열벽 적층 성장법에 의한 자성 반도체 Zn_1-xMnxTe 에피층의 성장과 특성

정양준,최용대 목포대학교 기초과학연구소 2000 基礎科學硏究誌 Vol.18 No.-

In this study, semimagnetic Zn1-χMnχTe epilayers were epitaxially grown by hot wall epitaxy, and their characterization were systematically examined. The maximum Mn composition χ of the Zn1-χMnχTe epilayers was χ=0.97. The crystallographic orientation and the structure of the Zn1-χMnχTe epilayers were the (100) orientation and the zincblende structure, respectively, identical to those of the GaAs substrate. Mn composition χ increased with increasing the substrate temperature, and the epilayers of the good quality were grown when the substrate temperature was 350∼370℃. Both the lattice constants and the bandgap energy linearly increased with increasing Mn composition χ.

F형 종골 금속판의 역학적 특성

양규현,박영희,원정훈,김대야 대한골절학회 2004 대한골절학회지 Vol.17 No.2

각종 피부종양에서 p53과 bcl-2 발현양상

정용민,양승하,이성열,김대중,김의한 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.1

Background : The function of p53 protein was known to accelerate the apoptosis, but bcl-2 protein was known to suppress the apoptosis. The overexpression of p53 and bcl-2 proteins has been reported in many malignant tumors. Although the mechanism of tumorgenesis of the p53 and bcl-2 protein took hasnot been proved, bcl-2 positive tumors contrast to p53, appeared to have good prognosis. The expression pattern of p53 and bcl-2 in epidermal tumors has not been well known. The author analyzed immunohistochemical expression of p53 and bcl-2 protein and investigated the role of p53 and bcl-2 protein in the developing tumors of epidermal origin. Method : 15 cases of squamous cell carcinoma, 20 cases of basal cell carcinoma, 10 cases of keratoacanthoma and 6 cases of Bowen's disease were stained immunohistochemically stain with anti p53 and anti bcl-2 monoclonal antibody. Results : 1. In squamous cell carcinoma, the reaction of p53 was positive in 13 cases(86%) and the stain pattern showed more intensive reaction in poorly differentiated cells in the same tumor. bcl-2 showed negative in all cases of squamous cell carcinoma(0%). 2. In basal cell carcinoma, the reaction of p53 was positive in 10 cases (50%). The positive cells were mainly observed in squamous metaplastic portion, but the reaction was weak. bcl-2 showed positive in all cases of basal cell carcinoma (100%) and the reaction was strong. 3. In keratoacanthoma, p53 was positive in 7 cases (70%). The positive cells were mainly observed in the cells around the basement membrane. This finding suggested that p53 positive basal cells were programmed to become keratoacanthoma. bcl-2 was negative in all 10 cases of keratoacanthoma. (0%) In some cases, bcl-2 positive cells were observed around the basement membrane in some cases., which were negative to p53 This finding suggested that the existence of these bcl-2 positive cells were related to the prognosis of keratoacanthoma. 4. In Bowen's disease, p53 was positive in 5 cases ( 83% ) and the reaction was strong, so the tumor cells in Bowen's disease appeared to be poorly differentiated type. bcl-2 was negative in all 6 cases ( 0% ) of Bowen's disease, but bcl-2 positive cells were observed in the basement membrane in some cases.

유세포 측정을 통한 CD34^(+)세포의 정량방법 비교

양형모,서영훈,엄현석,민창기,김희제,정대철,이종욱,진종율,한치화,김춘추,김학주 대한조혈모세포이식학회 1998 대한조혈모세포이식학회지 Vol.3 No.2

본 연구소에서는 현재 CD34^(+) 세포의 정량에 사용되고 있는 4가지 서로 다른 방법을 가지고 골수에 적용하여 그 결과를 비교하였다. 각각의 방법들이 편리한 점과 불리한 점들을 가지고 있었지만, 통계적으로는 유의한 차이를 보이지 않았다. 1) CD34-PE/CD45-FITC 방법13(ISHAGE: International Society of Hematotherapy and Graft Engineering), 2) CD34-PE/CD14-FITC 방법, 3) CD34-PE/CD14-FITC/CD45-PerCP 방법, 4) DNA dye/CD34-PE/CD45-PerCP4(Becton Dickinson) 등을 비교하였으며 그 결과 CD34^(+) 세포의 농도는 다음과 같았다. 1) 0.473±0.345, (%Mean±SD, N=70) 2) 0.663±0.519, (N=20), 3) 0.543±0.381 (N=46), 4) 0.624±0.341, (N=32). 시료로는 여의도 성모병원 카톨릭 조혈모세포이식 센터에서 채혈한 골수를 이용하였다. Four different methods for flow cytometric quantitation of CD34+ cell were compared using bone marrow samples (n=168). Following combination of antibodies were used for the analysis : A) CD45-FITC/CD34-PE (n=70), B) CD14-FITC/CD34-PE (n=20), C) CD14-FITC /CD34-PE /CD45-PerCP(n=46), D) DNA dye/CD34-PE/CD45-PerCP (n=32). Each method showed no significant differences among them (P=0.126, ANOVA test, SPSS Version 7.5). When we compare these methods using same samples (n=12), the P value became 0.832. The mean % of CD34+ cells calculated in this experiment were A) 0.474%, B) 0.663%, C) 0.548%, D) 0.624% respectively. In our laboratory, we decided to use CD45-FITC/CD34-PE methods as a routine protocol.

표준 원자력발전소 확률론적 안전성 평가의 인간 신뢰도 분석 평가

강대일,정원대,양준언 한국안전학회 2003 한국안전학회지 Vol.18 No.2

Based on ASME probabilistic risk assessment (PRA) and NEI PRA peer review guidance, we evaluate a human reliability analysis (HRA) in probabilistic safety assessment (PSA) for Korea standard nuclear power plants, Ulchin Unit 3&4, to improve it performed at under design. The HRA for Ulchin Unit 3&4 is assessed as higher than Grade I based on ASME PRA standard and as higher than Grade 2 based on NEI PRA peer review guidance. The major items to be improved identified through the evaluation process are the documentation, the systematic human reliability analysis, the participitation of operators in the works and review of HRA. We suggest the guidance on the identification and qualitative screening analysis for pre-accident human errors and solve some items to be improved using the suggested guidance.

체육수업에서의 운동상해에 관한 연구

윤기대,양정옥,김영수 신라대학교 교육과학연구소 2004 교육과학연구 Vol.- No.9

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

잉어 담즙이 간장에 미치는 영향에 대한 연구

김대중,양승하,안상묵,강상균,김의한 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1

To investigate the effect of Cyprinus carpio bile acid on human liver, concentrated and 10:1 diluted Cyprinus carpio bile acid were injected at the dose of 10ul at mouse tail vein One, three, five, seven and nine days after injection, the mice were sarcificed. The change in hepatic function were estimated by determining GOT, GPT and compared to histologic findings of liver tissue. The results of GOT level was not consistent, but the GPT was significant. From these, we concluded. 1. In concentrated injected group (A), the GPT level was highest in first day and the increased level lasted through observation. 2. In 10:1 diluted injected group (B), the GPT level was only high above normal in first day. Thereafter, the GPT level curiously decreased below the normal, which need more study. 3. Histologic hepatic changes in A group, until 3 days, hepatic cell cord disarrary and marked hepatic cellular degeneration around the central vein were seen. Therefater, although elevated GPT level, the hepatic changes showed only mild regenerated change Histologic hepatic change in B group showed no remarkable change. Above findings suggested that the liver injury was dependent on injected concentration and the hepatic injury, which was observed in early phase, appeared to be reversible. So the hepatic injury by the Cyprinus carpio bile acid appeared complete recovery course without specific complication.

단체교섭의 메카니즘에 관한 연구

강정대,양시영 全北大學校 1996 論文集 Vol.42 No.-

With the democratization of industrial and labor relations in Korea, collective bargaining has emerged as the most important social phenomena. This study, through the examination of various bargaining power, style theories and comparison the model of bargaining partner of three countries, if aimed at finding out the sucessful bargaining model that can satisfy both labor and management. Bargaining partner model (1)Germany : The ability to conclude collective agreements (2)U.S.A. : Appropriate bargaining unit (3)Japan : Bargaining partner under the provisions of constitional law and trade union act Collective bargaining power various according to the viewpoint of bargaining power, collective bargaining power depends upon several complex requestes rather than a single one. The study on collective bargaining power theories has been made through several board approaches such as the economics approach, behavioral secience approach, integative approach(Kochan, T.A. & Katz, H.C.,). It is necessary to apply rigorous methodologies such as study on the bargaining partner in various types of bargaining, study on the bargaining power, and study on the strike-adjustment ability in order to expand the application of integrate collective bargaining study.

강자성체에서 상전이의 수치적 모의실험

유대영,양해정,양회룡,정진,최승평,장차익 조선대학교 기초과학연구소 2001 自然科學硏究 Vol.24 No.-

It is difficult to explain the magnetic phase transition with classical physics in Curie temperature. We studied qualitatively with the well known Ising model in statistical mechanics. We simulated systems of finite size by Monte Carlo methods with Metropolis algorithm. Thus we could estimate the values of quantities such as the magnetization(m) per spin the specific heat(c) per spin the magnetic susceptibility(χ) per spin, and the mean energy per spin compare with the numerical values in infinitive size. The quantities of c, m, χ, e varied rapidly within 2.3∼2.4 temperature at J/k units. Those values show that the critical temperature can be within the range. The hysteresis loop was obtained with this model.