C형 간염바이러스항체 검출을 위한3세대 효소면역측정 시약의 비교

이장혁,서순팔,기승정,송정원,신명근,신종희,양동욱,김세종 대한임상병리학회 1997 대한임상병리학회지 Vol.17 No.4

동종 골수이식 후 만성 이식편대숙주반응 환자에서 발생한 폐렴구균에 의한 수막뇌염 1예

신완식,김병욱,유진홍,김동집,김춘추,박종원,이종욱,김동욱,강문원,김양리 대한감염학회 1993 감염 Vol.25 No.3

Graft-versus-host disease (GVHD) is a frequent complication after bone marrow transplantation. Infectious complications are common in GVHD patients due to defect in cell-mediated immunity. A rare case of S. pneumoniae meningoencephalitis occured in a patient with extensive form of chronic GVHD after allogeneic bone marrow transplantation. He was immediately treated with full dosage of ceftriaxone and ampicillin. He suffered from various complications such as sepsis, acute renal failure, atelectasis, and seizure. Despite of aggressive treatment, he died probably due to renal shutdown and massive subacute cerebral infarction of left cerebral hemisphere. This report showed two unusual and rare features. First, the infection site was CNS rather than respiratory system. Second, the causative organism was S. pneumoniae, which is rare cause of CNS infection in immunocompromised patients.

혈관질환 정보관리 시스템

김동익,김덕경,허세호,이병붕,김용신,김은숙,문지영,도영수,신성욱,김동수,김만태,진재욱,김용신 대한혈관외과학회 2002 Vascular Specialist International Vol.18 No.1

As medical technology progresses rapidly, there is a rise in the average age along with the Korean dietary lifestyle becoming more westernized, which leads to an increase in the number of vascular disease patients in Korea. Thus, we need to manage the medical information of a disease systematically in order to diagnose and treat constructively. However, since there has been no standardized method of man agement to date, a great deal of information could not be properly utilized nor studied. Therefore, the departments of Cardiology, Radiology and Neurology of Samsung Seoul Hospital recently got together to develop an information management system called the Vascular Data System. This program was developed to be run on win98 O/S, upper Pentium Ⅲ, and upper 128 MB Memory, and its source code is Dephi 4.0. It was configured for the user to set the configurations as well as do a variety of search and analysis. If this program were to be updated continuously, it may be used extensively as well as in various parts of clinical research activities.

조혈모세포이식 환자에서 발생한 Cytomegalovirus 질환의 특징 : 일개 대학변원에서 최근 10년간의 경험

최수미,이동건,박선희,김시현,김유진,민창기,김희제,이석,최정현,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Studies on cytomegalovirus (CMV) diseases in Korean hematopoietic stem cell transplant (HSCT) recipients are lacking and do not reflect the recent trends of advances and changes. Therefore, we tried to analyze the clinical features of CMV diseases in HSCT recipients over the past 10 years at a tertiary university hospital in Korea. Methods : Retrospective review of medical records was done for all adult HSCT patients who received transplant at the Catholic HSCT Center from January 1998 to January 2008. Results : Forty-four cases (2.2%) of CMV diseases were identified. CMV pneumonia was diagnosed in 17 patients, retinitis in 16 patients, enterocolitis in 7 patients, esophagitis 1 patient, gastritis in 1 patient, duodenitis in 1 patient, and hepatitis in 1 patient. The median onset of symptom was 90 days after transplantation. Late CMV diseases accounted for 47.7%. CMV related death varied from 0 to 58.8% according to the involved organ. CMV retinitis was diagnosed relatively later in the course of transplantation mostly in patients who had chronic graft versus host disease (GVHD). On the contrary, CMV enterocolitis mainly occurred in patients who suffered from acute GVHD. The overall concurrent CMV reactivation was documented to be 63.6%: the concurrent CMV reactivation was observed only in 37.5% of patients with retinitis. Conclusions : We observed some differences in the pattern of CMV disease manifestation according to the involved organ and reconfirmed the fact that CMV pneumonia is the most common and fatal disease in HSCT recipients. Additionally, CMV retinitis was not uncommon in HSCT recipients. Since specific marker does not exist in predicting retinitis, regular ocular examination should be done thoroughly, especially in patients with chronic GVHD.

플라즈마 표지소자의 제작

이상윤,라병욱,박동수,황인헌,이덕동,신영남,박성배,이동욱,박용석,박형근,손상호,권태근,채경락,정경득 慶北大學校 自然科學大學 1986 自然科學論文集 Vol.4 No.-

An Ac-type Plasma Display Panel (PDP) operating with Ne-Ar(0.1%) Penning mixture gas is fabicated. The characterics of the panel with electrodes covered with thin and thick dielectric layers are studied. The brightness of the Neon-orange light emitted by the panel measured as function of applied voltage and frequency. As an application, a graphic display system equipped with PDP showing still and moving pictures is made.

대학생의 성별 스포츠에 대한 가치관과 태도 비교 연구

신영균,주동욱 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.3

The purpose of this study is to investigate an attitude and Value to nave cognizance of Sport on sex by University Students, concretely, the purpose of this study is to analyze and clarify the effects of the experience, Style, Proper degree of sports participation. For the study 323 sports and 333non-sports participation were selected(totaled 656 university students 342, college students 314). statistical analysis techniques for this study included multiple classification analysis, analysis of convenance, multiple regression analysis. Based on findings of these analysis the results of the study are as follow: First, there were differences on 0.1% an attitude and Value to have cognizance of Sport by sex. Second, University Style of according to an attitude and Value to have cognizance of Sport on differences 5%. Third, there were differences on 0.l% an attitude and Value to have cognizance of Sport by the grades. Fourth, there were differences on 0.1% an attitude and Value to have cognizance of Sport by regression. Fifth, there were differences on 0.1% an attitude and Value to have cognizance of Sport by reduction on marks of the arts and physical fitness. Sixth, an attitude and Value to have cognizance of Sport by total University Students were social intercourse and a cultural level in the higher.

백서 혈관평활근 세포에서 α-Lipoic acid가 PAI-1 발현, 세포의 증식, 주유능 및 신생내막 형성억제에 미치는 효과

신동우,이동욱,이상준,김혜순,강효경,안종덕,이인규 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.25 No.6

연구배경:당뇨병의 혈관 합병증의 발생에 있어서 산화스트레스는 중요한 역할을 하는 것으로 알려져 있다. 혈관 평활근세포에서 고혈당은 안지오텐신Ⅱ와 더불어 활성산소족(ROS)을 증가시키며, 산화스트레스에 민감한 전사인자들을 활성화시켜 동맥경화증을 유발하는 것으로 알려져 있다. 이에 저자들은 항산화제로 알려진 알파­리포산이 혈관 평활근세포의 증식속도와 이주에 미치는 영향과 PAI­1발현에 미치는 영향을 조사하였고 이와 동시에 백서의 혈관 손상 모델을 이용하여 알파­리포산이 신생내막 증식을 억제시킬 수 있는지를 알아보았다. 방법:In vitro 실험은 백서의 대동맥 평활근세포를 고농도의 포도당(22mM)과 100nM의 안지오텐신Ⅱ로 4시간 배양하였다. 알파­리포산을 처리 후, PAI­1 mRNA의 발현을 보기 위해 노던 블롯을 시행하였고 평활근세포의 유주능과 증식속도에 미치는 영향을 보기 위해 성장속도의 유주능 분석을 시행하였다. 또한 평활근세포의 유주능에 NF­μB 경로가 미치는 영향을 보기 위해 겔 지연 분석과 NF­μB 보고 유전자 분석을 시행하였다. In vivo 실험으로 백서의 혈관손상 모델을 이용하여 알파­리포산 처리 후 혈관의 신생내막 두께를 비교하였다. 결과:In vitro 실험에서 고농도 포도당과 안지오텐신Ⅱ에 의해 유도된 PAI­1 mRNA 발현증가는 알파­리포산 처리에 의하여 용량에 비례하여 억제되었다(p<0.05). 알파­리포산 처리로 혈관 평활근세포의 유주능은 유의하게 억제되었으나(p<0.01),증식속도는 유의하게 억제되지 않았다. 또한 알파­리포산 처리로 NF­μB 발현도 유의하게 억제되었다(p<0.01). In vivo 실험에서 알파­리포산을 주입한 군에서 혈관손상에 의한 신생내막의 증식이 유의하게 억제되는 것을 보여주었다(p<0.01). 결론:알파­리포산은 백서의 대동맥 평활근 세포의 증식속도는 억제하지 못했으나 유주능은 유의하게 억제하였으며, 혈관 손상 모델에서 신생 내막 증식도 유의하게 억제함을 확인할 수 있었다. 이러한 작용은 알파­리포산에 의한 NF­μB 경로의 억제와 연관이 있는 것으로 사료된다. Background : Exposure to large amounts of glucose causes a characteristic dysfunction and morphologic changes of the endothelium by an increased production of reactive oxygen species(ROS) in diabetes. The plasminogen activator inhibitor-1(PAI-1), which modulates fibrinolysis and cell migration may influence proteolysis and neointimal formation in vascular smooth muscle cells(VSMC). Antioxidants have been proposed to inhibit multiple proatherogenic events. This study investigated the effect of α-lipoic acid on PAI-1 expression and VSMC proliferation and migration both in vivo and in vitro. Methods : In the in vitro study, cultured rat aortic smooth muscle cells(RASMC) were incubated in a medium containing high glucose (22 mM) and 100 nM angiotensin Ⅱ for 4 hour. After α-lipoic acidtreatment, a -migration and growth assay of the RASMC, and a gelmobility shift assay and reportergene analysis for nuclear factor- иB(NF- иB) and northern blot analysis for PAI-1 were performed. In the in vivo study, the effect of α-lipoic acid on neointimal hyperplasia in a rat carotid balloon injury model was evaluated. Results : RASMC migration was inhibited significantly by α-lipoic acid (p<0.01), but their prolife ration was not inhibited. The NF-иB DNA binding activity and NF-иB promoter activity was inhibited by α-lipoic acid significantly (p<0.01). α-lipoic acid inhibited PAI-1 mRNA expression by high glucose and angiotensin Ⅱ in dose dependent manner (p<0.05). In the rat carotid artery balloon injury model, neointimal formation was reduced by α-lipoic acid treatment in a dose dependent manner significantly (p<0.01). Conclusion : α-lipoic acid suppresses migration, but not prolife ration in RASMC. α-lipoic acid also reduce neointima formation in a rat carotid balloon injured model. This effect might be related to the blocking of NF-иB which increase the expression of the genes associated with atherosclerosis including TNF-α, IL-1, IL-6, endothelin-1, MCP-1, VCAM-1, ICAM-1, E-selectin, tissue factor(J Kor Diabetes Asso 25:446~459, 2001).

實際批評과 그 문제점

신동욱 연세대학교 교육대학원 1979 연세교육과학 Vol.15 No.-

The trend of recent literary criticism in Korea has focused its attention on various methods or "approaches" to practical interpretation of literary works rather than the systematic study of literary theory. Many different kinds of "approach" have been categorized as psychological, historical, formalistic, mythopoeic criticism and etc, and have been applied to practical interpretations of literary works. The present proliferation of interpretive "approach" has resulted in the different kinds of interpretations on evaluations of the same literary text. Such a phenomenon provides some evidence that a crisis exists, whether or not the humanities in general and the literary science in particular. In addition, many more important and practicalissues have been arised: (1) the nature of Korean literature as a national literature, and the individual and unique features of Korean literature in the Weltliteratur. (2) the traditional and typicalfeatures of Korean literature and the Western literary impact uponthem. (3) the case for and against litte´rature engage´e. (4) the re-examination of realism and etc. In the verbal violence committed over the years by each side of the dispute on the other, we have observed that those who have involved in the various issues have confined themselves to the narrow circle of their own single position. As there is not only no agreement upon any distinctive method or "approach" but none even upon the possibility or impossibility of it, however, there is no an absolute and all-comprehending critical method or "approach". There is a ceaseless dispute as to what the function of literary criticism is or should be, hut in my opinion, the function of literary criticism should be in interpreting literary works and at the same time evaluating them. Such a critical function will contribute to maturing aesthetic and moral sense of reader. Much time is devoted to the study of literature and many voices are to be heard which argue that the study of literature is the most important kind of education. Therefore, the raisond'etre of "praetical criticism" should be in developing aesthetic and moral sense of every readers, if literature is to have some useful or educational function in our Society. For such a central role of literature in education, we should understand and sometimes accept the opinions and methods of each side without prejudice and with the sense of disinterest.

결정화 공정을 위한 L-ornithine aspartate의 용해도에 관한 연구

신동명,김용욱,김우식 慶熙大學校 1998 論文集 Vol.27 No.-

Study on the solubility of L-ornithine aspartate with temperature, alcohol, additive was invescated. Generally, the solubilities of amio acids are effected by orniganic solvent, so the solubility of L-ornithine aspartate was represented to reduce by adding alcohol. The solubility of L-ornithine aspartate with temperature incressed at methanol volume ratio 40%, but was slightly effected at methanol volume ratio 60% and 80%. The effect of aspartic acid was not signifigant, too.

Ornthine-aspartate의 용해도 및 Drowning-out 결정화 연구

신동명,김우식,김용욱 경희대학교 산학협력기술연구원 1997 산학협력기술연구논문집 Vol.3 No.-

오르니틴-아스파테이트의 용해도와 drowning-out결정화에 관한 연구를 수행하였다. 오르니틴-아스파테이트 용액에 알코올을 첨가하면 오르니틴-아스파테이트의 용해도가 극적으로 감소하며, 결과적으로 오르니틴-아스파테이트의 침전이 일어난다. 오르니틴-아스파테이트 침전공정에서 오르니틴-아스파테이트의 회수율과 결정크기는 주입속도, 교반속도 및 주입방식에 크게 영향을 받았다. 또한, 물과 알코올의 혼합액에서 오르니틴-아스파테이트의 용해도는 알코올 분율이 증가함에 따라 감소하는 것으로 나타났다. 알코올-물 혼합용액에서 오르니틴-아스파테이트의 용해도는 Cohn식과 Wilson식들에 의해 성공적으로 예측될 수 있다. Study on solubility and drowning-out crystallization of ornithine-aspartate was carried out. Addition of alcohol to ornithine-aspartate solution reduces dramatically the solubility of ornithine-aspartate and results in the precipitation of ornithine-aspartate. In the process of ornithine-aspartate precipitation the recovery and crystal size of the ornithine-aspartate were significantly affected by the feeding rate , agitation rate and feeding mode. In water and alcohol mixture, the solubility of ornithirne-aspartate was also presented to be reduced as increasing alcohol fraction. The solubility of ornithine-aspartate in solution of alcohol-water mixture can be successfully predicted by Cohn and Wilson equations.