안지오텐신 변환효소 억제제와 안지오텐신 II 수용체 차단제 투여 후 발생한 급성 신부전과 폐부종으로 전원된 선천성 단일신 환자의 치료 1예

백두현,김경진,홍성철,강석형,송하응,김혜인,김수현,오현정,강혜원,김서우,유민아,류동열,최규복,강덕희 이화여자대학교 의과대학 2010 EMJ (Ewha medical journal) Vol.33 No.1

Blockers of renin-angiotensin system(RAS) including ACE inhibitor or ARB are one of the most frequently prescribed medications for the treatment of hypertension, heart failure and proteinuria. One of the major side effects of these RAS blockers is the deterioration of renal function, mainly due to a reduction of intraglomerular pressure. Therefore, close monitoring of renal function is recommended when RAS blockers are initially prescribed, especially for the patients with impaired renal function. We report a patient who was transferred to our hospital due to the sudden development of oliguria and dyspnea after treatment for hypertension with ACEi and ARB. She was finally diagnosed as RAS blocker-induced acute renal failure with pulmonary edema complicated on congenital solitary kidney. After hemodialysis and conservative treatment, her renal function was recovered with maintenance of normal urine output. Conclusion:This case highlights the necessity of the functional and structural evaluation of kidney to prevent the serious complication such as acute renal failure before the administration of ACEi and/or ARB.

안검에 발생한 단발성 성인형 근섬유종 1예

김성준,박현수,서승리,이용석,전덕규 대한피부과학회 2003 대한피부과학회지 Vol.41 No.2

Solitary myofibroma is an uncommon myofibroblastic neoplasm, presenting as an asymptomatic nodule of the skin, which mainly occurrs in adults. It was thought to be the adult counterpart of infantile myofibromatosis. Although it has histopathological similarity to infantile myofibromatosis, it shows a discrete clinicopathological entity compared with infantile form on the basis of its much later onset, superficial location, invariable solitary occurrence and uniformly benign behavior. A 45-year-old woman had a skin lesion on the right upper eyelid for 2 years, which was a solitary, painless nodule with eyelid retraction. The excised tumor was diagnosed as myofibroma by light microscopy and immunohistochemistry. (Korean J Dermatol 2003;41(2) : 272∼275)

국부 컬러 정보를 이용한 내용기반 영상 검색

김태선,최덕규,박차훈 경운대학교 산업기술연구소 2002 産業技術硏究論文誌 Vol.5 No.1(A)

In general, color histogram method are widely used for the content based image retrieval. However, because of the absence of spatial information, it is difficult to discriminate images of the similar histogram. Thus this paper, we propose content based image retrieval method using local color information. Proposed method stores edge neighbor color histograms for edge pixel as index information, which combines spatial information with color information in images efficiently. The experimental results show that the proposed method can give better recall and precision performance than other methods using color histograms or color coherence vector(CCV).

掌葉大黃이 白鼠의 胸部大動脈 血管弛緩에 미치는 影響

김형환,구본식,박수연,안덕균,최호영,박성규 대한본초학회 2002 大韓本草學會誌 Vol.17 No.2

Objectives : We have examined the relaxational response to the water extract of Rheum palmatum L. in isolated thoracic aorta from sprague dawley (SD) rat in the presence and absence of endothelium. Methods : Rat thoracic aorta was investigated in vessel segments suspended for isometric tension recording by polygraph. Responses to Rhizoma Rhei were investigated in vessels precontracted with 5-hydroxytryptamine. We found that the thoracic aorta segments responded to the water extract of Rheum palmatum L. (ERP) with a dose-dependent vasorelaxation. Results : We found that 1. The thoracic aorta segments responded to ERP with a dose-dependent vasodilation. 2. The 5-HT induced contraction at 10^-4M were inhibited by 85.8% after addition of the 0.1 g/mL water extract of ERP. 3. The 5-HT induced contraction at 10^-4M with and without endothelium were inhibited by 86.4% and 85.8% after addition of the 0.1g/mL ERP. 4. After pre-treatment of the thoracic aorta with 10^-4M N^G-monomethyl-L-arginine (L-NMMA), inducible nitric oxide synthase inhibitor, the vessels has not response to the contraction. Conclusion : In conclusion, ERP induced relaxation in the isolated rat thoracic aorta were composed of dose-dependent relaxation and it has potent vasodilation.

천연 제올라이트에 의한 중금속 이온의 제거

김덕수,감상규 濟州大學校 基礎科學硏究所 1997 基礎科學硏究 Vol.10 No.2

The three natural zeloites collected in Pohang-shi and Kyeongju-shi, Kyungsangbug-do, Korea, were analyzed by means of X-ray fluorescence and X-ray diffraction. from the results, the primary species of those zeolite were mordenite and clinoptilolite mixed with quartz. These zeloites were chemically treated with NaOH, Ca(OH)??, and NaOH following HCl solution. The capabilities of removing divalent heavy metal ions, such as Cu??and Sr?? with chemically untreated and treated natural zeolites were investigated and compared in the single and mixed heavy metal ion solutions with varying initial heavy metal ion concentration and pH of solution. It was found that Daeshin-ri natural zeolite(D) was most efficient in removing Cu?? and Sr?? ions. The chemical treatment of natural zeloite improved the capabilities of removing Cu?? and Sr?? ions and the most effective chemical treatment of natural zeolite was NaOH treatment. The capabilities of removing Cu??and Sr?? ions in mixed ions solution were lower than those in single ion solution. The three natural zeolites collected in Pohang-shi and Kyeongju-shi, Kyungsangbug-do, Korea, were analyzed by means of X-ray fluorescence and X-ray diffraction. From the results, the primary species of those zeolite were mordenite and clinoptilolite mixed with quartz. These zeolites were chemically treated with NaOH, Ca(OH)₂, and NaOH following HCl solution. The capabilities of removing divalent heavy metal ions, such as Cu²+ and Sr²+ with chemically untreated and treated natural zeolites were investigated and compared in the single and mixed heavy metal ion solutions with varying initial heavy metal ion concentration and pH of solution. It was found that Daeshin-ri natural zeolite(D) was most efficient in removing Cu²+ and Sr²+ ions. The chemical treatment of natural zeolite improved the capabilities of removing Cu²+ and Sr²+ ions and the most effective chemical treatment of natural zeolite was NaOH treatment. The capabilities of removing Cu²+ and Sr²+ ions in mixed ions solution were lower than those in single ion solution.

반지세포(Signet-ring cell) 위암의 피부전이 1예

김성준,박현수,이용석,전덕규 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.6

Signet-ring cell(SRC) is formed by intracytoplasmic accumulation of various substances which push the nucleus to the cellular border so that the cell looks like a signet ring. Most cutaneous SRC neoplasms are metastatic adenocarcinomas. SRC, when seen in skin, may indicate that the primary origins are from the stomach, colon or breast. The SRC formations in cutaneous neoplasms other than metastatic adenocarcinoma have also been reported such as SCC, BCC, metastatic melanoma etc. We experienced a case of cutaneous metastasis of SRC gastric carcinoma which the first symptom was skin lesion of the scalp. (Korean J Dermatol 2003;41(6): 808~810)

서울지역 여대생들의 떡에 대한 인식 및 섭취 실태 조사

김영순,오순덕,김향미,신지홍,김현경,배유미,조규영,조성환 高麗大學校 倂設 保健大學 保健科學硏究所 2003 保健科學論集 Vol.29 No.1

This study conducted a survey of the improvement and popularization for Korea Rice Cakes, a Korean traditional food, on two hundred women students in five colleges in Seoul, Korea. It was investigated to get the information of the recognition, preference, and consumption patterns for the succession and improvement of Korean Rice Cakes. The results are as follows: 1. A portion of 41.5% among responders knows from three to six kinds of Korean Rice Cakes, and of 28% can make at least one among the kinds of Korean Rice Cakes. 2. A portion of 91% recognizes that Korean Rice Cakes are one of well-nourished food, but of 42% answers that Korean Rice Cakes cannot be replaced with the principle food. Also, there are no significant differences in the recognition of Korean Rice Cakes as the kinds of religions. 3. The frequency of purchase is about one or twice in a month (35.5%). Consumers (36.5%) intend to purchase Korean Rice Cakes for the commemoration of national holidays or anniversaries. 4. The reasons for the preference of other foods more than Korean Rice Cakes are the easiness of purchase (36.0%), the deliciousness (21.5%), the diverse kindness (17.5%), and the proper package (9.5%). It is important that constant and particular school / home education is need to improve and success Korean Rice Cakes.

주정중독에서의 근전도 바이오피드백의 치료적 적용에 관한 연구

김철규,황상종,장덕환 大韓神經精神醫學會 1986 신경정신의학 Vol.25 No.4

For the purpose of the therapeutic application of EMG biofeedback in the alcoholism, the authors investigated the tension-reduction hypothesis and the capability of reducing tension in alcoholics by EMG biofeedback. 21 alcoholics who were admitted to seoul National Mental Hospital from Jan. 1986 to Jun. 1986 and 21 control subjects entered for the experiment. A comparison between alcoholics and control subjects regarding frontalis muscle tension during 5 minutes of baseline recording on the first session was performed to examine the tension-reduction hypothesis indirectly. The data of muscle tension during 5 sessions of biofeedback training in both groups were analyzed to investigate the relative abilities of alcoholic subjects for neuromuscular learning, hypothesizing that alcoholics are less capable of reducing tension by nonalcoholic means than most people. The results were as follows; 1) Alcoholics(2.64±1.41μ) displayed a higher mean baseline level of frontalis muscle tension than did nonalcoholics (1.40±0.44μ) demonstrated by statistically significant difference. 2) Comparing the results of ANOVA by training condition at each session, a significant difference was found from the 3rd session in alcoholics and from the 4th session in nonalcoholics. 3) Comparing the results of t-test of mean muscle tension between types of three training conditions during each of the 5 sessions, BF(Biofeedback) group had a statistically significant difference in comparison with NF(No feedback) group or FF(False feedback) group in alcoholics and nonalcoholics. 4) The above-mentioned 2nd and 3rd results made in apparent that alcoholics can learn to reduce frontalis muscle tension by EMG biofeedback. 5) Comparison between below 2.0 μV and above 3.0 μV of baseline subgroup in alcoholics was performed, and there was a significant difference in age and duration of enforced abstinence.

當歸의 種類에 따른 四物湯이 白鼠의 胸部大動脈 血管弛緩에 미치는 影響

김형환,이주호,이제현,안덕균,박성규 대한본초학회 2001 大韓本草學會誌 Vol.16 No.2

We have examined the relaxational reponse to the water extract of Angelica gigas Nakai (AG), A. sinensis(Oliv.) Diels (AS), A. acutiloba Kitagawa (AA), and Four-Substance Decoctions (AG-FSD, AS-FSD, AA-FSD) in isolated thoracic aorta from sprague dawley(SD) rat in the presence and absence of endothelium. Rat thoracic aorta was investigated in vessel segments suspended for isometric tension recording by polygraph. Responses to AG, AS, AA and AG-FSD, AS-FSD, AA-FSD were investigated in vessels precontracted with 5-hydroxytryptamine(5-HT) were compared in vasodilation effect. We found that the thoracic aorta segments responded to AG, AS, AA and AG-FSD, AS-FSD, AA-FSD with a dose-dependent vasodilation. The 5-hydroxytryptamine induced contraction at 10-4M were inhibited by 26.3%, 2.7%, 2.1% and 24.6%, 1.1%, 3.2% after addition of the 0.1 g/㎖ water extract of AG, AS, AA and AG-FSD, AS-FSD, AA-FSD. The 5-hydroxytrptamine induced contraction at 10^-4M with and without endothelium were inhibited by 24.6% and 6.9% after addition of the 0.1 g/㎖ water extract of AG-FSD. In conclusion, AG, AS, AA and AG-FSD, AS-FSD, AA-FSD-induced relaxation in the isolated rat thoracic aorta were composed of dose-dependent relaxation. AG-FSD has very potent vasodilation.

주침 수치 방법에 따른 種大黃이 백서의 흉부대동맥 혈관이완에 미치는 영향

김형환,이현경,강순아,안덕균,박성규 대한본초학회 2004 大韓本草學會誌 Vol.19 No.1

Objectives: We have examined the relaxative response to the water extract of Rheum undulatuum (ERU) and water extract of alcohol processed Rheum unddatum (ARU) with isolated thoracic aorta from sprague dawley (SD) rat Methods: Rat thoracic aorta was investigated in vessel segments suspended for isometric tension recording by polygraph. Responses to ERU and ARU were investigated in vessels precontracted with 5- hydroxytryptamine(5-HT). Results: We found that the thoracic aorta segments responded to ERU and ARU with a dose-dependent vasorelaxation. 1. The thoracic aorta segments responded to ERU and ARU with a dose-dependent vasodilation. 2. The amounts of emodin were 0.063% and 0.076% in ERU and ARU, respectable. 3. The 5-HT induced contraction at 10^(-4) were inhibited by 85.2±4.76% and 83.4*8.82% after addition of the 0.lmg/mL. water extract of ERU and ARU. 4. The 5-HT induced contraction at l0^(-3)% were inhibited by 100% after 10^(-3) emodin. Conclusion: In conclusion, vasodilation effect of the water extract of Rheum undulatum L. in rat thoracic aorta was not decreased according to the alcohol processing of Rheum undulatum L.