보상형 PID 재어기를 이용한 DC-서보모터의 속도 제어 시뮬레이션

박윤명,장종승,추연규,임영도 東亞大學校 附設 情報通信硏究所 1999 情報通信硏究所論文誌 Vol.7 No.1

본 논문은 Fuzzy Logic Controller를 이용하여 입력을 보상한, 보상형 PID 제어기를 제안한다. 이 제어기를 사용하여 DC-서보모터의 속도제어 특성을 조사하고, 단순 PID 제어기와 비교하여 제안한 제어기의 성능을 평가하였다. 성능 평가 방법은 MATLAB을 이용하여 DC-Servo Motor와 유사한 가상 플랜트를 설정하고, 부하 및 무부하시의 보상형 PID제어기와 단순 PID 제어기의 속도제어 성능을 모의 실험하였다. 모의 실험 결과 보상형 PID 제어기의 성능이 더 우수한 것으로 나타났다.

官僚制的 組織構造에 대한 批判과 組織改革의 主流

朴雨淳,李道連 東亞大學校 1997 東亞論叢 Vol.34 No.-

Bereaucracy has been considered as one of the most influential structural form in organization history. Numerous organizational theorists devoted much time and efforts devoted much time and efforts in developing bureaucracy and replacing it in order to improve organizational performance,but they failed to invent an alternative Although it is obvious that bureaucracy will continue to exist, many researchers stand against bureaucratic structure because of its disfunction and maladaptation. THey argue that organizational reform is just another word for debureaucratization and bureaucracy put much constraints on organizational growth and performance improvement. In this paper the authors attempt a critical review on the argument that organizational reform can be achieved only through debureaucratization. Organizational reform literature reveals that organizational success is derived form flattening hierarchy or debureaucratization. The authors strobgly contend bureaucracy should be the point of departure in organizational change and reform, particularly in Korean bureaucracy which is completely different from that of western cultures.

농업소득 안정화을 위한 직접지불제 도입 방안

박진도,황연수 東亞大學校生命資源科學大學附設 農業資原硏究所 1996 農業生命資援硏究 Vol.5 No.1

Farm price and income instability will reemerge as a major problem of agriculture in the post Uruguay Round period. The Korean government attempts to introduce the various types of direct payment allowed by WTO, and the farm income stabilization program is one of those. The objective of this study is to examine necessities for and devices of farm income stabilization program. The major findings of the study are summarized as follows: 1. Considering Agreement on Agriculture of UR, foreign examples and characteristics of korean agriculture, it is desirable to introduce a whole-farm income stabilization program like Canadian NISA(Net Income Stabilization Account) rather than programs by commodity. 2. The farm income stabilization program recommended in this study is a voluntary program that helps producers save money in good times to stabilize their incomes when farm revenues drop. In the program, producers deposit funds(1.5% of gross receipts) into their own account and receive a matching contribution(3% of gross receipts) from the government. 3. By introducing this program, stabilization and support of the farm income, increase of food production and maintenance of regional society are expected. Opinion survey showed that 80 percent of regional experts were in favor of this program. 4. The problems to be solved in the process of the program include conflicts with other programs, low participation rate of farmers, moral hazard in investigating eligible gross receipts, and administrative and technical difficulties.

溫經湯에 關한 文獻的 考察

김연도,김철원,유심근,박병렬 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

Through the study of successive literatures form the Han-dynasty(漢代) when 《Keumjweyeuliak(금궤요략)》 was written to modern age, we inspected many types of Onkyungtang(溫經湯) and prescriptions including the term of ' Onkyung(溫經)' or Chokyung(調經)', and look into their composition and symptoms respond to administration of this medicine. The results of this study were as follows; 1. The medicine which makes up Onkyungtang was 38 kinds from the Han-dynasty to the Chung-dynasty(淸代), and up to the present it summed into 43 kinds. 2. Onkyungtang which was composed of different kinds of medicine was 10 types from the Han-dynasty to the Chung-dynasty and added 11 types in modern days. Therefore it sumed up into 21 types. 3. No Onkyungtang is seen more common than that of the same composition as in 《Keumjweyeuliak》 in successive literature. The next is the same constituents as in 《Buinyangbangdaejeon(婦人良方大全)》. Others were rare. 4. Onkyungtang in《Keumjweyeuliak》was used to treat cold syndrome of the penetration and conception vessles or uterus of deficiency type and that in 《Buinyangbangdaejeun》was for cold syndrome of the penetration and conception vessels or uterus of excess type. 5. Other names of Onkyungtang in《Keumjweyeuliak》were Daeonkyungtang(大溫經湯), Chokyungsan(調經散), Chokyungtang(調經湯), Chunkeumchokyungtang(千金調經湯), Chunkeumchokyungsan(千金調經散) and Soonkyungtang(小溫經湯). And the prescription in the same constitution was also called Chungkyungonkyungtang(仲景溫經湯), Keumkweonkyungtang(금궤온경탕) and Sibbionkunghwan(十二溫經丸). 6. Onkyungtang in 《Buinyangbangdaejeon》was called Soonkyungtang(小溫經湯) and the very prescription was also called in the name of Yangbangonkyungtang(良方溫經湯), Jinmionkyungtang(指迷溫經湯), Kungkwiinkyungtang and Jinssionkyungtang(陳氏溫經湯).

Ex Vivo Expansion and 3-D Culture of Human Chondrocytes

Ji-Young Han,Seah Park1,Su Yeon An,Kyung Suk Kim,Seung H. Kim,Seung-Ho Koh,Wonjae Roh,Byung-Rok Do,Yong-Dal Yoon,Haekwon Kim 한국동물생명공학회(구 한국동물번식학회) 2004 발생공학 국제심포지엄 및 학술대회 Vol.2004 No.1

성인에서 Haemophilus influenzae 감염증의 임상양상과 미생물학적 특성

이종섭,황병연,정희진,김우주,박승철,이도현,이창규,신종희,황규잠,이영희 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.2

목적 : H. influenzae는 성인에서 흔히 호흡기 감염을 일으키는 균주로, 최근 ampicillin 내성 β-lactamase 생성 균주들이 지속적인 증가를 보이고 있어, 이에 국내 성인에서 H. influenzae에 의한 감염의 임상양상과 분리된 균주들의 미생물학적 특성을 조사하고자 하였다. 방법 : 1998년 3월부터 1999년 9월까지 고려대 구로병원에 내원한 환자중에서 H. influenzae가 분리된 68명을 대상으로 임상양상을 조사하고 항균제 감수성 검사를 시행하였다. 분리된 33주에 대해서 혈청형, 생물형, 세포외막 단백분석을 시행하였고, β-lactamase 생성여부에 따른 감염 환자군간 임상상 및 예후의 차이를 비교하였다. 결과 : 환자의 평균연령은 68세였고, 지역사회 획득감염이 전체의 85%를 차지하였다. 폐렴과 기관지염과 같은 하기도 감염이 전체환자의 75%를 차지하였고 분리 검체 역시 객담이 84%로 가장 많았다. 환자의 71%가 기저질환을 가지고 있었으며, 그 중에 만성 폐쇄성 폐질환, 심혈관 질환, 악성종양, 당뇨병이 대부분이었다. 혈청형으로는 nontypeable 형이 68%로 가장 많았고 b형은 한 예도 없었다. β-lactamase 생성율은 63.2%였고, β-lactamase 양성균주의 항균제 내성율이 음성균주에 비하여 높았으나 β-lactamase 생성 여부에 관계없이 cefotaxime, azithromycin, ciprofloxacin에 대하여 100%의 감수성을 나타내었고 cefaclor, cefuroxime에 대해서는 10% 이하의 낮은 내성율을 보여 이들 항균제들이 치료에 효과적일 것으로 사료된다. 세포외막 단백분석에서는 C형과 D형이 전체의 64%로 가장 많았으며, 혈청형과의 유의한 연관성은 보이지 않았다. 결론 : 성인에서 H. influenzae는 주로 만성 기저질환자에서 급성 호흡기감염 또는 만성 폐쇄성 폐질환의 급성 악화를 유발한다. 기존의 보고에 비해 β-lactamase 양성율이 증가하였고, 이에 따른 항균제 내성율도 증가하여 항균제의 선택에 유의하여야 할 것으로 생각된다. 세포외막 단백분석상 특정한 유형의 균주에 의해 감염이 집중적으로 발생하고 있어 향후 역학 조사의 도구로 이용할 수 있겠다. Purpose : H. influenzae is one of the common causative microorganisms of respiratory tract infections in adults. Recently. β-lactamase producing, ampicillin-resistant H. infiuenzae has become worldwide problem as well as in Korea. We studied to investigate the clinical features and microbiologic characteristics of H. infiuenzae infections in adults. Materials & Methods : From March 1998 to September 1999, 68 patients were enrolled in this study. Clinical features of H. infiuenzae infections were investigated, 68 isolates were subjected to the β-lactamase test, and 33 isolates were used for serotyping. biotyping, antibiotic susceptibility and outer membrane protein (OMP) analysis. Results : Mean age of study patients was 68 years-old and the acquisition rate in community was 85%. Pneumonia and bronchitis were the most common type of infection such as 80%, sputum was the most common clinical specimen for H. mQuenzae isolation. 70% of patients had chronic underlying diseases. Non-typeable strains were 68% and β-lactamase producing rate was 63%. There was no difference in the clinical features and prognosis of H. influenzae infection between the β-lactamase positivie and -negative groups. The susceptibility of cefotaxime, azithromycin, and ciprofloxacin was 100% and that of cefaclor, cefuroxime was under 10% in spite of β-lactamase positivity. In OMP analysis, C and D types were dominant (64%). Conclusion : H. influenzae caused acute respiratory infections in adults with chronic underlying disorders. This study shows higher β-lactamase producing rate and antibiotic-resistance rate than that were reported previously. OMP analysis shows that two major types of strains cause clinical infections intensively.

일차적 비확공성 골수강 고정술로 치료한 제3형 개방성 경골 골절

오창욱,경희수,김도헌,박일형,김풍택,인주철,우연기,이정엽 대한골절학회 2004 대한골절학회지 Vol.17 No.2

원발성 위장관 악성 림프종의 임상적 고찰 : 치료 결과를 중심으로

원종호,백승호,홍대식,오도연,박희숙 순천향대학교 1994 논문집 Vol.17 No.4

저자들은 1984년 3월부터 1992년 12월까지 순천향 대학교 부속병원에서 원발성 위장관 악성 림프종으로 진단되었던 23명을 대상으로 다음과 같은 결론을 얻었다. 1. 대상 환자의 나이의 중앙치는 44(23-75)세로 남녀비가 2.8 : 1이었다. 2. 원발병소는 위 10예(43.5%), 소장 8예(34.8%) 및 회맹장 이행부위 5예(21.7%)였고, 병기 Ⅰ??기 8예(34.8%), Ⅱ??기 12예(52.2%), Ⅲ기 2예(8.7%), Ⅳ기 1예(4.3%)였다. 동반된 다른 장기는 주로 복부 임파절이었으며 폐 임파절 침범이 1예 있었고, 간을 침범한 경우가 1예, 위장과 소장에 병발한 경우가 1예 있었다. 조직학적 분류로는 중등도 19예(82.6%) 및 고도 4예(17.4%)였고 10예(43.5%)에서 B 증후가 있었다. 3. 치료를 시행한 20예중 Ⅰ??기 7예는 수술적 치료후 보조항암화학요법을 시행하였으며, Ⅱ??기 13예중 진단적 개복술후 완전절제가 확인된 3예는 보조항암화학요법을, 불완전절제로 확인된 7예는 관해유도 항암화학요법을 시행하였고, 3예는 항암화학요법만을 시행하였다. 4. 치료를 시행한 20예의 생존기간은 중앙치 43(4-100??개월이었으며, 3년 생존율 60.9%, 5년 생존율 40.6%였다. 5. Ⅰ??기 7예의 생존기간은 중앙치 42(11-100??개월이었으며, Ⅱ??, Ⅲ기 13예에서 치료에 대한 완전 관해가 9례(70%), 부분관해(15%), 무반응이 2례(15%)로 관해율은 85%였으며, 생존기간은 중앙치 44(4-52??개월이었다. 6. 완전관해자가 진행시까지의 관해지속기간은 중앙치 43(10-56??개월이었으며, 3년 무병생존율 79.1%, 5년 무병생존율 36.2%였다. Over a 8-year period(March 1984 through December 1992), 23 patients with primary gastrointestinal non-Hodgkin's lymphoma treated at Soonchunhyang University Hospital were analyzed with the following results; 1. The mean age of the patients was 43(23-75) years with male to female ratio of 2.8 : 1. 2. The primary sites of lymphoma were stomach in 10(43.5%), small intestine in 8(34.8%), and ileocecal area in 5(21.7%) and by modified Ann Arbor system, stage Ⅰ?? was 8(34.8%), stage Ⅱ?? was 12(52.2%), stage Ⅲ was 2(8.7%), and stage Ⅳ was 1(4.3%). Histologic classification by Working formulation revealed 19 cases(82.6%) of intermediate grade and 4 cases(17.4%) of high grade. B symptoms were observed in 10 cases(43.5%). 3. Treatments were performed in 20 cases as follows : In 7 cases with stage Ⅰ, complete surgical resection with systemic combined chemotherapy was performed. In 13 cases with stage ⅡE and Ⅲ, complete resection with systemic combined chemotherapy in 3 cases, incomplete resection with combined chemotherapy in 7 cases, and combined chemotherapy only in 3 cases. 4. Median survival duration of 20 treated patients was 43(4-100?? months and 3-year survival rate and 5-year survival rate were 60.9% and 40.6%, respectively. 5. Median survival duration of 7 cases with stage Ⅰ?? was 42 months(11-100??. In 13 cases with stage Ⅱ??, Ⅲ, response to treatment was complete remission in 9(70%), partial remission in 2(15%), and no response in 2(15%) resulting 85% of response rate and median survival duration was 44(4-52?? months. 6. Disease free survival rate of achieving a complete remission was 43(10-56?? months and 3-year disease-free survival rate and 5-year disease-free survival rate were 79.1% and 39.2%, respectively.

돼지 신장세포(PK15)의 이종이식 거부반응에 대한 재조합 IL-18의 영향

최연실,김은미,김영관,박상연,심정현,윤도영,강형식,명평근 충남대학교 생물공학연구소 2004 생물공학연구지 Vol.10 No.1

Various cytokines including IL-1β, IL-2, IL-4, IL-10, IL-12p40, IFN-γ, and TNF-α have been recently reported to play important roles in both host and donor cell activations during xenotransplantation. Interleukin (IL)-18, a proinflammatory cytokine, can induce IL-4 and IL-13 production in T cells, NK cells, B cells, mast cells, and basophils. IL-18 has the capacity to stimulate innate immunity and both Th1-and Th2- mediated responses, but little is known to involve in the xenograft rejection. In order to investigate the role of IL-18 in xenograft rejection, we transplanted the pig kidney (PK15) cells to C57BL/6 mouse with or without intraperitoneal injection of mouse recombinatant IL-18. It was analyzed the population of T cell, B cell and NK cell in the mice transplanted with PK 15 cells and recombinant IL-18 by flow cytometry. We found that splenic CD3+ T cells were increased in mice injected PK15 cells with recombinant IL-18. These results suggest that recombinant IL-18 is critical in the xenograft rejection by increasing T cell population of the recipients.

돼지 신장세포(PK15)의 이종이식 거부반응에 대한 재조합 IL-18의 영향

최연실,김은미,김영관,박상연,심정현,윤도영,강형식,명평근 충남대학교 형질전환복제돼지연구센터 2004 논문집 Vol. No.8

Various cytokines including IL-1β, IL-2, IL-4, IL-10, IL-12p40, IFN-r, and TNF-α have been recently reported to play important roles in both host and donor cell activations during xenotransplantation. Interleukin (IL)-18, a proinflammatory cytokine, can induce IL-4 and IL-13 production in T cells, NK cells, B cells, mast cells, and basophils. IL-18 has the capacity to stimulate innate immunity and both Th1-and Th2- mediated responses, but little is known to involve in the xenograft rejection. In order to investigate the role of IL-18 in xenograft rejection, we transplanted the pig kidney (PK15) cells to C57BL/6 mouse with or without intraperitoneal injection of mouse recombinatant IL-18, It was analyzed the population of T cell, B cell and NK cell in the mice transplanted with PK 15 cells and recombinant IL-18 by flow cytometry. We found that splenic CD3+ T cells were increased in mice injected PKl5 cells with recombinant IL-18. These results suggest that recombinant IL-18 is critical in the xenograft rejection by increasing T cell population of the recipients.