정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

열형광 CaSO₄ : Dy 소자의 최적 제조조건에 관한 연구

양정선,장시영,김장렬,김두영,남영미,박재우 濟州大學校 産業技術硏究所 2000 산업기술연구소논문집 Vol.11 No.1

An experimental investigation has been performed to determine optimal conditions for preparing the thermoluminescent CaSO_(4):Dy pellets which have been widely used as personal radiation dosimeter material. Our investigation has shown that an optimal weight concentration of the dopant Dy in the bulk CaS0_(4):Dy is 0.1 mol%. and an optimal temperature of adding Dy in the preparing process is 320℃. An optimal time and temperature for sintering the CaSO_(4):Dy crystal produced from the chemical process are found to be 2 hours and 800℃. respectively. The maximum thermoluminescent sensitivity was observed when the CaSO_(4):Dy crystal was pulverized to grain sizes of 63 - 200 m in diameter before being fabricated into pellets. The commercial Teflon was selected as an adhesive for the fabrication of the CaSO_(4):Dy pellets with an optimal mixing ratio of the Teflon and CaSO_(4):Dy being 70 to 30 in weight.

Li 화합물을 첨가한 CaSO₄:Dy 열중성자 측정용 TLD 소자 개발

양정선,김두영,박재우,김장렬,장시영 제주대학교 방사능이용연구소 2003 연구보고 Vol.17 No.-

Personal neutron dosimetry is quite a difficult area because a neutron is always accompanied with gamma radiation, which is required of a capability for mixed field dosimetry. CaSO₄:Dy phosphor is known to have a very high sensitivity to gamma, but the neutron capture cross section of the constituents of CaSO₄:Dy are so small that the interactions between the thermal neutron and the phosphor are rare. One method to improve the neutron interaction is by introducing an impurity ion with a large thermal neutron captures cross section into the phosphor to act as a neutron target centre such as 6Li. In neutron-gamma mixed radiation fields, if two detectors for the 6Li-7Li compounds embedded CaSO₄:Dy TL pellets are used, a 6Li-compound embedded pellet can detect the neutron and gamma radiation together, and the other pellet can only detect the gamma radiation. Recently Korea Atomic Energy Research Institute (KEARI) has developed a new type of CaSO₄:Dy TL materials embedded with phosphorous (KCT-300) to detect beta and gamma radiation with a very high sensitivity[1]. This paper presents the development of CaSO₄:Dy TL pellets embedded with 6Li compound for a thermal neutron measurement, and the detection method of the neutron and gamma dose in mixed fields with CaSO₄:Dy TL pellets embedded with a 6Li compound(KCT-306) and CaSO₄:Dy TL pellets embedded with a 7Li compound(KCT-307) is introduced. The net neutron sensitivity of CaSO₄:Dy TL pellets embedded with 6Li compound developed in this study is higher than that of the TLD-600 (Harshaw Co.) dosimeter which is available in the open market.

열형광 CaSO₄:Dy 소자의 최적 제조조건에 관한 연구

김장렬,남영미,장시영,김두영,양정선,박재우 제주대학교 산업기술연구소 2000 尖端技術硏究所論文集 Vol.11 No.1

An experimental investigation has been performed to determine optimal conditions for preparing the thermoluminescent CaSO4:Dy pellets which have been widely used as personal radiation dosimeter material. Our investigation has shown that an optimal weight concentration of the dopant Dy in the bulk CaSO4:Dy is 0.1 mol%, and an optimal temperature of adding Dy in the preparing process is 320 ℃. An optimal time and temperature for sintering the CaSO4:Dy crystal produced from the chemical process are found to be 2 hours and 800 ℃, respectively. The maximum thermoluminescent sensitivity was observed when the CaSO4:Dy crystal was pulverized to grain sizes of 63 - 200 ㎛ in diameter before being fabricated into pellets. The commercial Teflon was selected as an adhesive for the fabrication of the CaSO4:Dy pellets with an optimal mixing ratio of the Teflon and CaSO4:Dy being 70 to 30 in weight.

고감도 CaSO_4 : Dy TL 분말의 TL 특성 및 고감도 TL 소자 제작 Dy TL powder and development of high sensitivity CaSO_4 Dy TL pellet

양정선,박재우,김두영,김장렬,장시영 제주대학교 방사능이용연구소 2002 연구보고 Vol.16 No.-

CaSO_4 : Dy series TL material is widely used as a personal dosimeter because of its high sensitivity to radiation. KAERI(Korea Atomic Energy Research Institute) has been produced CaSO_4 TL powder activated by Dy(rare earth elements) for several years and continually tried to improve its sensitivity having more than that of commercialized Teledyne CaSO_4 : Dy TL powders(USA). The TL powder is prepared by adding 0.1mol% Dy as an activator and by the acid evaporation method at first. And new step of washing this powder by distil-water is appended to separate non-crystalized powder in the initial crystal of CaSO_4 : Dy powder. CaSO_4 : Dy crystal TL powder which is produced by applying this new method has higer sensitivity than before washing step, and it has also higher sensitivity than that of Teledyne CaSO_4 : Dy TL powder. This CaSO_4 : Dy TL powder shows good TL characteristics such as dose response, energy response and fading. It is not possible to make solid detectors of only CaSO_4 : Dy TL phosphor without any binding material. Until now widely used sintered pellets. which were made from a mixture of CaSO_4 : Dy TL phosphor and Teflon. But, due to reduction in content of CaSO_4 : Dy TL phosphor in pellets(15∼20wt%) the TL sensitivity of pellets was reduced correspondingly. To variously use the CaSO_4 : Dy TL phosphor, research for preparing detectors by mixing CaSO_4 : Dy TL phosphor with different binding substances has been conductedThis paper described development of a new type of CaSO_4 : Dy pellets by using P-compounds as a bonding material(KCT-300), and compared the TL sensitivity with that of the commercialized Teledyne CaSO_4 : Dy pellets. Sensitivity of a new developed KCT-300 shows about 6 times than Teledyne ones, and can be used to measure very low radiation dose.

광대역 전압제어발진기의 설계기법에 관한 연구

김윤영,양두영 濟州大學校 情報通信硏究所 1999 情報通信硏究所論文集 Vol.2 No.-

In this paper. Design methodology of Voltage Controlled Oscillator( VCO) using varactor diode. which furnish wideband tuning range. good tuning linearity and low phase noise at microwave frequencies. are proposed. The series double-tuned oscillator with additional microstrip line and inductor is optimized to improve the phase noise and the fast tuning speed. The design and simulation have been done by Serenade-8.0 design tool used in the extracted nonlinear model parameters. The designed wideband VCO has shown the phase noise of -9jdBciHz at lOKHz offset frequency and the tuning sensitivity of 50MHz/V from 2.3GHz to 2.8GHz.

악관절 강직증의 치험례

현영옥,강창희,노양호,천영두,김신헌,이희원 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.1

Temporomandibular ankylosis is defined as a situation in which the condyle is fused to the fossa by bone or fibrous tissue. Conditons such as trauma, infection, or systemic disease may predispose to various types of ankylosis, bringing about different levels of limitation in mandibular movement. Most patients with temporomandibular ankylosis are associated with limitation of maximal mouth opening, deviation of the chin toward the affected side, impaired occlusion, chronic pain, compromised oral hygiene, severe facial asymmetry & impeded mandibular molar eruption occurring in childhood. Several techniques to release ankylosis have been described in the literature, showing variable and often unsatisfactory results. The most frequently used operations are gap arthroplasty, interpositional arthroplasty, and exicision and joint reconstruction with autogenous or alloplastic materials. We have managed the two patients of TMJ ankylosis. They had previously TMJ surgery and we treated with gap arthroplasty & active physial therapy. We have obtained favorable results and report these cases with literatures review.

직렬 결합형 PIN 다이오드를 이용한 WLL용 3-bit 위상천이기 설계

김윤영,양두영 제주대학교 산업기술연구소 1999 尖端技術硏究所論文集 Vol.10 No.2

In this paper, the 3-bit phase shifter using the series-coupled PIN diode to decrease the insertion loss is designed at WLL frequency bandwidth. The 30˚ bit and the 60˚ bit phase shifter are designed by the loaded-line type which is easy to obtain a small shift angle and the 90˚ bit phase shifter is designed by the reflection type obtaining a large shift angle. The 3-bit phase shifter is combined with the series connection of each bit phase shifter by the increasing arrangement of phase shift angle. From the results, the designed 3-bit phase shifter shows that the phase difference of input signal is shifted every thirty-degree intervals at output port. The average value of phase error is 0.53˚ , maximum phase error is 1.18˚ , and the insertion loss is 0.840dB~1.335dB at center frequency (2.315GHz).

CLOSED LOCK 증례에 대한 악관절 세정술의 임상적 연구

현영옥,강창희,노양호,천영두,이희원 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.1

Purpose : To evaluate the efficacy of arthrocentesis for treatment of closed lock. Material : 42 patients were diagnosed to closed lock by physical, radiographic examriation and undergone arthrocentesis. All patients have a pain and mouth opening limitation on affected site. Method : Arthrocentesis was done under conscious sedation and local infiltration anesthesia, normal saline and some steroid was injected on upper compartment of tempormandibular joint. After pumping and lavage, manual reduction procedure of anterially displaced disc was done. All the patients wear an anterior repositioning splint just after arthrocentesis. The result of arthrocentesis was assessed by pain and difference of mouth opening. Result : Difference of mouth opening after arthrocentesis was improved to 18.85mm and pain was gradually decreased. All patients were worn stabilization type splint after mean 1.84 months. 6 patients had relapse of mouth opening limitation so done arthrocentesis again and delivered good results.

폐수처리 공정 중 휘발성 유기화합물의 분석에 관한 연구

김영두,양용운,김재현 啓明專門大學 産業開發硏究所 2001 啓明硏究論叢 Vol.19 No.1

D염색단지 폐수처리장 유입원수 및 집수조, 1차 화학처리수, 2차 생물처리수 및 최종방류수의 VOC를 분석한 결과 dichloromethane, chloroform, toluene 등이 검출되었으며, 유입원수에서는 각각 45.8㎍/ℓ, 40.8㎍/ℓ, 24.5㎍/ℓ가 검출되었다. VOC성분은 대부분 집수조 및 cooling tower공정에서 휘발에 의해 제거되었고. 최종방류수의 dichloromethane, chloroform, toluene은 0.37㎍/ℓ, 0.29㎍/ℓ, 0.46㎍/ℓ를 나타내었다. 그리고 원수에 함유된 VOC 농도는 여름철이 겨울철에 비해 높았고, 제거효율은 여름철이 더 우수하였다. This study was conducted to investigate VOCs concentration of influent wastewater, storage tank, 1st chemical treatment effluent, 2nd biological treatment effluent and final effluent in D dyeing complex wastewater treatment plant for one year from July 1999 to June 2000. As a result, the small amount of VOCs such as dichloromethane, chloroform, toluene were detected and concentration of dichloromethane, chloroform, toluene in influent wastewater were 45.8㎍/ℓ, 40.8㎍/ℓ and 24.5㎍/ℓ respectively. The VOCs such as dichloromethane, chloroform, toluene were removed by volatilization in storage tank and cooling tower process. After wastewater treatment process, concentration of dichloromethane, chloroform, toluene in final effluent were 0.37㎍/ℓ, 0.29㎍/ℓ and 0.46㎍/ℓ, respectively. In addition, seasonal variation of VOCs concentration in influent wastewater showed higher in the summer than winter, but removal efficiencies were excellent in the summer.