아세틸 콜린 유발 검사시 허혈성 심전도 변화와 흉통의 발생이 내피세포 기능장애에 미치는 영향

최철웅(Cheol Ung Choi),나승운(Seung-Woon Rha),김선원(Sun Won Kim),나진오(Jin Oh Na),임홍의(Hong Euy Lim),김진원(Jin Won Kim),김응주(Eung Ju Kim),한성우(Seong Woo Han),박창규(Chang Gyu Park),서홍석(Hong Seog Seo),오동주(Dong Joo Oh) 대한임상노인의학회 2010 대한임상노인의학회지 Vol.11 No.4

연구배경: 아세틸 콜린 유발 검사시 발생하는 흉통과 허혈성 심전도 변화가 아세틸 콜린에 의해 발생하는 관상동맥의 내피세포 기능에 어떤 영향을 주는지 알아보고자 했다. 방법: 흉통으로 내원하여 관상동맥 조영술과 아세틸 콜린 유발검사를 시행받은 1,085명의 환자를 대상으로 하였다. 아세틸 콜린 유발 검사를 하는 동안 허혈성 심전도 변화 및 흉통의 발생 유무에 따른 관상동맥 내피세포 기능의 특징을 비교하였다. 결과: 539명의 환자에서 아세틸 콜린 검사시 내피세포 기능 장애가 발생 하였다. 허혈성 심전도 변화가 있었던 그룹이 심전도 변화가 없었던 그룹보다 흉통이 더 많았고(78.1% vs. 60.8%, P=0.007), 관상동맥 조영술상 다발성 관상동맥 경련이 빈번하였고(59.4% vs. 40.6%, P=0.004), 관상동맥의 경련 정도도 더 심하였다(64.1% vs. 46.5%, P=0.006). 흉통이 있었던 그룹이 흉통이 없었던 그룹보다 허혈성 심전도 변화의 빈도가 더 높았다(14.7% vs. 7.5%, P=0.007). 또한 흉통이 있었던 그룹이 관상동맥 경련이 다발성으로 발생하는 경우가 많았고 (50.7% vs. 29.5%, P<0.001), 미만성으로 발생하는 경우가 많았고(87.1% vs. 75%, P<0.001), 관상동맥의 경련의 정도도 더 심하였다(51.6% vs. 43.5%, P=0.041). 결론: 아세틸 콜린 유발검사시 발생하는 허혈성 심전도 변화와 흉통은 관상동맥 경련의 정도와 경련이 발생하는 관상동맥 개수와 연관이 있다. Background: ECG changes and chest pain during acetylcholine (Ach) provocation tests may constitute important clinical parameters for Ach-induced endothelial dysfunction. We investigated the association between ischemic ECG changes and chest pain during the Ach-provocation test and angiographic characteristics of Ach-induced endothelial dysfunction. Methods: A total of 1,085 patients with anginal symptoms underwent diagnostic coronary angiography (CAG) and Ach-provocation tests. We compared angiographic characteristics of Ach-induced endothelial dysfunction according to the presence of ECG change and chest pain. Results: A total of 539 patients experienced Ach-induced endothelial dysfunction. Patients who experienced ECG change group suffered more frequent chest pain (78.1% vs. 60.8%, P=0.007), angiographically more frequent multiple coronary artery spasm (59.4% vs. 40.6%, P=0.004), and more severe coronary artery spasm (64.1% vs. 46.5%, P=0.006) than patients without ECG change. However, there was no difference in the length of endothelial dysfunction between the groups. The incidence of ischemic ECG changes in patients with chest pain was higher than in patients without chest pain (14.7% vs. 7.5%, P=0.007). Patients who experienced chest pain more often experienced multiple (50.7% vs. 29.5%, P<0.001), diffuse (87.1% vs. 75%, P<0.001), and severe coronary artery spasm (51.6% vs. 43.5%, P=0.041) than patients without chest pain. Conclusion: Ischemic ECG changes and chest pain during the Ach-provocation test are associated with multi-vessel involvement and severe coronary artery spasm. Chest pain is associated with the length of endothelial dysfunction, but ischemic ECG change is not.

Dipyridamole 부하 심근 SPECT에서 Dipyridamole의 작용과 부작용

고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),이동수(Dong Soo Lee),최창운(Chang Woon Choi),배상균(Sang Kyun Bae),양형인(Hyung In Yang),여정석(Jeong Suk Yeo) 대한핵의학회 1993 핵의학 분자영상 Vol.27 No.2

N/A Dipyridamole is an agent that may be used to noninvasively evaluate coronary artery disease. The effect of dipyridamole infusion its generally related to its induced peripheral vasodilatory effect. In normal person, heart rate is generally increased slightly while blood pressure decrease, but the achieved double product and related myocardial oxygen consumption have no significant change. The purpose of this study is to examine the effect and side effect of dipyridamole, and to compare different response to dipyridamole among the patients. We evaluated 847 patients who underwent dipyridamole stress myocardial SPECT. 93.6% of them had induced hypotension 0.9% showed no change of blood pressure, 5.5% had increased blood pressure 8.3% had no change of pulse rate more than 10% of basal pulse rate. Among diabetes, 16.9% was not change of pulse rate, 6.7% in non-diabetes. There was no significant correlation between age and rate pressure product rest(RPPr), in patients without perfusion defects on SPECT(y=7.1x+48.4r=0.13 p>0.01). As increasing age, RPPs/RPPr was declined(y=-11.6x+68.9 r=0.17 p〈0.01), similar results were obtained in patients with perfusion defect. The size of perfusion defect on myocardial SPECT have no correlation between RPPr and RPPs/RPPr. The side effects of dipyridamole included chest pain and chest tightness, headache, abdominal pain, dizzness, nausea, and dyspnea. As increasing age, dipyridamole-induced cardiac work at rest was increased, cardiac response to dipyridamole was decreased.

Synergistic Improvement in Insulin Resistance with a Combination of Fenofibrate and Rosiglitazone in Obese Type 2 Diabetic Mice

Choi, Woon-Seok,Lee, Jung-Jin,Kim, Yo-Han,Kim, In-Su,Zhang, Wei-Yun,Myung, Chang-Seon 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.4

Peroxisome proliferator-activated receptor (PPAR) ${\alpha}$, which is abundant in the liver, increases lipoprotein lipase activity, resulting in a decrease of triglyceride (TG) levels. $PPAR{\gamma}$, which is abundant in adipose tissue, stimulates adipocyte differentiation and adipogenesis, and results in an increase in insulin sensitivity. Fenofibrate, a $PPAR{\alpha}$ agonist, is commonly used to treat dyslipidemia, and rosiglitazone, a $PPAR{\gamma}$ agonist, is effective in improving glycemic control. To examine the synergistic effects of rosiglitazone in combination with fenofibrate, an obese type 2 diabetes mellitus (DM) mouse model was established by the combined administration of streptozotocin and nicotinamide and fed on a high-fat diet (35% of energy as fat) for 3 weeks. The mice had significantly higher plasma glucose concentrations and insulin resistance, as examined by an oral glucose tolerance test and insulin challenge test compared with normal mice. After establishing a dose-response curve for each drug, the drugs were orally administered for 3 weeks either alone or in combination. After individual administration of fenofibrate, HDL cholesterol levels significantly increased, and plasma glucose and TG levels decreased in obese type 2 DM mice. The individual administration of rosiglitazone showed increased insulin resistance (QUICKI). However, HDL cholesterol and TG levels were not significantly changed. In a combination of fenofibrate at 25 mg/kg and rosiglitazone at 1.25 mg/kg there was a decrease in plasma glucose and TG levels, and a combination of fenofibrate at 50 mg/kg and rosiglitazone at 2.5 mg/kg showed an increase in plasma HDL cholesterol levels. Moreover, parameters related to insulin resistance (HOMA-IR) and insulin sensitivity (QUICKI) were improved significantly. Thus, our results show that combination therapy with lower doses of fenofibrate and rosiglitazone ameliorates the type 2 DM condition to a greater extent than high doses of either individual monotherapy.

십이지장 결핵 2예의 내시경적 고찰

장린,박충기,민영일,장영운,우정택,방익수,최학림,장주희 대한소화기내시경학회 1985 Clinical Endoscopy Vol.5 No.1

Today, the duodenal tuberculosis is a very rare disease. Final diagnosis of duodenal tuberculosis is difficult due to inconsistent symptoms and nonspecific duodenal lesions. We found 2 cases of duodenal tuberculosis by gastrascopy. In gastroscopic findings, there were undetermined ulcers and irregular nodular mucosal changes.

악성종양에서 골수면역신티그라피를 이용한 골수전이의 평가 : 99mTc-MDP 뼈스캔과의 비교

고창순(Chang Soon Koh),김노경(Noe Kyeong Kim),김병국(Byoung Kook Kim),최창운(Chang Woon Choi),정준기(Jun Key Chung),방영주(Yung Jue Bang),이경한(Kyung Han Lee),정홍근(Hong Keun Chung),이명철(Myoung Chul Lee) 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.1

N/A Although bone scan is a highly sensitive test for detecting bone metastasis, its findings are often limited in specificity and cannot be used for assessing the bone marrow. Bone marrow scintigraphy may provide useful information but previous experience with radiolabelled colloid has been disappointing. Recently, 99mTc labeled anti-granulocyte rnonoclonal antibody (anti-NCA-95 MAb) has been introdueed as a new bone marrow imaging agent. To evaluate the usefulness of 99mTc anti-NCA MAb bone marrow scans for detecting skeietal metastasis, bone marrow scans of 44 malignant tumor patients were evaluated and compared with bone scan fmdings. Bone scan showed abnormal lesions in 26(59%) cases, and 18 of these patients also had an abnormal bone marrow scan. Seven of the 8 patients who had normal bone marrow scan despite bone scan lesions were confirmed to be free from metastasis. There was one case with a marrow defect despite normal bone scan but the presence of metastasis was not determined due to loss of follow up. Bone scan demonstrated a total of 64 lesions while bone marrow scan showed 38 lesions. Fifty percent (32/64) of the bone scan lesions had matching marrow defects while the rernaining 50% did not. Most of these non matched lesions were suggested to be nonspecific 1esions such as rib fractures or degenerative change. Meanwhile bone marrow scan was able to detect 6 new lesions not detected by bone scan, but metastasis in each lesion was not confirmed. Bone marrow scan was also helpful in assessing equivocal bone scan lesions to be of metastatic nature in 10 patients by demonstrating a matched marrow defect. Thus 99mTc anti-NCA MAb bone marrow scan can help exclude metastasis in patients with nonspecific bone scan lesions and may be able to detect metastatic lesions not seen with bone scan. It appears useful as a complementary study to bone scan in evaluating malignant tumor patients.

甘草가 흰쥐肝의 cytochrome P_450 관여 藥物代謝酵素活性에 미치는 影響

최성운,권창호 慶熙大學校 1990 論文集 Vol.19 No.-

Drug metabolizing enzymes containing Cytochrome P-450 of liver microsomes of rat were induced by phenobarbital sodium injection and extractum Glycyrrhizae then they were purified partially. Then these enzymes were tested on activities catalizing the hydroxylation of anisole of aromatic ethers. The results are summarized as follow : 1. As a result of injection phenobarbital sodium and p.o. extractum Glycyrrhizae into rat, protein content was most highest between 38∼40 fraction of the enzymes containing Cytochrome P-450 eluted with Emalgen 913. And the group pretreated wit Extractum Glycyrrhizae has been increased by 6.5% and with phenobarbital sodium injection by 64% in comparison with the control group. 2. From the reaction of anisole and the reconstituted enzyme containing Cytochrome P-450, guaiacol has been obtained 5∼6% in the control group and 6∼7% in the group pretreated with Extractum Glycyrrhizae and 7∼10% in the group pretreated with phenobarbital sodium. 3. Based on all above results, it is concluded that the Drug Metabolizing Enzyme containing Cytochrome P-450 was induced slightly by Extractum Glycyrrhizae and induced strongly by phenobarbital sodium.

男女平等의 國際的保障 : 國際條約上 男女平等規定의 國內的 適用性을 中心으로 special references to the domestic application of sexual equality under international treaties

崔創東,金泰雲,韓相秀 부산 외국어 대학교 1987 外大論叢 Vol.5 No.1

One of the most constant themes underlying the great historical struggles for social justice has been the demands for equality. The international guarantee of the principles of equality can not be exaggerated in evaluating of its importance. But various kinds of inequalities in the international societies are found such as the Indian Caste System, the South African Apartheid System, and discriminations on politic, economic, social, cultural, religion, race, etc. Nowadays there are discriminations in particular on account of sex in the fields of employment and occupation. This thesis put the stress on the sexual- equality under the international treaties, and emphasize the domestic application of sexual equality provisions under international law. The contents of this thesis may be summarized as followings ; Ⅰ. introduction Ⅱ. notion of the sexual equality and its grounded base. Ⅲ. sexual equality provisions under the international treaties. Ⅳ. fundamental principles of sexual equality in emploment and occupation. Ⅴ. domestic application of sexual equality under international treaties. Ⅵ. conclusion Equal Rights is called "grundnorm" in the constitutional values. The principles of equality is not created by the statute, but only confirmed in the legal rules. Moreover, sexual equality is more important concept in the, human rights, because women's growing economic importance and the demands for equal treatment and better employment opportunities have been influential in the development of public polices intended to improve their position in the labour market. There are some reasons why the provisions on sexual equality under international law could be effective in the domestic rules; Firstly, the principle of equality is "grundnorm" of the fundamental rights and so the sexual equatity could be valid throughout the world, not only in domestic laws but also in the international law. Secondly, our Constitution of the 5th Republic do ordain the domestic effectiveness of international law in Article5, saying "treaties duly concluded and promulgated in accordance with the constitution and the generally recognized rules of international law shall have the same effect as the domestic laws of the republic of Korea." And the Constitution declare the general principles of equality, or equality before the law, in Article 10 ;"......there shall be no discrimination in political, economic, civil or cultural life on account of sex, religion or social status." Lastly, the international guarantee of human rights is the global tendency in the modem democratic society. As the above mentioned, that the provisions on equality of the sexes under the "conventions and declarations" such as "Universal Declaration of Human Rights"(1948), "International Covenant of Human Rights"(1966), "ILO Convention no.l00"(1919), "European Economic Community Legislation"(1957), could be applicable,to the domestic legal rules. In accordance with the growing participation and changing roles of wemen in the labour market, moreover, we emphasize in particular on the problems of achieving equality of pay and employment, the influence of education and training, flexibility of working time and child-care arrangements for working parents, and the evolution of social security legislation to deal in a consistent way with men and women.

Giant Dermatofibroma with Granular Cell Change: Side Effect of Bee venom Acupuncture?

( Do Young Rhee ),( Woon Kyong Chung ),( Gyeong Hun Park ),( Sung Eun Chang ),( Mi Woo Lee ),( Jee Ho Choi ),( Kee Chan Moon ),( Jai Kyoung Koh ) 대한피부과학회 2008 초록집 Vol.46 No.10

특집 : 마그네슘판재 응용기술 ; 마그네슘 부품제조를 위한 용접기술

이목영 ( Mok Young Lee ),장웅성 ( Woong Seong Chang ),윤병현 ( Byung Hyun Yoon ),김숙환 ( Sook Hwan Kim ),최상운 ( Sang Woon Choi1 ) 대한금속재료학회 ( 구 대한금속학회 ) 2007 재료마당 Vol.20 No.5

흉요추에 발생한 Aspergillosis 치험 1례

박시용,김규홍,이운기,최정훈,이인창,배상도 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.12