(±)-Camphor가 ICR 마우스 수컷의 간 cytochrome P450 효소 활성에 미치는 영향

오은경,박형건,배기현,최옥진,최은경,최창근,한진희,정태천 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.4

Effects of (±)-camphor on liver cytochrome P450 enzymes were investigated in male ICR mice. Mice were treated intraperitoneally with 0, 200, 400 and 800 mg/kg of (±) -camphor in corn oil for 3 consecutive days. Twenty four hr after the final treatment, the animals were subjected to necropsy. The activities of serum aspartate aminotransferase and serum alanine aminotransferase were slightly changed by the treatment with (±)-camphor at the doses used. Administration o(±)-camphor to mice significantly induced the hepatic activities of pentoxyresorufin O-depentylase and benzyloxyresorufin O-debenzylase and weakly induced ethoxyresorufin O-deethylase in dose-dependent manners. The present results suggested that (±)-camphor might act as a relatively specific inducer of hepatic cytochrome P450 213 in male ICR mice.

분자역학적 방법을 이용한 부산시내 대형건물 냉각탑수의 레지오넬라균의 형별 분류

김정만,정석훈,서대영,박은희,송은주,최재철,이은엽,장철훈 대한임상미샐물학회 2004 Annals of clinical microbiology Vol.7 No.1

억제대 적용지침 개발을 통한 불필요한 억제대 적용율 감소활동

곽경선,김성은,배은경,이은숙,이은혜,최윤정,이윤경 한국의료QA학회 2009 한국의료질향상학회지 Vol.15 No.2

문제: 억제대 적용에 대한구체적 적용지침 없이 의례적으로 억제대를사용함으로 인해 환자들의 신체적 또는 정신적 안전을 위협할 수 있다. 목적: 완전 진정상태 이거나 근력이 약하여 발관능력이 없는 환자에 대한 예방적 적용, 바빠서 환자를볼수 없 는경우, 간호사본인의 판단이 없이 타인의 요구에 따르는등의 불필요한 억제대 적용이 증가하는 원인을 파악하여 중환자실의 특수성에 맞는 억제대 적용및 제거 지침을 마련하고자 한다. 의료기관: 인천광역시에 소재한 의과대학 소속병원의 집중치료실 개선효과: 억제대 적용에 대한중환자실 간호사에게 미치는 영향을 보면 태도 정도 p=0.09(p<0.1), 올바른 수행 능력은 p= 0.005 (p <0.0히로통계적으로유의한것으로 나타났다. 지식 정도 p=0.172(p<0.05) 통계적으로 유의 하지는 않지만 모든항목이 개선 활동전 에 비해 2,3차 개선 활동후에 향상한 것으로 나타났다. 개선활동전에 8.1%였던 간호 기록, 0.7%였던 간호중재, 0%였던 의사처방율이 3차 개선 활동 후 3가지 모두 100% 달성되었다. 이는 억제대 적용율 갑소 및 부적절한 억제대 적용율은 유의하게 감소하였다. 교훈: 중환자실 간호사의 억제대 적용에 대한태도, 지식, 올바른 간호 수행 능력은 지속적으로 재평가 되어지고, 교육내용은좀더 나은 간호제공을 위하여 개발 되어져야 할 것이다. 억제대 적용 기준과 제거 기준을 Check List 하여 객관성의 유지를 위한 개선 활동은계속적으로 Feedback 되어야 할 것이다.

Effect of 2-Deoxy-D-Glucose on Metabolic Status, Proliferative Capacity and Growth Rate of FSall Tumor

Hyesook Chang(장혜숙) , Eun Kyung Choi최은경) , Jeong Gill Cho(조정길) , Tae-Hwan Lim(임태환) , Tae-Keun Lee(이대근) ,Yun Yi(이윤) ,Young Joo Cho(조영주) , Gon Sup Kim(김곤섭) 대한방사선종양학회 1991 Radiation Oncology Journal Vol.9 No.1

2-DDG가 쥐의 섬유육종(FSall)에 미치는 영향에 대한 연구로 에너지 신진대사는 체내에서의 ³¹P - 자기공명 분광기를 이용하여 관찰하였고 세포 증식 능력은 유세포 분석기를 사용하여 연구하였다. 성장속도는 개의 세포를 C₃Hj/Sed 쥐의 발등에 이식한 후 3차원적으로 측정하여 관찰하였다. 2-DDG를 투여한 경우에는 이식후 12일에 복강내로 주사하였다. 이식후 12일의 종양의 평균 크기는 250㎣이었다. FSall 종양의 성장속도는 semilog graph의 기울기와 종양의 doubling time으로 측정하였다. 2-DDG를 투여한 후 성장속도가 감속되었다. 5~12일 사이의 성장속도의 기울기가 0.828, 종양의 Idubling time이 0.84일이고 대조군에서는 13~28일 사이의 기울기가 0.218, doubling time이 3.2일인 반면 2-DDG 투여군에서는 성장속도의 기울기가 0.135이고 doubling time이 5.1일이었다. ³¹P-자기공명 분광기를 이용하여 2-DDG의 영향을 분석해 본 결과 2-DDG 투여후 종양증식 속도의 감속과 더불어 phosphomonester (PME)와 inorganic phosphate (Pi)의 증가속도가 감소하였다. 이것은 2-DDG 투여후 세포의 괴사가 감소하였다는 의미가 있다. 유세포 분석기를 이용하여 종양의 증식 능력을 분석한 결과는 2-DDG 투여후 S-phase와 G₂+M phase의 DNA 분포가 크게 증가하였다. 이것은 2-DDG 투여후 세포가 좀더 방사선에 민감한 cycle로 진행함을 의미하는 것으로 해석할 수 있다. 이에 저자들은 2-DDG가 FSall 종양세포에 미치는 흥미있는 결과를 토대로 방사선 치료에 미치는 영향과 실제 이용 가능성에 대하여 더 연구하고자 한다. The effect of 2-deoxy-d-glucose (2-DDG) on C₃H mouse fibrosarcoma(FSall) was studied, Metabolic status, especially for energy metabolism, was studied using in vivo P-MRS, prolifer-ative capacity was observed on flow cytometry(FC) and growth rate was measured after trans-plantation of viable tumor cells in the dorsum of foot of C₃Hf/Sed mice. One gram of 2-DDG per kg of body weight was injected intraperitoneally on 12th day of implantation. Average tumor size on 12th day of implantion was 250㎣. Growth rate of FSall tumor was measured by tumor doubling time and slope on semilog plot. After 2-DDG injection, growth rate slowed down. Tumor doubling time between tumor age 5-12 days was 3.2 days with slope 0.218 in control group. After 2-DDG injection, tumor doubling time was elongated to 5.1 days with slope 0.136. The effect of 2-DDG studied in vivo P-MRS suggested that the increase of phosphomonoes-ter (PME) and inorganic phosphate (Pi) by increasing size of tumor, slowed down after 2-DDG injection. Flow cytometry showed significantly increased S-phase and G₂ + M phase fraction suggesting increased proliferative capacity of tumor cells in the presence of 2-DDG. Authors observed an interesting effect of 2-DDG on FSall tumor and attempt to utilize as an adjunct for radiotherapy.

과학 문제해결 과정을 활용한 초등 과학 수행평가 도구의 개발과 적용

최회정,임채성,김은진 부산교육대학교 과학교육연구소 2003 科學敎育硏究 Vol.28 No.-

In this study, the performance assessment tools using processes of solving problems in science were developed and applied to instruction, then their effects were analyzed both quantitatively and qualitatively. The results of the research can be summarized as follows: First, among the performance assessment tools developed in the study, the students' response formats were shown to be a useful method to understand collectively the processes and products of learning, and the students' appreciation toward it was also found to be positive. Second, in science instruction which proceeded through each step of science problem solving the science attitudes of the experimental group, although not statistically significant, showed more improvement than comparison one. Among the categories of science attitudes, 'attitudes toward science subject and the unit or topic studied' showed statistically significant improvement, which is interpreted as results of making harmony of preexisting students' interests with difficulty levels of tasks. Third, for overall several science process skills, there were no significant improvement. However, the subskills of inferring, data interpretation, and drawing conclusion were found to be increased significantly, which might be due to the frequency and depth of use of these skills in real instruction. Fourth, for aspect of the understanding of science knowledge and applying of it, there were statistically significant increase. That is, it was interpreted, through active participation in learning task across the whole range of performance of problem solving, that the abilities to applying science knowledge to the given problems were significantly increased.

폐모세포종 : 1례보고 A Case Report

최영호,서홍주,임영혁,김정중,박성강,이석기,임진수,김은규 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Pulmonary blastoma is a very rare primary neoplasm of the lung. We experienced a case of pulmonary blastoma in a 40 years old man. The mediobasal segmentectomy of the right lower lobe was performed. The patient was discharge on the postoperative days 6. There is no evidence of recurrence or metastasis on followup study during 7 months period after operation.

급성 호흡곤란을 호소하는 노인 중환자에서 혈청 N-Terminal Pro-Brain Natriuretic Peptide 검사의 유용성

최정은 關東大學校 醫科大學 醫科學硏究所 2004 關東醫大學術誌 Vol.8 No.1

Background N-terminal pro-Brain type natriuretic peptide (NT-proBNP) originates mainly from the ventricle and has been shown to be of diagnostic value in congestive heart failure, predictive of sudden cardiac death and prognostic for death in acute coronary syndrome. And recent studies suggested NT-proBNP can be increased in various disease such as pulmonary embolism, primary pulmonary hypertension and essential hypertension. Sometimes it is difficult to differentiate a cause of dyspnea in aged patients with variable underlying diseases. In this study, the NT-proBNP were measured from aged dyspneic patients in intensive care unit to evaluate the usefulness of NT-proBNP in differentiating the cause dyspnea and in predicting prognosis of that patients. Methods 42 aged patients with dyspnea in ICU, who were hospitalized from April to October 2003 were enrolled in this study. Elecsys proBNP with electrochemiluminescence method was used for measurement of serum NT-proBNP. The acute physiology and chronic health evaluation (APACHE) II score and mortality were recorded. Results The mean age was 76.2±6.3 years old. There were 14 males and 28 females. The mean NT-proBNP level was 8186.4±1742.2 pg/ml, which showed marked elevation compared to normal values. There were significant differences in NT-proBNP levels among the variable diseases (p=0.017). The mean APACHE Ⅱ score was 13.4±0.8 and predicted mortality was 16.9±1.8%. The correlation between the NT-proBNP and APACHE Ⅱ score, between the NT-proBNP and mortality were significant (r=0.355, p=0.021 & r=0.346, p=0.025) Conclusion The measurement of serum NT-proBNP is helpful and noninvasive tool for differentiating of various cause of dyspnea and also useful for predicting prognosis in aged patients with dyspnea.

호흡율 측정기를 이용한 폐수의 외부탄소원 이용가능성 평가

최은희,고주형,임정훈,부경민,김창원 부산대학교 환경문제연구소 2000 環境硏究報 Vol.18 No.-

In this research, we measured Readily Biodegradable COD(Ss) using respiration meter which measured OUR and calculated respiration rate due to calculate organic matter portion of external carbon sources because known organic matter analysis methods i.e. COD, BOD did not measure amount of organic matter which was used in denitrification. Based on the experimental results, leather wastewater had 40.3% Ss in TCOD and food fermentation liquid, alcoholic wastewater and petrochemical wastewater was 38%, 38% and 28.3% respectively. However in case of considering of flowrate and concentration, flood fermentation and alcoholic wastewater was revealed that they were effective external carbon sources

옥타데케인 마이크로캡슐 슬러리를 이용한 관내대류 열전달에 관한 연구

정동주,최은수 명지대학교 대학원 1998 대학원논문집 Vol.2 No.-

As a method of heat transfer enhancement, octadecane was micro-encapsulated and added to water. The capsule wall was made of melamin. Its outer diameter was about 10㎛. 75% of the capsule mass was octadecane. The slurry did not show non-newtonian viscosity when the fraction of the capsules in the slurry was under 20%. Even though the pressure drop did not become high, but effective heat capacity was measured high. Nusselt number measured in the heating test section was similar with expected value when the octadecane was not melted, but higher than expected value when the octadecane was melted.

여러 가지 상변화물질 슬러리의 원형관내 대류 열전달에 관한 연구

崔恩洙,鄭東柱 明知大學校 産業技術硏究所 2003 産業技術硏究所論文集 Vol.22 No.-

To investigate convective heat transfer of various the phase-change-material slurries in a circular tube, paraffin slurry, MC-lauric acid slurry, MC-octadecane slurry and ice slurry were tested in two kinds of heat transfer experimental apparatus with constant heat flux test section. Nusslet numbers of the phase-change-material slurries were found to increase when the phase-change- material melted. Nusselt number of the phase-change material slurry increased, as the size and fraction of the phase-change material increased. The effective thermal capacities of the phase-change-material slurries were higher than those of water. As fraction and fusion energy of the phase-change-material increased, the effective thermal capacity increased.