Interaction between Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Recent Negative Stressor in Harm Avoidance

Kim, Seog Ju,Cho, Seong-Jin,Jang, Ha Min,Shin, Jonghan,Park, Pil-Whan,Lee, Yu Jin,Cho, In Hee,Choi, Jung-Eun,Lee, Heon-Jeong S. Karger AG 2009 Neuropsychobiology Vol.61 No.1

<P>There have been controversial results regarding the association between brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and anxiety-related traits such as harm avoidance (HA). We aimed to investigate the interaction between <I>BDNF</I> Val66Met polymorphism and negative life stressors in HA. <I>BDNF</I> Val66Met polymorphism was genotyped in 391 community-dwelling Koreans (152 males, 239 females; 43.2 ± 14.1 years old). The Temperament and Character Inventory (TCI) and the Center for Epidemiological Studies for Depression Scale (CES-D) were self applied. The Structured Clinical Interview for DSM-IV axis I disorders and face-to-face interviews investigating negative life stressors within the last 6 months were also performed. There was no significant difference in TCI score, major depressive disorder prevalence and CES-D score among the 3 genotypes (94 Met/Met, 188 Val/Met and 109 Val/Val subjects). There was no significant difference in TCI scores between subjects with stressors and those without stressors, while more common major depressive episodes (p = 0.03) and higher CES-D scores (p < 0.001) were found in subjects with stressors. However, there was a significant interaction between the <I>BDNF</I> genotype and negative life stressors in HA (p = 0.02). Only subjects with the Val/Val genotype showed higher HA with recent negative stressors. Our finding suggests that <I>BDNF</I> Val66Met polymorphism might influence HA by interacting with recent negative stress experience.</P><P>Copyright © 2009 S. Karger AG, Basel</P>

소와 및 열구의 인공 초기 법랑질 우식병소에 대한 불소유리 전색재의 영향

하은숙,김신 大韓小兒齒科學會 1993 大韓小兒齒科學會誌 Vol.20 No.1

With the view of comparing the effects of pit and fissure sealant of conventional and F-releasing type upon early fissure caries, an experimental study was performed. The sealants of both types were applied upon caries-induced enamel surface respectively, and their remineralizing effects were evaluated. On the other hand, early enamel caries was induced artificially at sealed occlusal surfaces with sealants of both types. Specimens were observed under polarized light microscope, and lesion depths of each group were measured. The obtained results were as follows: 1.There showed classical features of negative refringence at surface zone and positive refringence at subsurface zone in all specimens under polarixed light. 2.Comparing the lesion depths under the sealed areas with sealants of both types after caries induction,lesion depths of F-releasing sealant group(69.6± 12.5㎛) were shallower than those of conventional sealant group(100.7±20.6㎛) (P<0.01). Surface zone was more remarkable in F-releasing sealant group. 3.Comparing the lesion depths around the sealed areas after cariesinduction over sealed areas with sealants of both types, lesion depths of F-releasing sealant group(75.8±21.9㎛)were shallower than those of conventional sealant group(139.2±18.4㎛) (P<0.01).

모감주나무(Koelreuteria paniculata) 種子發芽에 光과 溫度의 影響

申永澈,朴永達,韓銀河 충북대학교 농업과학기술연구소 1995 農業科學硏究 Vol.12 No.2

seed of Koelreuteria paniculate ware germinated at 25℃ at 25℃/15℃ with daily photoperiod of 0, 1/2, 1, 4. 6 and 24hr seed exhidited an obligate light requirement, the alternating temperature of 25℃/15℃ enhanced germination when light was 1 hour. It is suggested that seed stored at room temperature and sacrified with pin will exhibit improved germination.

유색미의 첨가량과 발효방법에 따른 증편의 품질특성

신은하,이재경 한국조리과학회 2004 한국식품조리과학회지 Vol.20 No.4

This study was carried out to investigate the quality characteristics of Jeung-Pyun with respect to the addition ratio of pigmented rice and fermentation method. As the amount of pigmented rice was increased, the moisture content of the products added with yeast tended to increase more than those made in the traditional way. Regardless of fermentation method, L value and b value of Jeung-Pyun without pigmented rice were higher than those of Jeung-Pyun with pigmented rice, for which the values were significantly low. The samples with 5% or 10% pigmented rice had a high degree of expansion. The other samples showed no visible difference. The hardness, cohesiveness, springiness and chewiness tended to decrease. On the other hand, the adhesiveness was increased. In both fermentation methods, as the amount of pigmented rice was increased, the gelatinization degree was raised. In sensory evaluation, the characteristics of Jeung-Pyun with 30% pigmented rice were very poor, except for the characteristics on pore uniformity. The other samples and both fermentation methods were hardly different.

Expansin으로 형질전환 된 담배의 생장 특성

신하정, 성현정, 백승준, 김보미, 엄유리, 조은정, 정찬문, 이이 충북대학교 연초연구소 2008 煙草硏究 Vol.21 No.-

-본문참고-

태아·영유아의 환경보건에 대한 가임기여성 인식도 조사

신지영,박은교,신정은,하은희 이화여자대학교 의과학연구소 2018 EMJ (Ewha medical journal) Vol.41 No.2

Objectives: The accumulated evidence shows that adult disease may have origins during the fetal period and maternal environmental exposure may affect fetus and infant health. To assess the environmental health of fetus and infants and examine women’s concerns about environmental health, we designed and conducted an environmental health survey in reproductive-aged women in 2011. Methods: A stratified multi-stage design was adopted for our survey, and 1,000 reproductive- aged women aged 25 to 39 years participated. The participants were asked to complete an electronic questionnaire using the computer-assisted web interviewing method. All the participants were married woman, and 80% had experienced pregnancy before completing the survey. Results: In the study, 86.3% of the participants responded that they are worried about the environmental problems that may affect the fetus and infant. The participants responded that they were most worried about global warming and climate change (36.2%), electromagnetic waves (31.4%), and endocrine disrupting chemicals (25.1%). Moreover, participants responded that environmental problem can cause children’s allergic disease, such as atopic dermatitis, metabolic syndrome and growth development. Conclusion: We found reproductive-aged women have high awareness of children’s environmental health. We also recommended that additional surveys on mother and child environmental health be conducted to make a health policy for women, fetus and infant.

n-CdS_(0.46)Se_(0.54)/p-Cu_92-x)S_(0.46)Se_(0.54) 이종접합 태양전지의 제작과 그 특성에 관한 연구

유상하,최승평,이상열,홍광준,서상석,김혜숙,전승룡,윤은희,문종대,신영진,정태수,신현길,김택성,유기수 全北大學校 基礎科學硏究所 1994 基礎科學 Vol.16 No.-

승화방법에 의해 CdS_0.46Se_0.54 단결정을 성장하여 결정구조를 조사하고, Van der Pauw 방법으로 Hall effect를 측정하여 carrier density의 온도 의존성과 mobility의 온도 의존성을 조사하였다. 성장된 CdS_0.46Se_0.54 단결정을 치환반응하여 n-CdS_0.46Se_0.54/p-Cu_2-xS_0.46Se_0.54 이종접합 태양전지를 제작하였다. Spectral response, 전류-전압특성 및 전력변환 효율을 조사하여 그 결과로부터 개방전압은 0.48V, 단락 전류 밀도는 21mA/㎠, fill factor와 전력변환효율은 각각 0.75와 9.5%를 얻었다. CdS_0.46Se_0.54 single crystal was grown by a sublimation method. The crystal structure and the temperature dependence of carrier density and mobility of CdS_0.46Se_0.54 single crystal were studied. Heterojunction solar cells on n-CdS_0.46Se_0.54/p-Cu_2-xS_0.46Se_0.54 were fabricated by the substitution reaction. The spectral response, the J-U characteristics and the conversion efficiency of the n-CdS_0.46Se_0.54/p-Cu_2-xS_0.46Se_0.54 heterojunction solar cells were studied. The open-cricuit voltage, short-circuit density, fill factor and conversion efficiency of n-CdS_0.46Se_0.54/p-Cu_2-xS_0.46Se_0.54 heterojunction solar cells under 80mW/㎠ illumination were found to be 0.48V, 21mA/㎠, 0.75 and 9.5%, respectively.

황사 기간 동안에 어린이, 성인, 노인에서의 자각증상과 예방행동에 대한 조사연구

이보은,하은희,박혜숙,권지숙,신경림 韓國學校保健學會 2005 韓國學校保健學會誌 Vol.18 No.1

Purpose: Recently there are scientific evidences for the health effects of Asian dust-storms. Particularly in 2002, the daily average of PM_(10) exceeded 600 and 700 ㎍/㎥ in March and April respectively. We examined the effects of Asian dust-storms on perceived symptoms and preventive behaviors among children, adults, and elders. Method: The subjects of this study were 425 children, 444 adults and 60 elders. A questionnaire survey was carried out on the children and the adults by teachers and on the elders by interviewers to obtain information on demographic variables, perceived symptoms and preventive behaviors, previous respiratory disease, environmental tobacco smoke, and proximity between the house and the road during Asian dust-storms. We analyzed using descriptive statistics, X_(2) test and multiple logistic regression models. After adjustment for potential confounders, we estimated the odds ratios and 95% confidence intervals of the children and the elders for perceived symptoms and preventive behaviors. Result: The elders had a significantly higher prevalence of respiratory symptoms than the other groups. The children had a significantly higher prevalence than the adults in getting URI (1.51), coughing (1.68), rhinorrhea (1.46), fever (2.39) and medication for allergy or asthma (1.90). The children had better behaviors than the elders in closing windows (3.57), taking less outdoor recreational activity (2.59) and staying home (2.60).

송화분이 Chloroform 투여 흰쥐의 혈청 및 간장에 미치는 영향

백경연,하은주,신해경,한준표 동아시아식생활학회 2000 동아시아식생활학회지 Vol.10 No.4

This study was attempted to investigate the effect of pine pollen on the chloroform toxicity in rat serum and liver. The subjects were administrated with the graded concentration of two different levels of chloroform(1%. 5%) and an additional amount of pollen(19%, 5%) to some groups, The results were as follows : The activity of aspartate aminotransferase(AST), alanine aminotransferase(ALT) and lactate dehydrogenase(LDH) in serum, liver, and kidney increased in proportion to the chloroform concentration, but decreased in the pine pollen-treated groups. The amount of total cholesterol in serum of the chloroform administration groups was higher than that of the control group, and it decreased gradually with pine pollen administration.

한국 자생 구절초 종류의 정유성분 비교분석 및 항생제 내성 Salmonella 속 균주에 대한 억제효과

변연희,정은영,정하숙,이연희,신승원 德成女子大學校 藥學硏究所 2008 藥學論文誌 Vol.19 No.-

The essential oils from the aerial parts of three varieties of Chrysanthemum zawadskii cultivated in the herbal garden of Duksung Women' s University were extracted by steam distillation method and their compositions were compared by GC-MS analysis. The composition of essential oil fractions from the three varieties of C. zawadskii significant differences in their compostion. While the predominant components of C. zawadskii were camphor and borneol, C. zawadskii var. tenuisectum contained myrtenol and germacrene D as representing compound of its essential oil. C. zawadskii var. nakdongense oil showed higher contents of germacrene D than other two varieties of C. zawadskii. As the results of the determination of the effects of this oil and its main components on antibiotic-susceptible and -resistant strains of Salmonella enteritidis and S. typhimurium, the main components of C. zawadskii oil fraction, borneol and camphor, significantly inhibited all strains of the two Salmonella species examined, while its oil fraction showed relatively weak activity. In evaluation tests of the combination effects of the oils with kanamycin or streptomycin using a checkerboard microtiter assay, C. zawadskii oil fraction combined with streptomycin resulted the most significant synergism in this study with the fractional inhibiting concentration index (FICI) of 0.19.