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중심부에 주입구가 존재하는 플레이트를 통한 방사성동위원소의 항균능력 측정
조은하 ( Eun Ha Joh ) 한국미생물생명공학회(구 한국산업미생물학회) 2013 한국미생물·생명공학회지 Vol.41 No.4
본 연구를 통하여 우리는 새로운 실험기구를 사용하여 방사성동위원소(Lu-177)의 항균능력을 측정하였다. 기존에 약물의 항균능력을 측정하는데 사용되었던 디스크법은 배지로의 약물 확산에 의해서 항균능력을 측정하는 방법이기 때문에 방사성동위원소에 적용하기는 적합하지 않아 새로운 실험 방법이 요구된다. 방사성동위원소의 항균능력을 측정하기 위해서는 배지로의 약물 확산을 막고 한점에 머무르게 하는 방법이 필요하다. 본 연구에서 우리는 새로운 실험도구를 이용하여 Lu-177의 방사능량이 증가할수록 항균능력이 증가함을 확인하였다. 본 연구에서 사용된 실험방법을 통해 다른 방사성동위원소의 항균능력도 쉽게 측정할 수 있을 것으로 기대된다. In this study, we measured the anti-bacterial activity of radioisotope Lu-177 using a new laboratory instrument. The disk method used for the measurement of existing anti-bacterial antibiotics is drug diffusion into the medium. To measure the antimicrobial activity of a radioisotope, a new type of laboratory instrument is necessary to prevent the drug from spreading and the present invention was thus tested. In the medium, a space isolated separately for radioisotope injection was used to prevent the radioisotope from spreading and radioisotopes are actually injected by this system. We found that the antibacterial activity increased according to the radiation dose increases. It is expected that, through the present study, measuring the antibacterial activity of the other radioisotopes easily in the laboratory will be possible.
Lancemaside A inhibits lipopolysaccharide‐induced inflammation by targeting LPS/TLR4 complex
Joh, Eun‐,Ha,Kim, Dong‐,Hyun Wiley Subscription Services, Inc., A Wiley Company 2010 Journal of cellular biochemistry Vol.111 No.4
<P>In our previous study, lancemaside A isolated from Codonopsis lanceolata (family Campanulaceae) ameliorated colitis in mice. In this study, the anti-inflammatory effects of lancemaside A was investigated ill lipopolysaccharide (LPS)-stimulated mice and their peritoneal macrophage cells. Lancemaside A suppressed the production of pro-inflammatory cytokines. TNF-alpha and IL-1 beta, in vitro and in vivo. Lancemaside A also down-regulated inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as the inflammatory mediators, :nitric oxide (NO), and PGE(2). Lancemaside A also inhibited the expression of IL-1 receptor-associated kinase-4 (IRAK-4), the phosphorylation of IKK-beta and I kappa B-alpha, the nuclear translocation of NF-kappa B and the activation of mitogen-activated protein kinases in LPS-stimulated peritoneal macrophages. Furthermore, lancemaisde A inhibited the interaction between LPS and TLR4, as well as IRAK-4 expression in peritoneal macrophages. Based on these findings, lancemaside A expressed anti-inflammatory effects by regulating both the binding of LPS to TLR4 on macrophages. J. Cell. Biochem. 111: 865-871,2010. (C) 2010 Wiley-Liss, Inc.</P>
Flower Color and Scent: How to Regulate the Flower Color and Fragrance in Ornamentals?
Eun-ah Joh,Ha-seung Pak,Geung-Joo Lee 한국화훼학회 2020 화훼연구 Vol.28 No.4
화훼류 중 절화류의 화색과 향기 특성을 조절하는 것은 주 요한 육종 목표로써 인지되어 왔다. 최근 다양한 소비자 계층이 증가하면서 파란색 장미, 카네이션 등과 같은 특이화색이 라든지, 독특한 향기를 갖고 있거나 그 강도를 조절하고자 하 는 연구방향 또한 다양해졌다. 그러나 이것은 일반적으로 수 행하고 있는 교배방식으로는 특정 목표형질을 가진 품종을 개 발하기란 쉽지가 않다. 그래서 화색과 향기와 관련한 형질을 조절할 수 있는 유전공학적인 방법뿐만 아니라 다방면의 연구 가 진행되어 왔다. 이는 화색과 향기의 관련 식물 대사산물을 생산 하는 것을 비롯하여 유전공학적인 방법으로 조절하는 방 식 등 여러 가지 방법이 있다. 많은 예 중에 화훼작물의 화색 과 향기를 조절한 성공한 사례를 바탕으로 어떻게 하면 우리 가 원하는 방향에 가까운 화색과 향기의 특정 형질을 만들어 낼 수 있을지에 대해 정리해보고자 하였고, 이러한 것들은 잘 응용하여 추후 좀 더 많은 화색과 향기를 만들어낼 수 있는 전략을 수립하는 데 도움이 되고자 한다. In diverse ornamentals, flower color and fragrance traits have been recognized as major attractive elements in plant breeding purposes. Many consumers want more specific things such as blue rose and carnation in color and unique smell in fragrance. However, these are impossible to develop by traditional breeding tools without available genetic resources carrying these alleles. We studied broad technological methods that have been used to control the multiple traits with regards to flower color and fragrance production. Phytochemicals related to color and fragrance are produced by epigenetic regulation and various genetic factors in the biosynthesis pathways. In this review, we summarized different knowledge about the components biosynthesis pathway and how to control them to make wide ranges of flower color or fragrance. More research outcomes for improving flower color or fragrance through various advanced technologies in the future are thought to be reported.
A New Design Method for T-S Fuzzy Controller with Pole Placement Constraints
Joh, Joongseon,Jeung, Eun-Tae,Chung, Won-Jee,Kwon, Sung-Ha Korean Institute of Intelligent Systems 1997 한국지능시스템학회논문지 Vol.7 No.3
A new design method for Takagi-Sugeno (T-S in short) fuzzy controller which guarantees global asymptotic stability and satisfies a desired performance is proposed in this paper. The method uses LMI(Linear Matrix Inequality) approach to find the common symmetric positive definite matrix P and feedback fains K/sub i/, i= 1, 2,..., r, numerically. The LMIs for stability criterion which treats P and K'/sub i/s as matrix variables is derived from Wang et al.'s stability criterion. Wang et al.'s stability criterion is nonlinear MIs since P and K'/sub i/s are coupled together. The desired performance is represented as $ LMIs which place the closed-loop poles of $ local subsystems within the desired region in s-plane. By solving the stability LMIs and pole placement constraint LMIs simultaneously, the feedback gains K'/sub i/s which gurarntee global asymptotic stability and satisfy the desired performance are determined. The design method is verified by designing a T-S fuzzy controller for an inverted pendulum with a cart using the proposed method.