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Eshun, Derek,Saraf, Rabya,Bae, Soochan,Jeganathan, Jelliffe,Mahmood, Feroze,Dilmen, Serkan,Ke, Qingen,Lee, Dongwon,Kang, Peter M.,Matyal, Robina American Physiological Society 2017 environmental and exercise physiology Vol.122 No.6
<P>NEW & NOTEWORTHY Our research project proposes a novel method for drug delivery. Our patented PVAX nanoparticle can detect areas of ischemia and oxidative stress. Although there have been studies about delivering angiogenic molecules to areas of ischemic injury, there are drawbacks of nonspecific delivery as well as short half-lives. Our study is unique because it can specifically deliver NPY3-36 to ischemic tissue and appears to extend the amount of time therapy is available, despite NPY3-36's short half-life.</P>
Kinetics of penetration influence the apparent potency of vanilloids on TRPV1.
Lazar, Jozsef,Braun, Derek C,Tó,th, Attila,Wang, Yun,Pearce, Larry V,Pavlyukovets, Vladimir A,Blumberg, Peter M,Garfield, Susan H,Wincovitch, Stephen,Choi, Hyun-Kyung,Lee, Jeewoo American Society for Pharmacology and Experimental 2006 Molecular pharmacology Vol.69 No.4
<P>Evidence that the ligand binding site of TRPV1 lies on the inner face of the plasma membrane and that much of the TRPV1 itself is localized to internal membranes suggests that the rate of ligand entry into the cell may be an important determinant of the kinetics of ligand action. In this study, we synthesized a BODIPY TR-labeled fluorescent capsaicin analog (CHK-884) so that we could directly measure ligand entry. We report that CHK-884 penetrated only slowly into Chinese hamster ovary (CHO) cells expressing rat TRPV1, with a t1/2 of 30 +/- 4 min, and localized in the endoplasmic reticulum and Golgi. Although CHK-884 was only weakly potent for TRPV1 binding (Ki = 6400 +/- 230 nM), it was appreciably more potent when assayed by intracellular calcium imaging and was 3.2-fold more potent with a 1-h incubation time (37 nM) than with a 5-min incubation time. Olvanil, a highly lipophilic vanilloid, yielded an EC50 of 4.3 nM upon intracellular calcium imaging with an incubation time of 1 h, compared with an EC50 value of 29.5 nM for calcium imaging assayed at 5 min. Likewise, the antagonist 5-iodo-resiniferatoxin (5-iodo-RTX) displayed a Ki of 4.2 pM if incubated with CHO-TRPV1 cells for 2 h before addition of capsaicin compared with 1.5 nM if added simultaneously. We conclude that some vanilloids may have slow kinetics of uptake; this slow uptake may affect assessment of structure activity relations and may represent a significant factor for vanilloid drug design.</P>
Performance Progress and Leadership Behavior
Frode Moen,Rune Hoigaard,Derek M. Peters 한국코칭능력개발원 2014 International Journal of Coaching Science Vol.8 No.1
The aim of this study was to investigate the relationship between athletes’ perceptions of their coaches’ leadership behaviours and their rating of their own satisfaction with their performance progress whilst under the guidance of this coach. Participants were 120 competitive athletes (M age = 20.3 years, SD =4.6) from different individual sports. Participants completed the Leadership Scale for Sports (LSS) and rated their own perceived satisfaction with their own performance progress underneath their present coach on a scale of 1 ‘extremely dissatisfied’ to 7 ‘extremely satisfied’. A one-way ANOVA analyses was used to test the differences between three composite satisfaction categories of ‘not satisfied (1-4)’, ‘satisfied’ (5) and ‘more than satisfied’ (6-7). The results indicate that the athletes who are most satisfied with their performance progress, evaluate their coaches’ leadership behavior higher in the following domains: Training and Instruction, Democratic behavior, Social Support, and Positive Feedback. Findings from the present study highlight the importance of coaches’ training and instruction behavior. The present study also highlights that the coach-athlete relationship must entail elements of reciprocity, trust, as well as being of a genuine and helping nature, and that coach’s democratic behaviour, supportive style and their ability to give positive feedback seem to support such values.
Team Identification Reduces Social Loafing and Promotes Social Laboring in Cycling
( Rune Høigaard ),( Filip Boen ),( Bert De Cuyper ),( Derek M Peters ) 한국스포츠정책과학원(구 한국스포츠개발원) 2013 International Journal of Applied Sports Sciences Vol.25 No.1
The purpose was to examine if heightened team identification reduced social loafing and promoted social laboring in 1 and 3 minute cycling time-trials with participants alone and then in either salient or non-salient teams. Salient teams were created using 30 minutes of team building activities prior to their team time trials. Social loafing occurred in both team trials in the non-salient teams (P < .05). In the salient teams, social loafing was eliminated in the 1 minute team trial and social laboring was apparent in the 3 minute team trial (P < .05). Heightened team identification therefore reduced social loafing and significantly enhanced team performance.
아시아지역 고추 토마토 품종육성 기술 개발 협력 과제 수행 결과 및 금후 계획
조명철,양은영,정효봉,조인숙,김우재,박종윤,권택윤,장성회,Derek Barchenger,Peter Hanson,Lawrence Kenyon 한국국제농업개발학회 2022 한국국제농업개발학회 학술대회 Vol.2022 No.09
본 연구과제는 아시아지역 AFACI(Asian Food & Agriculture Cooperation Initiative) 회원 13개국을 대상으로 토마토 또는 고추 품종육성 기술을 지원하기 위해 수행 되었다. AFACI 회원국 별 채소 육종 및 종자 생산, 가공, 유통 기술 수준 차이가 크다. 라오스, 미얀마, 캄보디아 등의 회원국에서는 자가 종자 생산이 어려워 필 요 종자의 70~80%를 다른 나라에서 수입하여 활용하고 있다. AFACI 회원국들의 자가 종자 생산기술 향상을 통한 자체 종자 생산을 지원하기 위해 회원국들의 요 청을 받아 고추 또는 토마토 작목의 품종육성 기술지원을 수행하였다. 회원국에서 보유하고 있는 다양한 재래종 자원들의 수집, 평가 및 선발과 세계채소센터에서 육성한 자원들을 공급받아 육종 재료로 활용하였다. 본 과제는 2019년 11월부터 2022년 10월까지 1단계 과정을 통해 회원국별로 다양한 성과들을 창출하고 있다. 효율적인 기술지원을 위해 세계채소센터 전문가들을 활용하여 육종 기술과 재료 들을 공급하였다. 2단계에서는 1단계에서 확보된 다양한 자원들을 활용한 우수 고 정종 품종 등록과 일대잡종 품종육성 기술을 지원할 계획이다. 육성된 품종들은 국가별 품종 등록 절차에 따라 품종보호출원 및 농가 보급을 추진할 계획이다. 1 단계에서는 코로나 19로 인한 대면 교육이 불가능하여 국내 종자회사들과의 소통 이 어려웠다. 하지만 2단계에서는 대면 교육 기회를 확대하고, 국내 채소 종자 업 체와 회원국의 연구원들 간의 소통을 확대하여 국내 종자 기업들의 해외 진출에 도 기여 할 수 있도록 노력할 계획이다.