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韓國人에서 四種의 STRs 遺傳座位에 대한 遺傳的 多樣性
송은섭,황적준,남용석,한길로 大韓法醫學會 1997 대한법의학회지 Vol.21 No.1
The four tetrameric STRs loci(MUMvWA31, HUMTHO1, HUMF13A1, HUMFES/FPS) were studied to confirm the allele frequency distribution and to see whether these results can be used for identity and paternity testing in a population of Koreans using multiplex PCR and laser-fluorescence detection method. In the Korean population (n=227), 8 alleles with their relative frequency range of 0.002-0.249 are detected in the HUMvWA31 locus, 6 alleles with those of 0.007-0.500 in the HUMTHO1 locus, 6 alleles with those of 0.002-0.487 in the HUMF13A1 locus, and 6 alleles with those of 0.004-0.434 in the HUMFES/FPS locus. The highest observed heterozygosity is found at the locus HUMvWA31(0.8077), with those of the loci HUMTHO1, Humf13A1, and HUMFES/FPS being 0.6581 0.6324 and 0.6804, respectively. All loci meet Hardy-Weinberg expectations: there are good agreements between observed and expected heterozygosity, number of observed genotypes. Pairwise comparisons between loci show allelic independence for all the 4 loci. The power of discrimination (PD) determined for the locus HUMvWA31 is 0.933, that for the HUMTHO1 is 0.836, 0.798 for HUMF13A1, and 0.844 for the HUMFES/FPS; the combined power of discrimination for the quadruplex is 0.9997. Thus, these allelic frequency distribution can be used to construct the database of the multiplex PCR-based DNA profile in the Korean population. The calculated parameter, "combined power of discrimination(PD)" show the informativeness of these loci for the determination of identity and relatedness of individuals.
정기섭,홍지웅,최기송,지상철,박은석 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.4
The oral bioavailability of itraconazole is variable and low in fasting state. This is mainly due to the low solubility of this drug. Bioavailability can be improved by changing the formulation and it is general that the liquid preparations show greater bioavailability than the solid dosage forms such as tablets and capsules do. Benzyl alcohol-water binary mixture showed the excellent solubilizing capacity for itraconazole but the release of the drug from the preparation needs to be enhanced. In this study, various nonionic surfactants and hydrophilic polymers, poloxamers, were screened to investigate their effects on the release of itraconazole from the liquid preparations. Poloxamer 407 showed the most enhancing effect on the drug release and the release rate was proportional to the amount of poloxamer 407 added. A liquid preparation of itraconazole, consisting of benzyl alcohol/water/poloxamer 407 ternary solvent system, released more than 80% of the total drug amount at 5 min and showed the possibility of a new formulation development.
지속적인 운동으로서의 골프가 아마추어 골퍼의 스트레스에 미치는 효과
오대성,송은섭,나정란 圓光大學校附設 生活體育硏究所 2001 生活體育硏究 Vol.11 No.-
This survey for the purpose of finding out the effects of Golf as a continuative exercise on the mental stress has made the following conclusion with the research results having examined the effects by using the stress measuring paper to the subjects of the amateur Golfers consisted of 183 (Male 98 and Female 85) in Chonbuk province. 1. The effects on the total stress levels as a continuative exercise shows that the male subjects (105.96±14.38) is higher than the female (104.05±11.49). 2. In the following stress levels the Golf has the effect showing that the male (19.72) is higher than the female (19.54) in the mental factor, and the male (35.74) is higher than the female (34.82) in the emotional and the anxiety factors. And it shows statistical significance (p=0.79). 3. The effects of Golf as a continuative exercise on the total stress levels according to the subjects' career shows that the group (108.03) whose career is more than 83 months is higher than the group (101.68) whose career is more than 49-82 months. 4. The effects of Golf as a continuative exercise on the mental stress in the following levels shows that the group (20.31) whose career is more than 83 months is higher than the group (18.71) whose career is more than 49-82 months in the mental factor, and the group (28.30) who career is more than 83 months is also higher than the group (25.76) whose career is more than 49-82 months in the physical and mental health factor respectively.
Song, Eun-Seop,Lee, Hun Jae,Hwang, Tae Sook The Korean Academy of Medical Sciences 2007 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.22 No.1
<P>A considerable number of adult Korean women avoid a Pap smear due to fear and discomfort of the pelvic examination. A reliable but noninvasive and comfortable screening method would considerably increase the participation rate. To evaluate the clinical efficacy of urine-based human papillomavirus (HPV) detection by oligonucleotide microarray, the results of HPV test from matched cervical swab specimens were compared. HPV DNA was detected in 70 of 100 cervical samples. HPV 16 was the most prevalent type (38/70), followed by types 18, 58, 52, 33, 35, 31, and 51. HPV DNA was identified in 47 of 90 urine samples. HPV 16 was the most prevalent type (30/45), followed by types 18, 52, 35, 51, 58, 33, and 56. The HPV detection rates of the cervical swabs increased in accordance with the severity of the cytologic and histologic diagnosis. The type specific agreement of HPV DNA tests between cervical swabs and urine was good in HPV 16 (kappa index=0.64 [95% CI: 0.50-0.79]), 18, 52, and 58 and fair in HPV 33 and 35. We propose that a urine HPV test is a valuable adjunctive method for a conventional Pap smear and can be used in population screening for cervical cancer in countries where it is difficult to obtain colposcopic specimens for cultural or religious reasons.</P>
초음파영상조준하 고강도집속초음파치료기 (HIFU)의 자궁근종 융해의 안전성에 대한 연구
송은섭 ( Eun Seop Song ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.8
목적: 초음파영상조준하 고강도집속초음파치료기 (HIFU)의 자궁근종 치료에 대한 안전성을 연구하고자 하였다. 연구 방법: 2008년 9월부터 2009년 2월까지 생리통 또는 생리과다를 호소하는 환자를 대상으로 HIFU를 실시하였다. HIFU는 1MHz에서 400 W/cm2의 강도로 70번의 치료를 하였으며, 150 msec의 치료시간과 치료간격을 반복하였다. 점과 점들을 치료하였으며 한 면이 끝나면 다음 면으로 4 mm 이동하여 치료하였다. 환자가 통증을 호소하면 치료를 일시 중단한 후에 다시 시작하였다. 결과: 11명의 환자의 나이 분포는 29세에서 48세였으며, 종괴의 크기는 최대직경이 36에서 115 mm였다. 아무도 통증이나 다른 이유로 치료를 포기하지 않았다. 치료는 한 단면에 40~60분 정도 소요되었고, 하루에 한 시간에서 한 시간 반 동안에 한 면에서 세 면을 치료하였다. 모든 환자는 투약없이 바로 귀가하였다. 환자들이 심각한 합병증을 호소하는 일이 없었다. 모든 환자는 치료 다음날 일상에 복귀하였다. 치료 후 첫 생리 이후로 질출혈도 호소하지 않았다. 결론: 초음파영상조준하 HIFU는 자궁근종 치료에 안전한 방법으로 생각된다. Objective: to test the safety of ultrasound imaging guided high intensity focused ultrasound (HIFU) to ablate uterine myoma. Methods: From September 2008 to February 2009, patients with dysmenorrhea and/or menorrhagia for uterine myomas had been enrolled. HIFU ablation was performed at 1 MHz. 400 W/cm2 of pulses were delivered for 150 m second with 150 m second interval at the target point for 70 cycles. This process was repeated on a point by point basis. After one slice was treated, the target was shifted 4 mm laterally. If patient were complaining of pain, the procedures were stopped for a while. Results: The distribution of age was 29~48 years old, and of longest diameter was 36.0~115.0 mm, and of target distance from skin was 55~100 mm, and of number of treatment was 2~6. Nobody gave up the procedure for pain or any other reason. The procedures took 40 to 60 minutes for a slice. One or three slices were treated in a day. All patients went home after HIFU without medication. Nobody reported any clinically severe complications. Everybody returned to normal activities 1 day after the procedure. Nobody complained of vaginal spotting after one cycle of menstruation. Conclusion: Ultrasound imaging-guided HIFU treatment appears to be safe to ablate the uterine myomas.
송은섭 ( Eun Seop Song ),박지현 ( Jee Hyun Park ),황성욱 ( Sung Ook Hwang ),임문환 ( Moon Whan Im ),이병익 ( Byoung Ick Lee ),이우영 ( Woo Young Lee ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.5
목적: 우리나라의 자궁체암은 점차 늘어나고 있다. 저자들은 단일 기관에서의 자궁내막암 중에서 가장 흔한 세포형태인 자궁내막양 자궁내막암의 임상적 자료를 정리하여 보고하고자 한다. 연구 방법: 1998년부터 2009년까지 11년간 본 기관에서 자궁내막양 자궁내막암으로 진단받은 환자의 의무기록을 통하여 후향적으로 연구하였다. 결과: 연구기간 동안 자궁내막양 자궁내막암 환자는 총 96명이었다. 평균 나이는 51.1세, 평균 추적기간은 36.6개월이었다. 병기는 1기가 73명, 2기가 10명, 3기가 12명, 미확인이 1명이었다. 치료는 수술만 받은 경우가 42명, 수술 후 방사선치료를 받은 경우가 46명이었다. 수술을 받은 95명 중 32명은 림프절 제거 수술을 받지 않았고 63명은 받았으며, 이 중 10명에서 림프절양성이 나왔다. 사망은 총 6명이 있었으며 1기에서 한 명, 2기에서 3명, 3기에서 한 명이 있었다. 결론: 96례의 증례와 여러 치료법 및 림프절 제거 수술 등의 여부를 정리하여 제시하고자 하였다. Objective: The incidence of endometrial cancer is increasing. We would like to report our institution`s clinical data of endometrioid adenocarcinoma (EC) which is the most frequent type. Methods: From 1998 to 2009, patients` clinical data were reviewed through medical records, retrospectively. Results: For 11 years, there were 96 patients with EC. The average age was 51.1 years old and mean follow duration was 36.6 months. There were 73 patients with stage I, 10 patients with stage Ⅱ, and 12 patients with stage Ⅲ. 42 patients were treated by operation only and 46 patients were treated by operation and adjuvant radiotherapy. Among 95 patients who underwent operations, 32 patients did not get lymph node removal and 63 did, and 10 patients had malignant cells at the lymph nodes removed. 6 patients died of EC, 1 with stage I, 3 with stage Ⅱ and 1 with stage Ⅲ. Conclusion: This study had retrospective limitation but could show the profile of 96 patients with EC.
자궁경부이형상피증과 자궁경부암에서의 claudin-1과 claudin-7의 발현 증가 양상
송은섭 ( Eun Seop Song ),이병익 ( Byoung Ick Lee ),김준미 ( Joon Mee Kim ),이건영 ( Keon Young Lee ),안경신 ( Kyung Sin An ),성승미 ( Seung Mi Sung ),권혜진 ( Hye Jin Kwon ),박지현 ( Jee Hyun Park ),한지영 ( Jee Young Han ),최석진 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.5