사염화탄소 투여 흰쥐에서 간섬유화 진행에 따른 Propranolol 의 약동학적 지표들의 변화

이민호,강주섭,강문수,윤병철,이오영,함준수,변재원,윤창옥 대한간학회 2001 Clinical and Molecular Hepatology(대한간학회지) Vol.7 No.2

Background/Aims : This study was designed to determine the effect of hepatic fibrotic severity on pharmacokinetics of propranolol in CC1q - treated rats. Methods - 1 mL/kg of 10% CC14 in olive oil was injected intramuscularly to rats twice weekly for 4, 6, 8 and 10 weeks, respectively (n=6). Control (n=6) was a sham - injected equal dose of olive oil for 10 weeks. After intravenous bolus injection of 2 mg/kg propranolol to rats, the serum propranolol concentrations were analyzed for 4 hours at various time points by a HPLC - fluorimetric system, and pharmacokinetic parameters such as Co, MRT, AUC, Vdss, tl/2(p) and CLp were determined. Then, a small amount of hepatic tissue was obtained and subjected to determination of the hepatic 4 - hydroxyproline content, which confirmed the hepatic fibrotic severity. Results : The serum concentrations of propranolol at 0.5, 1, 2 and 4 hours were significantly increased in CC1q-treated rats (p$lt;0.01). In proportion to the duration of CC4 treatment, Co and AUC were significantly increased, and Vdss and CLp were significantly decreased (p$lt;0.001). But MRT and t1/2(β) were not significantly changed. The hepatic 4 -hydroxyproline content was gradually increased in CC4-treated rats (p$lt;0.001). Conclusion - Gradual changes in pharmacokinetic parameters of propranolol were seen to be dependent on the hepatic fibrotic severity. We suggest that gradual dosage modification, according to their hepatic fibrotic severity, is necessary for many drugs administered to patients with chronic liver disease.(Korean J Hepatol 2001;7:181-188)

안구적출에 따른 위둔덕의 칼슘결합단백질의 재구축 및 상호 연관성

안병수,고길석,안명수,김경주,권안성,정명섭,박춘매,조병옥,김진우,Samudra Acharya,Parmeshwar Narayan Amatya,장인엽 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.1

Background: Superior colliculus is a part of midbrain, and participates in the visual reflexes, It receives afferent fibers from optic nerve, visual cortex, and spinotectal tract. After optic deprivation, the microscopic structure of the superior colliculus changed. Calcium-binding proteins (CBPs) Play an important role in the neuronal protection, differentiation and reorganization of the central nervous system, Objectives and Methods: The effects of neonatal retinal deafferentation on a CBPs, calbindm D-28k (CB), Parvalbumin (PB) and calretimn (CR), and the existence of colocalization between the CBPs were examined immunohistochemically in the rat superior colliculus. Results: On the experimental (contralateral to enucleation) side of superior colliculus, the number of CB-immunoreactive (IR) cells was reduced (77.4% compared to control), but not fibers. The number of PB-IR neurons and fibers was also reduced on the experimental side (88.5% compared to control), In the other hand, the CR-IR cells were dramatically increased (642% compared to control), but CR-IR fibers were markedly decreased on the experimental side. The colocalization between CB-CR and PV-CR was rarely observed in the superior colliculus Conclusion: These results suggest that the changes of retinotectal projection may alter the expressional pattern of CBPs in different manners; relatively stable in CB- and PV-IR neurons and plastic in CR-IR neurons.

한국인 담석증에 대한 임상적 고찰

김광하(Gwang Ha Kim),옥창민(Chang Min Ok),김병진(Byung Jin Kim),주형준(Hyung Jun Joo),송철수(Chul Soo Song),송근암(Guen Am Song),조몽(Mong Cho),양웅석(Ung Suk Yang) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.3

N/A Background/Aitns: It has been reported frequently that clinical features of gallstone diseases in Koreans were different from those of Occidentals. These differences were thought to be due to inherent racial difference and acquired living habits. The purpose of this study is to evaluate whether the pattern of gallstone disease changes or not in Korea. Methods: We analyzed 5,488 cases of gallstone diseases which were reported in Korea frorn 1966 to 1994. We divided the period into 6 groups: the first period was 1,000 cases reported from 1966 to 1970, the second was 331 cases from 1971 to 1975, the third was 1,000 cases from 1976 to 1980, the fourth was 1,957 cases from 1981 to 1985, the fifth was 1,000 cases from 1986 to 1990, and the sixth was 200 cases from 1991 to 1993. Results: The age group of highest incidence was the fifth and sixth decade. The incidence below the third decade showed a decreasing tendency. In contrast, the incidence above sixth decade showed an increasing tendency. The male to female ratio was 1:1.25 to 1:1.71 and had no periological change. The duration of illness of highest frequency was below 6 months. In the case of duration above 5 years these was a decreasing tendency. The major complaints of biliary stone were right upper quadrant pain and tenderness. Nausea, vomiting, jaundice, and radiating pain showed a decreasing tendency. The major laboratory findings were leukocytosis, elevated SGOT and SGPT, elevated alkaline phosphatase, hyperbilirubinemia and hypoalbuminemia. Of these, only hypoalbuminernia had a decreasing tendency. By the second period, the main diagnostic procedures were oral cholecystogram and intravenous cholecysto- graphy. From the fourth period, ultrasonography, ERCP, CT and PTC were been used comrnonly. For the location of gallstone, the gallbladder stone revealed the only increasing tendency, the common bile duct stone had a decreasing tendency, and the intrahepatic duct stone had no periological change. From 1980, the cholesterol stone became the main composition of gallstones. But, there was no periological change between early and late 1980s. Positive bacterial culture rate was 57.0% and the most common microorganism was E. coli. Klebsiella and Enterobacter. Pseudomonas showed an increasing tendency. Of the diseases associated with gallstone, only diabetes had an increasing tendency. The frequency of residual stone had an increasing tendency. Conclusions: The age of peak incidence of gallstone diseases was the fifth and sixth decades and there was a little predominance in females. From 1980, the cholesterol stone becarne the main composition of gallstones. For the location of gallstone, the gallbladder stone showed an increasing tendency and the common bile duct stone revealed a decreasing tendency. These suggested clinical features of gallstone diseases in Koreans are somewhat similar to those of Occidentals. (Korean J Gastroenterol 1997;29:352 - 361)

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

放射線照射에 의한 濟州産 鹽乾옥돔의 貯藏性向上에 관한 硏究

金洙賢,鄭昌朝,趙韓玉,金在河 제주대학교 방사능이용연구소 1985 연구보고 Vol.1 No.-

濟州産 鹽乾옥돔(yellow sea bream ; Branchiostegus japonicus japonicus)을 Vinyl 眞空包裝 0, 0.5, 1.0, 1.5 및 2.0Mrad 水準으로 放射線 照射후 室溫과 冷藏으로 60日間 貯藏하여 鹽乾옥돔의 理化學的變化 및 官能檢査를 수행하였다. 貯藏期間中 總菌數는 放射線 照射水準이 높아짐에 따라 抑制되고 있었으며, 放射線照射와 冷藏處理가 더욱 效果的이었다. TMA의 增加率은 高線量水準에서 적었으며 2.0Mrad水準은 도리어 貯藏初期에 비하여 末期에 이르러 TMA의 含量을 減少시켰다. TMAO의 減少率은 貯藏條件에 관계없이 照射後 20日傾부터는 急激한 減少現象을 나타내었다. Total nitrogen의 減少는 無照射區에서 가장 컸으며, 照射水準이 높아짐에 따라 變化의 폭은 적었다. VBN含量은 各 處理區 모두 D30에서 顯著한 增加를 보이고 있었으며, 放射線處理에 따라 多少 抑制되었다. 放射線照査와 室溫貯藏區에서는 20日까지, 放射線照査 및 冷藏處理區에서는 40日까지 鹽乾옥돔의 鮮度를 유지시킬 수가 있었다. 組織變化, 總菌數, 腐敗 등 要因을 考慮할 때 鹽乾옥돔의 貯藏性向上을 위해서는 1.0Mrad가 適正水準으로 推定되었다. Salted dry yellow sea bream were vaccum packed in a plastic bags and irradiated at differents levels (0.0.5, 1.0, 1.5 and 20 Mrad) using ?? source. The irradiated samples were stored at room temperature and 5℃. Physical and chemical properties were examined during storage. The total bacterial count was depressed according to level of irradiation applied. It was noted that cold storage after irrdiation was more effective than room temperature. TMA contents slowly increased with higher dosage rates up to 1.5 Mrad but there was a gradual decrease of TMA at the 2.0 Mrad level.It was observed that there was a rapid decrease of TMAO 20 days after irradiation irrespective of storage temperature. The reduction of total nitrogen content was highest in the control but to a lesser degree when irradiation was applied. VBN content increased in all treatments 30 days after irradiation but it was also noted that there was a tendency toward depression of VBN by irradiation. The shelf life of salted dry sea bream was extended by 20 days with irradiation plus room temperature, and by 40 days with irradiation plus cold storage. To extend shelf life of salted dry sea bream, the most effective dosage rate was 1.0 Mrad based on tenderness, bacterial count and rancidity.

放射線照射에 의한 柑橘貯藏에 관한 硏究

鄭昌朝,趙漢玉,金洙賢,金在河 제주대학교 방사능이용연구소 1985 연구보고 Vol.1 No.-

柑橘의 貯藏性 向上을 爲한 ?? 線 照射가 濟州産 溫洲柑橘에 미치는 影響을 調査하였다. 溫洲柑橘 4個 系統을 10,000Ci, ?? 線源을 利用 0, 50, 100, 150Krad水準으로 照射하여 92日間 半地下式 貯藏庫에 貯藏, 調査한 結果를 要約하면 아래와 같다. 1. 貯藏終了時까지의 柑橘 累積腐敗率은 中生系인 米澤(T₂) 74.32%, 早生溫洲(T₁) 69.67%, 中晩生系林溫洲(T₃) 61.79%와 晩生系 靑島(T₄)가 64.33%였다. 反面 서울地域의 腐敗率은 D-72에서 T₁; 28%, T₃; 25% 및 T₄; 24%로 濟州地域에 比해 越等히 낮았다. 柑橘의 腐敗는 貯藏初期에 徐徐히 增加하나 照射後 59日부터는 急激히 上昇하기 始作하였다. 腐敗率과 柑橘系統 사이에는 高度의 相關關係가 있었으며 貯藏性은 T₃와 T₄가 가장 우수하였다 ??. 高放射線 照射水準(100, 150Krad)은 貯藏中期까지 柑橘貯藏에 效果가 있었으나 照射 76日 以後에는 對照區와 差가 없었다. 2. 放射線 照射는 貯藏期間中 柑橘의 酸度를 減少 시켰으며 平均 酸度는 T₁; 1.01%, T₃; 1.01%, T₄; 0.84% 및 T₂; 0.77%로 柑橘系統 및 照射線量間에는 高度(P<0.01)의 有意差가 認定되었다. 3. 모든 處理區에서 還元糖과 全糖含量은 增加하고 있었으나 統計的 有意性은 없었고 50Krad照射區에서만은 對照區에 比해 有意的(P<0.01)으로 減少하고 있었다. 糖度는 T₁,T₄가 T₂, T₃에 比하여 높았으며 高線量水準(100, 150Krad)에서 Control에 比해 有意的인 減少가 있었다(P<0.01). Ascorbine 酸含量은 모든 處理區에서 貯藏時期가 經過됨에 따라 減少하였으며 高照射線量水準에서 對照區에 比해 有意的인 減少가 있었다(P<0.01). A study was conducted to evaluate the effect of ?? irradiation on the preservation of Satsuma mandarin in Cheju Island. Four varieties (S. m. early, S. m. Komezawa, S. m. Hayashi and S. m. Aoshima) were irradiated using 10,000 Ci, ?? ray with dosages of 0, 50, 100 and 150Krad. During 92 days of storage the effects of irradiation on mandarin properties were as follows; 1. At the end of storage period the accumulated fruit rotting percentage were S. m. Komezawa (T₂); 74.32%, S. m. early (T₁); 69.67%, S. m. aoshima (T₄); 64.33% and S. m. Hayashi (T₃); 61.79%. The rottings steadily increased from the early stage of storage and rapid spoilage continued after 59 days of irradiation. A high correlation existed between fruit rotting and varieties (T₃; Y=0.78x-15.30, T₄; Y=0.79x-12.29, T₁; Y=0.93x-9.01 and T₂; Y=0.79x-13.49). High dosages (100 and 150 Krad) improved fruit preservation during the mid storage stage. However 76 days after high dose irradiation there was no significant difference a rotting between irradiated fruit and the control. 2. Irradiation decreased acidity of fruit during storage (P<0.01). The mean acidities of examined varieties were T₁; 1.01%, T₃; 1.01%, T₄; 0.84% and T₂; 0.77%. A significant differences were observed in acidity between varieties and dosages (P<0.01). 3. With one exception in all treatments, the increase in free and total sugar content was not statistically significant. The exception was the 50 Krad treatment where the total sugar content decreased. T₁and T₄showed slightly higher value of Brix than T₂and T₃and were significantly (P<0.01) decreased by higher dosage. The ascorbic acid content in all treatments decreased with length of storage and also decreased significantly with a higher dosage.

뇌성마비 환자의 뇌자기공명영상

강용수,김봉옥,김종철,송창준 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

Brain MRI findings were analyzed in 30 patients with clinical cerebral palysy to determine clinical role in assessment of time of brain damage. The patients (1 day to 14 yrs. old) underwent MR scanning and findings were correlated with clinical history retrospectively. Among 13 prematurely born patients, 11 cases showed abnormal findings in brain MR, which were periventricular leukomalacia in 10 patients and cortical gray matter disease in 1 patient. And MR scans of 17 patients born at or around the expected date of confinement were reviewed. Fifteen cases showed abnormal findings in MR, which are, cortical gary matter disease in 10 patients, deep white matter lesion in 3 patients and neuronal migration anomaly such as schizencephaly, polymicrogyria and pachygyria in 3 patients. Abnormality in contour of ventricle in prematurely born patients were dilatation of trigone & irregular ventricular contour in 4 patients and diffuse enlargement in 3patients. Among patients born at term, dilatation of trigone & irregular ventricular contour in 3 patients and diffuse enlargement in 6 patients were observed. Corpus callosal abnormalities were thinning of posterior body in 7 patients, diffuse thinning in one patient and irregularity in 4 patients among the prematurely born and thinning of posterior body in 9 patients, diffuse thinning in 2 patients, abscent in 1 patient and irregularity in 3 patients among the patients born at term. MR imaging seemed to be very useful in determining the time of the insult which could have been the cause of the cerebral palsy.

좌우 대장게실 질환의 비교

임정수,손창용,배옥석,박성대 대한대장항문학회 1999 Annals of Coloproctolgy Vol.15 No.3

계획된 행동이론을 적용한 사업장 여성근로자의 운동실천 차이 분석 : An Application of the Theory of Planned Behavior

배상수,이훈재,이창옥,조희숙 韓國保健敎育.健康增進學會 2003 보건교육건강증진학회지 Vol.20 No.1

The objectives of this study were to verify the determinants of regular exercise behavior in female worker by applying a modified Theory of Planned Behavior. The variables investigated for this study were health status, health concern, health habit, attitude (7 items), subjective norm (3 items), and perceived behavioral control( 5 items). Data was collected from 204 female workers using a self-administered questionnaire. The results of this study were as follows. 1) Regular exercise behavior was significantly influenced by perceived behavior control for time, pleasurable attitude, and the subjective norm of their colleagues. 2) A modified Theory of Planned Behavior is particularly useful in explaining exercise behavior of female workers. We suggest that health care providers should focus on not only attitude and social norms but also perceived behavioral control in order to improve the exercise behavior of female workers.

연구논문 : 종분포모형을 이용한 히어리 서식지의 분포 특성 연구

권혁수 ( Hyuk Soo Kwon ),류지은 ( Ji Eun Ryu ),서창완 ( Chang Wan Seo ),김지연 ( Ji Yeon Kim ),임동옥 ( Dong Ok Lim ),서민환 ( Min Hwan Suh ) 한국환경영향평가학회 2012 환경영향평가 Vol.21 No.5

Since the CBD(Conservation on Biological Diversity)`s 10th Conference of the Parties adopted the protocol on access to genetic resources and benefit sharing in Nagoya 2010, the importance of endangered species studies such as habitat distribution, protection and management have been more emerged. Corylopsis coreana, an endangered species in Korea, was isolated nationally and has been damaged by anthropogenic factors. In this paper, we identified the factors affecting C. coreana habitat at the national scale and regional scale using National Survey of Natural Environment and predicted the distribution of C. coreana. Annual precipitation, precipitation of wettest quarter, temperature seasonality and Digital Elevation Model(DEM) were derived as important factors at the national scale, and precipitation of wettest quarter, DEM and solar radiation on spring were identified as important factors at regional scale. Colylopsis distribution was affected by an effect of climate significantly at the national scale, and by additionally the microclimate and topography at regional scale. These findings will be used as the basis on habitat conservation and restoration plan and climate change.