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인천지역 한 대학병원에서 진단된 기관지천식 중 직업관련성 천식
채창호,진영우,김은아,최승원,강성규,최용휴 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.2
Bronchial Asthma could be developed by occupational origin. 4-16% of bronchial asthmas are known to be related to occupational exposure. However, occupational asthma has not been reported from the periodic occupational health examination, but reported through case report from clinicians. The authors analysed hospital records to find out work-related bronchial asthma and their occupational characteristics at a university hospital in Inchon. All records which were confirmed as bronchial asthma in adult by an allegist from June, 1996 to May, 1998 were selected. Through record reviewing, any suspected work related asthma was selected and the inteview was done by phone or at the out-patient clinic. The possible cases were confirmed by additional tests including specific bronchial provocation test. Sixteen(3.9%) out of 411 bronchial asthma were confirmed as work-related asthma. Eight cases out of 16 worked at furniture industry, three worked at dye manufacturing and two worked at musical instrument manufacturing industry. Others worked at farm and machinary industry. The confirmed asthmogen were toluene diisocyante(8), reactive dye(3), and grain dust(1). None of the cases was detected as work-related asthma in the periodic health examination. Twelve out of sixteen occupational asthma patients discontinued their work. The results suggested that many patients with occupational asthma were not reported and the periodic health examination was not an effective system for detecting the workrelated asthma. Thus setting up the surveillance system involving allergist or pulmonologist would be important to detect and prevent occupational asthma.
솔-젤공정에 의한 한외알루미나 여과막의 기공보정에 관한 연구
채만병,조원준,정은정,이진휘,서동호 서울産業大學校 1996 논문집 Vol.44 No.1
서로 다른 입자 크기의 3층 구조를 갖는 튜브 형태의 한외 알루미나 분리막은, 일반적으로 제조공정중 분리층에 결손부분이 발생하기 때문에 낮은 선택도 및 제거율을 보인다. 이와같은 결손부분을 보정하기위하여 습도조절에 의한 선택적 적심(alternative wetting by controlled humidity)을 한 수 colloidal silical 솔을 적용하여 처리하고 특성을 평가 하였다. Sealing처리한 분리막에 대한 누수여부를 평가하기 위하여 3가지의 염료로 조사하였고, 보정전분리막과 보정후분리막에 대한 SEM, 액체으 투고도, 선택도 및 P.E.G./물 혼합물의 제거율을 측정하였다. P.E.G 2000, 12000 및 35000에 대한 제거율은 각각 약 0.6, 18 및 17% 향상된 결과를 보였으나 colloidal silica 솔의 deposition에 기인하여 투과율의 감소는 77%였다. 이상의 결과에서 보면 습도조절에 의한 선택적 적심법은 비록 deposition에 의한 문제점을 내포하고 있으나 액체분리를 위한 알루미나 한외여과막의 보정에 효과적인 방법이다. The 3-layer type alumina membrane consisting of different pore size shows the decreased selectivity and rejection because of cracks in the separation layer generally occurred during the manufacturing process. To modify these cracks, the colloidal sol is applied by sol-gel process after treating by alternative wetting method using controlled humidity(Alternative Wetting Method by controlled humidity) and evaluated the characteristics. For the evaluation of the leakage for the sealed membrane, the sealed membranes were tested by 3 kinds of dyes. For the comparing of native and modified membranes, the modified membranes for the cracks treated by Alternative Wetting Method by controlled humidity were also tested by SEM, permeability by liquid equipment, selectivity and rejection of the P.E.G./water mixtures. The results showed that the rejections were increased ca. 0.6, 18 and 17 % for the P.E.G. polyethyleneglycol 2000, 12000 and 35000 individually. The permeabilities are decreased, however, 77% for the pure water caused by deposition of colloidal silica sol after caulking. In conclusion, the Alternative Wetting Method by humidity control had the effect for the modification of ultrafiltration alumina membrane for separation of liquids and gases, though having problem of deposition.
초등 과학에서 STS 주제에 대한 수행 평가 도구의 개발과 적용
임채성,김은진,심주옥 부산교육대학교 과학교육연구소 2004 科學敎育硏究 Vol.29 No.-
In this study, we developed an elementary science performance assessment tool on STS theme and applied it in science instruction. It is constituted with performance task, students' response format, scoring system, and it has various objective domains such as science knowledge applying, ICT using, communicating, reflective thinking. It offers teachers a tool by which they can assess students' abilities on a whole. The task is made with the motivation evoked content, that is "no smoking". It is constructed an the activity of writing a Letter to father not to smoke. The students' response format is made by problem solving process, and the scoring system is matched with the steps of students' response. As according to the results of applying it, there were statistically significant improvement for overall several science process skills, for aspect of the understanding of science knowledge, and many students were aware of it positively as well.
자궁내막암 수술시 임파절 전이의 예측인자로서 CA 125의 임상적 유용성
김진휘,이성종,임채춘,남궁성은 대한부인종양 콜포스코피학회 2002 Journal of Gynecologic Oncology Vol.13 No.4
목적 : 자궁내막암 환자에 있어서 골반 임파절 전이의 예측인자로 수술 전 CA 125 값의 유용성을 알아보고자 하였다. 연구 방법 : 1992년 10월부터 2002년 10월까지 가톨릭대학교 의과대학 강남성모병원에서 자궁내막암 진단하에 수술받은 환자 100명을 대상으로 의무기록을 토대로 수술전 CA 125와 임파절 전이유무의 관계를 살펴보았다. 통계적 방법으로는 만-휘트니 유 테스트와 카이 제곱 피셔 테스트를 사용하였다. 결과 : 수술 전 CA 125 값은 병기가 증가함에 따라, 자궁근층을 1/2 이상 침범한 경우, 자궁경부나 부속기를 침범한 경우, 골반 임파절 전이가 있는 경우 유의하게 높게 측정되었다(p<0.05). 결론 : 수술 전 CA 125의 증가는 자궁내막암의 골반 임파절 전이를 예측하는데 있어 유용하다고 할 수 있다. Objective : The aim of this study is to evaluate the clinical usefulness of preoperative CA 125 levels in determining the need for lymphadenectomy in patients with endometrial carcinoma. Methods : CA 125 levels were measured in 100 patients diagnosed with endometrial carcinoma who underwent surgery at Kangnam St. Mary's Hospital between October 1992 and October 2002. Statistical analysis was performed using the Mann-whitney U test and x-Fisher's exact test. Results : Univariate analyses showed that elevated CA 125 levels were significantly correlated with an advanced stage, increasing depth of myometrial invasion, cervical invasion, adnexal involvement, high grade hystology and lymph node metastases (p<0.05). Conclusion : Our data provide an evidence that the elevation of preoperative CA 125 levels can be considered as a predictor for full pelvic lymphadenectomy in the surgical staging of endometrial cancer.
한은진,채옥희 圓光大學校大學院 1996 論文集 Vol.17 No.-
This Study is to know personal ploblems thoughout case study of life-time management for elderly woman who lives alone. This sample is consisted of the woman who is 70 years in Ik-San rural province. This study was using Case Study Method. The Results of this study are as follows ; She was free for 24 ours a day. And her day was not usually planned. Physiological time was 8:15 include sleep time, and free time was 9:00, household work time was 4:45, rural work was 2:00 ; total work time was 6:45. Because she had more time for a work, most of free time was spend for relaxing.
생물 야외 탐구 학습을 통한 초등 예비교사의 생물 교수 효능감의 변화
임채성,배진호,김은진 부산교육대학교 과학교육연구소 2004 科學敎育硏究 Vol.29 No.-
In this research we took a lesson of the biology outdoor inquiry with preservice elementary teachers and investigated the science and biology teaching efficacy belief of theirs and analyzed it comparing with pre and post-lesson efficacy beliefs, their detailed major in university, their departments in high school, taking a course of applied biology Ⅱ in high school. The following results were obtained. First, preservice elementary teachers' science and biology teaching efficacy belief was changed positively after the lesson of the biology outdoor inquiry. Second, preservice elementary teachers' detailed major in university wasn't related with their science teaching efficacy belief of pre and post-lesson significantly in statistics, but related with their biology teaching efficacy belief of post-lesson significantly in statistics. Third, preservice elementary teachers' departments of high school wasn't related with their science and biology teaching efficacy belief. Fourth, taking a course of applied biology Ⅱ in high school wasn't related with science teaching efficacy belief, but related with biology teaching efficacy belief of pre-lesson significantly in statistics. However, That wasn't related with biology one of post-lesson significantly in statistics. That is, who haven't taken a course of applied biology Ⅱ in high school had not biology teaching efficacy belief before the lesson of the biology outdoor inquiry, but acquired much biology teaching efficacy belief after the lesson.
박물관 브랜드 마케팅 및 공간 프로모션 전략 -숙명여자대학교 내 정영양자수박물관 C·E·M 공간디자인을 중심으로-
김은애,김예은,정채림,이진민,장미정,이성애 숙명여자대학교 산업디자인연구소 2017 숙명디자인학 연구 Vol.24 No.-
본 연구는 정영양자수박물관의 콘텐츠를 활용한 통합 브랜드를 개발함에 있어 브랜드·디자인 ·마케팅을 융합한 시점에서 바라보고 그래픽아이덴티티, 제품아이덴티티, 공간아이덴티티 통합브랜드를 구축하는 일련의 프로세스를 밝히는데 목적이 있다. 이에 본 연구는 기존의 박물관 방문자들과 20-30대 여성을 대상으로, 디자인과 마케팅의 융합된 측면에서 도출된 ‘C·E·M’을 物, 事, 人, 場가 융합된 문화로 한정한다. 그 결과, ‘C·E·M’은 디자인과 마케팅 전략을 융합하여 로고 및 사인물의 그래픽디자인부터 제품디자인, 공간디자인에 이르기까지 일관성과 객관성, 스토리성을 도출한다. 끝으로 본 연구는 브랜드가 디자인과 마케팅을 융합하여 더 체계화된 G·I, P·I, S·I의 통합 브랜드 매뉴얼을 만든 것에 의의가 있다. 아울러 향후 이와 관련된 통합브랜드 디자인 개발에 있어서 기초 자료로 활용될 것으로 기대된다
cDNA array 방법을 이용한 망간에 노출된 흰쥐 뇌기저핵의 유전자발현 분석
이채관,노성민,문덕환,,김정호,손병철,김대환,이창희,김휘동,김정원,김종은,안진홍,이채언 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4
Objectives: This study investigated the gene expression profile in basal ganglia of manganese-exposed rats based on cDNA array analysis. Methods: For cDNA array, 25 male Sprague-Dawley rats (250±25 g) were intraperitoneally injected with 25 ㎎/㎏ B. W./day of MnCl2 (0.3 ㎖) for 10 days. For dose-related gene expression analysis, rats were intraperitoneally injected with 0.2, 1.0, and 5.0 ㎎/㎏ B. W/day of MnCl2 for 10 days. Control rats were injected with an equal volume of saline. RNA samples were extracted from brain tissue and reverse-transcribed in the presence of [α^(32)P]-dATP. Membrane sets of the Atlas Rat 1.2 array Ⅱ and Toxicology array 1.2 kit (Clontech, Palo Alto, CA) were hybridized with cDNA probe sets. Northern blot hybridization method was employed to assess the dose-related gene expression. Results: Fifty-two genes showed significant changes in expression of more than two-fold. Twenty-eight were up-regulated and 24 were down-regulated in the manganese-exposed group compared to the control. Among the 52 genes, 28 genes including nuclear factor I-X1 (NF1-X1), neuroligin 2 and 3, mitochondrial stress-70 protein (MTHSP70), neurodegeneration-associated protein 1 (Neurodap 1), multidrug resistance protein (MDR), and endoplasmic reticulum stress protein 72 (ERP72), were reported for the first time related to the manganese-induced neurotoxic-metabolism in the rat basal ganglia. According to the dose-related gene expression analyses, MTHSP70, Neurodap 1 and ERP72 genes were up-regulated compared to the control even in the group exposed to low manganese dose ( 0.2 ㎎/㎏ B.W./day). Conclusions: Twenty-eight genes detected for the first time in this study were closely related to the manganese-induced neurotoxic-metabolism in the rat basal ganglia and further study of these genes can give some more useful information about the manganese metabolism.