Incidence and Mortality after Proximal Humerus Fractures Over 50 Years of Age in South Korea: National Claim Data from 2008 to 2012

Park, Chanmi,Jang, Sunmee,Lee, Areum,Kim, Ha Young,Lee, Yong Beom,Kim, Tae Young,Ha, Yong Chan The Korean Society for Bone and Mineral Research 2015 대한골대사학회지 Vol.22 No.1

<P><B>Background</B></P><P>There has been lack of epidemiology of proximal humerus fracture using nationwide database in Asia. The purpose of this study was to investigate the incidence of proximal humerus fracture and its mortality following proximal humerus fracture in Korean over 50 years of age.</P><P><B>Methods</B></P><P>The Korean National Health Insurance data were evaluated to determine the incidence and mortality of proximal humerus fracture aged 50 years or older from 2008 through 2012.</P><P><B>Results</B></P><P>Proximal humerus fracture increased by 40.5% over 5 year of study. The incidence of fracture increased from 104.7/100,000 in 2008 to 124.7/100,000 in 2012 in women and from 45.3/100,000 in 2008 to 52.0/100,000 in 2012 in men, respectively. One year mortality rate after proximal humerus fracture was 8.0% in 2008 and 7.0% in 2012. One year mortality rate were 10.8% for men and 7.0% for women in 2008 and 8.5% for men and 6.4% for women in 2012.</P><P><B>Conclusions</B></P><P>Our study showed that the proximal humerus fracture in elderly was recently increasing and associated with high mortality in Korea. Considering proximal humerus fracture was associated with an increased risk of associated fractures and an increased mortality risk, public health strategy to prevent the proximal humerus fracture in elderly will be mandatory.</P>

CaLEA1 is a late embryogenesis abundant protein in pepper that positively regulates abscisic acid signaling, drought and salt stress response

Chanmi Park,Hyunhee Joo,Woonhee Baek,Sung Chul Lee 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

Drought and high salinity are the most important abiotic factors limiting plant development, growth, and crop productivity in agriculture (Munns and Tester 2008, Sengupta and Majumder 2009, Zhu 2002). As sessile organisms, plants are frequently exposed to drought and high salinity conditions, which alter water potential and cause osmotic stress, leading to serious damage to plant tissues (Bartels and Sunkar 2005, Boudsocq and Lauriere 2005). During exposure to water stress, plants display many physiological changes, such as reduction of water content, closure of stomata, and decreased cell enlargement and growth. In addition, severe and continuous water stress in plants causes the cessation of photosynthesis and disturbance of metabolism, and finally results in death (Nath et al. 2005, Shao et al. 2008). To adapt to these abiotic stress conditions, plants show a variety of responses, including the accumulation of abscisic acid (ABA) and expression of a large number of stress-related proteins (Krasensky and Jonak 2012, Lee and Luan 2012, Skriver and Mundy 1990, Stewart and Lee 1974). Although the cellular and molecular responses to environmental stress are well studied (Hasegawa et al. 2000, Thomashow 1999), the mechanisms underlying the functional modifications caused by osmotic stress are yet to be clarified, because of the complexity at the cellular level as well as at the whole plant level (Ashraf and Harris 2004, Flowers 2004, Foolad et al. 2003a, 2003b, Xiong et al. 2002).

The Pepper RING-Type E3 Ligase, CaAIP1, Functions as a Positive Regulator of Drought and High Salinity Stress Responses

Park, Chanmi,Lim, Chae Woo,Lee, Sung Chul Oxford University Press 2016 Plant & cell physiology Vol.57 No.10

Umbilical Cord Mesenchymal Stem Cell-Conditioned Media Prevent Muscle Atrophy by Suppressing Muscle Atrophy-related Proteins and ROS Generation

Park CHANMI 한국생물공학회 2015 한국생물공학회 학술대회 Vol.2015 No.10

The putative E3 ubiquitin ligase CaAIR1 in pepper regulates abscisic acid signaling and drought stress response

Chanmi Park,Hyunhee Joo,Woonhee Baek,Sung Chul Lee 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

Several E3 ubiquitin ligases have been associated with the response to abiotic and biotic stresses in higher plants. Here, we report that the hot pepper (Capsicumannuum) abscisic acid (ABA)-InsensitiveRINGprotein1gene(CaAIR1) is essential for a hypersensitive response to drought stress. CaAIR1 contains a C3HC4-type RING finger motif, which plays a role for attachment of ubiquitins to the target protein, and a putative transmembrane domain. The expression levels of CaAIR1 are upregulated in pepper leaves by ABA treatments, drought, and NaCl, suggesting its role in the response to abiotic stress. Our analysis showed that CaAIR1 displays self-ubiquitination and localized in the nucleus. We generated CaAIR1-silenced peppers via virus-induced gene silencing (VIGS) and CaAIR1-overexpressing (OX) transgenic Arabidopsis plants to evaluate their responses to ABA and drought. VIGS of CaAIR1 in pepper plants conferred an enhanced tolerance to drought stress, which was accompanied by low levels of transpirational water loss in the drought-treated leaves. CaAIR1-OX plants displayed an impaired sensitivity to ABA during seed germination, seedling, and adult stages. Moreover, these plants showed enhanced sensitivity to drought stress because of reduced stomatal closure and decreased expression of stress-responsive genes. Thus, our data indicate that CaAIR1 is a negative regulator of the ABA-mediated drought-stress tolerance mechanism.

성향점수 활용방법

박찬미 ( Chanmi Park ) 대한간학회 2020 임상연구방법론워크숍 Vol.2020 No.1

자기자비와 관계만족에서 갈등대처행동의 매개: 자기효과와 상대방효과 분석

박찬미 ( Park Chanmi ),설경옥 ( Seol Kyoung Ok ) 한국가족관계학회 2017 한국가족관계학회지 Vol.22 No.3

Objectives: The purpose of this study was to investigate a role of self-compassion in conflict resolution strategies among dating couples. Further, we examined conflict resolution strategies as mechanisms to explain in the relationship between self-compassion and relationship satisfaction. Method: Two hundred forty two dating couples were recruited. Actor and Partner Independence Model(APIM) was used to examine actor and partner effects of self-compassion on relationship satisfaction as well as conflict resolution strategies. The total of 4 APIMs, two positive conflict resolution strategies(i.e., positive emotional reactions, active coping) and two negative conflict resolution strategies(i.e., negative emotional reactions and hostility, avoidance) were analyzed. Positive conflict resolution strategies had only actor effect in the link between self-compassion and relationship satisfaction. That is, self-compassionate men and women were more likely to use positive conflict resolution strategies and, in turn, led to their higher relationship satisfaction. Both actor and partner effects were found in the negative conflict resolution strategy models. In terms of actor effect self-compassionate men and women were less likely to use negative conflict resolution strategies and that, in turn, led to their higher relationship satisfaction. In terms of partner effects we found that women's negative emotional reactions and hostility mediated the link between women's self-compassion and their male partners' relationship satisfaction. Men's avoidance mediated the link between men's self-compassion and their female partners’ relationship satisfaction.

The Arabidopsis abscisic acid receptors RCAR4 and RCAR5 promote disease resistance through regulation of stomatal aperture

Woonhee Baek,Chanmi Park,Hyunhee Joo,Sung Chul Lee 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

Stomata are natural pores of plants and constitute the entry points for water during transpiration. However, they also facilitate the ingress of potentially harmful bacterial pathogens. The phytohormone abscisic acid (ABA) plays a pivotal role in protecting plants against biotic stress, by regulating stomatal closure. In the present study, we investigated the mechanism whereby ABA influences plant defense responses to Pseudomonas syringae pv. tomato (Pst) DC3000, which is a virulent bacterial pathogen of Arabidopsis, at the pre-invasive stage. We found that overexpression of two ABA receptors, namely, RCAR4/PYL10-OX and RCAR5/PYL11-OX (hereafter referred to as RCARs), resulted in ABA-hypersensitive phenotypes being exhibited during the seed germination and seedling growth stages. Sensitivity to ABA enhanced the resistance of RCAR4-OX and RCAR5-OX plants to Pst DC3000, through promoting stomatal closure leading to the development of resistance to this bacterial pathogen. Protein phosphatase HAB1 is an important component that is responsible for ABA signaling and which interacts with ABA receptors. We found that hab1 mutants exhibited enhanced resistance to Pst DC3000; moreover, similar to RCAR4-OX and RCAR5-OX plants, this enhanced resistance was correlated with stomatal closure. Taken together, our findings demonstrate that alteration of RCAR4- or RCAR5-HAB1 mediated ABA signaling influences resistance to bacterial pathogens via stomatal regulation.

Functional roles of the pepper lipoxygenase, CaLOX1, in osmotic, drought, and high salinity tolerance

Woonhee Baek,Chanmi Park,Hyunhee Joo,Sung Chul Lee 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

In plants, lipoxygenases (LOXs) are involved in various physiological processes, including defense responses to biotic and abiotic stresses. Our previous study has shown that pepper 9-LOX gene, CaLOX1, plays a crucial role in cell death due to pathogen infection. Here, the function of CaLOX1 in response to osmotic, drought, and high salinity was examined using CaLOX1-overexpressing (CaLOX1-OX) Arabidopsis plants. Changes in the temporal expression pattern of the CaLOX1 gene were observed when pepper leaves were treated with drought and high salinity, but not with abscisic acid (ABA), the primary hormone in response to drought stress. During seed germination and seedling development, CaLOX1-OX plants were more tolerant to ABA, mannitol, and high salinity than wild-type plants. In contrast, expression of the ABA-responsive marker genes RAB18 and RD29B was higher in CaLOX1-OX Arabidopsis plants than in wild-type plants. In response to high salinity, CaLOX1-OX plants exhibited enhanced tolerance, compared with wild-type, which is accompanied by decreased accumulation of H2O2 and high levels of RD20, RD29A, RD29B, and P5CS gene expressions. Similarly, CaLOX1-OX plants were also more tolerant than wild-type plants to severe drought stress. H2O2 production and relative increase of lipid peroxidation were lower, and the expression of COR15A, DREB2A, RD20, RD29A, and RD29B was higher in CaLOX1-OX plants, relative to those of wild-type plants. Taken together, our results indicate that CaLOX1 plays a crucial role in plant stress responses by modulating the expression of ABA- and stress-responsive marker genes, lipid peroxidation, and H2O2 production.

A Series of Novel Terpyridine-Skeleton Molecule Derivants Inhibit Tumor Growth and Metastasis by Targeting Topoisomerases

Kwon, Han-Byeol,Park, Chanmi,Jeon, Kyung-Hwa,Lee, Eunyoung,Park, So-Eun,Jun, Kyu-Yeon,Kadayat, Tara Man,Thapa, Pritam,Karki, Radha,Na, Younghwa,Park, Mi Sun,Rho, Seung Bae,Lee, Eung-Seok,Kwon, Youngjo American Chemical Society 2015 Journal of medicinal chemistry Vol.58 No.3

<P>A series of novel terpyridine-skeleton molecules containing conformational rigidity, 14 containing benzo[4,5]furo[3,2-<I>b</I>]pyridine core and 15 comprising chromeno[4,3-<I>b</I>]pyridine core, were synthesized, and their biological activities were evaluated. 3-(4-Phenylbenzo[4,5]furo[3,2-<I>b</I>]pyridin-2-yl)phenol (<B>8</B>) was determined to be a nonintercalative topo I and II dual catalytic inhibitor and 3-(4-phenylchromeno[4,3-<I>b</I>]pyridine-2-yl)phenol (<B>22</B>) was determined to be a nonintercalative topo IIα specific catalytic inhibitor by various assays. These two catalytic inhibitors induced apoptosis in addition to G1 arrest in T47D human breast cancer cells with much less DNA toxicity than etoposide. Compounds <B>8</B> and <B>22</B> significantly inhibited tumor growth in HCT15 subcutaneously implanted xenografted mice. The modification of compounds <B>8</B> and <B>22</B> with the introduction of a methoxy instead of a hydroxy group enhanced endogenous topo inhibitory activity, metabolic stability in diverse types of liver microsomes and improved pharmacokinetic parameters in rat plasma such as augmentation of bioavailability (41.3% and 33.2% for 2-(3-methoxyphenyl)-4-phenylbenzofuro[3,2-<I>b</I>]pyridine (<B>8-M</B>) and 3-(4-phenylchromeno[4,3-<I>b</I>]pyridine-2-yl)methoxybenzene (<B>22-M</B>), respectively).</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jmcmar/2015/jmcmar.2015.58.issue-3/jm501023q/production/images/medium/jm-2014-01023q_0017.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jm501023q'>ACS Electronic Supporting Info</A></P>