Association Between Gut Regulatory Hormones and Post-operative Weight Loss Following Gastrectomy in Patients With Gastric Cancer

Hye-Kyung Jung,Chung Hyun Tae,Hye Ah Lee,Ko Eun Lee,Chang Mo Moon,Seong Eun Kim,Ju Young Seoh,Joo-Ho Lee 대한소화기 기능성질환·운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.3

Background/AimsPost-operative weight loss in patients with gastric cancer lead to a poor quality of life and long-term survival. This study aims to evaluate the effects of gut regulatory hormones on post-operative weight loss in patients with subtotal gastrectomy for gastric cancer. MethodsThis prospective study was conducted for 12 months post-surgery in 14 controls and 13 gastrectomy patients who underwent subtotal gastrectomy for gastric cancer. Serum plasma ghrelin, glucagon-like peptide-1, gastric inhibitory peptide-1, peptide YY, insulin, and homeostatic model assessment for insulin resistance responses to a standardized test meal were recorded at multiple time points before and after gastrectomy at 4 and 12 months. ResultsThe mean weight difference between the pre-operative state and the 4-month period was significantly reduced to 6.6 kg (P = 0.032), but significant weight reduction was not observed from 4 months to 12 months. The plasma levels of glucagon-like peptide-1, gastric inhibitory peptide-1, and peptide YY were significantly increased 4 months postoperatively compared to the pre-operative state (all P = 0.035); however, pre-operative levels and relative changes over a period of 0-4 months of hormones were not correlated with body weight changes. Only the pre-operative ghrelin at peak had a negative correlation with changes in weight reduction in the 4 months after surgery (ρ = −0.8, P = 0.024). ConclusionsSignificant weight reduction was common after subtotal gastrectomy for gastric cancer with a negative correlation pre-operative plasma ghrelin levels. Incretin hormones are modestly but significantly increased after subtotal gastrectomy; however, these changes did not affect the weight changes.

레진 표면처리제가 열가소성 의치상 레진과 자가중합형 이장 레진 간의 결합강도에 미치는 여향

정창모,문태성 大韓齒科器材學會 2001 대한치과재료학회지 Vol.28 No.4

The introduction of several thermoplastic polymers was intended to overcome the disadvantages of methacrylate denture base resins. Existing dentures often require denture base relines to improve the fit against the tissue bearing mucosa because of gradual changes of underlying bone structure. Chair-side reline that used autopolymerizing acrylic resin is not only convenient but inexpensive means to improve the fit and function of denture bases. However, it is not known whether the differences in chemical composition of resin surface primers affect the bonding strengths between chair-side reline resin and thermoplastic denture base resin. This study evaluated two kinds of primers(exclusive primer recommended by manufacture of thermoplastic resin and primer supplied with chair-side reline resin) to determined their effect on the bond strengths of a chair-side reline resin to two different thermoplastic denture base resins(polycarbonate and polyacetal resin) by use of a three-point transverse flexural strength test. In both polycarbonate and polyacetal resin, each exclusive resin surface primer resulted in higher bond strength than chair-side reline resin primer(p<0.05). Bond strengths of polycarbonate with chair-side reline resin were higher than those of polyacetal resin, despite the type of resin surface primer(p<0.05).

다발성 골수종으로 이행한 단일형질세포종 1예

정재용,모성환,기장도,문철호,김창욱,전용준,박유환,정춘해,오윤경 조선의대 1995 The Medical Journal of Chosun University Vol.20 No.2

Thiabendazole에 衣한 腸內線?의 驅?實驗

金鍾煥,朴柄宰,文昌模,蘇鎭琸 中央醫學社 1941 中央醫學 Vol.10 No.2

Clinical trials of Thiabendazole(HK-8642) suspension upon 62 cases included 37 ascaris infestations, 34 trichiural infestations, 23 hook worm. infestations and 6 Trichostrongylus orientalis infestations were reported, and they were medicated with Thiabendazole approximately 50 mg/kg body weight. 1. 56.8% negative conversion rate among ascaris infestations, 11.4% among trichiural infestations, 26.1% among hook worm cases and 66.7% of 'T. orientalis cases were observed at 10 days after the medication of Thiabendazole respectively. 2. The reduction rates of E.P.G. (egg per gram) were 84.4% in ascaris cases, 34.4 in trichiural cases, 31.5% in hook worm cases and 73. 3% in T. orientalis cases. 3. The side effects were observed 33 cases(84.6%)out of 39 cases and the main symptoms were dizzeness(51%), nausea(41%) headache(41%), fever(24%), and vomiting(21%) No abnormal :laboratory findings in hematology, in blood chemistry and in urinalysis among 5 cases who were medicated.

IL-10 Plays a Pivotal Role in Tamoxifen-Induced Spasmolytic Polypeptide-Expressing Metaplasia in Gastric Mucosa

( Chansu Lee ),( Hyuk Lee ),( Seo Yun Hwang ),( Chang Mo Moon ),( Sung Noh Hong ) 대한간학회 2017 Gut and Liver Vol.11 No.6

Background/Aims: Gastric cancer evolves in the pathologic mucosal milieu, and its development is characterized by both the loss of acid-secreting parietal cells and mucosal cell metaplasia, called spasmolytic polypeptide-expressing metaplasia (SPEM). Cytokines, such as interleukin (IL)-10, IL-1β, and IL-6, play a key role in gastric carcinogenesis. However, changes in the cytokine profile of SPEM have not been evaluated. Methods: To induce SPEM in mouse stomachs, C57BL/6 mice were intraperitoneally injected with tamoxifen and sacrificed at 3, 10, and 21 days after treatment. RNA-sequencing (RNA-seq) and a multiplex bead array were used to measure cytokines in the stomachs of tamoxifen-treated/control mice. Results: The administration of tamoxifen led to the rapid development and histological normalization of SPEM 3 and 10 days after administration, respectively. RNA-seq revealed that the expression of IL-10 was decreased 3 days after tamoxifen administration. The multiplex assay identified a significant decline in IL-10 levels 3 days after tamoxifen treatment (58.38±34.44 pg/mL vs 94.09±4.98 pg/mL, p=0.031), which normalized at 10 and 21 days after tamoxifen treatment. Immunofluorescence staining confirmed that IL-10 expression was markedly decreased at the time of SPEM development and subsequently returned to normal, accompanied by a reversal in histologic changes. Conclusions: IL-10 may play a pivotal role in the tamoxifen-induced acute development of gastric SPEM. (Gut Liver 2017;11:789-797)

Poster Session : PS 0850 ; Upper GI Tract : Gastric Sarcoidosis Accompanied with Non-Specifi c Lymphadenopathy

( Sohyeon Hong ),( Min Sun Ryu ),( Kwang Jin Woo ),( Jeong Mi Lee ),( Heywon Yoon ),( Chunghyun Tae ),( Chang Mo Moon ),( Seongeun Kim ),( Hyekyung Jung ),( Sungae Jung ),( Kinam Shim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Gastric sarcoidosis is a rare disease accounting for 0.1-0.9 % of all sarcoidosis. We report our experience with a patient with lung and stomach sarcoidosis accompanied by an enlarged abdominal lymph nodes. A sixty-year-old female patient visited our hospital with an abnormal chest x-ray. The patient has no smoking history and no noticeable medical history. There were no fever, cough, dyspnea, nor weight changes. Physical examination showed clear breathing sound and no palpable lymph node. The chest x-ray showed reticular opacity in the right lower lung zone and chest computed tomography indicated that it was an interstitial thickening in the right middle and right lower lobes. A soft tissue density nodule, 9 mm in diameter, neighboring inferior pulmonary vein was also found. Furthermore, multiple enlarged lymph nodes were observed in the left gastric vessel area, which could be suspected as metastatic lymphadenopathy of intra-abdominal malignancy. Abdominal computed tomography showed that the enlarged lymph node spanned over left gastric area, splenic artery area, greater omentum, and gastro-colic trunk, with no mass or thickening in the walls of the stomach. Esophagogastroduodenoscopy revealed a satellite-shaped shallow whitish discoloration accompanied by mucosal irregularity in the anterior wall side of lower body and mucosal depression in the greater curvature side of lower body. Biopsies on both lesions showed chronic active gastritis with foreign-body type granuloma and Sydney grade 1 Helicobacter pylori. Laparoscopic biopsy on intra-abdominal lymph node was conducted. It was negative in mycobacterium tuberculosis and non-tuberculous mycobacterium, confi rming multiple well-formed non-caseating granulomas, satisfying our diagnosis as sarcoidosis. The patient was prescribes with methylprednisolone and follow-up CT 6 months after treatment indicated signifi cant improvement.

Associations between genetic variants in the IRGM gene and inflammatory bowel diseases in the Korean population.

Moon, Chang Mo,Shin, Dong-Jik,Kim, Seung Won,Son, Nak-Hoon,Park, Ahram,Park, Boram,Jung, Eun Suk,Kim, Eun Soo,Hong, Sung Pil,Kim, Tae Il,Kim, Won Ho,Cheon, Jae Hee Raven Press 2013 Inflammatory bowel diseases Vol.19 No.1

<P>Recent European ancestry genome-wide association studies have identified genetic variants of IRGM as significant susceptibility loci for Crohn's disease (CD). Therefore, we investigated whether genetic variants of IRGM confer genetic susceptibility to CD or ulcerative colitis (UC) and evaluated the genotype-phenotype associations in the Korean population.</P>

Poster Session : PS 0880 ; Lower GI Tract : Clinical Factors and Disease Course Associated with Diagnostic Delay in Korean Patients with Crohn`s Disease; Results from the Connect Study

( Chang Mo Moon ),( Sung Ae Jung ),( Seong Eun Kim ),( Byong Duk Ye ),( Jae Hee Cheon ),( You Sun Kim ),( Young Ho Kim ),( Joo Sung Kim ),( Dong Soo Han ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Crohn`s disease (CD) is the chronic and disabling inflammatory disorder of the gastrointestinal tract over time. Diagnostic delay frequently occurs in CD patients due to its unspecific clinical symptoms and inappropriate diagnostic accuracies. However, Diagnostic delay and its related clinical factors remain elusive. Thus, this study aimed to identify clinical factors associated with diagnostic delay and to evaluate the impact of diagnostic delay on clinical course in a Korean CD cohort. Methods: We conducted a retrospective multicenter analysis of a total of 1,306 CD patients registered in the Crohn`s disease clinical network and cohort (CONNECT) study in Korea. Diagnostic delay was defined as the time period from consulting a physician for specific symptoms to establishment of CD diagnosis. Results: The mean period of diagnostic delay was 16.1 ± 32.3 months. In multivariate analysis, female gender, concomitant upper gastrointestinal (UGI) disease, penetrating disease behavior at diagnosis were significantly associated with long diagnostic delay (> 12 months) (p < 0.05). When analyzed the association of clinical variables with the risk of CD-related abdominal surgery, there was no significant difference among diagnostic delay groups. In contrast, diagnostic delay (> 18 months) was independently predictive of further development of intestinal stenosis (hazard ratio [HR], 1.42; 95% confidence interval [CI], 1.11 to 1.83; p = 0.006) and internal fistula (HR, 1.39; 95% CI, 1.03 to 1.89; p = 0.033). Conclusions: Diagnostic delay occurs in a considerable number of Korean CD patients and female gender, UGI involvement, and penetrating disease behavior are related to the diagnostic delay. Diagnostic delay is significantly associated with an increased risk of CD-related complications such as intestinal stenosis and internal fistula.

Prediction of Free Bowel Perforation in Patients with Intestinal Behçet’s Disease Using Clinical and Colonoscopic Findings

Moon, Chang Mo,Cheon, Jae Hee,Shin, Jae Kook,Jeon, Soung Min,Bok, Hyun Jung,Lee, Jin Ha,Park, Jae Jun,Hong, Sung Pil,Kim, Tae Il,Kim, Nam Kyu,Kim, Won Ho Springer-Verlag 2010 Digestive diseases and sciences Vol.55 No.10

SELECTED SUMMARY : New Treatment Option for Recurrent Clostridium difficile Infection

( Chang Mo Moon ) 대한장연구학회 2013 Intestinal Research Vol.11 No.2

Clostridium difficile 감염은 주로 항생제 복용 이후 발생하는 원외 또는 원내 설사의 주요 원인으로, 최근 그 빈도가 증가하고 있으며, 표준 치료에 반응하지 않거나 재발하는 경우가 늘고 있는 추세이다. 현재 metronidazole 또는 경구 vancomycin을 이용한 치료는 높은 재발률 등으로 인해서 만족스럽지 못한 상황이다. 이러한 항생제는 C. difficile에 대해서 저항성을 부여하는 정상 장세균총을 변경시키는 문제가 있다. 성공적인 초기 치료에도 항생제 중단 이후 35% 이상의 환자들이 재발을 경험하게 되며, 재발하는 C. difficile 감염은 거대결장, 천공, 쇼크, 또는 사망에 이르는 심각한 합병증과 연관될 수 있다. 이에 연구자들은 재발한 C. difficile 감염 치료로서 분변 이식의 효과를 분석하고자 하였다. 5개 기관에서 분변 이식을 시행받은 재발성 C. difficile 환자 70명의 임상기록을 후향적으로 조사하였으며, 분변 이식은 대장내시경으로 맹장에 신선한 공여자의 분변을 주입하는 방법을 사용하였다. 포함된 환자들은 모두 일반적인 치료에 불응성이었고, 대변 공여자는 최근 6개월 이상 항생제 치료를 받지 않고 어떤 위장관 증상도 없는 사람들로서, 친척, 배우자, 직계 가족들을 우선적으로 고려하였다. 대상환자는 분변 이식 전 4 L polyethylene glycol 용액으로 충분히 장정결을 시행하였으며, 12주 후에 임상 양상을 확인하였고, 치료 실패는 C. difficile 독소 대변 검사 양성과 함께 지속적인 설사로 정의하였다. 이렇게 진행한 연구 결과, 분변 이식 12주 후 027 C. difficile (C. difficile 균주 중 virulence가 높은 것으로 알려져 있으며, 감염 환자에서 중증 설사 증세와 높은 사망률과 재발률이 보고되어 있는데, 이에 대한 한 연구에서는 다른 균주와 비교하여 보다 낮은 치료 반응률[86.6% vs. 94.3%, P<0.001]과 높은 재발률[27.4% vs. 16.6%]을 보고하였음6)을 제외한 모든 환자에서 증상 개선을 확인하였다. 또한 027 C. difficile 감염환자 36명 중 32 환자(89%)에서 증상 호전을 보였으며, 반응이 없었던 4명의 환자들은 모두 심각한 동반 질환을 가지고 있었다. 분변 이식 후 첫 1년 동안, 초기 좋은 반응을 보였던 환자들 중 4명에서 C. difficile 감염 재발이 발생하였는데, 이들 중 2명은 다시 분변 이식으로, 나머지 2명은 항생제 치료로 호전되었다. 분변 이식 후 이와 관련된 초기 합병증은 관찰되지 않았다. 이에 연구자들은 대장내시경을 이용한 분변 이식이 027 C. difficile 균주를 포함한 재발성 C. difficile 감염에 효과적인 치료가 될 수 있다고 제안하였다.