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The clinical significance of Inca serum CA-125 in gynecological diseases
( Dae Gy Hong ),( Su Kyung Seong ),( Gun Oh Chong ),( Yoon Soon Lee ),( Il Soo Park ),( Young Lae Cho ) 대한산부인과학회 2010 Journal of Womens Medicine Vol.3 No.3
Objective: The goal of this study was to evaluate the level of Inca serum CA-125 of women with gynecologic diseases, including malignant diseases, and to assess the usefulness of these levels in the diagnosis and screening for gynecologic diseases. Methods: We retrospectively analyzed the level of serum CA-125 of 3,920 women who visited the outpatient clinic in Department of Obstetrics and Gynecology or the Health Screening Center of the Kyungpook National University Hospital between January 1999 and December 2007. Among the women, some were diagnosed with gynecologic diseases and others were disease-free, including gynecologic and other diseases. The level of serum CA-125 was measured using enzyme immunoassays. The distribution of serum CA-125 was made into a normal distribution through log substitutions (Inca serum CA-125). Statistical analysis was performed by independent t-tests. Results: Compared with the normal group, pelvic inflammatory diseases (P<0.01), endometriosis without adenomyosis (P<0.01), uterine leiomyomas (P<0.01), adenomyosis (P<0.01), and ovarian cancer (P<0.01) showed a statistically significant increase. The CA-125 level in the group with adenomyosis (P=0.57) did not show any statistically significant difference compared to the ovarian cancer group. As the stage of ovary cancer advanced, the level of Inca serum CA-125 was statistically increased (P-trend=0.0046). Conclusion: The level of Inca serum CA-125 is useful in the diagnosis of ovary cancer and adenomyosis, but not useful in differentiation between the two diseases in this study.
홍대기 ( Dae Gy Hong ),( Eun Hee Kim ),( Joo Young Kim ),( Yoon Hee Lee ),( Gun Oh Chong ),( Ji Young Park ) 대한산부인과학회 2015 대한산부인과학회 학술대회 Vol.101 No.-
Objective: This study was aimed to compare immunohistochemical expression of estrogen receptor (ER)a, progesterone receptOf (PR), and calponin in gonadotrophin-releasing horrrone agonist (GnRH-a)-sensilive and -resistant uterine fibroids. Methods: We collected data retrospectively. The sensitive group consisted of women who had reduction in uterine volume greater than 40% following GnRH-a treatment. Uterine volume was either reduced by less than 10%, or was increased in the resistant group. A tissue microarray was constructed using formalin-fixed, paraffin-embedded tissues, 31 and 26 patients for the sensitive and resistant groups, respectively. Tissue sections were immunostained with antibodies against ER-a, PR. and calponin. The intensity and area of the immunohistochemical reactions were evaluated using a semi-quantitative scoring system. The Mann-WhitneyU-test, Fisher``s exact test. and Spearman``s rank correlation test were used for analysis of data. Results: PR (P= 0.04) and calponin (p= 0.03) showed a significantly higher staining intensity in the resistant group than in the sensitive group. Both groups showed comparable expression of ER-a (P = 0.23). In correlation analysis between changes in uterine volume after GnRH-a therapy and clinicopathological factors, the immunohistochemical intensity 01 PR (P= 0.04) 2nd calponin (P= 0.03) was significantly correlated with changes in uterine volume. Conclusion: This study shows that GnRH-a resistance of uterine fibroids is not related to ER-a content. but the expression of PR and calponin is related with GnRH-a resistance.
DNA and the SU(3) Invariant of Knots and Links
Jeong, Myeong-Ju,Hong, Dae Gy Department of Mathematics 2013 Kyungpook mathematical journal Vol.53 No.3
To analyze the enzyme reaction on DNA knots and links, we study tangle embedding and the number of reaction. By using the quantum SU(3) invariant of knots and links we get a necessary condition for a tangle to be embedded in a knot or link. Moreover we give a relationship between the number of reactions and the changes of the value of quantum SU(3) invariant for the corresponding knots and links in a processive recombination.