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Lee, Jin-A,Lee, Sue-Hyun,Lee, Changhoon,Chang, Deok-Jin,Lee, Yong,Kim, Hyoung,Cheang, Ye-Hwang,Ko, Hyoung-Gon,Lee, Yong-Seok,Jun, Heejung,Bartsch, Dusan,Kandel, Eric R.,Kaang, Bong-Kiun The Rockefeller University Press 2006 The Journal of cell biology Vol.174 No.6
<P>Long-term memory requires transcriptional regulation by a combination of positive and negative transcription factors. <I>Aplysia</I> activating factor (ApAF) is known to be a positive transcription factor that forms heterodimers with ApC/EBP and ApCREB2. How these heterodimers are regulated and how they participate in the consolidation of long-term facilitation (LTF) has not, however, been characterized. We found that the functional activation of ApAF required phosphorylation of ApAF by PKA on Ser-266. In addition, ApAF lowered the threshold of LTF by forming a heterodimer with ApCREB2. Moreover, once activated by PKA, the ApAF–ApC/EBP heterodimer transactivates enhancer response element–containing genes and can induce LTF in the absence of CRE- and CREB-mediated gene expression. Collectively, these results suggest that PKA-activated ApAF–ApC/EBP heterodimer is a core downstream effector of ApCREB in the consolidation of LTF.</P>