알레르기 ; 알레르기 환자에서 한방 이외의 대체 요법의 사용 현황에 대한 다기관 조사

이현정 ( Hyun Jung Lee ),이재현 ( Jae Hyun Lee ),이용원 ( Yong Won Lee ),김철우 ( Cheol Woo Kim ),동헌종 ( Hun Jong Dhong ),박해심 ( Hae Sim Park ),조영주 ( Young Joo Cho ),조진희 ( Jin Hee Cho ),조상헌 ( Sang Heon Cho ),편복양 ( 대한내과학회 2011 대한내과학회지 Vol.80 No.1

목적: 한국에서 알레르기 질환 치료를 위한 한방 치료뿐만 아니라 대체 요법이 많이 이용되고 있으며, 그 현황에 대하여 다기관 조사를 시행하였다. 방법: 10개의 대학병원 외래로 내원한 647명의 알레르기 환자를 대상으로 설문조사를 시행하였으며, 이 중 510명이 한방 이외의 대체 요법에 응답하였다. 이환되어 있는 알레르기 질환은 천식(50.0%), 알레르기 비염(36.0%), 아토피 피부염(36.0%), 그리고 두드러기(9.3%)였다. 각각 환자들에게 12 문항의 설문조사를 시행하였으며, 한방 이외의 대체 요법의 사용 빈도 및 종류, 대체 요법에 의지하게 된 이유, 비용, 그리고 치료효과에 대한 의견을 물어 보았다. 결과: 16.7%의 알레르기 환자에서 한방 이외의 다른 대체 요법을 받았으며, 평균 1.6종의 한방 이외의 대체 요법을 받았다. 가장 많이 의지하는 대체 요법은 민간 식이요법 (48.6%)이었고, 그 다음이 아로마 요법(23.8%), 지압(14.3%), 건강 호흡법(7.6%), 마인드 컨트롤(5.7%), 목욕요법(5.7%) 순이었다. 대체 요법을 받은 환자 중 마인드 컨트롤(50%), 식이요법(50%), 그리고 건강 호흡법(75%)의 경우 치료 효과가 만족스럽다는 응답이 높았으며, 목욕요법, 아로마 요법, 그리고 지압은 만족도가 각각 33.3%, 28.0%, 26.7%로 저조하였다. 대체 요법 사용자의 63.6%가 5회 미만의 대체 요법을 받았고, 91.8%가 1년 이내로 치료받았으며, 1인당 평균 연 37 만원을 지출하였다. 대체 요법을 선택한 가장 큰 이유는 체질이 개선될 수 있을까 해서(44.2%)였으며, 대체 요법이 몸에 부담이 없어서(31.4%), 면역기능이 강화되어서(22.9%) 순으로 나타났고, 15.7%는 양약치료가 도움이 되지 않아서 대체 요법을 선택하였다고 응답하였다. 결론: 한국에서 알레르기 환자의 상당수가 한방뿐만 아니라 여러 가지의 대체 요법을 사용하고 있음을 알 수 있었다. 대체 요법의 사용 빈도가 증가하고 그 종류가 다양함을 고려할 때, 의료진은 대체 요법의 현황에 대하여 정확히 인지하고 이에 대해 관심을 가지고 환자를 대하여야 하며 올바른 알레르기 질환 치료법에 대해 환자뿐만 아니라 의료인에게 교육하는 것이 필요하다. Background/Aims: The use of unproven complementary/alternative medicine (CAM) to treat allergies is popular in Korea. We conducted a multicenter survey of the current use of CAM other than herbal medication in Korean allergy patients. Methods: This study enrolled 510 adults with allergic diseases, including asthma, allergic rhinitis, atopic dermatitis, and chronic urticaria, from ten hospitals. They underwent a structured questionnaire interview and clinical assessment of the prevalence, motivation, costs, and subjective assessment of CAM. Results: Of the patients, 16.7% used at least one type of CAM to treat their allergic diseases. Common types of CAM were diet (48.6%), aroma therapy (23.8%), massage (14.3%), breathing exercises (7.6%), baths (5.7%), and mind control (5.7%). The therapeutic effects of CAM included improved in patients using mind control (50%), diet (50%), breathing exercises (75%), and baths (33.3%), but worse in patients using aroma therapy (28%), and massage (26.7%). About 36.4% of the patients used CAM more than four times per year, and the average cost per CAM user was 370,000 won/year. The main reason for trying CAM was `hope to improve my constitution`. Conclusions: CAM is used widely for treating allergic diseases in Korea. Detailed knowledge of CAM and patient education are important. Further studies of the clinical efficacy of CAM are needed. (Korean J Med 2011;80:68-77)

Three-dimensional computed tomography evaluation after single-bundle anterior cruciate ligament reconstruction: comparison of the position of femoral tunnel between modified transtibial and outside-in techniques

Dhong Won Lee,Sung Rak Lee,Sang Bum Kim,Jeong Ku Ha,Jin Goo Kim 대한정형외과 스포츠의학회 2014 Arthroscopy and Orthopedic Sports Medicine Vol.1 No.1

Background: The purpose of this study was to compare the femoral tunnel position by three-dimensional computed tomography (3D-CT) after anatomic single-bundle anterior cruciate ligament (ACL) reconstruction was performed using either a modified transtibial technique or outside-in technique. Methods: We evaluated 98 patients (group 1) who underwent the modified transtibial technique from December 2010 to October 2011, and 51 patients (group 2) who underwent the outside-in technique from May 2012 to March 2013. We retrospectively investigated the femoral tunnel position by taking postoperative 3D-CT scans. The femoral tunnel length was measured during surgery using a depth gauge. Results: When 3D-CT results were analyzed using the quadrant method, the mean t-value was 32.94% ± 5.16% and 33.27% ± 5.58% for groups 1 and 2, respectively (P = 0.717). Whereas, the mean h-value was 41.89% ± 5.58% and 42.32% ± 9.02% for groups 1 and 2, respectively (P = 0.725). A statistically significant difference was not seen between the two groups for either value. The femoral tunnel length was 36.77 ± 3.69 mm and 34.15 ± 3.16 mm for groups 1 and 2, respectively, and the tunnel length was found to be significantly longer for the modified transtibial group (P < 0.001). Conclusion: Our modified transtibial technique can be used to make an anatomical femoral tunnel during single-bundle ACL reconstruction to a similar degree as the outside-in technique. Thus, our technique is recommendable to use for the anatomical ACL reconstruction.

Correlation between Magnetic Resonance Imaging Characteristics of the Patellar Tendon and Clinical Scores in Osgood-Schlatter Disease

( Dhong Won Lee ),( Min Jeong Kim ),( Woo Jong Kim ),( Jeong Ku Ha ),( Jin Goo Kim ) 대한슬관절학회 2016 대한슬관절학회지 Vol.28 No.1

Purpose: This study aims to evaluate magnetic resonance imaging (MRI) findings in young adults with symptomatic Osgood-Schlatter disease (OSD) and compare those in young adults without OSD. Materials and Methods: We compared MRI findings between young adults with OSD (OS group, n=30) and the equivalent number of young adults without OSD (control group). Visual analog scale scores and Kujala scores were evaluated and correlation analysis was performed in the OS group. Results: In the OS group, MRI revealed that the patellar tendon was attached to the tibia more widely, resulting in a reduced free tendon portion, and more proximally to the articular surface (p<0.001). The correlation analysis between MRI findings and clinical scores showed statistically significant correlations (p<0.01). In the OS group, 43% presented with patellar tendinopathy or bone marrow edema at the distal attachments. Conclusions: Compared to the control group, the relatively small free portion and relatively proximal attachment of the patellar tendon were observed with MRI in the OS group. The free portion of the patellar tendon was positively correlated with the clinical scores. Patellar tendinopathy was also frequently encountered in the OS group.

Gene Expression Patterns Analysis in the Supraspinatus Muscle after a Rotator Cuff Tear in a Mouse Model

Lee, Yong-Soo,Kim, Ja-Yeon,Kim, Hyo-Nam,Lee, Dhong-Won,Chung, Seok Won Hindawi 2018 BioMed research international Vol.2018 No.-

<P>Rotator cuff tear is a muscle-tendinous injury representative of various musculoskeletal disorders. In general, rotator cuff tear occurs in the tendon, but it causes unloading of the muscle resulting in muscle degeneration including fatty infiltration. These muscle degenerations lead to muscle weakness, pain, and loss of shoulder function and are well known as important factors for poor functional outcome after rotator cuff repair. Given that rotator cuff tear in various animal species results in similar pathological changes seen in humans, the animal model can be considered a good approach to understand the many aspects of the molecular changes in injured muscle. To comprehensively analyze changes in gene expression with time following a rotator cuff tear, we established a rotator cuff tear in mouse supraspinatus tendon of shoulder. At weeks 1 and 4 after the tear, the injured muscles were harvested for RNA isolation, and microarray analysis was performed. Expression patterns of genes belonging to 10 muscle physiology-related categories, including aging, apoptosis, atrophy, and fatty acid transport, were analyzed and further validated using real-time PCR. A total of 39,429 genes were analyzed, and significant changes in expression were observed for 12,178 genes at 1 week and 2,370 genes at 4 weeks after the tear. From the list of top 10 significantly up- and downregulated genes at the 2 time periods and the network evaluation of relevant genes according to the 10 categories, several important genes in each category were observed. In this study, we found that various genes are significantly altered after rotator cuff tear, and these genes may play key roles in controlling muscle degeneration after a rotator cuff tear.</P>

Medial Meniscus Posterior Root Tear: A Comprehensive Review

( Dhong Won Lee ),( Jeong Ku Ha ),( Jin Goo Kim ) 대한슬관절학회 2014 대한슬관절학회지 Vol.26 No.3

Damage to the medial meniscus root, for example by a complete radial tear, destroys the ability of the knee to withstand hoop strain, resulting in contact pressure increases and kinematic alterations. For these reasons, several techniques have been developed to repair the medial meniscus posterior root tear (MMPRT), many of which have shown complete healing of the repaired MMPRT. However, efforts to standardize or optimize the treatment for MMPRT are much needed. When planning a surgical intervention for an MMPRT, strict surgical indications regarding the effect of pullout strength on the refixed root, bony degenerative changes, mechanical alignment, and the Kellgren-Lawrence grade should be considered. Although there are several treatment options and controversies, the current trend is to repair the MMPRT using various techniques including suture anchors and pullout sutures if the patient meets the indications. However, there are still debates on the restoration of hoop tension and prevention of arthritis after repair and further biomechanical and clinical studies should be conducted in the future. The aim of this article was to review and summarize the recent literature regarding various diagnosis and treatment strategies of MMPRT, especially focusing on conflict issues including whether repair techniques can restore the main function of normal meniscus and which is the best suture technique to repair the MMPRT. The authors attempted to provide a comprehensive review of previous studies ranging from basic science to current surgical techniques.

Quantitative measures of pivot shift on knee rotatory instability

Dhong Won Lee,Ji Hwan Lee,김두한,Jung Ho Park,Jin Goo Kim 대한정형외과 스포츠의학회 2018 Arthroscopy and Orthopedic Sports Medicine Vol.5 No.1

One of the key prerequisites to returning to sports activities after knee injury is restored rotatory instability. The pivot shift test is the standard way to evaluate rotatory instability. However, manual testing methods reliant on the subjective judgment of examiners may fail to discriminate the dynamic stages of rotatory instability, especially because the pivot shift phenomenon occurs as a result of combination of translation and rotation movements of the tibiofemoral joint. To this end, several studies have investigated novel ways to quantitatively measure kinematics of the pivot shift test by developing new measurement devices. Measurement devices, such as navigation, electromagnetic, and inertial sensors, and image analysis systems have been developed. Low-cost, non-invasive, and self-contained devices are gaining popularity for their ease of use. Here, we review the advantages and disadvantages of current measurement systems of pivot shift tests and summarize the relevant scientific knowledge of this field for future research.

Functional Effects of Single Semitendinosus Tendon Harvesting in Anatomic Anterior Cruciate Ligament Reconstruction: Comparison of Single versus Dual Hamstring Harvesting

Dhong Won Lee,Jae-Chan Shim,Sang Jin Yang,Seung Ik Cho,Jin Goo Kim 대한정형외과학회 2019 Clinics in Orthopedic Surgery Vol.11 No.1

Background: This study aimed to determine the effects of single semitendinosus tendon (ST) harvesting for anterior cruciate ligament (ACL) reconstruction by comparing outcomes of single ST and semitendinosus-gracilis tendon (ST-G) harvesting. Methods: ACL reconstruction with ST-G harvesting (D group, n = 60) or single ST harvesting (S group, n = 60) were included according to inclusion criteria. Subjective assessments included subjective International Knee Documentation Committee score, Lysholm score, and Tegner activity scale score. Objective assessments included isokinetic strength and functional tests. These tests were completed at 36 months of follow-up. Magnetic resonance imaging (MRI) and second-look arthroscopy findings were evaluated. In the S group, regeneration properties were assessed by serial ultrasonography (US). Results: The S group showed significantly less deep flexor strength deficit than the D group (p < 0.001). Deep flexor power deficits showed significant correlation with the shift of musculotendinous junction of the ST. There was significant difference in the cocontraction test between the groups (p = 0.012), and the S group tended to show better results in other functional tests at the last follow-up. There were no significant differences in graft tension and synovial coverage on second-look arthroscopy between the groups. In the S group, the regeneration rates assessed by US at the joint line and distal insertion were 81.7% and 80%, respectively at 6 months of follow-up. Conclusions: The S group showed significantly less deficit in deep flexor strength and tended to show better clinical results at the last follow-up than the D group. In the S group, more than 80% showed good regeneration at the 6-month follow-up. Hence, single ST harvesting is effective in minimizing flexor weakness and functional deficits and shows great potential for regeneration.

전방십자인대 재건술의 최근 경향 및 향후 발전 방향: 최신 지견 리뷰

Lee Dhong Won,Kim Ji Nam,Kim Se Woong,Cho Seung Ik,Kim Na Yeon,Park Byung Sun 대한스포츠의학회 2023 대한스포츠의학회지 Vol.41 No.4

As the number of anterior cruciate ligament (ACL) reconstructions has increased significantly, surgical techniques have also made a lot of progress, and clinical outcomes are improving accordingly. However, the authors still have different opinions on ACL anatomy, femoral tunnel position, how to make a femoral tunnel, and graft selection, and many parts are controversial. Major factors contributing to the failure of ACL reconstruction, such as technical errors and biological healing failures. To reduce technical errors, a comprehensive understanding of ACL anatomy and the ability to create a well-positioned femoral tunnel are crucial. This involves recognizing the advantages and disadvantages of three surgical techniques: modified transtibial, transanteromedial portal, and outside-in. To improve biological healing, the four principles of tissue engineering (cells, growth factors, scaffolds, and mechanical stimuli) have been increasingly explored in various methods of bioaugmentation. Residual rotational instability of the knee joint remains a significant concern. Since the rediscovery of the anterolateral ligament (ALL) in the knee joint, the role of anterolateral complex, including the ALL and the deep iliotibial band, as secondary stabilizers of anterolateral rotatory instability, has gained attention. In the quest to reinforce the anterolateral complex, there are two approaches: ALL reconstruction as anatomical reconstruction concept and lateral extraarticular tenodesis as a nonanatomical reinforcement concept.

Simultaneous Osteoperiosteal Autologous Iliac Crest Graft and Lateral Meniscus Allograft Transplantation for Osteochondral Lesion with Bony Defect and Lateral Discoid Meniscus Tear

( Dhong Won Lee ),( Jin Goo Kim ),( Jeong Ku Ha ),( Woo Jong Kim ) 대한슬관절학회 2016 대한슬관절학회지 Vol.28 No.2

The optimal treatment for combined osteochondritis dissecans (OCD) with considerable bony defect of the lateral femoral condyle (LFC) and torn discoid lateral meniscus is unclear. We present a case of a 15-year-old female who was a gymnast and had a large OCD lesion in the LFC combined with deficiency of the lateral meniscus. The patient underwent the "one-step" technique of osteoperiosteal autologous iliac crest graft and lateral meniscus allograft transplantation after a failure of meniscectomy with repair at another hospital. Twenty-four months postoperatively, clinical results were significantly improved. Follow-up imaging tests and second-look arthroscopy showed well incorporated structured bone graft and fibrous cartilage regeneration as well as stabilized lateral meniscus allograft. She could return to her sport without any pain or swelling. This "one-step" surgical technique is worth considering as a joint salvage procedure for massive OCD lesions with torn discoid lateral meniscus.

Clinical, Functional, and Morphological Evaluations of Posterior Cruciate Ligament Reconstruction With Remnant Preservation : Minimum 2-Year Follow-up

Lee, Dhong Won,Jang, Hyoung Won,Lee, Yong Seuk,Oh, Soo Jin,Kim, Jae Young,Song, Han Eui,Kim, Jin Goo SAGE Publications 2014 AMERICAN JOURNAL OF SPORTS MEDICINE - Vol.42 No.8

<P><B>Background:</B></P><P>Numerous posterior cruciate ligament (PCL) reconstruction techniques have evolved and have revealed satisfactory outcomes; however, the optimal operative method for PCL reconstruction remains controversial.</P><P><B>Hypothesis:</B></P><P>Transtibial PCL reconstruction with a remnant preservation technique would result in successful clinical, radiological, functional, and morphological outcomes. In addition, it was hypothesized that the results of combined PCL and posterolateral corner (PLC) reconstruction would be comparable with those of isolated PCL reconstruction.</P><P><B>Study Design:</B></P><P>Case series; Level of evidence, 4.</P><P><B>Methods:</B></P><P>A total of 168 patients who underwent arthroscopic PCL reconstruction with or without reconstruction of the PLC between March 2006 and June 2011 were retrospectively reviewed. Ninety-two patients who met the inclusion criteria were enrolled, and 47 of 92 patients who underwent combined PCL and PLC reconstruction were evaluated as a subgroup. The PLC was reconstructed using the single fibular sling method. The patients were assessed by means of the Lysholm score, International Knee Documentation Committee (IKDC) subjective knee score, and Tegner activity score. Stability was evaluated using a KT-2000 arthrometer and Telos device. Proprioception was assessed using the Biodex System. Follow-up magnetic resonance imaging (MRI) was performed in 34 patients, and second-look arthroscopic surgery was conducted in 36 patients.</P><P><B>Results:</B></P><P>The minimum follow-up duration was 24 months in all patients. Clinical outcomes and posterior instability improved significantly. The mean Lysholm score improved from 56.7 ± 7.1 to 89.3 ± 7.3, the mean IKDC subjective knee score improved from 53.3 ± 9.6 to 86.2 ± 6.1, and the mean Tegner activity score was 2.5 ± 0.8 preoperatively and 5.1 ± 1.3 postoperatively (all <I>P</I> < .001). The mean side-to-side difference on posterior stress radiography with the Telos device improved significantly, decreasing from 12.1 ± 2.5 mm to 2.7 ± 1.3 mm (<I>P</I> < .001). The mean side-to-side difference on varus stress radiography was reduced from 5.9 ± 0.8 mm preoperatively to 1.3 ± 1.0 mm after combined PCL and PLC reconstruction (<I>P</I> < .001). Postoperative proprioception recovered to a level similar to that of the uninvolved side, and MRI and second-look arthroscopic surgery showed a high rate of complete healing and synovialization in patients who underwent either isolated PCL reconstruction or combined PLC and PCL reconstruction.</P><P><B>Conclusion:</B></P><P>Transtibial PCL reconstruction with remnant preservation resulted in satisfactory clinical, functional, radiological, and morphological outcomes. The results of combined posterolateral rotatory instability were comparable with those for isolated PCL reconstruction with adequate PLC reconstruction.</P>