한국어 판 WHO-CIDI(Composite International Diagnostic Interview)-Alcohol의 개발:신뢰도 및 타당도 검사

남궁기,유계준,조은영,송선미,이희상,길계선,조현상,우용일 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.6

CIDI-Alcohol의 한국어 판 개발을 위해 이를 우리말로 번역, 수정하고, 정신병원에 입원한 환자 90명과 일반인 50명에게 시행한 후 임상 진단과 비교하여 일치도를 봄으로써 그 신뢰도 및 타당도를 조사하였다. 결과는 다음과 같다. 1) 주정 사용 각 진단 범주에 대한 한국어 판 CIDI-Alcohol의 일반 면담자간 진단 일치도는 97%∼100%의 높은 일치도를 보였다. 2) 임상 진단을 기준으로 한 한국어 판CIDI-Alcohol의 주정 사용 장애의 진단 일치도는 각 진단 범주별로 kappa치가 0.43∼0.55로 기존의 연구에 비해 비교적 낮았다. 3) CIDI-Alcohol의 진단 기준을 변화시켜, 각 진단 범주에 대한 임상 진단과의 일치도를 알아본 결과 ICD-10/harmful use는 진단 기준 항목의 수를 2개 이상으로 하였을 때, DSM-Ⅲ-R/주정 의존은 진단 기준 항목의 수를 4개 이상으로 하였을 때 임상 진단과 가장 일치하였다. 이런 결과는 한국어 판 CIDI-Alcohol의 진단 기준이 대체적으로 민감도는 높으나, 특이도가 떨어지는 것으로 생각할 수 있으며, 따라서 본 연구자들에 의해 작성된 한국어 판 CIDI-Alcohol는 일반인구 집단을 대상으로 하는 역학 조사보다는 주정 사용 장애로 이루어진 순수한 실험군의 연구에 적합하다고 생각된다. he authors translated a CIDI-Alcohol, a highly structured diagnostic interview, into Korean and examined the validity and reliability of the Korean version of CIDI-Alcohol. In order to examine the validity and reliability of CIDI-Alcohol, the authors calculated the degree of agreement of CIDI-Alcohol diagnoses between the two lay interviewers and sensitivity, specificity, kappa coefficient between clinical and lay CIDI-Alcohol diagnoses. The results were as follows: 1) Agreement rates of CIDI-Alcohol diagnoses between the two lay interviewers ranged from 97% to 100%. The kappa coefficient for each diagnosis was quite high(0.96-1.0). 2) The kappa value of agreement between clinical and lay CIDI-Alcohol diagnoses ranged from 0.43 to 0.55, which was lower than those of other studies. 3) With canging the diagnostic criteria of CIDI-Alcohol, The highest agreement rate between clinical and CIDI-Alcohol diagnoses was acquired when the authors used two or more diagnostic criteria of ICD-10/harmful use and four or more diagnostic criteria of DSM-Ⅲ-R/ alcohol dependence.

혐기·호기공정을 이용한 생물막법에서 유기물, 질소 및 인제거에 관한 연구

이성기,송영일,김현중,진성기,김은영 조선대학교 환경연구소 2001 環境硏究 Vol.17 No.1

Anoxic and Oxic process with contact media is used to remove an organic matter, nitrogen and phosphorus in sewage which derives from domestic wastewater. Experiments have been done with various conditions that concentration of oxygen can be 3mg/ℓ, 4∼5mg/ℓ and 5∼6mg/ℓ by controlling an retention time can be 10hr, 12hr and 14hr, return rate can be 0%, 100% and 200%. As the concentration of oxygen is 2∼3mg/ℓ. The rate of removal of BOD. COD. SS. T-N and T-P is 87%, 76%, 82%, 34% and 24%. As the concentration of oxygen is 5∼6mg/ℓ. The rate of removal of BOD, COD, SS, T-N and T-P is 92%, 84%, 88%, 45% and 33%. In the rate of removal of an organism, nitrogen and phosphorus thus It well be known that the rate of removal an organic matter, nitrogen and phosphorus will be increased as the concentration of oxygen becomes higher. As th retention time is increased, the rate of removal of BOD, COD, SS, T-N and T-P is gradually higher in the rate of removal of an organic matter, nitrogen and phosphorus. Because contact time and contact area will be increased, which generates active substrate transfer and metabolic react according to increment of retention time. As the return rate is increased. The rate of removal of BOD, COD and SS is likely to be increased. In the case of T-N. It is also increased by 28% at 0% of the return rate and by 60% at 200% of the return rate. In the case of T-P, however, It is deceased, as the return rate is increased by 42% at 0% of the return rate and by 30% at 00% of the return. As the return rate is increased the retention time is decreased, which causes less activity of bacterial which affects that the rate of removal of Phosphorus is decreased.

혐기·호기공정을 이용한 생물막법에서 유기물, 질소 및 인제거에 관한 연구

이성기,송영일,김현중,진성기,김은영 조선대학교 환경공해연구소 2001 環境公害硏究 Vol.17 No.1

Anoxic and Oxic process with contact media is used to remove an organic matter, nitrogen and phosphorus in sewage which derives from domestic wastewater. Experiments have been done with various conditions that concentration of oxygen can be 3㎎/ℓ, 4~5㎎/ℓ and 5~6㎎/ℓ by controlling an retention time can be 10hr, 12hr and 14hr, return rate can be 0%, 100% and 200%. As the concentration of oxygen is 2~3㎎/ℓ, The rate of removal of BOD. COD, SS, T-N and T-P is 87%, 76%, 82%, 34% and 24%. As the concentration of oxygen is 5~6㎎/ℓ, The rate of removal of BOD, COD, SS, T-N and T-P is 92%, 84%, 88%, 45% and 33%. In the rate of removal of an organism, nitrogen and phosphorus thus It well be known that the rate of removal an organic matter, nitrogen and phosphorus will be increased as the concentration of oxygen becomes higher. As th retention time is increased, the rate of removal of BOD, COD, SS, T-N and T-P is gradually higher in the rate of removal of an organic matter, nitrogen and phosphorus. Because contact time and contact area will be increased, which generates active substrate transfer and metabolic react according to increment of retention time. As the return rate is increased, The rate of removal of BOD, COD and SS is likely to be increased, In the case of T-N, It is also increased by 28% at 0% of the return rate and by 60% at 200% of the return rate. In the case of T-P, however, It is deceased , as the return rate is increased by 42% at 0% of the return rate and by 30% at 200% of the return. As the return rate is increased the retention time is decreased, which causes less activity of bacteria which affects that the rate of removal of Phosphorus is decreased.

출생 직후 호흡부전으로 사망한 Thanatophoric dysplasia 1례

신상원,김은영,박영봉,박상기,송창훈 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.3

Thanatophoric dysplasia is a severe skeketal disorder characterized by extremely short limbs and folds of extra skin on the arms and legs, narrow chest, small ribs and underdeveloped lungs. Affected infants are usually stillborn or die shortly after birth from respiratory failure. We experienced a case of thanatophoric dysplasia died shortly after birth from respiratory failure.

난소에 전이된 간세포암 1예

박용관,박치영,조은택,조기섭,박찬국,송창훈,이미자,기근홍 朝鮮大學校 附設 醫學硏究所 1995 The Medical Journal of Chosun University Vol.20 No.2

Hepatocellular carcinoma frequently metastasizes through direct extension, lymphatic, and hematogenous routes. The most common sites of metastasis are the lungs and the lymph nodes, glands, bones, spleen, kidneys, colon, and pleura are the sites of metastasis in decreasing order of frequency. But metastasis to the ovary is very rare. It is thought that metastasize to the ovary occurs through infiltration or dissemination. However, we observed ovarian metastasis of primary hepatic tumor in a 34-year old female who suffered from lower abdominal pain. At first, it was diagnosed as a primary ovarian tumor. But histologically, it presented sinusoidal pattern surrounded by the tumor cells and contained rounded by the tumor cells and contained round hyaline globules in minority of the cytoplasm. Then, the histologic features of percutaneous, sono-guided liver biopsy speecimen of the liver mass are similar to those of resected ovarian tissues. Therefore, we concluded that ovarian tumor was originated from hepatocellular carcinoma. In summary, this report examines a case of hepatocellular carcinoma with ovarian metastasis in a female and reviews the literature.

치료저항 만성 정신분열증 환자에서 Clozapine과 Haloperidol의 치료효과에 대한 비교

이홍식,김찬형,이희상,남궁기,송동호,이영문,한은선 大韓臨床藥理學會 1993 臨床藥理學會誌 Vol.1 No.2

POSTERS / PW-040 : NOVEL FUNCTION OF FAS ASSOCIATED FACTOR 1(FAF1) AS NDP KINASE

(Eun Joo Song),(Sun Young Kim),(Eun Hee Kim),(Suhn Kee Chae),(Kong Joo Lee) 한국생화학분자생물학회 (구 한국생화학회) 1999 6th IUBMB SEOUL CONFERENCE Vol.- No.-

VDUP1 Is Required for the Development of Natural Killer Cells

Lee, Kee Nyung,Kang, Hyung-Sik,Jeon, Jun-Ho,Kim, Eun-Mi,Yoon, Suk-Ran,Song, Hyunkeun,Lyu, Chil-Youl,Piao, Zheng-Hao,Kim, Sun-Uk,Han, Ying-Hao,Song, Su-Sung,Lee, Young-Ho,Song, Kyu-Sang,Kim, Yong-Man,Y Elsevier 2005 Immunity Vol.22 No.2

<P><B>Summary</B></P><P>Vitamin D<SUB>3</SUB> upregulated protein 1 (VDUP1) is a stress-response gene that is upregulated by 1,25(OH)<SUB>2</SUB>D<SUB>3</SUB> in tumor cells. The in vivo roles of VDUP1 were investigated by producing mice lacking VDUP1 (VDUP1<SUP>−/−</SUP> mice). VDUP1<SUP>−/−</SUP> mice showed minimal changes in the development of T and B cells, but there was a profound reduction in the numbers of natural killer (NK) cells. As well, these mice showed decreased NK activity. In the VDUP1<SUP>−/−</SUP> mice, the expression of CD122 was reduced, demonstrating that VDUP1 is required for CD122 expression and NK maturation. In addition, severe lymphoid hyperplasia in the small intestine was observed in VDUP1<SUP>−/−</SUP> mice. Taken together, these results suggest that VDUP1 is a critical factor for the development and function of NK cells in vivo.</P>

Polysaccharides Extracted from Inonotus Obliquus Inhibited Tumor Migration and Invasion in Human Gastric Cancer AGS Cells

Jeong Eun SONG,In Kyu SONG,Eock kee HONG 한국생물공학회 2014 한국생물공학회 학술대회 Vol.2014 No.4

특발성혈소판감소증에서 위나선균 제균요법의 효과: 세 가지 증례 보고

송은기 ( Eun Kee Song ),이나리 ( Na Ri Lee ),곽재용 ( Jae Yong Kwak ),임창열 ( Chang Yeol Yim ) 대한내과학회 2008 대한내과학회지 Vol.74 No.3

위 나선균 감염이 특발성혈소판감소증을 일으키고 위 나선균 제균요법을 통해 혈소판 수치의 상승을 시킬 수 있다는 몇몇 보고들이 있다. 하지만 위 나선균의 발병율이 특발성혈소판감소증 환자들과 일반인들 사이에 차이를 보이지 않고, 제균요법 이후 혈소판 회복 정도가 보고에 따라 큰 차이를 보이고 있다. 저자들은 최근 세 가지의 다양한 임상상황에서 위 나선균 제균요법을 통해 성공적인 말초혈액 및 혈소판 수치의 회복 효과를 경험하였기에 보고하는 바이다. 첫번째 증례는 기존의 치료에 불응성 환자였고, 두번째 증례는 재발성 환자였고, 마지막 증례는 초치료로 제균요법을 시행한 경우였다. 저자들은 한국인들 중 일부 환자의 경우에서는 위 나선균 제균요법 만으로도 특발성혈소판감소증을 치료 할 수 있으며, 향후 많은 수의 환자를 대상으로하는 전향적 연구를 통해 위 나선균 감염과 특발성혈소판감소증 사이의 연관성을 밝힐 수 있는 연구들이 필요하리라 생각한다. There are several reports suggesting Helicobacter pylori can initiate and perpetuate idiopathic thrombocytopenic purpura (ITP) and eradication of H. pylori can increase the platelet counts, however, the prevalence of H. pylori infection in patients with ITP is similar to that found in the general population and a recovery of thrombocytopenia after H. pylori eradication therapy has not been identified reliably. We report three different cases of H. pylori infected patients with ITP who recovered completely after eradication of H. pylori. The first case was refractory, the second was recurred after conventional treatment for ITP, and the third was treated with H. pylori eradication on first line treatment. We believe that the eradication of H. pylori is useful in some patients with ITP in Korea and well controlled randomized study is necessary for further identification of such population. (Korean J Med 74:330-335, 2008)