http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : ( Dipendra Raj Pandey ) (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
( Amar Nagila ),( Dipendra Raj Pandey ),( Basant Kumar Tamrakar ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: The aim of this study was to determine the level of serum paraoxonase 1 (PON1) in young children with Non-Al coholic Fatty Liver Disease compared to healthy controls, and to examine the association of biochemical and hematological parameters with oxidative stress. Methods: Anthropometric measurements, blood pressure, biochemical and hematological parameters, abdominal ultra sonography (USG) and clinical examinations were assessed in all subjects to diagnose NAFLD. Forty seven young children di agnosed Non-Alcoholic Fatty Liver Disease and Forty seven age and gender matched healthy controls were enrolled and Serum PON1 levels, total antioxidant status (TAS), total oxidant status (TOS) were measured. Oxidative stress index (OSI) was calculat ed to indicate the degree of oxidative stress. Results: A total of ninety four children (51 boys, 43 girls) were included in this study, with 33 children age ≤ 10 years and 61 adolescents. Serum PON1 activity is significantly reduce in NAFLD children than control (110.81±7.43 Vs 152.73±12.72, P=0.003). In children with NAFLD, TAS level is significantly lower than control (1.19±0.22 Vs 1.37±0.41, P=0.03), where as TOS is increased significantly (0.24±0.05 Vs 0.17±0.03, P=0.05). Our results show that OSI is significantly higher in NA FLD group in comparison to the control groups (0.20±0.08 Vs 0.12±0.06, P<0.05). Conclusions: Our results suggest that NAFLD are associated with decreased PON1 activity and increased oxidative stress. Thus, in NAFLD patients, low level serum PON1activity may contribute in pathogenesis of carotid atherosclerosis from the childhood.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
