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서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)
김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2
Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.
The Relationship between Mitochondrial ROS and ER Stress in Allergic Airway Diseases
( So Ri Kim ),( Yong Chul Lee ),( Dong Im Kim ),( Mi Ran Kang ),( Yang Keun Rhee ),( Heung Bum Lee ),( Seoung Ju Park ),( Chi Ryang Chung ),( Seung Yong Park ),( Hee Jung Kim ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Mitochondria and the Nox family of NADPH oxidase are the two major sources of reactive oxygen species (ROS) that are induced by external stimuli, and the mitochondria respiratory chain is considered as an important site of ROS production within most cells. Recent evidence has demonstrated that various biological stimuli increase accumulation of unfolded or mis-folded proteins in ER lumen, which is referred to as "ER stress". Moreover, these various pathologic stimuli have been reported to provoke oxidative stress as well as ER stress. In this study, we used the mice sensitized with OVA and LPS and then challenged with OVA (OVALPS-OVA mice) for elucidation of the relationship between mitochondrial ROS and ER stress in bronchial asthma. The OVALPS-OVA mice showed that the expression of ER stress markers and the protein levels of un-folded-protein response (UPR)-related marker in lung tissues were significantly increased after OVA challenge. In addition, we visualized the localization of mitochondrial ROS in BAL cells isolated from OVALPS-OVA mice using confocal microscopy; the significant increase in mitochondrial ROS in BAL cells was observed after OVA challenge. Our results also showed that Necrox-5 or 4-PBA significantly reduced the increases in ER stress, mitochondrial ROS, inflammatory cytokines, airway in-flammation, and bronchial hyperresponsiveness. These findings suggest that mitochondrial ROS and ER stress plays an im-portant role in the induction and maintaining allergic airway diseases synergistically.
( So Ri Kim ),( Yong Chul Lee ),( Dong Im Kim ),( Yang Keun Rhee ),( Heung Bum Lee ),( Seoung Ju Park ),( Chi Ryang Chung ),( Seung Yong Park ),( Mi Ran Kang ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Oxidative stress is well known to be implicated in the development of asthma. The mitochondrial respiratory chain is a major site of intracellular reactive oxygen species (ROS) generation and, at the same time, an important target for the damaging effects of ROS. Mito-Tempo is a specific mitochondrial ROS inhibitor and it is known to be associated with opening of mi-tochondrial permeability transition pore and inhibition of cell necroptosis or apoptosis. However, there is little information on the protective effects of Mito-Tempo on the inflammatory airway disorders including bronchial asthma and its acute exacerbation. We investigate the effects of Mito-tempo on the allergic airway inflammation and hyperresponsiveness using the mice sensitized with OVA and LPS and then challenged with OVA (OVALPS-OVA mice). The OVALPS-OVA mice showed the typical features of neutrophilic asthma; increased airway inflammatory cells, the pathologic changes, the increased levels of Th2 cytokines in lungs of OVALPS-OVA mice, increased mitochondrial ROS generation, and increased bronchial hyperresponsiveness. Interestingly, we found that in OVALPS-OVA mice, Mito-Tempo, a novel mitochondrial targeting agent significantly reduced the increases in inflammatory cytokines, mitochondrial ROS generation, airway inflammation, and bron-chial hyperresponsiveness. These findings indicate that mitochondrial dysfunction including oxidative damage may be im-plicated in the pathogenesis of bronchial asthma and provide the therapeutic potential of a mitochondrial targeting agent, Mito-Tempo, for bronchial asthma.
체형별 승용차 구매 평가기준의 차이 : 경영혁신의 체형별 성공요인 Sucess Factors with Body Types in Business Innovations
김임곤,김수동 한국정보전략학회 2001 한국정보전략학회지 Vol.4 No.1
It is supposed that if consumers' purchasing behaviors are different according to body types, these difference could be utilized for the sales policy of products. The purpose of this research is to analyze, with body types, whether there are any difference in a degree of values of the purchasing evaluation criteria, when they purchase automobiles. Weight and height of men from 25 year-old to 29 year-old are measured and then how to evaluate the 10 purchasing evaluation criteria of automobiles presented in questionaires are investigated. And body types are classified as lean, slightly lean, normal, slightly obese, and obese type with measured weight and height, The founding of this analysis is that there are significant difference in a degree of values of each purchasing evaluation criteria. This result shows that lean type and obese type are considerably different from the other body types, and also the types are different from each other in a degree of values of the criteria. Obese type highly evaluate factors related to comfort, lean type highly evaluate related to design and dignity, but slightly lean type and slightly obese type lowly evaluate factors related to comfort and design. Improved some problems and carried out more concrete researches, the result of the research could be better utilized for establishing automobile sales-production policies and strategies.
임영빈,김동완 釜慶大學校 1997 釜慶大學校 論文集 Vol.2 No.2
The purpose of this study is to obtain reliability of heating equipments in apartment building. Field data concerning the failure of heating equipments in recorded at the apartments constructed 14 years ago are used. As a result of the field data analysis, failure time distribution and cumulative hazard function of boiler, heat exchanger, steam head and various pumps are expressed in Weibull probability graph. The scale and shape parameters, MTBF of each equipments are presented by regression line of Weobull probability graph. Presented parameter will be come into use a reference data to evaluate the reliability. to plan the maintence scheme, and to evaluate economic renewal of equipments.
任晶淳,朴東俊,金鎭大 경기대학교부설산업기술종합연구소 1990 산업기술종합연구소 논문집 Vol.6 No.-
The natural aggregates of main materials in concrete, such as sand and gravel, are exhausted, due to the increase of large scaled construction works. It therefore leaves us badly in need of the man-made aggregates. While we can use the stone which has been crushed as the coarse aggregate, we still depend on the sand as the fine aggregate. As the results of the effective reduction of fine aggregate content(s/a), we can obtain cheaper concrete by saving natural resourses and cement. The material test consists of two kinds of water cement ratio(w/c;45%, 40%) and each has four classes of unit cement:400㎏, 360㎏, 320㎏, 280㎏, each of which has five classes of fine aggregate content; 45%, 40%, 35%, 30%, 25% with annexed Fly ash of ten percents of cement weight. The results obtained from the data in this test are summarized as follows; 1. The maximum compressive strength of concrete(??) shows around 35% of s/a 2. We can notice more effective reduction of s/a in poor mixing concrete(below 320㎏ of unit cement). 3. It is advisable to use adequate Fly ash and admixture agents to improve the consistency and the bond strength of concrete.
김동석,임채경 대구대학교 외국어교육연구소 1993 외국어교육연구 Vol.8 No.-
In second language acquisition, some of the parameterized principles of UG seem to be obstacles rather than aids with the result of may errors in the actual use and interpretation of the target language. The purpose of this study is to suggest some ways to learn and properly use English anaphors and pronominals which are reported to be one of the most difficult categories for Korean students. The results obtained are summarized as follows: 1) The blind application of Binding Principles for English anaphora to Korean anaphoric expressions should be reconsidered. Parametric studies on the governing category for caki and ki should be counted in teaching or interpreting – self and he(she). 2) Honorification in Korean should be taken into consideration. Many Korean anaphoric expressions have no equivalents in English, which has no way to show social difference between speaker and hearer. 3) Ki, which is of relatively recent origin, is not widely accepted as equivalent for he. Some studies even show that ki is not a pronominal, but a deictic expression. From the above results, we can conclude that many errors in learning and using English anaphora can be attributed to the fact that simple translation method has been used in teaching English anaphora without considering the different parametric values between the two languages.