소아 특발성 중추성 요붕증의 임상경과, 내분비학적 소견 및 뇌자기공명 영상 소견의 경과 관찰

정윤하,정우영 인제대학교 2008 仁濟醫學 Vol.29 No.-

Idiopathic central diabetes insipidus (CDI) can be diagnosed when it occurs in the absence of a cause known to be responsible for diabetes insipidus. Some patients initially diagnosed as idiopathic CDI progressed to brain tumors. We reviewed clinical, endocrinological and brain MRI courses in patients with pediatric idiopathic central diabetes insipidus, to assess the predicting factors for progression to brain tumors. We reviewed the medical records of all patients who had documented cases of idiopathic CDI from 1988 to 2008, and studied clinical, endocrinological and brain MRI courses at diagnosis and during follow up. The patients include 6 males and 5 females. Their mean age at diagnosis was 10.0±4.5(4-19) years and mean follow up duration is 4.3±4.7(0.3-14) years. After mean follow up duration of 4.3±4.7(0.3-14) years, follow up Brain MRI showed brain tumor in 3(27%) patients and no interval change in 4(36%) patients with pituitary stalk thickening and in 3(27%) patients with loss of posterior pituitary signal. 4(27%) patients had growth hormone deficiency and 3(27%) patients had multiple pituitary hormone deficiency. Because some patients of idiopathic CDI progressed to brain tumor, we should follow up more carefully brain MRI and pituitary hormone deficiency.

VRE 감염증의 임상상, 미생물학적 특성 분석 및 유전적 관련성 비교 : 전국 6개 병원에서 분리된 VRE를 중심으로

정희진,박정원,엄중식,하경임,신종희,김정미,이혜수,박영희,김우주,박승철 대한감염학회 2002 감염 Vol.34 No.5

建築物 外觀의 造形的特性에 關한 基礎 硏究 : 大學圖書館의 形態分析을 中心으로 Focused on the Pattern Analysis of University Libraries

李晴雄,하주아,朴佶雨 朝鮮大學校 建設技術硏究所 1998 建設技術硏究 Vol.18 No.2

Visual and perceptual expression which has been considered as the area of sensory and psychological mysticism is recognized as an important factor to be treated in the type of building by today's scientific systems, perceptual researchers and architectural theorists and more positive and concrete research of it is required. Accordingly, this study aims at seeking the qualitative improvement of exterior of building through the pattern analysis of structure with the object of university libraries and suggesting the basic data and direction which can be a guide in planning university library in future by examining the physical characteristics of perceptual and cognitive sides related to pattern property of building. This research seeks the orientation of research through the survey of literatures related and extracts the pattern components of building through classification and analysis of exterior of building. In addition, it extracts the physical and psychological amount of perceptual and cognitive dimension of pattern characteristics of building by means of meaning analysis measurement with the object of actual library users, reveals the correlation of related variables and makes it the standard of evaluating the exterior image of university library by users.

Sweet syndrome like lesion: an uncommon dermatologic manifestation in patient with systemic lupus erythematosus

( Cheong Ha Woo ),( Jae Hong Oh ),( Hee Jae Park ),( Seung Pil Ham ),( Sik Haw ),( Hai-jin Park ),( Mira Choi ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease with many clinical manifestations. Approximately 80% of SLE patients are reported to have various cutaneous features such as malar rash and discoid rash, but some lesions can be confused with other skin diseases. Sweet syndrome-like lesionwith SLE is nonspecific and rarely reported. A 29-year-old male presented with a month history of multiple erythematous painful nodules on face. Fever was also accompanied. The patient was initially diagnosed with acne vulgaris at a local clinic and treated with systemic doxycycline. During treatment, the lesions progressed and the patient visited our hospital. Clinically, we suspected sweet syndrome and performed skin biopsy. Histological findings showed perivascular infiltration of neutrophils and lymphocytes with leukocytoclasia, fibrinoid necrosis of the vessel wall and periadnexal lymphohistiocytic infiltration within the dermis. In addition, laboratory investigations demonstrated marked decrease of C3 and C4 level with leukopenia. Anti-nuclear antibody, Anti-smith, Anti-SSA/Ro and Anti-SSB/La were all positive. Thereby, we confirmed the final diagnosis of SS-like lesion having underlying SLE. The lesions started to decrease after starting systemic hydroxychloroquine and steroid. If a sweet syndrome like lesion appears at the sun exposure site, the possibility of skin symptoms of SLE should be considered.

[P512] Paradoxical psoriasis in patient with ankylosing spondylitis treated with golimumab

( Cheong Ha Woo ),( Hee Jae Park ),( Seung Pil Ham ),( Sik Haw ),( Hai-jin Park ),( Mira Choi ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Golimumab, a human anti-tumor necrosis factor alpha(TNF-α) monoclonal antibody, was approved by the US Food and Drug Administration for treatment of autoimmune diseases, such as rheumatoid arthritis, ankylosing spondylitis and psoriasis. Commonly known side effects of golimumab are injection site reaction, headache, and gastrointestinal discomfort. Paradoxically, golimumab can induce or aggravate psoriasis. The underlying mechanisms of the paradoxical event still remain unknown, but plasmacytoid dendritic cells and interferon-α seem to be key factors. A 44-year-old woman presented with 1-week history of asymptomatic erythematous scaly patches on trunk appeared after injection of golimumab. She had ankylosing spondylitis that had been treated with golimumab for 3 years. She denied any personal or family history of psoriasis. The histologic findings showed focal parakeratosis, psoriasiform hyperplasia and perivascular infiltration of inflammatory cells including lymphocytes and histiocytes. Clinical and histological features were consistent with psoriasis. As golimumab is thought to be the cause of psoriasis, we decided to discontinue golimumab and treat with oral steroid, antihistamine and topical calcipotriol and corticosteroid combination cream. The skin lesions resolved. We present herein a case with clinical and histopathologic evidence of psoriasis in patients with rheumatologic disease treated with TNF-alpha inhibitors.

A case of collision tumor basal cell carcinoma and seborrheic keratosis

( Cheong Ha Woo ),( Seung Pil Ham ),( Ho Yeol Lee ),( Sik Haw ),( Mira Choi ),( Hai Jin Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Collision tumor defined as coexistence of two different tumors in the same anatomical site. The pathogenic mechanism of collision tumor is mostly unknown and most of the cutaneous collision tumors do not arise from similar cell types or pathogenic mechanism. A 71-year-old woman visited our department complaining solitary, asymmetrical, black-colored, indurated, well-defined, round patch on right side of upper abdomen. The lesion had slowly increased in size over the six months, after its initial appearance two years prior. Histopathologic examination of an incisional biopsy revealed the presence of two different components. One part of the specimen revealed papillomatosis, acanthosis and horn cysts in epidermis, which was consistent with seborrheic keratosis. The other part of the specimen revealed peripheral palisading of basaloid cells, clefts between epithelium and stroma in epidermis, which was consistent with basal cell carcinoma. According to these findings, the patient was diagnosed with collision tumor. The lesion was removed by an elliptical excision with a 1cm margin due to basal cell carcinoma. We report an interesting case of collision tumor representing basal cell carcinoma and seborrheic keratosis

A case of apocrine hidrocystoma on palm

( Cheong Ha Woo ),( Ho Yeol Lee ),( Ji Young Seo ),( Sik Haw ),( Hai Jin Park ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Apocrine hidrocystoma is a rare, benign, cystic tumor derived from the secretory portion of the apocrine gland. It usually presents as superficial, solitary, cutaneous nodule on the head and neck, especially at the external canthus of the eyes. It is extremely rare for apocrine hidrocystoma developing on palm. A 65-year-old female presented with 1 cm X 1 cm sized, erythematous to purplish patch with central cysts on her right palm for 2 years. The histopathologic examination showed multilocular cystic spaces with papillary projections in the dermis. The epithelial lining of the cyst was composed of double layersof cells which are an outer layer of myoepithelial cells and an inner layer of columnar cells with decapitation secretion, consistent with apocrine hidrocystoma. Herein we reported a rare case of apocrine hidrocystoma on palm.

A Case of Subungual Melanoma In Situ in an 18-Year-Old Girl Presented with Total Melanonychia

( Cheong Ha Woo ),( Seung Pil Ham ),( Mira Choi ),( Hai-jin Park ) 대한피부과학회 2017 Annals of Dermatology Vol.29 No.5

Study on the usefulness of thyroid function test in various skin diseases

( Cheong Ha Woo ),( Hee Jae Park ),( Seung Pil Ham ),( Sik Haw ),( Hai-jin Park ),( Mira Choi ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Thyroid dysfunction is well known to the association with a variety of skin diseases, especially hair disease, vitiligo and chronic urticaria. Objectives: This study is to investigate the usefulness of serum thyroid function test(sTFT) in various skin diseases. Methods: We retrospectively reviewed five-year clinical data of 503 patients who were tested for sTFT(triiodothyronine(T3), free thyroxine(fT4), thyroid stimulating hormone(TSH)) and thyroid autoantibody(thyroglobulin antibody, thyroid peroxidase antibody) at their visit of dermatology department. Results: A total of 503 patients(M:F=206 : 297, mean age 44.7±16.4 year) were evaluated in this study. Hair diseases(46.5%) were the most common disease and followed by urticaria(21.9%), vitiligo(21.5%). Among the hair diseases, alopecia areata(35.0%) was most frequently reported. The rate of TFT abnormalities in hair diseases, urticaria and vitiligo group were 6.9%, 9.4%, and 8.9%, respectively. The most common TFT abnormalities were low T3(63/404, 15.6%). Percentage of patients who underwent thyroid antibodies test was 15.5% (78/503). Thyroid autoantibody were positive only in hair disease(8/50, 16.0%) and urticaria(2/14, 14.6%) group. Out of 28 patients who transferred to the endocrinology department, hypothyroidism(57.1%) was the most common. Conclusion: Considering of frequency of TFT abnormalities in hair disease, urticaria and vitiligo, TFT in these diseases is helpful to find out underlying diseases such as hypothyroidism.

Two cases of subcutaneous fat necrosis of the newborn

( Cheong Ha Woo ),( Seung Pil Ham ),( Ho Yeol Lee ),( Sik Haw ),( Mira Choi ),( Hai Jin Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Subcutaneous fat necrosis of the newborn (SCFN) is an unusual form of panniculitis which occurs in full-term or post-term neonates in the first few weeks of life. It generally occurs after traumatic delivery, hypoxia, meconium aspiration, hypothermia, cord accident, and placenta previa. Indurated erythematous to violaceous subcutaneous nodules or plaques appear on the trunk, buttocks, cheeks or proximal extremities. Treatment is almost unnecessary, because spontaneous resolution of the lesions is the rule, although it may be complicated by hypercalcemia which can be fetal if left untreated. We report two cases of subcutaneous fat necrosis of the newborn. The first baby was full-term neonate delivered by an emergency cesarean section because of meconium staining and cord accident. His mother was a hepatitis B virus carrier and had diabetes mellitus. On the 3th day of life, hard palpable erythematous plaques appeared on both upper arms. The second baby was also full-term neonate delivered by an emergency cesarean section due to induction failure. On the 1st day of life, erythematous elevated plaques with mild central fluctuation appeared on both upper arms. Skin biopsy of two patients revealed a lobular panniculitis with a dense infiltrate of lymphocytes, histiocytes, neutrophils, and radially arranged needleshaped clefts in adipocytes and histiocytes. The diagnosis of SCFN was made based on clinical and histopathologic findings.