-Press 2017 Coupled systems mechanics Vol.6 No.1

Shape-memory alloys (SMA) have interesting behaviors and important mechanical properties due to the solid-solid phase transformation. These phenomena are dominated by the evolution of microstructures. In recent years, the microstructures in SMAs have been studied extensively and modeled using molecular dynamics (MD) simulations. However, it remains difficult to identify the crystal variants in the simulation results, which consist of large numbers of atoms. In the present work, a method is developed to identify the austenite phase and the monoclinic martensite crystal variants in MD results. The transformation matrix of each lattice is calculated to determine the corresponding crystal variant. Evolution of the volume fraction of the crystal variants and the microstructure in Ni-Ti SMAs under thermal and mechanical boundary conditions are examined. The method is validated by comparing MD-simulated interface normals with theoretical solutions. In addition, the results show that, in certain cases, the interatomic potential used in the current study leads to inconsistent monoclinic lattices compared with crystallographic theory. Thus, a specific modification is applied and the applicability of the potential is discussed.

Identification of novel rheumatoid arthritis-associated MiRNA-204-5p from plasma exosomes

Wu Long-Fei,Zhang Qin,Mo Xing-Bo,Lin Jun,Wu Yang-Lin,Lu Xin,He Pei,Wu Jian,Guo Yu-Fan,Wang Ming-Jun,Ren Wen-Yan,Deng Hong-Wen,Lei Shu-Feng,Deng Fei-Yan 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Rheumatoid arthritis (RA) is an autoimmune disease characterized by infiltration of immune cells in the synovium. However, the crosstalk of immune cells and synovial fibroblasts is still largely unknown. Here, global miRNA screening in plasma exosomes was carried out with a custom microarray (RA patients vs. healthy controls = 9:9). A total of 14 exosomal miRNAs were abnormally expressed in the RA patients. Then, downregulated expression of exosomal miR-204-5p was confirmed in both the replication (RA patients vs. healthy controls = 30:30) and validation groups (RA patients vs. healthy controls = 56:60). Similar to the findings obtained in humans, a decreased abundance of exosomal miR-204-5p was observed in mice with collagen-induced arthritis (CIA). Furthermore, Spearman correlation analysis indicated that plasma exosomal miR-204-5p expression was inversely correlated with disease parameters of RA patients, such as rheumatoid factor, erythrocyte sedimentation rate, and C-reactive protein. In vitro, our data showed that human T lymphocytes released exosomes containing large amounts of miR-204-5p, which can be transferred into synovial fibroblasts, inhibiting cell proliferation. Overexpression of miR-204-5p in synovial fibroblasts suppressed synovial fibroblast activation by targeting genes related to cell proliferation and invasion. In vivo assays found that administration of lentiviruses expressing miR-204-5p markedly alleviated the disease progression of the mice with CIA. Collectively, this study identified a novel RA-associated plasma exosomal miRNA-204-5p that mediates the communication between immune cells and synovial fibroblasts and can be used as a potential biomarker for RA diagnosis and treatment.

Does H3K27M Mutation Impact Survival Outcome of High-Grade Spinal Cord Astrocytoma?

Fan Zhang,Lei Cheng,Ze Ding,Shengxi Wang,Xingang Zhao,Zijun Zhao,Cong Liang,Kun Wu,Dongao Zhang,Yinqian Wang,Tao Fan 대한척추신경외과학회 2023 Neurospine Vol.20 No.4

Objective: To evaluate the impact of H3K27M mutation in the prognosis of histological high-grade intramedullary astrocytoma. Methods: A total of 78 patients who were diagnosed with high-grade spinal cord astrocytoma were included. Clinical data consisting demographic, radiological, molecular features and treatment data were recorded. Univariate and multivariate Cox analysis were performed to investigate variables associated with survival outcome of histological high-grade spinal cord astrocytoma. Results: Median survival time was 21 months. Overall survival (OS) at 1 and 3 years was 65.7% and 40.7%, respectively. Sex, location, and tumor span did not present significant association with OS. Patients with H3K27M mutation showed significant shorter duration of symptom than patients with H3K27 wild-type. As respect to adjuvant treatment, adjuvant radiotherapy and chemotherapy were associated with favorable OS (both p = 0.01). Younger patients (age ≤ 18 years) had shorter OS (p = 0.008) than adult patients (age > 18 years). Of note, H3K27M mutation did not show significant impact on the survival outcome, regardless of histology grade 3 or grade 4 (p = 0.3). Conclusion: Histological high-grade spinal cord astrocytoma has dismal prognosis. Our study demonstrated that H3K27M mutation did not show significant impact on survival outcome of histological high-grade spinal cord astrocytoma.

LETTER TO THE EDITOR : Pseudo-Clubbing Complicated by Dermatophyte Onychomycosis

( Fan Wu ),( Jiao Feng ),( Hong Sang ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.2

Identification of crystal variants in shape-memory alloys using molecular dynamics simulations

Wu, Jo-Fan,Yang, Chia-Wei,Tsou, Nien-Ti,Chen, Chuin-Shan 테크노프레스 2016 Multiscale and multiphysics mechanics Vol.1 No.3

Shape-memory alloys (SMA) have interesting behaviors and important mechanical properties due to the solid-solid phase transformation. These phenomena are dominated by the evolution of microstructures. In recent years, the microstructures in SMAs have been studied extensively and modeled using molecular dynamics (MD) simulations. However, it remains difficult to identify the crystal variants in the simulation results, which consist of large numbers of atoms. In the present work, a method is developed to identify the austenite phase and the monoclinic martensite crystal variants in MD results. The transformation matrix of each lattice is calculated to determine the corresponding crystal variant. Evolution of the volume fraction of the crystal variants and the microstructure in Ni-Ti SMAs under thermal and mechanical boundary conditions are examined. The method is validated by comparing MD-simulated interface normals with theoretical solutions. In addition, the results show that, in certain cases, the interatomic potential used in the current study leads to inconsistent monoclinic lattices compared with crystallographic theory. Thus, a specific modification is applied and the applicability of the potential is discussed.