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RISS 인기검색어
- 검색키워드
- 저자 : ( Dong Wook Jekar ) (검색결과 3 건)
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( Dong Wook Jekar ),( Pil Soo Sung ),( Bo Hyun Jang ),( Kwang Il Seo ),( Jeong Won Jang ),( Si Hyun Bae ),( Jong Young Choi ),( Yonggoo Kim ),( Seung Kew Yoon ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+-M2BP) was recently identified as a biomarker for hepatic fibrosis in patients with chronic hepatitis C (CHC) infection, and it has also been proven as a predictive marker in patients with CHC-related hepatocellular carcinoma. In this study, we investigated the association between WFA+-M2BP levels and liver histological findings for patients with chronic hepatitis B virus (HBV) infection, comparing with transient elastography (FibroScan) measurements or the Enhanced Liver Fibrosis (ELF) score. Methods: Biopsy proven, 106 chronic hepatitis B (CHB) patients with alanine aminotransferase (ALT) less than 150 were analyzed. We examined the effect of WFA+-M2BP level on severity of liver fibrosis, comparing with transient elastography (FibroScan) measurements and the Enhanced Liver Fibrosis (ELF) score, a serum ECM marker set consisting of tissue inhibitor of metalloproteinases 1 (TIMP-1), amino- terminal propeptide of type III procollagen (PIIINP) and hyaluronic acid (HA). Receiver operating characteristic curve (ROC) analysis was performed to calculate the area under the ROC (AUROC). Results: The WFA+-M2BP value ranged from 0.2 cutoff index (COI) to 2.42 COI (median value, 0.55 COI). The median values in each Knodell fibrosis stage are: 0.22 COI in A, 0.38 COI in B, 0.62 COI in C, and 0.82 COI in D (P = 0.0044). For predicting liver cirrhosis (Knodell fibrosis stage D), WFA+-M2BP level had the AUROC of 0.753. By correlation analysis, serum M2BG level significantly correlated with ELF score (r2 = 0.1764, P < 0.0001) and FibroScan measurements (r2 = 0.2239, P < 0.0001). In the validation cohort, serum WFA+-M2BP levels were significantly higher in chronic hepatitis patients without cirrhosis and even higher in patients with liver cirrhosis than normal controls (P < 0.0001). Conclusions: Our data suggest that the serum WFA+-M2BP value may be useful for predicting liver cirrhosis in patients with chronic hepatitis B infection.
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( Kang Kyun Park ),( Jeong Jun Park ),( Sang Bong Han ),( Dong Wook Jekar ),( Yeon Joon Park ) 대한임상병리사협회 2009 임상미생물검사학회 발표자료집 Vol.2009 No.-
Background: The accuracy of antimicrobial susceptibility testing (AST) of Acinetobacter baumannii (ABA) and Pseudomonas aeruginosa (PAE) with VITEK2 and BD Phoenix automated systems were evaluated with one hundred of non-duplicated isolates. Methods: MICs of amikacin, imipenem, meropenem, piperacillin, piperacillin/tazobactam, cefepime, ceftazidime and aztreonam (PAE only) were determined by agar dilution method according to the CLSI guidelines. In this study, we compared the accuracy of two automated systems with the acceptability criteria of less than 3%, and 10% for major error (ME) and minor error (mE), respectively, but the acceptability of very major error (VME)s (less than 3%) were determined only when there were more than 35 resistant isolates. Results: Of the ABA, more than 35 isolates showed resistance to amikacin, piperacillin, piperacillin/tazobactam, cefepime and ceftazidime. Of them, the antibiotics for which the VMEs were over 3% were amikacin (12%), piperacillin/tazobactam (4%) and cefepime (4%) by Vitek2 and none by BD Phoenix. The ME rates were ≤3% for all antibiotics tested by both systems. However, the mE rates were ≥10% for most of the antibiotics except imipenem and meropenem by Vitek2 and amikacin, imipenem, meropenem and ceftazidime by BD Phoenix. As for the PAE, only for aztreonam, more than 35 isolates showed resistance. The VME rates of both systems were ≤3%. The ME rates of Vitek2 were ≤3% for all the antibiotics tested, and that of BD phoenix were >3% for piperacillin and piperacillin/tazobactam. mE rates were ≥10% for imipenem, ceftazidime and aztreonam with Vitek2 and cefepime and aztreonam with BD Phoenix. Discussion: Although the number of isolates tested was not large, the antimicrobial susceptibility test results of automated systems were not accurate enough for a few drugs for which alternative testing are not recommended according to the manufacturer’s instruction. Further studies with a larger number of isolates with various mechanisms of resistance are needed.
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( Min Ju Kim ),( Jeong Won Jang ),( Jung Hyun Kwon ),( Chan Ran You ),( Nam Ik Han ),( Chang Don Lee ),( Hyun Suk Jung ),( Dong Wook Jekar ),( Seung Ok Lee ),( Kyu Won Chung ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Although alterations in cytokine profile after therapy can affect the outcome and prognosis of cancer patients, there are no comprehensive data on multiple cytokine profiles during transarterial chemotherapy (TACE). Methods: Cytometric bead immunoassay was used to simultaneously measure 13 cytokines (interleukin [IL]-12p70, IFN-γ, IL-17A, IL-2, IL-10, IL-9, IL-22, IL-6, IL-13, IL-4, IL-5, IL-1β, and TNF-α) in the sera of 83 patients with hepatocellular carcinoma (HCC) and 18 healthy controls. Those cytokines were serially monitored at baseline, day 3, day 7, and 2 months after TACE in 63 evaluable patients. Results: Serum levels of IL-17A and IL-5 were higher in HCC patients than healthy controls, whereas IL-22 and IL-1β levels were lower in HCC patients. Although the overall patterns of cytokine changes were diverse at each set date, certain cytokines specifically increased after TACE, with the early-phase increase in IL-6 and IL-22 levels and late-phase increase in IL-4, IL-6, and IL-10 levels. With relatively minor changes of cytokines after TACE, Childs B/C group had higher IL-6 and lower IL-22 levels than Childs A group. Patients with larger tumors (>5 cm) had higher IL-6 levels at baseline and showed a transient but significant early-phase increase in IL-6 levels as well as late-phase increase in IL-4, IL-10, and IL-13 levels after TACE. With regard to hepatic events, IL-2 and IL-22 levels at baseline were predictive of grade 3 or more hepatic toxicity, while those levels of IL-6 and IL-13 significantly increased at day 3 in patients suffering from post- TACE hepatic morbidity. Conclusions: TACE induces various changes of multiple cytokines. Distinct panels of cytokine changes are not uniform, influenced by treatment-induced inflammation, underlying liver function, and HCC stage. The increased Th2 cytokine profiles after TACE suggests the immune suppression in patients with large tumor and post-treatment hepatitis.
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