일개 대학병원에서 치료중인 만성질환자의 금연,절주 및 운동 실천 정도

손혜숙,전진호,이종태,정귀원,김성준,엄상화,유병철 韓國保健敎育.健康增進學會 2001 보건교육건강증진학회지 Vol.18 No.3

Background: Many chronic diseases are associated with the lifestyle such as smoking, alcohol drinking and exercise. Attention is increasingly paid on the effect of exercise for the management of chronic disease these days. Objective: The purpose of this study was to evaluate the status of the smoking habit, alcohol drinking and physical exercise of the patients with chronic diseases. Methods: Total 793 persons(normal:422, chronic disease patients:371) in a hospital were questioned regarding the habits of smoking and alcohol drinking, and a practice of physical exercise in 1999. The patients with chronic illness were divided into three groups(Group I included the patients of hypertension and diabetes mellitus. Group II includes respiratory disease and cancer. Group III included liver disease ). The rate of exercise, the rate of smoking cessation and the rate of abstinence were assessed. In logistic regression analysis with each independent variables in each disease groups(I, II and III), odds ratio for the presence of disease was controlled for age and education. Results: The rate of exercise, the rate of smoking cessation and the rate of abstinence was 31.5%, 27.3% and 9.5% in the patients with chronic disease, respectively. In control group, those were 31.5%, 21% and 2.1%, respectively. In logistic regression analysis with exercise as independent variable, odds ratios(95% CI) for age and education were significantly high, with smoking cessation, odds ratio for age was high and with abstinence, odds ratio for disease was high in all disease groups. Conclusion : It was suggested that an effort for proper changes of lifestyle related to disease such as smoking, alcohol drinking and exercise should be intervened in the patients with chronic diseases.

전해 알칼리수 처리에 의한 감귤의 저장효과

강선철,서해정 대구대학교 생명과학연구소 2002 생명과학연구 Vol.1 No.2

매우 뛰어난 살균소독 및 세척 기능이 있으면서도, 생체에 대한 안전성과 무공해성의 장점을 동시에 갖고 있는 전해 알칼리수의 감귤에 대한 저장성 향상 효과를 검정하였다. 전해 알칼리수를 감귤에 세척처리하여 저장성을 살펴본 결과, 중량, 부패율 및 경도변화는 전해 알칼리수를 1/500로 희석처리 했을 때 그 효과가 가장 뛰어났으며, 이 경우 감귤의 저장기간이 무처리구에 비해 10일 이상 연장될 수 있음을 확인하였다. 또한 감귤의 상품성 평가에 중요한 척도가 될 수 잇는 당도는 무처리구에 비해 전해 알칼리수를 1/100 농도로 처리했을 때 1˚ Brix 이상 높았으며, 산도의 경우는 당도와 정반대로 전해 알칼리수 처리구가 무처리구에 비해 그 값이 크게 낮아지는 것으로 나타났다. 이상의 결과로부터 전해 알칼리수를 이용한 감귤의 세척처리는 이들의 저장성 향상에 유용하게 활용될 수 있는 새로운 기술로 평가된다. This study was conducted to improve circulation system and the storage of horticultural products. The influence of electrolyzed alkaline water(EAW) (oxidation/reduction potential : above -200 ㎷, pH : 12.0 ± 0.2) on the removal of some spoiling microorganisms was investigated. For this, citrus fruits was washed with the EAW, and then stored at 4, 10 and 25℃ for 3 weeks and its qualities such as weight retention, decay rate, texture, sugar content and acidity were evaluated during the storage. It has a very outstanding sterilization effect and no detectable toxic chemicals against human. The EAW diluted to 500 times gives the most effective result during citrus fruits' storage at 4, 10 and 25℃, that extends its storage period over 10 days, respectively. This study shows that the EAW has a potential for the sterilization of horticulture products such as fruits and vegetables not to he sterilized. The usefulness of EAW, an important and new element, will contribute in increasing circulation period of horticulture products and technological development for their storage.

억새즙액 배지를 이용한 Bacillus lentimorbus G-74 균주의 배양 최적화

강선철,서해정 한국환경농학회 2004 한국환경농학회지 Vol.23 No.1

억새즙액을 이용하여 유용한 미생물의 대량배양을 위한 새로운 배지를 개발하고자 본 연구 를 수행하였다. 억새즙액의 성분을 조사한 결과 칼륨 (37,952 ㎎/L), 질소 (14,000 ㎎/L), 인 산 (6,800 ㎎/L), 마그네슘 (5,969 ㎎/L) 칼슘 (5,910 ㎎/L) 등이 주성분을 차지하였다. 본 연 구를 위하여 먼저 식물 병원성균인 뿌리썩음병 원인균인 Rhizoctonia solaru, 잿빛곰팡이 병 을 일으키는 Botrytis cinerea에 대하여 강력한 저해 활성을 갖는 길항균 G-74를 토양으로 부터 분리하였으며, 이 균의 형태관찰과 MIDI 분석을 통하여 Bacillus lentimorbus G-74 균 주로 최종 동정하였다. 이 균의 억새즙액 배지에 대한 최적 배양조건을 조사한 결과 30%(V/V) 희석배지, 35℃ 배양온도, 5.0의 초기 배지 pH에서 가장 좋은 성장을 기록하였다. EH한 이 배지에 탄소원으로서 2.0% (W/V)의 com starch 및 질소원으로서 1.0% (W/V)의 yeast extract를 추가적으로 첨가하면 최상의 성장을 보여주었으며, 이 경우 대조구인 LB 배지보다도 균체성장이 66% 이상 증가하였다. Miscanthus purpurascens juice containing potassium (37,952 ㎎/L), nitrogen (14,000 ㎎/L), phosphorus (6,800 ㎎/L), magnesium (5,969 ㎎/L), calcium (5,910 ㎎/L), etc, was investigated to develop a novel meidum for the mass cultivation of useful microorganisms. For this research, we first isolated an antagonistic bacterium G74 from soil, which showed strong growth inhibition against two phytopthogenic fungi, Rhizoctonia solani and Botrytis anerea, and identified as Bacillus lentimorbus G74 based on the morphological characteristics and MIDI analysis. Culture conditions for G74 strain in the M. purpurascens juice medium were optimized. Dilution rate of the medium, temperature and initial pH for the optimum growth of G74 strain were 30% (V/V), 35T and 5.0, respectively. It was found that additions of 2.0% (V/V) corn starch as a carbon source and 1.0% (V/V) yeast extract as a nitrogen source in this medium increased lentimorbus G74 growth to 66% more efficient than Luria Bertani medium.

자궁내 태아사망의 임상적 고찰

이권해,이정재,조현철,이석민,이임순,이해혁,김권대,이순곤,남계현 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

Objective: This study was designed to evaluate diagnosis and complication, prognosis during clinical study of cases of intrauterine fetal death. Methods and materials: This is a clinical study of 56 cases of the intrauterine fetal death among 8064 deliveries at Seoul Sunchunhyang university hospital during 5 years from January, 1994 to December, 1998. Results: The incidence was 0.7%. The age distribution of mothers was 18 - 44 years and was highest in the 25 - 29 years range(46.4%). The parity was the most highest in the nulliparous group(51.8%). The most common gestational weeks was 20 - 28 weeks gestational period(46.4%), and most common presentation was cephalic(73.5%). The most common weights of the intrauterine fetal death was from 5,00gm to 1,000g(48.2%). The mode of the most common delivery was the induction of delivery(57.2%). The etiologic factors were: unknown(42.9%), preeclampsia(17.9%), chorioamnionitis(14.3%), congenital anomaly(12.5%), abruptio placenta(7.1%), cord complication(3.6%), placenta previa, death of one for twin. There were 2 cases of maternal complication(DIC, Uterine atony). Conclusion : Intrauterine fetal death should be diagnosised early and treated properly to reduce risk of the maternal complication.

정상인에서 양가감정과 관련되 뇌 영역 : 양전자방출단층촬영 상관 연구

정영철,석정호,전지원,박해정,이종두,김재진 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.3

Objectives : The present study investigated the brain regions that correlate with ambivalence in schizotypy, a latent personality organization that is proposed to precede and contribute to the liability of developing schizophrenia. Methods : Using ^(18)F-FDG PET scan, we investigated the brain activity of twenty one normal healthy subjects during the resting state. Questionnaires, including the Korean Version of Schizotypal Ambivalence Scale (K-SAS), were administrated after the scan in order to assess the self-rated individual differences in ambivalence. Results : The Schizotypal Ambivalence Scale (SAS) scores showed positive correlation with the metabolic rates in the left parahippocampal gyrus and the fornix. In contrast, the Ambivalence over Expression of Emotion Questionnaire (AEQ) scores showed negative correlation with the metabolic rates in the right putamen. Although scores of the two ambivalence scales Correlated positively (Pearson correlation coefficient 0.477, p<0.050), there was no substantial overlap between the neural correlates. Conclusion : This study suggests that the hippocampal complex, which dysfunction has been reported to correlate with impaired information processing in schizophrenia, may underlie schizotypal ambivalence.

일부 도시지역 여성의 건강과 가족생활 및 사회생활에 대한 조사

김학균,김정혜,김해연,배철영,신동학 대한가정의학회 1994 Korean Journal of Family Medicine Vol.15 No.6

위절제술 환자의 표준진료지침 개발 및 적용 효과

김은희,김철규,이순교,김순덕,이혜옥,권정순,이경미,이민미,심순미,유용만,신종식,강은희,이상일,김병식,오성태,육정환,박수길 한국의료QA학회 2003 한국의료질향상학회지 Vol.10 No.2

Background : Gastric cancer is the most common malignant tumor in Korea. surgical operation is one of the major treatment modalities for gastric cancer patients. Therefore, gastrectomy is one of the most common procedures in General Surgery. There were variation in length of hospital stay and medical treatment for gastrectomy between three surgeons at Asan Medical Center. Clinical pathways have received considerable attention as a tool for recucing the medical practice variation, increasing the efficiency of care process, and improving the quality of care. The aim of this study was to evaluate the effect of a clinical pathway for gastrectomy in gastric cancer patients. Methods : The clinical pathway for gastrectomy was developed and implemented by a multidisciplinary group in Asan Medical Center. A computerized clinical pathway program was developed and revised after a pilot test. A total of 145 patients underwent gastrectomy by three surgeons at Asan Medical Center. We compared the length of hospital stay, patient satisfaction, and unplanned readmission rate between the pre-pathway group(n=67) and the post-pathway group(n=78). We also investigated the degree of satisfaction among the physicians and nurses who were main end-users of the clinical pathway. Results : The clinical pathway was applied to all target patients. The average length of hospital stay was shortened from 12.7days to 10.6days(p<0.01). The degree of patient satisfaction with the care process changed from 90.3% to 89.2% after the implementation of the clinical pathway, but the difference was of satistically significant(p=0.761). Unplanned readmission rate was 2.9% in the pre-pathway group. More than 90% of physicians and nurses answered that the clinical pathway had been a useful tool in their medical practice. Conclusions : The findings of the study demonstrated that implementation of the clinical pathway for gastrectomy produced substantial reduction in the length of hospital stay while improving the quality of patient outcomes. The computerized clinical pathway program can be used as one of the powerful patient management tools for reducing the practice variations and increasing the efficiency of care process in Korea hospital settings.

노인에서 정서 인식의 저하

이경욱,채정호,최인철,이해국,권용실,이정태 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : The purpose of this study was to investigate whether elderly and young adults differ in their recognition of facial expressions of emotion. Methods : A total of 120 (elderly group 53, young group 67) subjects participated in this study. Korean facial expressions of emotion including happiness, sadness, fear, anger, disgust, surprise and neutral were used as stimuli for facial affect recognition test. Computerized facial affect recognition test that consists of facial affect discrimination test and facial affect intensity test was performed. Results : For facial affect discrimination test, there was a significant difference between two groups (F==3.986, P<.01) after controlling the effect of education. Elderly participants showed significantly less correct recognition rate with sadness, anger and disgust (p<.05). For facial affect intensity test, there was no significant difference between the groups in recognition of emotional intensity. Chi-square test or t-test was done according to the clinical variables. Multivariate analysis of covahance was done to test group differences of correct recognition rate and emotional intensity. Conclusion : This is the first report of differential decrease of facial affect recognition in elderly using Korean facial expressions. This study suggests that the decrement of facial affect recognition maye be a part of normal aging process.

정신분열병 환자에서 통계적 확률 해부학 지도를 이용한 확산텐서영상 연구 : 겉보기 확산 계수 지도를 이용한 고찰

홍순범,신용욱,김대진,문원진,정은철,이재성,박해정,권준수 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.4

Objectives : Diffusion tensor imaging (DTl) studies of schizophrenia, thus far, have mainly focused on white matter abnormalities reflected in anisotropy indices such as fractional anisotropy (FA), but recently, new implications of apparent diffusion coefficient (ADC) have been proposed. This is. to our knowledge, the first study to analyze ADC maps of schizophrenic Patients using statistical parametric anatomical mapping (SPAM). Methods : DTl was performed in 20 schizophrenic patients and an equal number of age- and sex-matched healthy controls. ADC maps were then generated, from which 98 volumes of interest were extracted using SPAM. Probability-weighted mean values of ADC were calculated from each volume of interest and compared between the two groups. Results : Significantly higher mean ADC values were observed in patients with schizophrenia compared to healthy controls in the following volumes of interest: bilateral hippocampal formation, bilateral uncus, nght thalamus, light temporal lobe white matter, right superior temporal gyrus, bilateral insula and right lateral ventricle. Conclusion : The results support the recently proposed assertion that regionally increased ADC may reflect cortical brain atrophy. In addition, a new possibility is raised that a neuropathological event involving both the gray and the white matter may also play a role.

정신분열병환자의 뇌량에 대한 신경병리적 고찰 : 확산텐서영상(Diffusion Tensor Image)기법의 적용

이경진,신용욱,하태현,이종민,김인영,김선일,문원진,정은철,박해정,오정은,박지영,강경훈,권기원,권준수 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.4

Objectives : Diffusion tensor imaging (DTI) is a new technique that can be used to visualize and measure the diffusion of water in brain tissue. It is particularly useful for evaluating white matter abnormalities. In this paper, we investigated the neuropathology of the corpus callosum in patients with schizophrenia through the new methods, diffusion tensor imaging. Methods : Diffuse tensor imaging was performed in 19 schizophrenic patients and 26 healthy controls. One complementary measure, fractional anisotropy (FA), which is considered to be sensitive indices of axonal integrity, was obtained from regions of interest in the five areas of the corpus callosum. Neuropsychological measurement also underwent for measurement of frontal lobe function in two groups. Results : There were no significant differences of FA in the DTI measures for either the schizophrenic patients compared with controls. FA was significantly decreased in women compared with men. Neuropsychological measurements such as Wisconsin card sorting test were correlated with FA of patients with schizophrenia. Conclusion : FA measures revealed no differences between schizophrenia and controls. The findings suggest that the structural integrity of white matter in patient with schizophrenia was not disrupted. The results are discussed in relation to previous studies reporting positive and negative findings. It is concluded that further studies using DTI in larger samples, improved and standardized methods of data acquisition and analysis are needed.