자궁경부 상피종양에서 human papillomavirus 감염과 survivin 발현

윤재호,정동준,이정은,박동명,배동한,선우재근,백무준,김창진 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Human papillomavirus (HPV) has been considered a causative agent of uterine cervical carcinoma. HPV is a DNA oncogenic virus, which is well known as a causative virus in uterine cervical carcinoma. The virus is classified into two groups genotypically, low risk and high risk, according to the carcinogenic potentiality, and the determination of the viral genotype is important in clinical practice. Recently, numerous genotypes can be determined by high throughput method using DNA chip. Survivin is a recently characterized inhibitor of anti-apoptosis (IAP) protein, which is abundantly expressed in most solid and hematological malignancies, but undetectable in normal adult tissues. In this study, HPV genotypes are determined by DNA chip and the expression of survivin was examined by immunohistochemistry in 80 cases of uterine cervical intraepithelial neoplasia (CIN) and invasive carcinoma to see the roles of HPV and survivin in the carciogenesis of uterine cervical epithelial neoplasia. The results were as follows: 1. HPV positive rate was 72.5%, while negative rate was 27.5% in 80 cases of CIN and invasive carcinoma. The CIN and invasive carcinoma showed higher HPV positive rate (p <0.05). 2. HPV positive rate according to the histologic grade were 60%, 65%, 77% and 90% in CINI, CINII, CINII and invasive carcinoma, respectively. HPV positive rate showed increasing tendency according to the histologic grade, though there was no statistical significance. 3. The most frequent genotype was type 16 and the next were 58, 52, 18 and 33 in order of frequency. 4. Survivin was expressed in 96.3% of CIN and invasive carcinoma. The expression rate of survivin showed no significant difference between the histologic grade of CIN and invasive carcinoma, but showed tendency of increased expression rate in invasive carcinoma. 5. Survivin was expressed in HPV positive and in HPV negative each as in 95.5% and 96.6% respectively. There was no significant difference of survivin expression between HPV positive and negative cases. The above results suggest that HPV has no effect on the regulation of survivin expresson level in the uterine cervical intraepithelial neoplasia and invasive carcinomas.

관동맥질환에서 저밀도 지단백 입자 크기의 분포

임효영,김인숙,승기배,강동헌,전두수,장기육,박준철,이수영,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

자동차 수동 트랜스미션 기어의 손상과정 예측

베효준,조연상,김동호,서영백,박흥식 동아대학교 생산기술연구소 2000 生産技術硏究所硏究論文集 Vol.5 No.2

The wear particles is released from the moving surfaces in gear systems of transmission and its morphology is directly related to the damage and failure to gear systems from which the particles originated. It is the effective method to diagnosis damage process of gear systems of automobile transmission to observe wear particle in gear oil. We tested with new transmission and took out gear oil according to drive distance. To be applied to damage diagnosis of gear system in transmission of automobile, 4 shape parameters of wear particles in gear oil were calculated and wear volume were presumed with the image processing system.

충남 서북부지역의 개발 잠재력 분석 : 아산시를 중심으로

배성의,박동진,윤준상,황인극,최승철 공주대학교산업개발연구소 2000 産業開發硏究 Vol.8 No.-

This study was purpose for develop potential analysis of Chungnam north-west area and propose to regional development strategy. To arrived at a result for develop direction of Chungnam north-west area, Asan city will be development of central city for Asan bay, new indusrial city, tourist industrial city and ecological city.

NO_x 가스 센서의 개발 Ⅱ

최동한,전춘배 경북대학교 센서기술연구소 1994 연차보고서 Vol.1994 No.-

제 1차년도에서 얻은 결과에서 가장 유망한 감지물질로는 PbPc였다. 이를 토대로 제 2차년도에서는 PbPc의 결정구조와 NO_2와의 감지기구를 규명하였다. PbPc의 정확한 승화점을 얻기 위해 DTA/TG 분석을 시행하였으며, 승화점은 약 410℃ 정도였다. PbPc 감지막은 5×10 exp (-6) Torr의 초기진공도 下에서 진공증착법으로 형성하였다. 증착된 PbPc 막의 두께는 약 6000Å이였다. SAW NO_x 가스센서의 압전기판으로는 LiTaO_3를 사용하였다. 기준 지연선과 감지지연선의 두개의 지연선을 갖는 dual delay line SAW 소자의 IDT 패턴을 설계한 뒤 사진식각기술을 이용하여 SAW IDT를 제조하였다. 제조된 dual delay line SAW IDT에 AGC 회로와 rf 증폭기를 가지고 dual delay line SAW oscillator를 제작하였으며, NO_2 가스 감지특성 조사를 위해 측정 시스템을 구성하였다. 또한 습도에 대한 의존성을 조사하기 위한 측정시스템을 구성하였다. 완성된 dual delay line SAW NO_2 센서의 NO_x 가스에 대한 주파수 편이, 선택성, 그리고 온도 및 습도에 의한 영향 등의 특성을 조사하였다. The best sensing material among the metal phthalocyanines was lead-phthalocyanine from the result of the 1st year. On the basis of the result we suggested the behavior of the PbPc molecular structure and the NO_2 gas sensing mechanism at the 2nd year. The DTA/TG analysis to get the correct sublimation point of PbPc thin film were investigated and it was about 410℃. PbPc sensing thin film was prepared at the vacuum sublimation at the base pressure of 5 × 10 exp (-6) Torr. Thickness of the sublimed PbPc thin film was about 6000Å. SAW NO_2 sensors using 112° rot. x-cut LiTaO_3 wafer as a substrate have been fabricated and the sensing properties have been investigated. Dual delay line SAW device with IDTs which consist of the reference delay line and the sensing delay line was formed on the substrate. Dual delay line SAW oscillator was made of the fabricated dual delay line SAW IDT with AGC circuits and rf amplifier. The measuring systems for the properties of NO_2 gas sensing and the humidity dependence of the SAW sensor were constructured. Oscillation frequency shifts were investigated as a function of the temperature, the humidity and the concentration of NO_2 gas.

개원의의 진료의뢰시 기대요인 및 만족도에 관한 연구 : 협력병원체제 여부를 중심으로

김동일,김해준,윤석준,문영배 한국의료QA학회 2002 한국의료질향상학회지 Vol.9 No.2

Background : This research, as a part of improving management process of college hospital in this rapidly changing circumstances, is searching for the actual state of private clinics referring patients to referral center including college hospitals. Methods : This research examined the sense of satisfaction and requesting degree in using referral center and by analyzing the correlation and differences among factors such as primary factors regarded as selecting ones in referring patients to a referral center in college hospital and expecting factors expected to be supported to patients and cooperative hospitals. Results : The main researched results are as follows. First, as for the primary factors, the differences between cooperative and uncooperative hospitals revealed the fact that choosing target hospital in accordance with cooperative relation and convenient process in referring patients are important. Second, satisfaction rates, analyzed from the paired t-test revealed kindness and convenience as the top priorities, while sending patients back again and benefit of supporting such as the use of facilities were revealed as the least satisfactory aspects, despite the fact that they should be fulfilled through actual service. Conclusion : The recognition of the practitioner is examined and analyzed in this research by examining primary factors in selecting college hospitals, expecting factors expected to be supported to patients and satisfaction degree, which are expected to be used as basic materials for the development of referral center of college hospitals.

우리 나라 재해 의료의 문제점 : 수원시 재해 대응 훈련의 평가를 통하여 본 ANALYSIS OF EMERGENCY RESPONSE EXERCISE IN THE MOCK DISASTER IN SUWON

곽동진,정윤석,진재우,조준필,김 철,김행재,배택환,김준식 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

Natural or man-made disasters are serious enough to paralyse the functions of the nation or regional distinct and affect the property and lives of numerous citizens. The first two hours after occurrence of the disaster are critical for determining death or permanent disabilities of the casualties. The current Disaster Medical Service(DMS) System in our country adopts mainly civil defense model which focuses the cause of the accident, compensation of the victims, or reconstruction. So in the initial phase of disaster, the appropriate rescue and emergency treatment is not provided effectively. In order to assess and reorganize the current status of DMS System in Korea, the Department of Emergency Medicine, Ajou University School of Medicine, planned and conducted an emergency response exercise in Suwon city on April 28, 1995. The exercise, which took place near the Kyunggido Culture and Art Center, coordinated the efforts of the Suwon Fire Department and other related agencies. As well as providing training on emergency response, the exercise was valuable for identifying areas of weakness which will be address in the future.

의약정보담당자(MR)의 기능 및 역할에 관한 연구

이동일,제해관,윤석준,안형식,문영배 한국의료QA학회 2003 한국의료질향상학회지 Vol.10 No.1

Background : Aim of this study is focused on the analysis of the needed abilities of medical representatives resulting in building up the market and increasing sales. It is to propose methods to increase this ability ensuring continuous growth in market share and profit. Methods : A survey was conducted between January 6 and May 31, 2003. Using SPSS(Version 10.0), the collected data was analyzed by Hotelling T2, factor analysis. Some hypotheses were selected to include the conclusion. Some questionnaires for physicians working in hospitals or clinics and the medical representatives working in a pharmaceutical company were created and asked to them to either prove or reject those hypotheses. The results were analyzed to find the primary factors that effect the interactions between physician and the medical representatives. These factors were also studied along with the theoretical research based on published references. Results : The results were as follows. The main reasons for the physician to meet with a medical representatives were collection of product informations needed for patient treatment and collection of informations on current medical issue and as well as personal interests. The main parameters by which physicians evaluate the medical representatives are human relationship including sincerity and manners and supply of accurate and unbiased information on products. Overall, the medical representatives’ perception on the importance of medical knowledge and ability to deliver it are lower than that expected by physicians. Conclusion : Medical and pharmaceutical companies’ environment are changed rapidly. And those changes forced medical representatives to set new roles and competency. In order to drive away from the past ‘rule of thumb’ and ‘adaptation to circumstance’, optimal method and systemic development to train and support the medical representatives should be quipped. They will help ,medical representatives to be specialists in medical knowledge and to understand the exact need of health care professions. Product competitiveness will be increased and eventually successful business can be achieved through it.

외상성 간손상의 선택적 치료

이준희,박기영,박동일,안우섭,서정욱,오민구,배성한,정병욱 대한외상학회 1995 大韓外傷學會誌 Vol.8 No.1

With the increment of the role of CT scan, nonoperative treatment is the recent trend in hemodynamically stable patients in the management of traumatic liver injuries. To investigate the trend of treatment and to suggest the possible criteria for nonoperative treatment, we reviewed 50 patients with traumatic liver injuries who were treated in the Department of Surgery, Dong-Guk University Hospital from January 1989 to June 1994. Of 50 patients, 35 patients were treated with nonoperative management and 15 patients were treated with operative management. Based on CT findings, we classified those 50 patients into each grade of liver injuries ranging from grade 1 to 5 and we classified t,he degree of hemoperitoneum ranging from grade 0 to gracle 3+, and we compared those results with the clinical outcome. The operation rate according to liver injury grade didn't increase with the increment of the grade, and the degree of hemoperitoneum corresponds well to the rate of operation. In the nonoperative cases, there was only one complication and there was no mortality. In conclustion, even major liver injuries including grade 4 by CT scan can be treated with nonoperative rnanagement if the patients are hemodynamically stable and they do not have combinded intraabdominal organ injury.

고요산혈증의 위험인자 : 아산시 지역 주민을 대상으로

김용배,장원기,황보영,김화성,안규동,이병국,이용진,이종은,이준숙,이찬구,이한정,이성수 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

Objective : Serum uric acid has now been identified as a marker for a number of metabolic and hemodynamic abnormalities. The aim of this study is to evaluate risk factors which influence hyperuricemia in the citizens of Asan. Method : The study design was cross-sectional and research subjects were 1086 citizens of Asan. General characteristics, cigarette smoking, alcohol consumption, and past history were obtained by interview using a structural questionnaire. Also, we measured height, weight and blood pressure, and serum uric acid of the subjects. Results : The mean serum uric acid level was 5.27 ㎎/㎗ in men and 4.01 ㎎/㎗, in women, In the multiple logistic regression analysis, statically significant risk factors of hyperuhcemia were gender, body mass index, blood lead concentration, and serum creatinine. Conclusion : Our results suggest that gender, body mass index, blood lead concentration, and serum creatinine might be the most important risk factors of hyperurcemia. Education program as well as routine check-up for serum uric acid was highly recommended for the effective prevention of hyperuricemia.