부산·울산·경남지역 직업병 감시체계

김정일,김병권,김정원,채창호,이철호,강동묵,김지홍,김진하,김영욱,이영하,이지호,김정호,윤형렬,유철인,정백근,장태원,김운규,윤동영,강진욱,김종은,안진홍,이동준,장준호,이광영,송혜란,최영희,이용환,조병만,최홍렬,고상백,김은아,이유진,홍영습,정갑열,김정만,김준연 大韓産業醫學會 2004 대한직업환경의학회지 Vol.16 No.1

Objective: Occupational medicine specialists in the Busan, Ulsan and Kyung-Nam areas established an area-based occupational disease surveillance system and used this system to collected case information for the purpose of preventing occupational diseases Methods: l l hospital participated in this system. The authors selected five main diseases, which were hand-arm vibration syndrome (HAVS), work-related musculoskeletal disorder (WRMSD), occupational asthma, occupational skin disease and occupational and occupational lung cancer and established their case definitions. All cases were reported on the web, and real time analysis was conducted. Results: Between April 2001 and April 2003, 192 cases of HAVS, 118 cases of WRMSD, 33 cases of occupational asthma, 17 cases of occupational skin disease and 17 cases of occupational lung cancer (for a total of 377 cases of these five main diseases) were reported. most of the HAVS cases came from shipbuilding, and 172 of them (92.7%) were associated with grinding. Of the four main types of WRMSD, carpal tunnel syndrome (CTS) was the most prevalent with 46 cases and shipbuilding was also the main industry involved (83.9%). The ergonomic risk factors involved mainly associated with the hand. In 19 (57.6%) and 4 (12.1%) cases of occupational asthma, the agents involved. The causative agents of occupational lung cancer included Cr, welding fume, PAH, Ni, etc. 10(58.8%) of the cases were diagnosed as squamous cell carcinoma and 5(29.4%) as adenoma. Conclusion: This result showed that an area-based occupational disease surveillance system might provide an effective method of evaluating the prevalence of such diseases, however the Busan, Ulsan and Kyung-Nam provinces are too large to be treated as individual areas. Therefore, the authors suggest that each province should establish its own surveillance system.

산재보상을 신청한 뇌심혈관질환의 특성 분석

유재홍,하은희,김수근,김정연,김용규,이의철,이철호,손준석 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.1

목적: 이 연구는 뇌 · 심혈관 질환으로 업무상재해를 신청한 사례 중에서 승인된 사례와 불승인된 사례의 특성을 비교하여 뇌 · 심혈관 질환의 업무상 재해여부를 판단하는데 필요한 기초 자료를 제공하고자 한다. 방법: 2000년부터 2004년까지 근로복지공단에 업무상 재해로 요양이 신청되어 승인여부가 결정된 뇌 · 심혈관 질환자 12,309명을 대상으로 하였다. 승인여부와 관련된 특성을 확인하기 위해 연도별, 업종별, 규모별, 직업별, 성별, 연령별, 질환별, 생존유무별 그리고 기존질환 유무에 대하여 카이제곱 검정과 다변량 로지스틱 회귀분석을 이용하였다. 결과: 다변량 로지스틱 분석에서 뇌 · 심혈관 질환의 불승인에 대한 승인의 비차비는 광업을 기준으로 하였을 때에 전기가스 상수도업이 4.18(95% CI=1.43~12.17), 건설업이 2.39 (95% CI=1.22~4.69), 제조업이 2.10 (95% CI=1.08~4.07)이었고, 장치기계조작원 및 조립원에 비하여 서비스 근로자 및 상점과 시장 판매근로자 군이 1.90(95% CI=1.47~2.47), 전문가 군이 1.83(95% CI=1.50~2.23), 기술공 및 준전문가 군이 1.63(95% CI=1.35~1.97), 입법 공무원과 고위 임직원 및 관리자 군이 1.62(95% CI=1.24~2.12)이었고, 여성이 남성에 비하여 1.31(95% CI=1.13~1.53), 심장질환에 비하여 뇌혈관질환이 2.75(95% CI=2.42~3.13), 사망한 경우가 생존한 경우에 비하여 6.01(95% CI=4.89~7.38)이었다. 결론: 우리나라에서 뇌심혈관질환으로 업무상 재해를 신청하는 건수는 증가하고 있고 승인율은 비교적 높았으며 승인에 영향을 미치는 요인으로는 업종, 규모, 직종, 성, 연령, 질환, 생존유무 등이 확인되었다. 특히 업종과 직종에 따라서 승인율의 차이가 큰 것이 어떠한 요인의 영향 때문인지에 대한 검토가 필요하고, 특히 뇌실질내 출혈의 경우에 다른 질환에 비하여 승인율이 매우 높았던 것은 업무수행성에 대한 인정기준의 잘못된 적용의 결과 이므로 시정이 필요하겠다. Objectives: This study was performed to provide fundamental data to judge whether or not cerebro and cardiovascular diseases are work-related, by comparing the characteristics between approved and non-approved cases among the worker's compensation claims. Methods: We collected 12,309 cerebro and cardiovascular disease claims based on the worker's compensation records of the Labor Welfare Corporation from 2000 to 2004. The approved and non-approved cases were analyzed according to factors such as the calendar year, industry, company size, occupation, gender, age group, classification of cerebro and cardiovascular diseases, fatality and underlying diseases. We used x²-test and multivariate logistic regression for the analysis. Results: According to multivariate logistic regression, electricity gas and water supply (OR=4.18, 95% CI=1.43~12.17), construction (OR=2.39, 95% CI=1.22~4.69) and manufacturing (OR=2.10, 95% CI=1.08~4.07) industries had a higher approval rate than mining and quarrying industries. Service workers and sales & marketing department workers (OR=1.90, 95% CI=1.47~2.47), professionals (OR=1.83, 95% CI=1.50~2.23), technicians and associate professionals (OR=1.63, 95% CI=1.35~1.97) and legislators and senior officials and managers (OR=l.62, 95% CI=1.24~2.12) had a higher approval rate than plant and machine operators and assemblers. Female workers had a higher approval rate (OR=1.31, 95% CI=1.13~1.53) than male workers. Cerebrovascular diseases had a higher approval rate (OR=2.75, 95% CI=2.42~3.13) than cardiovascular diseases. Fatal cases had a higher approval rate (OR=6.01, 95% CI=4.89~7.38) than surviving cases. Conclusion: For cerebro and cardiovascular diseases, workers' compensation claims are increasing, approval rates are relatively high and factors such as industry, company size, occupation, gender and fatality are related. A remarkable difference in the approval rate was found according to industry and occupation, suggesting the need for further study to identify which factors influence the approval rate. The approval rate for intracerebral hemorrhage arising in the course of employment (COE) was significantly higher than that arising out of employment (AOE), suggesting the need to correct the approval criteria.

프랙탈변환 방법에 의한 컬러 영상 압축에서의 최적 컬러축약률 및 범위 이동

명연수,이상훈,이형원,임철홍 인제대학교 1993 仁濟論叢 Vol.9 No.2

프랙탈변환을 이용하여 256가지 색을 가진 영상을 압축하는 모사 실험을 수행하였다. 영역의 크기, 컬러축약률,범위 이동치 변화에 따른 압축 영상의 평균 강도 차를 비교하여 최적 압축 조건을 조사하였다. By using the fractal transform we perform the simulations that compress the 256-color real world images. The optimal compression conditions are examined by comparing the compressed images resulting from the variations of the size of domain, ratio of color contraction and range-shift.

뇌졸중 위험인자를 가진 어지럼 환자에서의 확산강조 자기공명영상

강형구,윤유상,이진희,박인철,이경룡,정상원,구홍두,김승호 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Background: The management of vertiginous patients is a great challenge to emergency physicians. We evaluated the diagnostic value of a diffusion-weighted image(DWI) in differentiating central vertigo from the peripheral vertigo in patients who presented no neurological symptoms other than risk factors for stroke. Methods: From March 2000 to February 2001, we retrospectively analyzed the cases of 68 patients who visited the emergency department with symptoms of isolated vertigo and who had risk factors for stroke. DWIs, computed tomograms(CT), and medical records were reviewed, and the final diagnose, the DWIs and the CT readings, the risk factors for stroke, and the time it took waiting for a DWI or CT scan were analyzed. Results: Of the 68 patients, 21(30.8%) had central vertigo: 15 vertebrobasilar transient ischemic attacks(VB-TIA), 4 brain stem infarctions, 1 cerebellar infarction, and 1 cerebellopeduncular infarction. The DWI showed a 28.6% sensitivity, a 97.9% specificity, and an 85.7% positive predictive value in diagnosing central vertigo. It also had a 100% sensitivity in detecting infarctions. Conclusion: A DWI had a comparable sensitivity to MRI in detecting central vertigo and small, but potentially, lethal infarctions in our patient population. We recommend clinical application of DWI in the emergency department evaluation of isolated vertigo patients with risk factors for stroke.

HFCVD법을 이용하여 제작한 n-형 다이아몬드 박막의 특성 연구

김병규,황윤식,권민철,김용,이재열,박홍준 동아대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.17 No.1

HFCVD법으로 암모니아 가스를 사용하여 n-형 도핑된 다이아몬드 박막을 제작하여, 기판온도와 암모니아 가스 첨가비에 따른 박막의 morphology의 변화를 조사하였다. 증착된 시료에 대한 SEM, Raman, XRD를 이용하여 박막의 특성을 분석하고, 도핑에 따른 전계방출 특성을 측정하였다. 양질의 n-형 도핑된 다이아몬드 박막을 증착시키기 위해 기판온도와 암모니아 첨가비에 따른 최적의 증착조건을 찾을 수 있었다. We fabricate n-doped diamond thin films by hot filament chemical vapor deposition method(HFCVD) using ammonia as a doping gas and investigate the effect of the substrate temperature and the ammonia gas ratio upon the diamond film morphology. The SEM, Raman spectroscopy, and the XRD analysis are executed to characterize film morphology. Field emission property of the film is measured also. We find optimum conditions of the substrate temperature and the ammonia gas ratio to deposit high quality n-doped diamond thin films.

탄소 나노튜브의 전계방출 특성

이경원,김은미,권민철,김용,이재열,박홍준 동아대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.17 No.1

본 연구에서는 emitter와 collector 사이의 간격과 current density 대 electric field (J-K)특성을 초점으로 카본나노튜브의 전계방출 특성을 조사하였다. 카본 소스로 CH4, 촉매 및 희석가스로서 NH3를 사용하고 HFCVD를 이용하여 실리콘 위에 카본나노튜브를 성장하였다. 나노튜브의 지름이 20-40nm이고 길이는 15㎛이다. I-V곡선에서 onset voltage는 Vons=3.36V/㎛이고, 2.5V/㎛ 의 전기장에서 8mA/cm2이상의 높은 전류밀도 특성을 보였다. Fowler-Nordheim 그래프를 그려서 팁의 특성을 나타내는 β값을 계산하였다. We report the field emission properties of carbon nanotube, focusing on current density versus electric field (J-F) characteristics and the spacing between the emitter and collector. We grow carbon nanotubes on sillicon using hot-fillament chemical vapor deposition, using CH4 gas as the carbon source and NH3 gas as the catalyst and dilution gas. Nanotubes are distributed from 20 to 40nm in diameter and 15㎛ long. Onset field of the field emission is 3.36V/㎛ and the current density is 8mA/cm2 at an electric field of 2.5V/㎛. A Fowler-Nordheim plot was made. Field enhancement factor β is calculated.

TNF-alpha as a Paracrine Factor in the Testis

Hong Cheol Yi,Park Jin Hee,Sub Ji Ho,Lee Keesook 한국발생생물학회 2004 한국발생생물학회 학술발표대회 Vol.18 No.-

Symposium 4 Nuclear Receptor and Gene Regulation : Modulation of AR transactivation by a component of the SWI/SNF complex

( Cheol Yi Hong ),( Ji Ho Suh ),( Rho Hun Seong ),( Kee Sook Lee ) 한국생화학분자생물학회 (구 한국생화학회) 2005 62회 KSBMB Annual Meeting in 2005 Vol.- No.-

Sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2)reduces the migratory capacity of CCL21-treated monocyte-derived dendritic cells

Cheol Yi Hong,이현주,Nu-Ri Choi,정성훈,Manh-Cuong Vo,My-Dung Hoang,김형준,이제중 생화학분자생물학회 2016 Experimental and molecular medicine Vol.48 No.-

The migration of dendritic cells (DCs) to secondary lymphoid organs depends on chemoattraction through the interaction of the chemokine receptors with chemokines. However, the mechanism of how lymphoid chemokines attract DCs to lymphoid organs remains unclear. Here, we demonstrate the mechanism of DC migration in response to the lymphoid chemokine CCL21. CCL21-mediated DC migration is controlled by the regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) expression rather than through the activation of mitogen-activated protein kinases CCL21-exposed mature DCs (mDCs) exhibited decreased SERCA2 expression but not decreased phospholamban (PLB) or Hax-1 expression, which are known to be SERCA2-interacting proteins. In addition, CCL21 did not affect the mRNA levels of SERCA2 or its interacting protein Hax-1. Interestingly, SERCA2 expression was inversely related to DC migration in response to chemokine stimulation. The migratory capacity of CCL21-treated mDCs was decreased by the phospholipase C inhibitor U73122 and by the protein kinase C inhibitor BAPTA-AM. The migratory capacities of mDCs were increased in response to SERCA2 siRNA expression but were decreased by SERCA2 overexpression. In addition, DCs treated with a SERCA2-specific inhibitor (cyclopiazonic acid) had significantly increased migratory capacities as mDCs regardless of SERCA2 expression. Moreover, SERCA2 expression was dependent on DC maturation induced by cytokines or Toll-like receptor agonists. Therefore, the migratory capacities differed in differentially matured DCs. Taken together, these results suggest that SERCA2 contributes to the migration of CCL21-activated DCs as an important feature of the adaptive immune response and provide novel insights regarding the role of SERCA2 in DC functions.

Atmospheric pressure air-plasma jet evolved from microdischarges: Eradication of<i>E. coli</i>with the jet

Hong, Yong Cheol,Kang, Won Seok,Hong, Yoo Beom,Yi, Won Ju,Uhm, Han Sup American Institute of Physics 2009 Physics of plasmas Vol.16 No.12