캡슐내시경과 단일풍선 소장내시경으로 진단된 공장의 간질종양 1예

송도경,심기남,태정현,김경진,송명은,송하응,윤혜원,정가영,정정화 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.2

Gastrointestinal stromal tumors (GISTs) are common mesenchymal tumors that arise in the wall of the gastrointestinal tract. We report a case of obscure gastrointestinal bleeding due to a GIST of the jejunum successfully documented by videocapsule endoscopy (VCE) and single-balloon enteroscopy (SBE). A 36-year-old man with hematochezia was referred for further evaluation of no evidence of bleeding focus on esophagogastroduodenoscopy and colonoscopy. A VCE showed a suspicious ulcerative hyperemic mass that located in about 1 hour apart from duodenal second portion. SBE revealed a nonbleeding 4×2 cm mass with an ulcer at the proximal jejunum. The patient underwent laparoscopic resection without complication. Histological examination revealed a well circumscribed, dumbbell-shaped firm mass comprised of spindle cells. Immunohistochemical staining for CD 117 was diffusely positive, whereas staining for S-100, CD 34 and MIB-1 was all negative. It was confirmed to be a low-grade GIST at the proximal jejunum.

효율적 영역 기반 부호화를 위한 인간 시각 특성에 기반한 계층적 영상 분할

송근원,정광민,도경훈 東西大學校 1998 동서논문집 Vol.4 No.-

본 논문에서는 주관적 화질 및 객관적 화질을 유지하면서 영역 기반 초저속 부호화에서 병목 현상을 유발하는 과다한 윤곽선 정보를 효과적으로 줄일 수 있으며, 또한 각 계층에서의 전송 정보량를 조절할 수 있는 계층적 영상 분할 알고리즘을 제안한다. 제안한 알고리즘은 각 계층에서 수리 형태학에 기반한 계층적 영상 분할과 인간 시각 시스템(HVS)특성을 고려한 영역 병합으로 구성된다. 계층적 영상 분할은 3계층으로 이루어져 있으며, 영상 분할 수 인간 시각이 구분할 수 없는 두 인접 영역을 병합한다. 이때 인간 시각 시스템 특성에 기반하여 병합 순서를 결정하는 병합 우선 순휘 함수(MPF)를 제한하여 영역 병합을 수행한다. 실험을 통하여 제안한 알고리즘은 기존의 알고리즘보다 PSNR은 평균 0.14dB 낮으나, 윤곽선 정보량은 30% 줄일 수 있었으며, 또한 각 계층에서 전송 정보량을 조절할 수 있는 적응성이 있는 영상 분할 구조임을 알 수 있었다. In this paper, a new hierarchical image segmentation algorithm based on human visual system(HVS) characteristic, which can efficiently reduce information quantity to be transmitted without the degradation of the subjective and objective image quality, and which is suitable for region-based very low bit coding because it can control information quantity to be transmitted, is proposed. It consists of image segmentation based on mathematical morphology and region merging considering HVS characteristic for the pairs of two adjacent regions at each level of the hierarchy. Image segmentation is composed of 3-level hierarchical structure and in the region merging structure of each level, we extract the pairs of two adjacent regions which human vision can't discriminate, and then merge them. Since the proposed region merging method selects two neighbor regions to be merged and performs region merging according to merging order based on HVS characteristics, it can efficiently improve bottleneck problem caused by excessive contour information at region-based very low bit rate coding. In experimental results, though the PSNR by the proposed algorithm is about 0.14dB lower than that of conventional method, the subjective image quality is almost the same and the contour information to be transmitted is reduced as much as 23.9% on the average.

親電子性 芳香族 置換反應의 轉移狀態에 關한 理論的 硏究

朴柄珏,郭庚度,宋寧大 嶺南大學校 基礎科學硏究所 1991 基礎科學硏究 Vol.11 No.-

The transition state for electrophilic aromatic substitution was estimated by EHMO and CNDO/2 method. The transition state has been found to be δ-complex like model rather than π-complex like model for the substitution of a hydrogen in benzene with both proton and brominum ion. The electronic energies of δ-complex like models revealed the parallelism between the observed rate constant and the number of the substituted methyl groups in benzene. Consequetly, it can be generally thought that electrophilic aromatic substitution proceeds via δ-complex like model.

식도암과 위암이 동시에 발생한 원발성 중복암 1예

윤혜원,심기남,나선경,송도경,정정화,정가영 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.2

Double primary cancers are two independently developed cancers in an individual. There have been some reports on double primary cancer since Billroth reported it for the first time in 1879. Double primary cancer of the stomach and esophagus has been revealed a very low incidence worldwide. The incidence of an esophageal cancer with another primary cancer is reported to be 9.5∼27%, but double primary cancers in the esophagus and stomach have been rarely reported to our knowledge. In this study, we present here a case of double primary esophageal and stomach cancer in a 66-year-old man because of progressive dysphagia.

유산소성 운동이 노인들의 신체조성과 등속성 슬관절 근력 및 요부근력에 미치는 영향

한종우(Jong Woo Han),이상석(Sang Sug Lee),송분도(Bun Do Song),지용석(Yong Suk Ji),김난수(Nan Su Kim),서경호(Kyeong Ho Seo) 한국사회체육학회 2000 한국사회체육학회지 Vol.13 No.-

This study was designed to investigate the effect of a year aerobic exercise training on body composition, isokinetic knee and trunk muscular strength of elders. The subjects for this study were eighty healthy elderly people who were members of seniors tower at Song-Do Hospital and didn`t have any history of cardiorepiratory disease. Subjects have been trained three times a week for a year. The exercise program was made up of a 15-minute warm-up, cool-down. Stretching was performed every eight minutes for the prevention of injuries which could occur during the main exercise and quick recovery of the used muscle. Aerobic training was performed for each 15-20minutes using the treadmill and cycle ergometer at the intensity of 50-70% HRmax. For the data, all the measurements were represented by mean and standard deviation using SAS package(version 6.12). Statistical techniques for data analysis were paired t-test to determine the difference between pre and post exercise program. The 5% level of significance was used as the critical level for acceptance of hypotheses for the study. The following results were obtained from this study. 1. There is a statistically significant difference in the VO_2max, fat mass, lean mass and %body fat both old men and women after a year training. 2. There is not a statistically significant difference in the weight, WHR and thigh circumference both old men and women after a year training. 3. There is a statistically significant difference in the right knee flexor/extensor peak torque, peak torque % body weight, total work and total work % body weight both old men and women after a year training. 4. There is a statistically significant difference in the left knee flexor/extensor peak torque, peak torque % body weight, total work and total work % body weight both old men and women after a year training.

Differentiation between polycystic ovary syndrome and polycystic ovarian morphology by means of an anti-Mullerian hormone cutoff value

( Do Kyeong Song ),( Jee-young Oh ),( Hyejin Lee ),( Yeon-ah Sung ) 대한내과학회 2017 The Korean Journal of Internal Medicine Vol.32 No.4

Background/Aims: Although increased serum anti-Mullerian hormone (AMH) level has been suggested to be a surrogate marker of polycystic ovarian morphology (PCOM), its association with polycystic ovary syndrome (PCOS) is controversial, and its diagnostic value has not been determined. We aimed to observe the relationship between the AMH level and PCOS phenotypes and to determine the optimal cutoff value of AMH for the diagnosis of PCOS in young Korean women. Methods: We recruited 207 women with PCOS (120 with PCOM and 87 without PCOM) and 220 regular cycling women with normoandrogenemia (100 with PCOM and 120 without PCOM). Subjects underwent testing at a single outpatient visit. Serum AMH level was measured. Results: Women with PCOS had higher serum AMH levels than did regular cycling women with normoandrogenemia (p < 0.05). Women with PCOM had higher serum AMH levels than women without PCOM, regardless of PCOS status (p < 0.05). The optimal AMH cutoff value for the diagnosis of PCOS was 10.0 ng/mL (71% sensitivity, 93% specificity). Serum AMH was an independent determinant of total testosterone after adjustment for age, body mass index, and the number of menses/year (β = 0.31, p < 0.01). An association between AMH and hyperandrogenism was only observed in women with PCOS, and it was independent of the presence of PCOM. Conclusion: The serum AMH level can be useful for the diagnosis of PCOS at any age less than 40 years, and the optimal cutoff value for the diagnosis of PCOS identified in this study of young Korean women was 10.0 ng/mL.

특집- 비만 : 비만: 서론

송도경 ( Do Kyeong Song ),성연아 ( Yeon Ah Sung ) 대한내과학회 2013 대한내과학회지 Vol.84 No.5

Obesity is defined as abnormal or excessive fat accumulation that presents a risk to a number of chronic diseases, including diabetes, cardiovascular diseases and cancer. Therefore, obesity is associated with decreases in life expectancy. Also weight loss of 5-10% is associated with clinically significant health benefits. In Korea, a person with a body mass index of 25 kg/m2 or more is considered obese. In 2012, the U.S. Preventive Services Task Force (USPSTF) recommended screening all adults for obesity and USPSTF advised that clinicians offer or refer patients with obesity to intensive, multicomponent behavioral interventions. In Korea, management of obesity 2010 recommendation was published but there is no recommendation about screening for obesity. Because of the increasing prevalence of obesity, new recommendations on screening and efficient treatment for obesity and overweight are needed in Korea. (Korean J Med 2013;84:619-623)

The etiology of potential small-bowel bleeding depending on patient’s age and gender

Song, Joo Hye,Hong, Sung Noh,Kyung Chang, Dong,Ran Jeon, Seong,Kim, Jin-Oh,Kim, Jinsu,Lee, Bo-In,Choi, Myung-Gyu,Kim, Kyeong Ok,Yang, Dong-Hoon,Song, Hyun Joo,Hyuk Do, Jae,Jeong Lim, Yun,Shim, Ki-Nam SAGE Publications 2018 United European gastroenterology journal Vol.6 No.8

<B>Background</B><P> Whether the etiology of potential small-bowel bleeding depends on the age and gender of the patient is not yet fully understood. </P><B>Methods</B><P> A total of 1953 patients who underwent video capsule endoscopy (VCE) to evaluate potential small-bowel bleeding and were registered in the Capsule Endoscopy Nationwide Database Registry from 2003 to 2014 were eligible for this study. VCE findings and the etiology of small-bowel bleeding were analyzed by age and gender. </P><B>Results</B><P> The diagnostic yield of VCE was 48.4% (95% CI: 46.2%-50.6%) and the diagnosis rate of etiology of potential small-bowel bleeding was 61.4% (95% CI: 59.2%-63.6%). The etiology of potential small-bowel bleeding depends on the age and gender of the patient. Crohn's disease and small-bowel diverticular diseases were more prevalent etiology of potential small-bowel bleeding in the young adults group (@@<@@ 40 years) whereas angiodysplasia was revealed to be a most common etiology in elderly group (≥ 60 years), reaching statistical significance ( p@@<@@0.00152) by Bonferroni correction. </P><B>Conclusions</B><P> The etiology of potential small-bowel bleeding depends on the age of the patient. Thus, an individualized lesion-specific diagnostic approach based on age might be needed for patients with potential small-bowel bleeding. </P>

Single Nucleotide Polymorphism (SNP) Discovery and Kompetitive Allele-Specific PCR (KASP) Marker Development with Korean Japonica Rice Varieties

( Kyeong-seong Cheon ),( Jeongho Baek ),( Young-il Cho ),( Young-min Jeong ),( Youn-young Lee ),( Jun Oh ),( Yong Jae Won ),( Do-yu Kang ),( Hyoja Oh ),( Song Lim Kim ),( Inchan Choi ),( In Sun Yoon ) 한국육종학회 2018 Plant Breeding and Biotechnology Vol.6 No.4

Genome resequencing by next-generation sequencing technology can reveal numerous single nucleotide polymorphisms (SNPs) within a closely-related cultivar group, which would enable the development of sufficient SNP markers for mapping and the identification of useful genes present in the cultivar group. We analyzed genome sequence data from 13 Korean japonica rice varieties and discovered 740,566 SNPs. The SNPs were distributed at 100-kbp intervals throughout the rice genome, although the SNP density was uneven among the chromosomes. Of the 740,566 SNPs, 1,014 SNP sites were selected on the basis of polymorphism information content (PIC) value higher than 0.4 per 200-kbp interval, and 506 of these SNPs were converted to Kompetitive Allele-Specific PCR (KASP) markers. The 506 KASP markers were tested for genotyping with the 13 sequenced Korean japonica rice varieties, and polymorphisms were detected in 400 KASP markers (79.1%) which would be suitable for genetic analysis and molecular breeding. Additionally, a genetic map comprising 205 KASP markers was successfully constructed with 188 F2 progenies derived from a cross between the varieties, Junam and Nampyeong. In a phylogenetic analysis with 81 KASP markers, 13 Korean japonica varieties showed close genetic relationships and were divided into three groups. More KASP markers are being developed and these markers will be utilized in gene mapping, quantitative trait locus (QTL) analysis, marker-assisted selection and other strategies relevant to crop improvement.

Compensation of Incomplete Round Trip in an Herriott Multipass-Based Kerr-Lens Mode-Locked Ti:Sapphire Oscillator via an Output Coupler Position

Song, Dong Hoon,Hwang, Sung In,Ko, Do-Kyeong IOP Publishing 2011 Japanese journal of applied physics Vol.50 No.r3