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Eosionophilic Colitis as an Unusual Cause of Chronic Diarrhea
( Eul Sik Jung ),( Woo Suk Choi ),( Soo Yong Park ),( Min Young Rim ),( In Ku Yu ),( Hyeon Su Park ),( Sang Min Lee ),( Jeong Woong Park ),( Sung Hwan Jeong ),( Sang Pyo Lee ),( Sang Hui Park ) 대한천식알레르기학회(구 대한알레르기학회) 2012 천식 및 알레르기 Vol.32 No.2
Background: Eosinophilic gastroenteritis is an uncommon condition characterized by focal or diffuse eosinophilic infiltration of the gastrointestinal tract. It is usually associated with non-specific gastrointestinal symptoms, such as abdominal pain, nausea, vomiting, diarrhea, weight loss, and abdominal distension. Case History: We present a case of eosinophilic colitis with normal-appearing colonic mucosa as an unusual cause of chronic watery diarrhea. Results: It can be overlooked by gastroenterologists because the incidence of eosinophilic colitis is very rare and normal- appearing colonic mucosa is frequently observed in patients with eosinophilic colitis. Conclusion: Endoscopic biopsy should not hesitate to perform be considered when colonic mucosa appears to be normal but we cannot rule out eosinophilic colitis which responds well to steroid therapy. (Korean J Asthma Allergy Clin Immunol 2012;32:122-125)
X 연관 부신백질이영양증의 분류, 진단 및 치료의 최신 지견
정을식(Eul Sik Jung),고아라(Ara Ko),강훈철(Hoon Chul Kang) 대한소아신경학회 2016 대한소아신경학회지 Vol.24 No.3
X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ATP binding cassette subfamily D member 1 (ABCD1), a gene that encodes peroxisomal membrane located on ABC half-transporter named adrenoleukodystrophy protein (ALDP). X-ALD is characterized by a highly variable clinical spectrum, including progressive cerebral type, adrenomyeloneuropathy, and addison-only phenotype. No genotype/phenotype correlation has been established. Thus, unidentified modifier genes and other co-factors are speculated to modulate the phenotypic variation and disease severity. Recent advanced sequencing methods and reprogramming technologies not only offer an affordable and applicable approach to investigate the pathophysiological mechanisms of adrenoleukodystrophy, but also provide means to develop therapy. A causal therapy of X-ALD is lacking. Lorenzo’s oil therapy is recommended for asymptomatic boys, but the longest study found that the oil was not beneficial at all to symptomatic X-ALD patients. Hematopoietic stem cell therapy has a relevant chance of success when performed during this early stage of cerebral type X-ALD. Recently, it has been insisted that lentiviral-mediated gene therapy of hematopoietic stem cells can provide clinical benefits in X-ALD. This review describes current knowledge on the clinical presentation, pathogenesis, diagnosis and management of X- ALD.
정원균,이병일,한승규,김우경,윤을식 大韓成形外科學會 1995 Archives of Plastic Surgery Vol.22 No.6
Finger tip injuries represent the most common type of injuries seen in the upper extremity. Their managements are important functionally and aesthetically, but at the same time perhapse the most controversial. From July 1984 to January 1995, 97 fingers in 90 patients with defect of distal phalanx were reconstructed by reverse digital island flaps at the Korea University Guro Hospital. We reviewed the medical records of our cases and analyzed them in several aspects. In 16 cases neurorrhaphy was performed. Majority of the cases were covered primarily and 21 cases it was used for defect after composit graft or replantation. The survival of these flaps was successful in all cases except one case. 38 fingers in 36 patients were involved in long term follow up more then 6 months. Light touch and temperature sensation could be detected in all the evaluated flaps. The mean values of the static two-point discrimination in sensate and nonsensate flaps were 6.4 and 10.4mm retrospectively. Our patients were usually satisfied with the end result of these flaps aesthetically and functionally. We consider that reverse digital island flap is a safe and reliable procedure with high survival rate and an excellent choice for coverage of defect of distal phalanx.
Jung Youl Park,정재호,Hyung Chul Lee,Byung Il Lee,Seung-Ha Park,Eul-Sik Yoon 대한성형외과학회 2018 Archives of Plastic Surgery Vol.45 No.5
Background Adjuvant therapy after breast surgery, including tamoxifen or aromatase inhibitors, improves the postoperative outcomes and long-term survival of breast cancer patients. The aim of this study was to determine whether volume changes occurred in the contralateral breast during hormonal or other adjuvant therapies. Methods This study reviewed 90 patients who underwent unilateral breast reconstruction between September 2012 and April 2018 using tissue expanders and a permanent implant after the surgical removal of breast cancer. The volume of the contralateral breast was measured using a cast before the first (tissue expander insertion) and second (permanent implant change) stages of surgery. Changes in breast volume were evaluated to determine whether adjuvant therapy such as hormonal therapy, chemotherapy, and radiation therapy influenced the volume of the contralateral breast. Results The group receiving tamoxifen therapy demonstrated a significant decrease in volume compared with the group without tamoxifen (−7.8% vs. 1.0%; P=0.028). The aromatase inhibitor–treated group showed a significant increase in volume compared with those who did not receive therapy (−6.2% vs. 4.5%; P=0.023). There were no significant differences between groups treated with other hormonal therapy, chemotherapy, or radiation therapy. Conclusions Patients who received tamoxifen therapy showed a significant decrease in volume in the contralateral breast, while no significant change in weight or body mass index was found. Our findings suggest that we should choose smaller implants for premenopausal patients, who have a high likelihood of receiving tamoxifen therapy.
Jeong, Eul Jo,Kang, Dae Hwan,Kim, Dong Uk,Choi, Cheol Woong,Eum, Jae Sup,Jung, Woo Jin,Kim, Pyo Jun,Kim, Yong Wuk,Jung, Kyung Sik,Bae, Yong Mok,Cho, Mong Lippincott Williams Wilkins, Inc. 2009 European journal of gastroenterology & hepatology Vol.21 No.12
BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) is more difficult and dangerous in patients with Billroth II (B II) gastrectomy than those with normal anatomy. OBJECTIVES: To evaluate the clinical efficacy of percutaneous transhepatic choledochoscopic lithotomy (PTCSL) for removing common bile duct stones in B II gastrectomy patients who are difficult to perform ERCP. METHODS: This study was designed as prospectively uncontrolled in a large tertiary referral center. In 20 patients, mostly men, with bile duct stones and an earlier B II gastrectomy, PTCSL was tried because of failed ERCP and high risk. The PTCSL was performed using electrohydraulic lithotripsy or papillary balloon dilation. Successful stone removal and complications were measured. RESULTS: Stone removal was achieved in all 20 patients. The mean number of procedures and session time were 4.5 and 45 min, respectively. Minor PTCSL-related complications, such as fever, hemobilia, hyperamylasemia, and wound pain, occurred in five patients (25%). There were no major procedure-related complications, including perforation or mortality. CONCLUSION: The PTCSL procedure is an effective and safe rescue therapy for common bile duct stones in B II gastrectomy patients with failed ERCP and high risk.