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이공범 ( Lee Gong Beom ),김용구 ( Kim Yong Gu ),박성천 ( Park Seong Cheon ) 한국수처리학회 2004 한국수처리학회지 Vol.12 No.1
N/A This study is to decide water concentration of instream flow to upgrade water quality of Gwangju cheon improving one of instream flow in the upper Gwangju cheon. Present water quality of Gwangju cheon (Based on BOO) maintains 3rd-4th level but this study intends to decide water concentration of instream flow assuming that target water quality is 1st and 2nd level to improve water quality. For QUAL2E applies to estimation form of water quality that is using widely in rivers. And, HEC-RAS form is used to estimate mathematical input value that is using in QUAL2E. In the result of estimation of water quality, it is difficult to upgrade to 1st level because Gwangju cheon is lack of self-purification ability. However, it is possible to improve water quality to 2nd level. According to analyzing of the result of QUAL2E form by 0.5,0.8,1.0 of instream flow, it is decided 0.5㎝s to 2.15㎎/ℓ, 0.8㎝s to 2.70㎎/ℓ, 1.0cms to 2.88㎎/ℓl based on BOO.
Correlation Analysis of General Parameters and Metals in the Lake Sediments of Geum River Basin
Lee, Jun-Bae,Cho, Yoon-Hae,Huh, In-Ae,Khan, Jong-Beom,Oh, Da-Yeon,Yang, Yoon-Mo,Gil, Gi-Beom,Lee, Soo-Hyung,Cheon, Se-Yeok,Lee, Bo-Mi 한국토양비료학회 2017 한국토양비료학회지 Vol.50 No.6
An investigation of grain size, organic compounds and metal distribution in lakes from Geum river basin (Republic of Korea) was conducted in two years (2014 and 2015). The samples of sediment were collected from the 3 lakes (12 sites). The samples were analyzed the concentration of metals (Pb, Zn, Cu, Cr, Ni, As, Cd, Hg, Al, and Li) and general indices including grain size. Spearman correlation coefficients were determined using general indices and metal concentrations respectively. The organic qualities of sediments were improved in 2015 compared with 2014. The concentrations of metals were lower than Sediment Criteria of Lakes in Korea. The significant Spearman correlation coefficients were presented only sand-clay, clay-water content, COD-TOC, Cu-Ni, Cd-Li, Zn-Li, and Cr-Ni of general and metal parameters in 2014, 2015 and both of two years.
Lee, Jun Beom,Choi, Hwan Jun,Kim, Jun Hyuk,Cheon, Nam Ju,Lee, Young Man The Korean Society for Microsurgery 2015 Archives of reconstructive microsurgery Vol.24 No.2
High-pressure (HP) injection injury to the upper extremity often causes a very serious clinical problem, leading to poor outcomes, including amputation, so that a true surgical emergency is required. The outcomes can be improved with emergent wide surgical debridement. However the diagnosis of these injuries is often delayed due to underestimated evaluation at first appearance and lack of common knowledge of the seriousness of this injury. The type and pressure of the infecting material is an important factor in prognosis and organic solvents infected pressure injury can cause poor outcome and increased amputation rate. In this case, we report on reconstruction of HP oil-based paint injection injuries of the finger using T-shaped pedicles and multiple venous anastomoses. In this concept, arterial flow can be maintained by the reverse flow of distal anastomosis when there is difficulty with the proximal anastomosis. And venous flow can be preserved by deep and superficial vein anastomosis. This concept has various advantages including preserving patency of the pedicle in chronic vasculopathy or trauma cases and maintaining the arterial flow by the reverse flow of distal anastomosis and can improve the free flap survival by a two vascular anastomosis system.
Cheon, Sun-Ha,Lee, Yu-Na,Kang, Sung-Il,Kye, Soo-Jeong,Lee, Eun-Kyoung,Heo, Gyeong-Beom,Lee, Myoung-Heon,Kim, Jeong-Won,Lee, Kwang-Nyeong,Son, Han-Mo,Lee, Youn-Jeong Elsevier 2018 INFECTION GENETICS AND EVOLUTION Vol.66 No.-
<P><B>Abstract</B></P> <P>Avian influenza viruses (AIVs) are genetically separated by geographical barriers, resulting in the independent evolution of North American and Eurasian lineages. In the present study, to determine whether AIVs possessing the North American-origin nonstructural (NS) gene were previously introduced into South Korea, we performed a genetic analysis of AIVs isolated from fecal samples of migratory birds. We detected seven viruses possessing the North American-origin NS allele B among 413 AIV-positive samples obtained during AI surveillance between 2012 and 2017. We found evidence for the intercontinental transmission of at least three genetically distinct clusters of the B allele of the North American-origin NS gene into Eurasia at a low frequency. The host species of three viruses were identified as the greater white-fronted goose (<I>Anser albifrons</I>) using a DNA barcoding technique. Moreover, we used GPS-CDMA-based telemetry to determine the migration route of the greater white-fronted goose between the Far East of Russia and South Korea and found that this species may play an important role as an intermediate vector in the intercontinental transmission of AIVs. To improve our understanding of the role of wild birds in the ecology of AIVs, advanced AIV surveillance is required in the Far East of Russia as well as in Alaska region of Beringia accompanied by host identification and wild bird tracking.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Seven AIVs carrying North American-origin NS allele B were identified in Korea. </LI> <LI> Three genetically distinct clusters of NS allele B were detected. </LI> <LI> Greater white-fronted goose was implicated in the intercontinental transfer of AIV. </LI> </UL> </P>
A Case of Basal Cell Carcinoma of External Auditory Canal
Beom-Jun Lee,박경호,Seong-Cheon Bae,Jae-Hong Lee 대한청각학회 2012 Journal of Audiology & Otology Vol.16 No.2
Malignant tumor originated from external auditory canal (EAC) is very rare with an annual incidence of around 1 per million. Pathologically, squamous cell carcinoma is incidentally most common, and adenoid cystic carcinoma, basal cell carcinoma, and melanoma follow in decreasing order. Due to the rarity of malignant tumor of EAC, there is no widely accepted treatment modality yet. But basal cell carcinoma, known to be less aggressive tumor, can be removed with a minimal safety margin and have better treatment results. Recently we experienced a case of basal cell carcinoma in the EAC, confined in the cartilaginous portion of EAC, presenting with intermittent otorrhea for several years. The patient was treated with a sleeve resection of the EAC with a safety margin reconstructed with a split-thickness skin graft. No tumor recurrence or complication was noted in the first postoperative year
Evaluation of the zoonotic potential of multiple subgroups of clade 2.3.4.4 influenza A (H5N8) virus
Lee, Yu-Na,Lee, Eun-Kyoung,Song, Byung-Min,Heo, Gyeong-Beom,Woo, Sang-Hee,Cheon, Sun-Ha,Lee, Youn-Jeong 3M Company 2018 Virology Vol.516 No.-
<P><B>Abstract</B></P> <P>Clade 2.3.4.4 H5N8 highly pathogenic avian influenza viruses (HPAIVs) have spread worldwide. Phylogenetic analysis identified two genetic groups of the H5N8 HPAIVs in South Korea; group A evolved further into four subgroups. Here, we examined the zoonotic potential, both in vivo and in vitro, of genetically distinct subgroups of H5N8 HPAIVs isolated in South Korea. When compared with other subgroups, A/mallard/Korea/H2102/2015 (H2102) virus caused relatively severe disease in mice at high doses. In ferrets, all H5N8 viruses replicated restrictively in the respiratory tract and did not induce significant clinical signs of influenza infection. <I>In vitro</I> studies, all viruses displayed a hemagglutinin phenotype that was poorly adapted for infection of mammals, although the H2102 virus exhibited higher replication kinetics at 33°C than the others. Although H5N8 HPAIVs have not yet acquired all the characteristics required for adaptation to mammals, their ability to evolve continuously underscores the need for timely risk assessment.</P> <P><B>Highlights</B></P> <P> <UL> <LI> H2102 HPAIV (H5N8) caused relatively severe disease in mice at high doses. </LI> <LI> All H5N8 viruses replicated restrictively in the respiratory tract of ferrets. </LI> <LI> All H5N8 viruses displayed a HA phenotype that was poorly adapted to mammals. </LI> <LI> H2102 HPAIV (H5N8) showed higher replication kinetics at 33°C than other strains. </LI> <LI> H5N8 HPAIVs have not yet acquired all features required for mammalian adaptation. </LI> </UL> </P>
Lee Eunhyeong,Lee Eun-Ah,Kong Eunji,Chon Haemin,Llaiqui-Condori Melissa,Park Cheon Ho,Park Beom Yong,Kang Nu Ri,Yoo Jin-San,Lee Hyun-Soo,Kim Hyung Seok,Park Sung-Hong,Choi Seung-Won,Vestweber Dietmar 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Tumor progression is intimately associated with the vasculature, as tumor proliferation induces angiogenesis and tumor cells metastasize to distant organs via blood vessels. However, whether tumor invasion is associated with blood vessels remains unknown. As glioblastoma (GBM) is featured by aggressive invasion and vascular abnormalities, we characterized the onset of vascular remodeling in the diffuse tumor infiltrating zone by establishing new spontaneous GBM models with robust invasion capacity. Normal brain vessels underwent a gradual transition to severely impaired tumor vessels at the GBM periphery over several days. Increasing vasodilation from the tumor periphery to the tumor core was also found in human GBM. The levels of vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR2) showed a spatial correlation with the extent of vascular abnormalities spanning the tumor-invading zone. Blockade of VEGFR2 suppressed vascular remodeling at the tumor periphery, confirming the role of VEGF-VEGFR2 signaling in the invasion-associated vascular transition. As angiopoietin-2 (ANGPT2) was expressed in only a portion of the central tumor vessels, we developed a ligand-independent tunica interna endothelial cell kinase 2 (Tie2)-activating antibody that can result in Tie2 phosphorylation in vivo. This agonistic anti-Tie2 antibody effectively normalized the vasculature in both the tumor periphery and tumor center, similar to the effects of VEGFR2 blockade. Mechanistically, this antibody-based Tie2 activation induced VE-PTP-mediated VEGFR2 dephosphorylation in vivo. Thus, our study reveals that the normal-to-tumor vascular transition is spatiotemporally associated with GBM invasion and may be controlled by Tie2 activation via a novel mechanism of action.
Jun Beom Lee,Tae Bong Kang,Sang-Hoon Choi,Uiyoung Lee,Ae-Jung Kim,Chang-Jin Jeong,Hak-Cheon Lee,Yong-Sun Cho,Jong-Gun Won,Jong-Cheol Lim,Taek Joon Yoon 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.1
Ability of water extract from Prunella vulgaris Labiatae to stimulate immune system and inhibit tumor metastasis in mice was assessed. In experimental lung metastasis, prophylactic intravenous (i.v.) administration of water extract from P. vulgaris significantly inhibited lung metastasis in a dose-dependant manner. Peritoneal macrophages stimulated with P. vulgaris produced various cytokines such as tumor necrosis factor (TNF)-α and interlukin (IL)-12 as well as induced tumoricidal activity. In an assay for natural killer (NK) cell activity, i.v. administration of P. vulgaris significantly augmented NK cytotoxicity. The depletion of NK cells by injection of rabbit anti-asialo GM1 serum abolished the inhibitory effect of P. vulgaris on lung metastasis of colon26-M3.1 cells. These data demonstrate that P. vulgaris activate innate immune system to inhibit the growth of foreign materials including tumor cells in mice.