임신중기 양수천자에 의한 태아의 세포유전학적 연구

정은환,김학순 충북대학교 의과대학 충북대학교 의학연구소 2003 忠北醫大學術誌 Vol.13 No.2

연구목적: 태아의 염색체 질환을 산전에 진단하기 위한 임신중기 양수천자의 효용성을 분석하고자 하였다. 대상 및 방법: 1995년부터 2002년까지 충북대학교병원에서 임신중기에 양수천자를 시행한 443명의 임부를 대상으로 태아 염색체 검사의 적응증, 이상소견, 및 합병증 유무에 따라 분류하고 비교하였다. 결과: 18명의 임부에서 의미있는 태아 염색체 이상이 발견되었으며 심한 합병증은 없었다. 종류별로는 숫적 이상이 11례, 구조적 이상이 5례, 모자이시즘이 2례였다. 결론: 임신중기 양수천자는 임상적으로 적응증이 되는 경우에는 반드시 시행해야 할 안전하고 정확한 방법임을 확인하였다. Purpose: This study was performed to analyse the efficacy of second trimester genetic amniocentesis for prenatal diagnosis of fetal chromosomal anomaly. Materials and Methods: Fetal karyotype, indications for genetic amniocentesis, and complications were analysed in 443 amniocentesis cases which were performed at Chungbuk National University Hospital from 1995 to 2002. Results: Clinically significant chromosomal abnormalities were found in 18 cases including 11 numerical abnormalities, 5 structural rearrangments, and 2 mosaisms. There was no significant complication. Conclusion: Second trimester genetic amniocentesis is a safe and accurate method to detect fetal chromosomal anomalies and should be performed if clinically indicated.

난황낭종 환자에서 보존적 수술 및 항암 화학요법 후 성공적인 자연임신

정은환, 홍승화, 박연진, 지일운, 김학순 충북대학교 의과대학 충북대학교 의학연구소 2012 忠北醫大學術誌 Vol.22 No.1

침윤성 난소암의 경우 생식력의 보존이 중요한 도전이라고 할 수 있다. 20대 중반의 여성에서 거대 한 난황낭종이 발견되어 생식력의 보존을 위해 보존적 수술과 복합항암화학요법을 시행한 후 임신 및 출산에 성공한 증례를 경험하였기에 문헌고찰과 함께 보고한다.

부산시 일개구 지역주민의 위암선별검사 수검 및 반복수검 실태 및 관련요인조사

정인숙,배은숙,천동환,전진호,이화자,박남희 韓國保健敎育.健康增進學會 2003 보건교육건강증진학회지 Vol.20 No.1

The importance of repeat screening for stomach cancer is well known to decrease deaths from stomach cancer. This study was aimed at assessing practice behaviors and to identify related factors in the aspects of demographic factors, health status and cancer risk recognition, attitude to cancer screening, health behaviors, and inhibiting or facilitating factors to stomach cancer screening in an urban area. Data was collected through self-administered questionnaires from 403 people aged 40 to 69 years from April 23th to May 15th, 2002. Practice behaviors were classified as :"ver"r "ver"and "peat"r "t repeat"rouped based on a recent 5 year screening history. The results were as follows: 1. Among the 403 subjects: "e ever group"as 23.8% and "e repeat group"as 4.0%. The rates of screening were 20.5% for men, 27.8% for those women, and 27.3% for aged 40-49, 24.5% for those aged 50-59, 19.0% for those aged 60-69. The rates of repeat screening were 4.0% for men, 4.1% for women, and 2.9% for those aged 40-49, 6.3% for aged 50-59, 2.5% for those aged 60-69. 2. The main factors associated with adherence to gastric cancer screening were education(post high school vs below : OR=2.44), previous cancer screening(yes vs no : OR=2.61), belief in personal health(no vs yes : OR=2.72), health status(unhealthy vs healthy : OR=3.40), possibility of cancer compared to others(low vs not low : OR=2.56), and regular exercise(yes vs no : OR=2.94). The main factor associated with adherence to gastric cancer repeat screening was other cancer screening (yes vs no : OR=6.33). Consequently, there is a need to change the recognition of the importance and necessity of stomach cancer screening in healthy conditions through health education, and to perform multiple screening tests each visit.

췌장암 환자에서 알코올 내장신경 신경파괴블럭 후 발생한 간염

이상은,최석환,김영환,임세훈,이정한,이근무,정순호,최영균,김영재,신치만 인제대학교 2008 仁濟醫學 Vol.29 No.-

Splanchnic neurolytic block(SNB) with alcohol improves the management of pancreatic cancer pain. Adverse effects of alcohol SNB which include regional pain, hypotension, diarrhea, and acute alcohol intoxication are common, but acute hepatitis caused by alcohol neurolytic block is rare. A 63-year-old patient with pancreatic head cancer and liver metastasis had complete pain relief after both retrocrural tansdiscal SNB with 100% alcohol 10 ml. But, 1 day later, liver function test showed a high elevation in the aspartate aminotransferase (AST, 2182 IU/L) and alanine aminotransferase (ALT, 1807 IU/L). The patient had slight jaundice, general weakness, chilling, nausea and vomiting after SNB. Both AST and ALT decreased to 46 and 119 IU/L within 10 days with only supportive therapy. But, 19 days later, the patient died due to pneumonia. Our case illustrates the importance of clinical surveillance especially in patient with hepatic disease after alcohol SNB.

대동맥판폐쇄부전으로 나타난 Supraaortic Ridge와 Subaortic Membrane의 증례

류정곤,김윤철,성보영,김준경,정준용,성인환,전은석,나명훈,이영 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

광양만으로 유입하는 하천하구에서의 이화학적 특성 : 우수기 직후 유입하천에 따른 영향 effect of inputting rivers after rainy season in summer

김은영,정흥호,정호승,조환익,황주찬,최상원 한국환경과학회 2004 한국환경과학회지 Vol.13 No.9

Physicochemical characteristics of Kwangyang Bay, have been investigated on the effects of inputting rivers just after rainy season in summer 2003. The results ranged from 4.96~8.01 mg/L for DO, 1.16~3.09 mg/L for COD, 7.21~67.71 μM for DIN and 0.12~121.84 μM for phosphate. The COD of Yeosu Area was 1.19~3.09 mg/L, Kwangyang Area was 1.23 ~ 2.76 mg/L. The COD of Wallae cheon in Yeosu Area was 3.09 mg/L and Donghoan in Kwangyang Area was 2.76 mg/L. The reason of high COD might be industrial sewage of organic chemical plants and iron foundry. DIN of Yeosu Area and Kwangyang Area were 7.21--63.43 μM and 8.43 67.71 μM respectively. The average phosphate of Yeosu Area was 23.65 μM. The source of phosphate might be industrial sewages of fertilizer plant and phosphate gypsum stocked with high amounts. The metal concentrations were measured in the range of 1.01~175.10 ㎍/L for Cu, 0.13~1.78 ㎍/L for Cd, 1.13~5.21 ㎍/L for Pb, 1.58~13.57 ㎍/L for Cr and 1.07~20.68 ㎍/L for As. The average Cu concentration was 78.99 ㎍/L in Kwangyang Area. The source of Cu might be industrial sewage of iron foundry. The average Cr concentration of Yeosu Area was 9.07 ㎍/L. That is 2 times higher than Kwangyang Bay 5.74 gg/L, because of sewage of chemical plants.

선천성 대사 이상 환아에서 발생한 대사 위기의 복막 투석 치료 효과

강정혜,이동환,문철,김은미 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2

Purpose : We have evaluated the outcomes of peritoneal dialysis in patients with metabolic crises caused by in born error of metabolism. Methods : There are 6 patients(8 episodes, 4 males and 2 females) who had inherited inborn errors of metabolism and were admitted to the department of pediatrics, Shoonchunhyang university hospital in Seoul from December 1991 to December 1994. The technique of dialysis is discribed, in short: A Tenckhoff catheter was inserted surgically in all patients through the lateral abdominal wall. Commerically available dialysate solutions(Peritosol, Korea Green Cross Co.) was applied to 5 patients(7 cases) with hyperammonemia. In a patient with propionic acidemia, we used a special custiom made dialysate that replaces lactate by bicarbonate. Results : 1) The mean age was 5.3 months old. There were 6 patients with 8 episodes. Six cases had Ornithin transcarbamylase deficiency. The remaining cases are Multiple carboxylase deficiency and Propionic acidemia (Table 1) 2) In 7 cases with hyperammonemia, mean levels of pre and post 24hrs peritoneal dialysis serum ammonia were 1000.2±310.9 ㎍/dl and 388.8 ±156.7 ㎍/dl at 24 hours respectively. Time on serum ammonia levels reached below 300 ㎍/dl was 88.7 ±39.6 ㎍/dl hours. 3) Four out of seven cases were a recorvert of mental status. Each episode of serum ammonia mean levels was 388.8 ±156.7 ㎍/dl after 19.7 ±5.8 hours of peritoneal dialysis (Table 3). 4) Peak serum ammonia levels of the survived group reached 1356.5 ㎍/dl, higher than the expired group of 847.5 ㎍/dl and time period of starting peritoneal dialysis after onset of the survived group was 15.5 hours earlier than the expired group of 23 hours(P>0.05)(Table 4). 5) 3 out of 7 cases of hyperammonemia died. The cause if death were 3 brain edema, 1 hyperkalemla and 1 intracranlal hemorrhage. 6) In onecase with Multiple carboxylase deficiency, serum ammonia level was normalized after 12 hours of peritoneal dialysis. The reduction of serum levels of the branched amino acid was also observed. 7) In a case of Propionic acidemia with severe metabolic acidosis, the prior serum bicarbonate level was 8 mmol/L and was increased up to 18 mmol/L by peritoneal dialysis lasting 19 hours. 8) Among 8 cases, complications of peritoneal dialysis were 5 hypoalbuminemia, 4 hyoercalcemia, 4 hyperglycemia and leakage of peritoneal dialysate. Conclusions : In cases of hyperammonemia, survival rate is 57.1%. They are showed excellant efficacy of treatment of peritoneal dialysis for metabolic crises. In a case of propinic acidemia is fastly corrected by peritoneal dialysis. But unfortunally clinical manifestations is not improved. Therefore, further studies is required with treatment of severe metabolic acidic conditions.

햄스터 구강암 발생 과정에서 Heat Shock Protein에 관한 면역조직화학적 연구

최규환,이동근,김은철,정창주 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.2

A IMMUNOHISTOCHEMICAL STUDY ON HEAT SHOCK PROTEIN IN ORAL CARCINOGENESIS IN HAMSTER Heat shock protein (HSP) expression is unto·emulated in tumor cells and, HSP expression is likely marker of the malignant potential of oral epithelial lesion. Furthermore, the 70kDa HSP is implicated in the degree of tumor differentiation, the rate of tumor proliferation and the magnitude of the anti-tumor Immune response. Accordingly, the distribution and intensity of HSP70 and HSP47 expression was assessed in the DMBA induced oral carcinogenesis in hamster. Golden Syrian hamsters which were 3 months-age and 90∼120g were collected. 9,10-dimethyl -1,2-ben-zanthracene (DMBA) in a 0.5% solution in mineral oil was painted on the buccal pouch mucosa 3 times per week in the study group. In each control and experimental groups of 6, 8, 10, 12, 14, 16, 18, 20 weeks, specined for immunohistochemical study with anti-HSP47 and anti-HSP70 antibody. The following results were obtained. 1.HSP47 positive cells were race or negative of normal oral mucosa, increased mildly in basal and suprabasal basal layer, and spinous cell layer after experimental 6 weeks (dysplastic or CIS stage). In CIS stage, HSP47 expression is prominent in dysplastic free or normal adjacent epithelium. 2.HSP47 positive cells in connective tissue were mainly inflammatory cells, which is gradually increased from control to precancerous and cancer stage. But HSP47 positive cells after 14 weeks were decreased, especially normal and cancer adjacent epithelium. 3.The positive staining cells of HSP70 in control, dysplastic, and CIS stage were not seen. But they were mild findings in basal layer and moderate findings in spinous layer after experimental 14 weeks (cancer stage). 4.HSP70 positive cells were increased in precancerous and cancer stage than control group in connective tissue. After experimental 16 weeks, we could not find the HSP expression in cancer cells according to cancer differentiation or cancer stage. It is concluded that HSP70 or HSP47 expression is not a definitive marker of oral malignancy or malignant potential. However, with further development, HSP immunoreactivity may be valuable as an adjunct to conventional histology for assessing the malignant potential of oral mucosal lesions.

Ⅱ급 과개교합 환자의 측두근 박리 전 후의 근육활성도에 관한 연구

김은경,김정기,김오환 全北大學校 齒醫學硏究所 1992 전북치대논문집 Vol.10 No.1

The purpose of the present study was to investigate the differences of EMG activity of the masticatory muscles between before and after the temporal muscle detachment from coronoid process in the Class Ⅱ deep bite patients. 12 persons of Class Ⅱ deep bite malocclusion whose mean age 18.4 years served for this study. The EMG data from the anterior temporal and superficial masseter muscles in both sides as mandibular elevators were recorded with the Physiograph MK-Ⅲ electromyographic machine. The EMG recordings were analysed during mandibular rest position, maximal biting and swallowing of saliva. The following results were obtained. 1. There was no significant difference during mandibular rest position and swallowing between before and after temporal muscle detachment at anterior temporal and masseter muscle. 2. The activity of the anterior temporal and masseter muscle during maximal biting showed slightly increase at 8 weeks and 12-24 weeks after temporal muscle detachment, whereas showed significant decrease at 4 weeks after temporal muscle detachment. 3. In comparison of EMG activity during maximal biting between before and 12-24 weeks after temporal muscle detachment showed statistically nonsignificant difference in the anterior temporal muscle, however masseter muscle showed statistically difference(P<0.05).

초등학생의 성격유형과 수학적 성향의 관계

김정혜,노은환 晋州敎育大學校 科學敎育硏究院 2006 科學敎育硏究 Vol.29 No.-

MMTIC (Murphy-Meisgeir Type Indicator for Children), which is a tool to measure the inborn psychological functions of children and adolescents, was developed based on Jung's theory of psychological patterns for the use by children and adolescents in their everyday life. We can use the tool to understand differences in personality type among people and to achieve educational goals in the field of education. The purposes of the present study were to survey the distribution of personality type of elementary students in the Sancheong -gun area, which is exposed to natural environment relatively much, to examine the relation between their personality type and their mathematical disposition, and to understand differences in personality type of people and use them for teaching- learning, adjustment to school life, counseling, etc. in the field of education. For these purposes, we formulated research questions as follows. 1. How is the distribution of personality type of elementary students in the Sancheong-gun area? 2. In the personality type of elementary students in the Sancheong-gun area related to their mathematical disposition? 2-1. How are the four preference indexes of personality type related to mathematical disposition? 2-2. How are the four psychological functions of personality type related to mathematical disposition? 2-3. How are the four temperaments of personality type related to mathematical disposition? In order to answer these questions, we surveyed 207 sixth-grade students in six elementary schools in Sancheong-gun, Personality type was tested MMTIC. and mathematical disposition was measured with a test composed of 22 questions, which was developed by the author and the reliability of which was confirmed through a preliminary test. Each question in the mathematical disposition test was on a scale of 4 points. A high score meant high mathematical disposition. MMTIC was analyzed by a special institution, and data for examining the relation between personality type and mathematical disposition were processed using SPSS 10.0. In order to examine the distribution of children's personality type by preference index, by psychological function and by temperament, we calculated frequencies and percentages. In addition, t-test was made to determine the significance of the relation between the preference indexes of personality type and mathematical disposition, and F-test was made to determine the significance of the relations between the psychological functions of personality type and mathematical disposition, and F-test was made to determine the significance of the relations between the psychological functions of personality type and mathematical disposition and between the temperaments of personality type and mathematical disposition. From the results of this study were drawn conclusions as follows. First, when children were compared based on preference indexes, a significantly larger number of students were external(E) in the external-internal(EI) index, intuition(N) in the sensing- intuition(SN) index. feeling(F) in thinking-feeling(TF) index, and perceptive in judging-perceiving(JP) index. In the distribution of psychological functions, intuition- feeling(NF) children were most frequent and, next, sensing-feeling (SF), intuition-thinking(NT) and sensing-thinking(ST) children. In the distribution of temperament, the percentage of children with intuition-feeling(NF) temperament was highest and it was particularly as high as 15.9% among male students and, next, the percentages of children with sensing-perception(SP), sensing-judging(SJ) and intuition-thinking(NT) temperaments in their order. Second, in order to examine the relation of mathematical disposition with the preference indexes(EI, SN, TF, JP) and the psychological functions(ST, SF, NT, NF) of personalty type, we conducted t-test and F-test. According to the results, no statistically significant difference was observed at significance level of 0.05 although there were slight differences of the means in all of the four types. Third, in order to examine the relation between mathematical disposition and the four temperaments (SP, SJ, NT, NF) of personal type, we conducted F-test. According to the results, statistically significant differences were observed at significance level of 0.05 and mathematical disposition was high in order of NT>NF>SJ>SP. Data collected through this research can be a guideline for establishing education plans for elementary students in Sancheong-gun. That is , because there are relatively many students with external disposition in the EI index, education may be focused more on activities. Because there are more students with emotional disposition in the TF index, small- group learning may be emphasized more than individual learning. With regard to the JP index, because most students have perceptive disposition, the tendency may be considered in teaching for higher educational effects. People who prefer the perceptive type generally want to adjust themselves to situations and to live with our restriction, tend to make efforts to understand life rather than control life, adjust themselves at a moment, and like to be openhearted. In addition, as they are fond of various opportunities, they can adapt themselves well to unorganized and uncertain situations. Moreover, they often fail to complete works and to be late in task performance. What is more, whenever such things happen, they usually cope with the situations appropriately by themselves. Understanding students' personality type does not necessarily mean better education. However, it is also absurd to establish education plans and give classes without knowing their characteristics. On the whole, research must begin with the identification of students' unique characteristics so that students' potential for future development can be acknowledged and their development can be promoted properly. Because students' mathematical disposition has a significant effect on their achievement in mathematics, this research began with the identification of students' personality type and explored the relation between students' personality type and their mathematical disposition. Researches should be continued on personality type and various factors affecting students' academic achievements. Such researches will enable customized education.