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( Choon Hee Son ),( Soo Jung Um ),( Mee Sook Roh ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: Lung cancer is the most common cause of cancer-related death worldwide and in Korea, and small cell lung cancer(SCLC) is the most deadly tumor type in the different lung cancer histology. Chemotherapy is the main strategy of the treatment for SCLC, and etoposide and platinum regimen has been the only standard chemotherapy for about 30 years. To test feasibility of weekly divided dose irinotecan and carboplatin for Korean patients is the aim of this study. Methods: Patients with histologically or cytologically confirmed extensive stage(ED) SCLC were included. Patients with limited stage(LD), who could not tolerate concurrent chemoradiotherapy were also included. All the patients received irrinotecan 60mg/m2, carboplatin 2 AUC at day 1, 8, and 15 every 4 weeks. Study regimen was discontinued when the disease progressed or intolerable side effects occured. No more than 6 cycles of chemotherapy were given. Results: Total 47 patients were enrolled, among them 9 patients were LD. Overall response rate was 74.5%(complete response, 14.9%: partial response, 59.6%). Side effects greater than grade 3 were neutropenia (25.5%), fatigue (12.8%), thrombocytopenia (8.5%), sepsis (4.3%), pancytopenia (2.1%). There was no treatment related death. Conclusions: Weekly divided irinotecan and carboplatin regimen is effective, and safe as a first line therapy for both stage of SCLC. Large scaled, controlled study is feasible.
( Choon Hee Son ),( Soo Jung Um ),( Mee Sook Roh ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Lung cancer is the most common cause of cancer-related death worldwide and in Korea, and small cell lung cancer(SCLC) is the most deadly tumor type in the different lung cancer histology. Chemotherapy is the main strategy of the treatment for SCLC, and etoposide and platinum regimen has been the only standard chemotherapy for about 30 years. To test feasibility of weekly divided dose irinotecan and carboplatin for Korean patients is the aim of this study. Methods: Patients with histologically or cytologically confi rmed extensive stage(ED) SCLC were included. Patients with limited stage(LD), who could not tolerate concurrent chemoradiotherapy were also included. All the patients received irrinotecan 60mg/m2, carboplatin 2 AUC at day 1, 8, and 15 every 4 weeks. Study regimen was discontinued when the disease progressed or intolerable side effects occured. No more than 6 cyclesof chemotherapy were given. Results: Total 47 patients were enrolled, among them 9 patients were LD. Overall response rate was 74.5%(complete response, 14.9%: partial response, 59.6%). Side effects greater than grade 3 were neutropenia (25.5%), fatigue (12.8%), thrombocytopenia (8.5%), sepsis (4.3%), pancytopenia (2.1%). There was no treatment related death. Conclusions: Weekly divided irinotecan and carboplatin regimen is effective, and safe as a fi rst line therapy for both stage of SCLC. Large scaled, controlled study is feasible.
Tetracycline계 항생물질들의 활성탄 흡착 및 생물여과 공정에 의한 생분해 특성
손희종 ( Hee Jong Son ),염훈식 ( Hoon Sik Yeom ),류동춘 ( Dong Choon Ryu ),장성호 ( Seung Ho Jang ),손형식 ( Hyung Sik Son ) 한국환경과학회 2014 한국환경과학회지 Vol.23 No.3
Adsorption and biodegradation performance of tetracycline antibiotic compounds such as ttetracycline (TC), oxytetracycline (OTC), minocycline (MNC), chlortetracycline (CTC), doxycycline (DXC), meclocycline (MCC), demeclocycline (DMC) on granular activated carbon (GAC) and anthracite-biofilter were evaluated in this study. Removal efficiency of seven tetracycline antibiotic compounds showed 54%∼97% by GAC adsorption process (EBCT: 5∼30 min). The orders of removal efficiency by GAC adsorption were tetracycline, demeclocycline, oxytetracycline, chlortetracycline, doxytetracycline, meclocycline and minocycline. Removal efficiencies of seven tetracycline antibiotic compounds showed 1%∼61% by anthracite biofiltration process (EBCT: 5∼30 min). The highest biodegradable tetracycline antibiotic compound was minocycline, and the worst biodegradable tetracycline antibiotic compounds were oxytetracycline and demeclocycline.
손춘희 ( Choon Hee Son ) 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.64 No.3
호산구성 폐렴은 혈중 호산구가 1,000/mm3 이상이거나 폐포 내 호산구 분획이 25% 이상으로 나타나는 다양한 폐 질환을 총괄하여 부르는 용어이다. 혈중 호산구증가증은 특발성 급성 호산구 폐렴의 초기나 이미 부신피질호르몬 제제를 투여받은 환자에서는 나타나지 않을 수 있다. 호산구성 폐렴은 무증상의 폐 침윤에서 기계 환기가 필요한 급성 호흡 부전 증후군까지 증상의 중증도도 다양하다. 호산구성 폐렴의 원인으로 약제나 기생충이 있지만 많은 경우 원인을 찾을 수 없다. 폐 외 증상이 동반될 경우 Churg-Strauss 증후군이나 과다호산구증가 증후군의 가능성을 생가해야 되며 이런 경우 심장을 침범하였는지 여부에 따라 예후가 결정된다. 가능한 원인에 대한 노출을 피하는 것 외에는, 부신피질호르몬 제제 투여가 가장 중요하며 대부분 극적인 호전을 보인다. 하지만 약제의 감량 중이나 치료 종결 후 재발하는 경우가 자주 있다. HES의 골수 증식성 변이형 치료에 imatinib의 효과가 최근 입증 되었다.
정수처리 공정에서 용존 유기물질 분류에 의한 haloacetic acid 생성능 평가
손희종 ( Hee Jong Son ),황영도 ( Young Do Hwang ),류동춘 ( Dong Choon Ryu ),정철우 ( Chul Woo Jung ),이건 ( Gun Lee ),손형식 ( Hyeng Sik Son ) 한국환경과학회 2014 한국환경과학회지 Vol.23 No.9
A comprehensive fractionation technique was applied to a set of water samples obtained along drinking water treatment process with ozonation and biological activated carbon (BAC) process to obtain detailed profiles of dissolved organic matter (DOM) and to evaluate the haloacetic acid (HAA) formation potentials of these DOM fractions. The results indicated that coagulation-sedimentation-sand filtration treatment showed limited ability to remove hydrophilic fraction (28%), while removal of hydrophobic and transphilic fraction were 57% and 40%, respectively. And ozonation and BAC treatment showed limited ability to remove hydrophobic fractions (6%), while removal of hydrophilic and transphilic fractions were 25% and 18%. The haloacetic acid formation potential (HAAFP)/dissolved organic carbon (DOC) of hydrophilic fraction was the highest along the treatment train and HAAFP/DOC of hydrophilic fraction was higher than hydrophobic and transphilic fraction as 23%∼30%, because of better removal for hydrophobic fraction both in concentration and reactivity.
Jun Hyeon Cho,Jong Hee Lee,Ji Yun Lee,Young Bo Son,Soo Kwon Park,Sang Yeol Kim,Choon Woo Lee,Un Sang Yeo,Dong Soo Park,You Cheon Song,Min Hee Nam 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
Geneally, rice seeds regardless indica or japonica are showing low germination ratio or completely lost germination ability together with lost of good eating quality under high temperature and humidity conditions. Thus, this study was designed to evaluate a longevity for conservation of good eating quality during long term storage in rice. For the longevity evaluation, germination ability was studied after 5 days of high temperature and humidity stress (50℃/RH 95%). Dharial, originated from Bangladesh and showing weedy type with red pericarp, was selected as a good donor for longevity genes. A mutant was developed from Dharial through EMS mutagenesis and two populations of Dharial/4*Ilmibyeo and Dharial/4*Gopumbyeo were also developed for genetic study. In the 2-DE analysis followed by MALDI-TOF MS with wild and mutant lines, several candidate genes were identified. In the longevity test of two populations, a few lines showing good germination ability after high temperature and humidity stress were selected and subjected to confirm the relationships between longevity and conservation of good eating quality under long term storage.