Water-soluble Genistin Glycoside Isoflavones Upregulate Antioxidant Metallothionein Expression and Scavenge Free Radicals

Chung, Mi-Ja,Kang, Ah-Young,Jun, Hee-Jin,Kim Sang-Yeon,Moon, Tae-Hwa,Park, Kwan-Hwa,Lee, Sung-Joon 생명자원연구 2005 생명자원연구 Vol.13 No.-

Head-Space SPME에 의한 생체시료 중 메스암페타민류 분석(Ⅲ)

박미정,최상길,손행자,최화경,최영남,허상철,박종서,정희선 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-

활동적 배호상 해분의 Zero Age Depth의 변화에 관한 연구

박충화 대전대학교 환경문제연구소 2001 환경문제연구소 논문집 Vol.5 No.-

Equations of the linear relationship including zero age depths between the basement depth and the square root of age for 6 active back-arc basins, were obtained from the statistical analysis of a great number of underway bathymetric profiles. Active back-arc basins show a large variety of zero age depths ranging from the shallowest Manus Basin to the deepest Mariana Trough. Variations in zero age depth appear to show glood correlations ulith the dipping angle of slab, convergence rate, spreading rate, and cooling coefficient. The dipping angle of subducting slab increases with the increase of the zero age depth. As the convergence rate decreases, the zero age depth also becomes deeper. The variation in zero age depth of active back-arc basin seems to be caused by the mechanical supporting of the subduction slab. Zero age depths are deeper with the decrease of spreading rates and cooling coefficients.

의약품의 효능별 안전성·유효성 평가에 관한 조사연구(Ⅰ) : 항균제 Antiboiotics

박윤주,최기환,김동섭,박인숙,정면우,임화경,오우용,강주희,박찬웅,김주일 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

새로운 물질이 개발되어 신약으로 탄생하기까지 많은 시간과 노력, 예산이 필요하다. 최근, 우리 나라에서도, 신약캐발이 어릴고 힘든 분야이지만 새로운 신약개발을 총해 얻어지는 분가가치가 막대함을 인식, 연구에 박차를 가하 있는 실정이다. 본 연구는, 의약품 개발 선진국인 미국 FDA에서 발행하는 참고자료 중 항균제 임상편가에 대한 가이드라인 및 주요 임상적응증별 항균제 기발(지역사획회득성 폐렴, 원내감염성 계렴, 급성기관지염의 2차세균감염, 만성기지염의 급성세균성 악화, 연쇄구균에 의한 인두영 및 편도염 , 단순성 요로감염증, 복합성 요로감염증 및 신우신영, 급성 세균성 부비동옆, 항 바이러스제 개발시 전임상단계에서 고려사항, 항 바이러스제 허가와 된련 잉상적 고려사항, 카레타 괸련 혈류감염)에 있어서의 파이드라인 등의 자료를 소개함으로져, 향후 제약사의 항균제 신약개발 및 허가 신청된 의악품의 전임상차료 및 잉상시험자료의 검토 평가업무에 참고자료로 활용될 수 있을 것이다. Changing or unclear interpretations of clinical trial data needed to demonstrate the effectiveness and safety of antimicrobial drug products have a times led to confusion and frustration on the part of both applicants and division of these drug products reviewers. The FDA published guidance on desing clinical protocols, implementing, and analyzing data from clinical trials for antimicrobial drug products has been presented and additional companion guidances introduced specific issues to individual infections. This document provides applicants and reviewers with minimal information appropriate for the clinical development of routine antimicrobial drug products and identifies issues common to many antimicrobial drug applications. The agency can use the kind of information to determine whether the antimicrobial drug product under study is safe and effective in the treatment of the specific infection studied.

多層神經回路網 學習方法의 一般化性能에 대한 考察

박두일,윤충화 명지대학교 공학기술연구소 1991 공학기술연구소 논문집 Vol.6 No.-

Artificial neural network has offered distributed processing power, error correcting capability and structural simplicity of the basic computing element. Basically, neural nets are self-adaptive systems that try to configure themselves to store new information. The Error Backpropagation Algorithm is one of the most widely-used learning algorithms for multi-layered neural networks, but it has a serious drawback that it requires a lengthy learning time, even for a moderate number of input patterns. In this paper, we proposed a specific definition of generalization concept and comparatively analyzed methods which enhance the generalization property and techniques which reduce the learning time, based on this definition.

女子老人의 衣服購買行爲에 관한 實態分析

박화순,배정숙 대구대학교 기초과학연구소 1984 基礎科學硏究 Vol.1 No.-

The purpose of this study were to explore the present conditions of ready-made, purchasing behavior, and satisfaction of old women who were more than sixty years old in Daegu City, and to aid the development of old women's clothing by analyzing to compare popular old women with College for the Aged. The participants consisted of 145 popular old women and 137 College for the Aged. The data were collected by questionnaires. The statistical analysis of the obtained data included Percentage Method. The specific findings of this study were as follows: 1. The percent of clothing concern showed higher College for the Aged than popular old women. 2. In the purchasing channel and discussion College for the Aged highly depended on their sons (daughters) and popular old women their own purchasing. 3. The ready made were more important in saving of effort and time. 4. Old women were not advertizing but effected a little by showwindow. 5. Old women chose more convenient, less expensive, and sellected the better things in color and style. 6. More than half of the old women were relevant from 20, 000 won to 50, 000 won in price. 7. On the ready made old women were highly satisfied with its textile, color, pattern, and purchasing-place and dissatisfied with comodities of bargain sale, sewing, waist-line, and sleeve-length in size.

만성 골수성 백혈병 환자에서 발생한 거대 후복막강내 혈종 1예

박기령,김영선,박사영,최진혁,이순남,정화순 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.1

Thrombohemorrhagic complications in chronic myeloproliferative disease(CMPD) including chronic myelogenous leukemia(CML) are not rare. Lower incidence of disordered hemostasis is reported in CML compared with other CMPD. The mechanism of thrombohemorrhagic complications might be a consequence of qualitative platelet abnormalites and prolonged bleeding time rather than that of thrombocytosis. Although defect of platelet function has been extensively investigated, there was no established consistent correlation between clinical bleeding and number and function of platelet. The most common site of bleeding complications in the CMPD is superficial mucosa. Bleeding in deep tissue and viscera is very unusual. We report a case of CML which developed a huge spontaneous retroperitoneal hematoma.

비정상적 심해성 연해해분에 관한 연구

박충화 大田大學校 環境問題硏究所 1998 환경문제연구소 논문집 Vol.3 No.-

One One remarkable correlation has been noticed with a number of marginal basins are being subducted by itself. For example, extinct Philippine Sea basins are subducted: the West Philippine Basin at the Philippine and Ryukyu Trenches, the Shikoku and Parece Vela Basins at the Nankai Trough. Similar cases are observed in China with the Manila Trench, the South Fiji Basin with two subduction zones: the Hunter subduction zone in the northwestern and of the basin, and the Kadavu subduction zone in the northeastern end of the basin and the Solomon Basin with three subduction zones, the New Britain, the Bougainville and the Trobriand Trenches. All these basin basins are several hundreds meters deeper than the normal oceans. The Sulu and Celebes Basins have traces of past subduction. These basins are also deeper than the normal oceans by about 600 m and 950 m, respectively. Among them fully subducting basins such as the Philippine Sea and Solomon Basin seem to be deeper than partially subducted basins such as the South Fiji and South China Basins. In sharp contrast several marginal basins with depths close to those of the normal oceans are not being subducted at the margin. High density of upper asthenosphere beneath deep back-arc basins is likely to be a necessary condition for occurrence of subduction in such small marginal basins.

칼라영상을 위한 그레이 스케일 로고 영상 워터마킹

박성용,정용덕,임수연,김정화 조선대학교 전자정보통신연구소 2002 電子情報通信硏究所論文誌 Vol.5 No.1

This paper is a method to maintain the right of possesion for color images. previous method used an binary data, image, or binary pattern etc. So watermarked image was declined in image quality. But the information for insertion was limited. This paper proposed the method which will change RGB mode of original image to YIQ, at first, we will insert the watermark in the Low frequency cofficient of wavelet transform domain. The watermark use the owner's photo of a digital contents. which is 256 gray-level watermark, and it's size can be changed by the size of original image. As the result of simulation, our method can provide the rightful1 ownership against Rotation, Cropping, JPEG, and Scaling attacks.

이소매복된 하악 제2소구치의 자가치아이식을 이용한 치험례

정윤주,궁화수,최성철,김광철,박재홍 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.4

악골내 이소매복된 치아로 인해 유치의 만기잔존, 교합이상과 같은 교정적인 문제가 발생할 경우 그 해결책으로 주기적 관찰, 최소한의 개입, 교정적 견인, 발치, 그리고 환자 자신의 매복치아를 이용하는 자가이식술 등을 들 수 있다. 자가치아이식은 치아를 구강내의 한 위치에서 다른 발치와나 외과적으로 형성된 치조와로 이동시키는 술식으로, 치아가 교정력을 가할 수 없는 위치에 존재하거나 치아 이동에 제한이 있어 통상적인 치료가 불가능할 경우에 발거에 앞서 고려할 수 있는 방법이다. 자가치아이식은 치료기간을 단축시키고, 치근 형성이 완료되지 않은 어린 환자의 경우 이식된 새로운 위치에서 치근 형성이 이루어지며, 새로운 치조골의 형성을 유도할 수 있다. 본 증례는 하악 우측 제2소구치의 매복과 하악 우측 제2유구치의 만기잔존을 주소로 본원에 내원한 11세 여아로, 하악 우측 제2소구치의 매복의 깊이가 깊고, 방향이 교정적 견인에 불리하다는 점, 미성숙 치근 발육 상태와, 만기잔존한 유구치로 인해 공간 상실이 없다는 점 등을 고려하여 자가치아이식을 시행한 뒤, 1년간의 주기적 관찰 결과, 양호한 결과를 얻어 이에 보고하는 바이다. In the case of the impacted teeth, the clinician has to consider development of tooth, site of impaction, eruption path, and cooperation of patient. Treatment options for the management of impacted teeth are separated into four categories: observation, intervention, orthodontic or surgical relocation and extraction. Autotransplantation may be defined as the transplantation of embedded, impacted or erupted teeth, from one site to another in the same individual into extraction site or surgically prepared sockets. Autotransplantation ensures preservation of natural tooth, induction of alveolar bone growth and root development, offers one of the fastest and most economically feasible means in the replacement of young patients' missing teeth. This case presents a malpositioned impacted mandibular premolar of an 11-year-old girl. It was thought that orthodontic traction was difficult because of its unfavorable impacted position. Therefore the tooth was treated by autotransplantation, we can observe good healing pattern during 12 months.