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Lilis Siti Aisyah,Yenny Febriani Yun,Tati Herlina,Euis Julaeha,Achmad Zainuddin,Ida Nurfarida,Ace Tatang Hidayat,Unang Supratman,Yoshihito Shiono 한국생약학회 2017 Natural Product Sciences Vol.23 No.2
Seven flavonoid compounds, kaempferol (1), quercetin (2), quercetin-3-O-b-D-glucopyranoside (3), kaempferol-3-O-b-D-glucopyranoside (4), kaempferol-3-O-a-L-rhamnoside (5), quercetin-3-O-sophoroside (6) and quercetin-3-O-rutinoside (7), were isolated from the methanolic extract of leaves of Kalanchoe prolifera. Compounds 1-7 were isolated for first time from this plant. These compounds were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds kaempferol (1) and quercetin (2) showed strongest cytotoxic activity with IC50 values of 4.45 ? 0.05 and 6.28 ? 0.02 mg/mL, respectively.