기관지 방선균증의 임상 1례

이은영,장태원,정만홍,옥철호,이규원,손창배,이지숙,신은경,서정아,백종현,김영옥 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Actinomycosis is a chronic suppurative infection, whitch infiltrates mucosa-associated tissues. Thoracic, pelvic and cervicofacial infections of actinomyces are not uncommon, but endobronchial actinomycosis is rarely reported. We report a case of a 29 year old man who presented with a recurrent pneumonia and chronic cough. Fiberoptic bronchoscopy revealed occlusion of the right. lower medio-basal segment bronchus with exophytic endobronchial mass. The diagnosis was confirmed histologically by demonstration of sulfur granules in the bronchoscopic biopsy of the mass. Intravenous administration of amoxacillin and clindamycin followed by oral amoxacillin and clindamycin therapy resulted in complete recovery.

In vivo study for the hemostatic efficacy and foreign body reaction of a new powder-type polysaccharide hemostatic agent

Yoonhyeong Byun,Eun Jin Kim,Areum Lee,Young-Ah Suh,Hee Ju Sohn,Jung Min Lee,Jae Seung Kang,Yoo Jin Choi,Youngmin Han,Hongbeom Kim,Wooil Kwon,Jin-Young Jang 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.102 No.2

Purpose: Various hemostatic agents have been introduced in therapy as postoperative bleeding is a poor prognostic factor for postoperative outcomes. These products can be divided into those that directly promote the hemostatic cascade and those that physically form a barrier by absorbing blood. The latter, powder-type hemostatic agents have the advantages of being inexpensive and more absorbable with less foreign body reactions (FBRs) and are applicable to a relatively wide area. This study was conducted to verify the safety and efficacy of a newly invented polysaccharide product (OOZFIX, Theracion Biomedical), which improves blood absorption and hemostatic effects. Methods: Two separate animal experiments were performed. The first evaluated FBRs histologically at 3 days, 2 weeks, and 4 weeks, after implantation of OOZFIX in rats, and the second compared hemostatic performance of OOZFIX and Arista AH (Bard) in the porcine liver punch biopsy model. Results: We found minimal FBRs in the 3-day group and no reactions in both the 2-week and 4-week groups after implantation of hemostatic agents. The time to hemostasis of OOZFIX was not significantly different from that of Arista AH (median [interquartile range]: 9 [6–10] minutes vs. 8 [6–10] minutes, respectively; P = 0.522). When comparing the serial bleeding grade tendency, there was no statistical difference between OOZFIX and Arista AH (P = 0.656). Conclusion: OOZFIX caused a minimal FBR that disappeared within 2 weeks in vivo, and its hemostatic performance was comparable with that of an existing agent, Arista AH. Further clinical studies are required in the future.

Bortezomib과 Dexamthasone으로 치료한 골수외 형질세포종 4예

백종현,이은영,장리라,손창배,신은경,서정아,이지숙,이호섭,이상민,신성훈,김양수 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Despite the use of aggressive local and systemic treatment including autologous stem cell transplantation in multiple myeloma, extramedullary recurrences are common and the prognosis of these patients is poor. Many novel drugs such as thalidomide, lenalidomide and bortezomib improve the response of treatment of multiple myeloma, but some reports failed to describe thalidomide has effect in extramedullary plasmacytoma. Recent data report on the successful treatment plasmacytomas with bortezomib in patients with advanced multiple myeloma. We treated 4 relapsed or refractory extramedullary plasmacytomas with bortezomib at our institution. We recognized all these extramedullary plasmacytomas decreased and showed more than partial response. This report lends support to the efficacy of bortezomib in the treatment of plasmacytoma and describes the safe use of bortezomib. Responses may, however, be of short duration. Therefore, despite our limited experience, we propose that bortezomib may be considered a therapeutic option for such patients who have risk of radiation therapy

갑상선 유두암이 병발된 가족성 대장 용종증 1예

백종현,소창배,이은영,이지숙,신은경,박은호,서정아,양재홍,송준영,박선자,박요한,최영식 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome, typically characterized by multiple colorectal adenomas and increased incidence of colorectal carcinomas if it is not treated. Moreover, a variety of extracolonic manifestation are seen. The prevalence of thyroid tumors developing in patients with FAP is about 1∼2%. Generally, papillary thyroid cancer indicates low mortality but ,however, as people get older, the cancer becomes more aggressive. So, the operation is required. Recently we experienced a case of FAP, presenting with papillary thyroid carcinoma, and reported with a brief review of literatures.

Predicting postoperative total calcium requirements after parathyroidectomy in secondary hyperparathyroidism

( Byung Heon Kang ),( Soon Young Hwang ),( Jeong Yeop Kim ),( Yu Ah Hong ),( Mi Yeon Jung ),( Eun Ah Lee ),( Ji Eun Lee3 ),( Jae Bok Lee ),( Gang Jee Ko ),( Heui Jung Pyo ),( Young Joo Kwon ) 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.6

Background/Aims: To prevent hypocalcemia after parathyroidectomy (PTX), parenteral calcium is required in addition to oral calcitriol and calcium. After switching to oral calcium, patients can be discharged from the hospital. The aim of this study was to analyze the clinical characteristics and outcomes of PTX performed at a single Korean center and to investigate the associated laboratory factors used to analyze the total amount of postoperative calcium required. Methods: We enrolled 91 hemodialysis patients undergoing PTX from November 2003 to December 2011. We collected clinical and laboratory data preoperatively, 12 and 48 hours postoperatively, at discharge, and 3 and 6 months postoperatively. Results: In total, 59 patients underwent PTX with autotransplantation (AT), 6 underwent total PTX without AT, 11 underwent subtotal PTX, and 15 underwent limited PTX. Total PTX without AT showed the lowest recurrence rate. At all postoperative time points, the mean levels of serum calcium, phosphorus, and intact parathyroid hormone (iPTH) decreased significantly, compared with preoperative levels; however, alkaline phosphatase (ALP) increased significantly from 48 hours postoperatively to discharge (p < 0.001). On multiple linear regression analysis, the total amount of injected calcium during hospitalization showed a significant correlation with preoperative ALP (p < 0.001), preoperative iPTH (p = 0.037), and Δphosphorus at 48 hours (p < 0.001). We developed an equation for estimating the total calcium requirement after PTX. Conclusions: Preoperative ALP, preoperative iPTH, and Δphosphorus at 48 hours may be significant factors in estimating the postoperative calcium requirement. The formula for postoperative calcium requirement after PTX may help to predict the duration of postoperative hospitalization.

올리고당 첨가 증편 발효 중 Dextran 형성과 증편의 내부구조에 관한 연구

이은아,우경자 동아시아식생활학회 2002 동아시아식생활학회지 Vol.12 No.1

This study was carried out in order to investigate dextran formation and internal structure during fermentation of the oligosaccharide Jeung-Pyun. The dextran and sugar reducing contents of Jeung-Pyun batter and the specific volume and the internal structure of Jeung-Pyun were analyzed as a function of fermentation time. The specific volume of Jeung-Pyun peaked at the 7th hour of fermentation. The dextran content of Jeung-Pyun batters peaked at the 7~13th hour of fermentation, and Fructooligosaccharide Jeung-Pyun had the least peak value. Reducing sugar content of Jeung-Pyun batters slowly decreased as fermentation progressed. From the air pore size and distribution of Jeung-Pyun observed by SEM, the sucrose Jeung-Pyun fermented for 3~7 hours and oligosaccharide one fermented for 7 hours were judged as the best. It was concluded that dextran may be formed by fermentation of oligosaccharides as well as sucrose and dextran has a significant role on the volume expansion of Jeung-Pyun.

집합주거단지의 치유조경 계획요소에 관한 연구

이은엽, 박진아, 심준영, 이시영 배재대학교 자연과학연구소 2014 自然科學論文集 Vol.25 No.1

본 연구는 집합주거를 대상으로 그 외부공간에 치유환경을 제공하고자 함이 궁극적 목표이며, 본 연구는 그 이전에 치유환경설계에 앞서 치유정원의 환경적 특성과 치유정원의 계획요소를 밝히고자 한다. 본 연구를 통해 치유공간계획을 위한 기초적 지침을 제시하고자 한다. 연구방법으로서, 기존 학자들의 치유정원에 관한 특성을 분석하여 공통적인 환경특성 요소들을 도출하고, 이를 바탕으로 국내·외의 문헌을 참조하여 세부항목을 설정하고 치유정원의 특성을 파악하였다. 치유정원의 계획원칙 및 요소를 도출하기 위해 문헌조사와 전문가의 의견을 취합하여 공동 집합 주거단지에 적용 가능한 조경계획요소를 설정하였다. 치유환경의 환경특성의 계획요소는 총 6가지의 항목을 설정하였다. 안전한 환경, 치료적 환경, 보조적 환경, 지남력 강화환경, 쾌적성, 사회적 환경으로 구분하였다. 계획원칙으로는, 안전감, 이용자 그룹과 요구에 대한 인식, 다양한 활동패턴의 제공, 다양하게 경험할 수 있는 치유공간, 휴식과 활동공간에 대한 특성부여, 사적공간과 사회적 교류, 주변환경과 전망, 유니버셜 디자인, 셉테드 디자인으로 구분하였다. The purpose of this study is to figure out planning guidelines and environmental characteristics of healing garden for providing healing surroundings on outdoor spaces of multiple housing complex. To do this, this study examined previous research papers and scholastic writings, related to healing environment and garden, and analyzed case studies. As a result, composition elements of planning for healing garden were classified 6 types; safe, therapeutic, assistance, orientation strengthen, comfort and social environment. Planning principles of healing landscape are set for 9 types; sense of safe, recognition of the user group and demand, offers a variety of activity patterns, healing space for various ways to experience, characteristics for relaxation and activities, private space and social interaction, surroundings and views, universal design and cpted design. From the precedent review and literature view planning guidelines for creating healing gardens will be created. These guidelines will then be applied to an existing healing site to create an informed design solution.

정밀기계가공을 위한 미세변위 계측·분석시스템

이재헌,김경아,이태수,차은종 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1

유치원 자연학습교육 프로그램에 대한 현황조사분석

이은희,김용아 韓國植物ㆍ人間ㆍ環境學會 1999 인간식물환경학회지 Vol.2 No.1

Interest in environmental learning programs, especially in nature learning programs in kindergartens has been increasing recently. Nature learning programs provide children with new activities and also help to preserve nature. It is necessary to find out what kinds of programs are provided and what problems they encounter in order to develope these programs. For these reasons, we investigated 50 kindergartens in Seoul registered by the Ministry of Education. The major questions in the questionnaire are as follows: teaching methodes of nature learning programs, the type of teaching programs, class schedule and the amount of instructional time. The results of this study shows that most kindergartens provide programs for regular classroom activity and extra programs taken outside school because of shortage of learning spaces for outdoor activity. The content of learning activity fort classroom is a pot planting and for outside school is simple harvest of vegetables such as sweet-potato. Most children were generally satisfied with the programs, but these are very simple programs in order to understand nature science. The results of study indicated that the teachers were lack of understanding in nature learning programs and the schools didn't have enough spaces for learning activity. It was hoped that kindergartens should provide leaning spaces nears the schools. There were needs for more support from the related public institutions and professions because it was important for children to participate in these kinds of programs in early stage.

스마트폰에 접속 가능한 소형 혈당 모듈

김경아, 이인광, 허아롱, 김경옥, 차은종 충북대학교 의과대학 충북대학교 의학연구소 2014 忠北醫大學術誌 Vol.24 No.1

연구목적: 스마트폰에 접속하여 혈당을 측정할 수 있는 소형 혈당 모듈을 개발하여 그 유용성을 실험 적으로 검증하고자 하였다. 대상 및 방법: 혈액이 전극에 주입되어 생성되는 전류가 전압의 형태로 변환되어 혈당값으로 변환되는 전기화학적 측정 원리를 적용하여 소형 혈당 모듈을 개발하였다. 혈당 모듈의 최소한의 측정 혈액 양은 0.5 μL이며, 5초 이내로 측정이 가능하도록 설계 및 제작하였다. 스마트폰과의 통신은 frequencyshift keying(FSK) 모뎀 방식을 적용하였다. 혈당 모듈의 정확도 실험을 위해 시판되는 혈당계와 인 공혈액으로 비교 실험을 수행하였다. 결과: 시판되는 제품과의 성능 비교 실험에서 시판 제품은 391 mg/dL를 나타내었으며, 소형 혈당 모 듈은 401 mg/dL를 나타내었다. 혈당 모듈의 크기는 50×30×7 mm로서 휴대의 편리성을 높였다. 결론: 스마트폰 기반의 소형 혈당 모듈을 개발하였으며, 기존 제품과의 혈당 측정 상대오차가 약 2.6%로서 정확한 혈당 측정이 가능함을 실험적으로 검증하였다.