조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

신장이식 환자에서 HCMV 항원혈증 검사의 임상적 유용성

김탁,성흥섭,박관태,김송철,김성한,최상호,김양수,우준희,박수길,한덕종,이상오 대한감염학회 2009 감염과 화학요법 Vol.41 No.2

Background : This study was performed to determine the cut-off value and the predictability of symptomatic human cytomegalovirus (HCMV) infection according to the peak value of HCMV antigenemia assay in kidney transplant recipients. Materials and Methods : We reviewed the results of HCMV antigenemia assay (Chemicon, CA, USA) in patients who received kidney transplantation at our institution from May 2003 through May 2008, and investigated the existence and the type of HCMV infection by the medical record review. Patients who underwent the test only once during the episode or those who received ganciclovir for more than 48hrs before the test were excluded. The receiver-operator characteristic curve was drawn and the point showing maximum likelihood ratio (LR) was chosen as the cut-off value of symptomatic HCMV infection. Results : A total of 689 episodes were screened and 134 episodes were enrolled. Thirty-three (24.6%) episodes were symptomatic HCMV infection, 23 (17.2%) episodes were associated with HCMV syndrome, and 10 (7.5%) episodes were tissue-invasive diseases. The maximum LR was 7.5 (95% confidence interval, 4.014.2) and the cut-off value was 29.5 cells/200,000 WBC. The sensitivity, specificity, Positive predictive value, and negative predictive value were 66.7%, 91.1%, 71.0%, and 89.3%, respectively. Conclusions : The cut-off value of symptomatic HCMV infection by the peak value of HCMV antigenemia assay in our study was similar with previous results, although the sensitivity was relatively low.

랜덤 키 분할을 이용한 모바일 RFID 사용자의 프라이버시를 보호하는 상호 인증 프로토콜

정윤수(Yoon-Su Jeong),김용태(Yong-Tae Kim),박길철(Gil-Cheol Park),이상호(Sang-Ho Lee) 한국통신학회 2011 韓國通信學會論文誌 Vol.34 No.9

이동 통신망에 RFID 기술을 접목한 모바일 RFID는 사용자 자신이 휴대한 휴대전화로 제품에 부착된 RFID태그의 식별자를 읽고, 이 식별자를 이동통신망을 통해 네트워크로 전달하여 제품에 대한 정보를 얻는 기술이다. 그러나 모바일 RFID는 기존 RFID에서 요구되어지는 보안 요구사항 중 프라이버시 문제가 여전히 존재하는 문제점이 있다. 이 논문에서는 모바일 RFID 사용자가 태그 정보를 백 엔드 서버로부터 안전하게 전달받기 위해서 초기화 과정과 상호 인증과정에서 모바일 RFID 리더와 태그가 생성한 랜덤키를 임의의 크기로 분할하여 프라이버시 보호가 필요한 태그에 대해서 모바일 RFID 리더가 매 세션마다 난수생성기에 의해 항상 다른 하부키 값을 생성함으로써 태그의 어떤 정보도 제 3자에게 제공하지 않도록 하고 있다. 성능 평가 결과 제안 프로토콜은 등록 계산량과 로그인 계산량에서 모듈러 연산을 사용하는 기존 프로토콜과 달리 일방향 해쉬 함수를 사용하여 사용자의 정보를 등록하기 때문에 MARP 기법<SUP>[7]</SUP>과 Kim 등의 기법<SUP>[12]</SUP>보다 저장 공간과 계산량에서 효율성이 높았다. Mobile RFID which integrates mobile network with RFID technique is the technique to get the information of products by transmitting the identifier through mobile network after reading the identifier of RFID tag. It attached on the equipment as the mobile phone. However, mobile RFID has the privacy-related problem among requested secure problems required from the existing RFID. In this paper, the random key created by mobile RFID reader and Tag during the inter-certificating and initialization procedure for mobile RFID users to receive tag information from backend server securely is divided into random sizes and any information on the tag which requires the protection of privacy shouldn't be provided to anyone. In performance analysis, previous protocol used modulo operation in registration and login computation. But the proposed protocol has higher efficiency in saving space and computation volume than MARP scheme<SUP>[7]</SUP> and Kim. et. al<SUP>[12]</SUP> scheme because our protocol is accomplished by mutual authentication and registering user information through one-way hash function.

이중 트라이를 이용한 한국어 단어 검색

金哲洙,李庸碩 全北大學校 1994 論文集 Vol.38 No.-

It is very important to minimize the searching time of words to perform efficiently the Korean information processing. Current methods have had problems such as the followings ; the insertion and deletion of words are difficult or searching time is too long. In this paper, the search method of phoneme unit and syllable unit using double trie with double array is discussed to speed up search time. In searching time, the method of syllable unit is faster than that of phoneme unit, but the method of phoneme unit is more efficient than that of syllable unit in memory spaces. We can reduce the memory spaces up to the half in phoneme unit by spliting one trie into multiple trie. The method of phoneme unit is somewhat slower than that of syllable unit in searching time, but the method of phoneme unit is much more efficient than that of syllable unit in efficiency of memory spaces.

광 형태학을 이용한 자동차 번호판의 숫자 추출

김철수 경주대학교 건설환경연구소 2000 建設環境論叢 Vol.- No.3

A new method for detection of an automobile registration plate using optical morphology is proposed. In this method, we recognize corners of an automobile registration plate and detect it. First of all, we design optimal structuring elements for corner recognition and they are applied to optical rank order HNT(Hit Miss Transform). Optical rank order HMT gives better performance than standard HMT in random noises and cluttered image. In the case of automobile registration plate with noise, we eliminated it by opening and closing. The computer simulation and optical experiment show that proposed method has good capability of detecting automobile registration plate.

산-염기 평형 장애 진단 전문가 시스템의 설계 및 구현

김기태,유석희,황수철 중앙대학교 기술과학연구소 1989 기술과학연구소 논문집 Vol.19 No.-

In this study, we designed and implemented a diagnostic system model to process the diagnosing problem of acid-base balance disorder by means of OPS5 and LISP which are a tool and a language, respectively for developing Al systems. The implemented knowledge base system consists of three kind of the knowldege : one analytic knowledge of blood test, two diagnostic knowledges obtained by etiologies and symptoms. The knowledge representation and the inference mechanism for diagnosis were implemented by OPS5, and all input / output was processed by a menu-driven method in support of the window functions of LISP.

원예치료가 만성정신분열증 환자의 자아존중감 및 사회성 향상에 미치는 영향

손기철,엄수진,김수연,송종은,백기엽 충북대학교 첨단원예기술개발연구센터 2000 연구보고서 Vol.5 No.-

만성정신분열증 환자들은 장기간의 치료를 필요로 하고, 지금까지는 대부분의 환자들이 약물치료나 전통적인 정신치료에만 의존해왔다. 최근에는 정신분열증 환자치료에 있어서 여러 가지 사회 재활 프로그램이 도입되고 있는 실정이나 원예치료프로그램의 적용사례는 미비한 실정이다. 이에 본 연구는 원예치료가 만성정신분열증 환자의 자아존중감 및 사회성 향상에 미치는 효과를 알아보기 위하여 음성 꽃동네 정신분열증 환자 남녀 대조군 20명, 치료군 남녀 25명을 선정하여 실험을 실시하였다. 대조군 20명에게는 원예치료를 실시하지 않았으나, 치료군 25명에게는 주 2회씩 2000년 4월 13일부터 9월 7일까지 원예치료를 실시하였다. 치료효과 검증을 위해 원예활동 평가표(evaluation of horticultural activity), 사회행동척도(social behavior scale), 자아존중감척도(self-esteem Scale), 인간관계측정지, 간이정신건강진단지(SCL-90-R) 등을 치료 전후로 시행하여 비교하였다. 자아존중감과 인간관계측정지에서는 대조군에서는 유의한 결과가 보이지 않은 반면, 치료군에서는 향상된 결과를 볼 수 있었다. 사회행동척도에서는 언어적인면보다 비언어적인면, 대화의 내용에서 치료군만 유의하게 향상된 결과를 보였다. 간이정신건강진단지 평가는 불안, 우울, 대인예민성 부분에서 역시 치료군만 유의하게 호전된 효과를 볼 수 있었다. 또한 신체화, 강박증, 적대감, 공포불안, 편집증 등이 호전된 것으로 보여졌으나 통계적으로 유의한 차이는 나타나지 않았다. 원예활동평가에서는 참여성과 자아개념 및 주체성에서 유의한 차이를 볼 수 있었다. 따라서 원예치료프로그램은 우울ㆍ폐쇄적인 대인관계를 보이는 정신분열증 환자들에게 심리ㆍ정서면과 사회성 향상에 효과적이라 판단된다. 또한 원예치료프로그램을 치료적인 목적뿐만 아니라 직업재활의 한 방면으로 이용가능 할 것이라 판단된다.

茵蔯淸肝場의 B型 및 C型 간염 바이러스에 대한 抗 바이러스 效果

김수성,김기열,윤철호,서운교,김종대,정지천 동국대학교 한의학연구소 1999 東國韓醫學硏究所論文集 Vol.8 No.1

우리나라와 같이 B형 간염 바이러스의 유병율이 높은 지역에서는 B형 간염 바이러스 뿐만 아니라 HCV에 대한 항 바이러스 효과도 동시에 시행함이 유용할 것으로 사료되었다. 본 연구에서는 茵蔯淸肝湯을 이용하여 B형 간염 바이러스에 대한 抗 바이러스 효과를 PCR을 이용하여 HBV의 DNA를 검색하였다. 茵蔯淸肝湯이 처리된 처리군의 경우 대조군에 비하여 농도 의존적으로 B형 간염 바이러스의 표면항원 생산을 억제하였고, PCR을 이용하여 증폭한 경우에도 증폭된 DNA의 양은 감소하였다. 또한 C형 간염 바이러스에 대한 抗 바이러스효과를 검색하기 위하여 복제에 필수적인 단백질인 HCV helicase의 ATPase에 대한 활성 억제 효과를 조사하였다. 茵蔯淸肝湯이 HCV helicase의 ATPase 활성을 억제하는 효과가 있음을 확인한 후 dose-respond에 따른 실험을 수행하여 HCV helicase의 ATPase 활성을 억제함으로써 탈인산화 되지 않은 ATP의 양을 이용하여 PSL로 분석한 결과 茵蔯淸肝湯이 HCV helicase의 ATPase 기능에 대한 억제효과가 우수함이 확인되었다. 이상의 결과로 보아 茵蔯淸肝湯이 B형 및 C형 간염 치료에 동시에 응용될 수 있을것으로 사료된다. For the purpose of investigate the inhibition effects of Injinchunggantang on Hepatitis and C Virus. The inhibition experiments were as follows : 1. The inhibition effects of Hepatitis B surface antigen production was remarkably increased in the pretreated group of Injinchunggantang compared with control group. 2. Amplified PCR products of HBV-DNA in culture media was considerably decreased in the pretreated group of Injinchunggantang compared with control group. 3. Results of ATP quantitation and ATPase inhibition percent was increased pretreated group of Injinchunggantang. Also ATPase activity of HCV helicase inhibition assay was increased with a dose dependent manner. These results may suggest that Injinchunggantang will have the inhibition effects of Hepatitis B and C Virus.

유기용제 취급근로자들의 요중대사물질과 말초임파구 자매염색분체교환 발현빈도에 관한 조사연구

김돈균,황인경,류철인,이수일,정갑열,이용환,이충렬,현원일,김석봉,전용덕 大韓産業醫學會 1990 대한직업환경의학회지 Vol.2 No.1

저자들은 유기용제 취급여성근로자 90명을 대상으로 1988년 7월부터 1989년 8월까지 말초혈액임파구에서의 자매염색분체교환의 발현빈도를 조사하고 이들의 업종, 근속연수, 요중마뇨산 농도등이 자매염색분체교환의 발현빈도에 미치는 영향을 조사하였으며 그 결과를 요약하면 다음과 같다. 1. 유기용제 취급근로자들의 말초혈액임파구에서의 자매염색분체교환의 발현빈도는 대조군에 비하여 유의하게 증가되었다. 2. 말초혈액임파구에서의 자매염색분체교환의 발현빈도가 가장 높은 업종은 프라스틱제품 제조업이었다. 3. 근속연수가 말초혈액임파구에서의 자매염색분체교환의 발현빈도에 미치는 영향은 현저하지 않았다. 4. 요중마뇨산농도와 말초혈액임파구에서의 자매염색분체교환의 발현빈도간에는 유의한 상관관계가 있었다. In order to know the possibility of utilizing the sister chromatid exchanges as an index which could evaluate the effect of organic solvents on the health in industrial workers, the authors studied the effects of the inductivity of sister chromatid exchanges in peripheral lymphocytes from 90 female workers expoxed to organic solvents and 20 non-exposed female workers. The results obtained were as follows : 1. The frequency of sister chromatid exchanges in peripheral lymphocytes from 90 female workers exposed to organic solvents was significantly increased in comparison with 20 control subject. 2. The frequency of sister chromatid exchanges was significantly increased in the workers who were employed in the manufacture of plastic materials than the other manufactures. 3. There were no significant differences in the frequency of sister chromatid exchanges by carriers of the exposed workers.

건설정보 국제산업표준(IAI/IFC)의 2차원 확장모델 개발에 관한 연구 : 모델 스페이스에서의 형상표현 엔티티 확장 중심으로 Focusing on the Extension of the Shape Representation Entities of Model Space

김인한,서종철,이수영,정철오 대한건축학회 2004 대한건축학회논문집 Vol.20 No.5

This research is focused on the enhancement of capabilities for 2D data representation to the IFC (Industry Foundation This research is focused on the enhancement of capabilities for 2D data representation to the IFC (Industry Foundation of IFC is that it is impossible to represent 2D elements, essential for the presentation of drawing elements. On top of that, the drawing information in IFC format can not be exchanged among the international standard complied formats such as KOSDIC, SCADEC, and STEP-CDS which are based on STEP AP202 subset. The main purpose of this research is to enhance the existing capability of IFC to represent 2D drawing elements. To achieve this goal, the presentation resources, based on ISO 10303-46 and ISO 10303-202, are annexed to the resource layer of IFC2.X. For the representation of 2D drawings, a Layer entity, Curve_styles entity, Text entity, Symbol entity, Hatch entity, Bezier curve entity, Dimension entity have been extended to the IFC2.X.